#032 Justin Maguire - Everything to know about Immunometabolism and the Cell Danger Response
Justin Maguire is a multidisciplinary practitioner and educator with a rich background in biochemistry, physiology, psychology and precision nutrition.
Specialising in complex health conditions such as chronic fatigue, PCOS, and neuroinflammatory disorders, Justin integrates cutting-edge research with genetic functional testing to craft highly personalised protocols for his clients. His work is deeply informed by systems biology and principles of psychoneuroimmunology, offering clients both clarity and practical tools for transformation.
Justin has shared his expertise as a speaker at international health summits, including the Health Optimisation Summit in 2022 and 2023. He also appeared at BodyPower in 2014 and 2015, engaging with audiences on topics related to health and wellness. Additionally, Justin has made guest appearances on various health and wellness podcasts, discussing topics pertinent to his field. As an accomplished author, he has published works that delve into his areas of specialization, further contributing to the broader discourse on health optimisation.
> During our discussion, you’ll discover:
(00:03:55) Justin's Journey: From Fitness to Integrative Health
(00:09:50) The Impact of Emotional Health on Physical Well-being
(00:13:00) Navigating Long-Haul COVID and Autonomic Coaching
(00:16:00) The Need for Holistic Healthcare
(00:21:18) Community-Centric Healthcare
(00:27:52) Understanding the Immune System
(00:35:07) Immunometabolism Explained
(00:53:36) Understanding Cell Danger Response (CDR) States
(00:58:38) The Impact of Modern Stressors on Health
(01:14:32) Exploring CDR2 and Its Pathological Associations
(01:32:05) Understanding Estrogen Dominance and Histamine Activity
(01:35:40) The Role of Gut Health in Immune Dysfunction
(01:48:52) The Barker Hypothesis and Lifespan Health
(01:52:29) Psychological Stress and Metabolic Dysfunction
(02:01:13) Rapid Fire Questions and Key Nutritional Insights
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Transcript
Welcome to the VP
Speaker:Live podcast, the
Speaker:show where we
Speaker:bring you
Speaker:actionable health
Speaker:advice for
Speaker:revealing minds.
Speaker:I'm your
Speaker:host, Rob.
Speaker:My guest today is
Speaker:Justin McGuire, a
Speaker:South
Speaker:African-based
Speaker:holistic health
Speaker:and performance
Speaker:coach who works
Speaker:with clients to
Speaker:help them
Speaker:optimize all
Speaker:aspects of their
Speaker:health and lives.
Speaker:Today's
Speaker:conversation
Speaker:centers around
Speaker:how the immune
Speaker:system ultimately
Speaker:governs
Speaker:metabolism.
Speaker:And while we
Speaker:certainly get
Speaker:into the weeds
Speaker:today, I really
Speaker:encourage you to
Speaker:listen through,
Speaker:as the
Speaker:information
Speaker:Justin provides
Speaker:is nothing short
Speaker:of pure gold.
Speaker:Expect to learn
Speaker:how the immune
Speaker:system actually
Speaker:operates, why
Speaker:chronic
Speaker:inflammation
Speaker:might actually be
Speaker:the cause of
Speaker:weight gain in so
Speaker:many populations,
Speaker:and Justin's top
Speaker:picks for
Speaker:nutrients that
Speaker:help to improve
Speaker:immune system
Speaker:function.
Speaker:Now, on to the
Speaker:conversation with
Speaker:Justin McGuire.
Speaker:Hey, Justin,
Speaker:thanks for
Speaker:being here.
Speaker:We've rubbed
Speaker:shoulders over
Speaker:the years, but
Speaker:we've never
Speaker:really sat down
Speaker:to have a
Speaker:conversation
Speaker:as such.
Speaker:So I'm excited to
Speaker:have this
Speaker:opportunity to
Speaker:pick your brain
Speaker:on this topic,
Speaker:which is
Speaker:something I'm
Speaker:becoming more and
Speaker:more passionate
Speaker:about by the day.
Speaker:And that's this
Speaker:concept of
Speaker:immunomatabolism.
Speaker:The idea, loosely
Speaker:speaking, that
Speaker:the metabolism is
Speaker:mediated, to some
Speaker:degree, by the
Speaker:immune system and
Speaker:vice versa.
Speaker:And again, just
Speaker:the idea that
Speaker:subsequently a
Speaker:lot of disease
Speaker:can be viewed
Speaker:through this lens
Speaker:and potentially
Speaker:solved through
Speaker:this lens
Speaker:as well.
Speaker:I know for the
Speaker:listeners that
Speaker:that probably
Speaker:sounds pretty
Speaker:convoluted, but I
Speaker:promise we'll
Speaker:break it down
Speaker:shortly.
Speaker:First, though,
Speaker:I'd love to learn
Speaker:a little more
Speaker:about you.
Speaker:I know through
Speaker:something of your
Speaker:story, through
Speaker:our mutual friend
Speaker:Ben Law, that
Speaker:beyond that, I'm
Speaker:ashamed to say I
Speaker:don't actually
Speaker:know too much
Speaker:about your
Speaker:backstory, but
Speaker:I'd love to
Speaker:understand a bit
Speaker:more about how
Speaker:you ended up in
Speaker:this sort of
Speaker:integrative
Speaker:health and
Speaker:performance
Speaker:space.
Speaker:It's good
Speaker:to be here.
Speaker:Thank you, Rob.
Speaker:Looking forward
Speaker:to sharing some
Speaker:insight.
Speaker:So my story is an
Speaker:interesting one.
Speaker:I just actually
Speaker:had a
Speaker:conversation with
Speaker:one of my
Speaker:metaphysicians.
Speaker:And yes, I'm
Speaker:probably the most
Speaker:hippie scientist
Speaker:you're ever going
Speaker:to come across.
Speaker:And in our
Speaker:conversation this
Speaker:morning, it was
Speaker:the fact that
Speaker:I've literally
Speaker:gone through four
Speaker:major personas
Speaker:just during this
Speaker:one single
Speaker:lifetime itself.
Speaker:So my previous
Speaker:persona narrative
Speaker:was very
Speaker:different as
Speaker:opposed to whom I
Speaker:am now today.
Speaker:And I think this
Speaker:can, many people,
Speaker:not many, but
Speaker:some may attest
Speaker:to having
Speaker:experienced the
Speaker:contrast of self.
Speaker:So my former life
Speaker:in my 20s and my
Speaker:teens, I was
Speaker:competitive in
Speaker:the fitness world
Speaker:and bodybuilding
Speaker:and martial arts
Speaker:and so on.
Speaker:I was a personal
Speaker:trainer.
Speaker:And it served
Speaker:purpose
Speaker:for a while.
Speaker:However, it
Speaker:didn't provide me
Speaker:with the mental
Speaker:stimulus that I
Speaker:inherently was
Speaker:craving.
Speaker:Suffice to say,
Speaker:like a soul,
Speaker:well, again,
Speaker:maybe not like a
Speaker:soul, these
Speaker:definitive
Speaker:statements really
Speaker:get me sometimes.
Speaker:And the more
Speaker:conscious you
Speaker:become, the more
Speaker:aware you are of
Speaker:the words you
Speaker:choose to use.
Speaker:For some of us,
Speaker:we go through
Speaker:dark nights of
Speaker:assault, some of
Speaker:which are
Speaker:self-inflicted in
Speaker:terms of the
Speaker:sequence of
Speaker:events that
Speaker:lead to it.
Speaker:Others are
Speaker:inflicted
Speaker:upon us.
Speaker:But for whatever
Speaker:reason it is that
Speaker:we, or however it
Speaker:is that we end up
Speaker:there, we go
Speaker:through a moment
Speaker:of reflection.
Speaker:So that happened
Speaker:in my 30th and
Speaker:31st year,
Speaker:between the 30
Speaker:and the 31st year
Speaker:of my life.
Speaker:And then shortly
Speaker:thereafter,
Speaker:having gone
Speaker:through that very
Speaker:extreme moment in
Speaker:my life, of which
Speaker:the majority of
Speaker:it was actually
Speaker:impacted by my
Speaker:own poor
Speaker:decisions,
Speaker:admittedly.
Speaker:But not knowing
Speaker:as to, at that
Speaker:time in my life,
Speaker:not knowing as to
Speaker:why it is that I
Speaker:had a propensity
Speaker:to create, to
Speaker:have, to choose
Speaker:wrongly.
Speaker:And only later on
Speaker:that I started to
Speaker:discover that
Speaker:there were so
Speaker:many more layers
Speaker:into the
Speaker:complexity of
Speaker:life,
Speaker:particularly our
Speaker:lives, that can
Speaker:influence one's
Speaker:perception and
Speaker:thus one's own
Speaker:personal
Speaker:identity.
Speaker:And when we are
Speaker:in a state of
Speaker:water pilot, and
Speaker:particularly if
Speaker:we're not
Speaker:self-conscious,
Speaker:we're not
Speaker:conscious of
Speaker:self, not
Speaker:self-conscious,
Speaker:we're not
Speaker:conscious of
Speaker:self, it can lead
Speaker:us astray.
Speaker:So in any case, I
Speaker:would let myself
Speaker:astray based upon
Speaker:a whole lot of
Speaker:variables that
Speaker:are unnecessary
Speaker:to divulge into,
Speaker:because it's not
Speaker:about what led
Speaker:you there, it's
Speaker:the fact that it
Speaker:happened, and
Speaker:what are you
Speaker:gonna do
Speaker:about it?
Speaker:Where taking
Speaker:responsibility
Speaker:requires letting
Speaker:go of things that
Speaker:got you there,
Speaker:but taking full
Speaker:hold of what it
Speaker:is that you were,
Speaker:or what it is
Speaker:that you are, and
Speaker:wanting to
Speaker:change, unless
Speaker:you don't
Speaker:want to change.
Speaker:And if life is
Speaker:going the right
Speaker:direction, I want
Speaker:me to keep on
Speaker:doing what it is
Speaker:that you feel
Speaker:necessary, but
Speaker:mine wasn't.
Speaker:And I was
Speaker:confronted with
Speaker:an opportunity to
Speaker:either pass away,
Speaker:because
Speaker:literally, that's
Speaker:how thin my
Speaker:lifeline was, or
Speaker:to make a change.
Speaker:And I made a
Speaker:change, and
Speaker:subsequently
Speaker:making a change,
Speaker:and the universe
Speaker:really threw a
Speaker:spanner into the
Speaker:works and
Speaker:challenged me to
Speaker:yet
Speaker:another degree.
Speaker:And about 18
Speaker:months after I'd
Speaker:made a change,
Speaker:I went through a
Speaker:bit of a depth,
Speaker:an emotional
Speaker:depth that
Speaker:resulted in a...
Speaker:What happens when
Speaker:you've been
Speaker:sober, and then
Speaker:you slip up?
Speaker:Oh, come on, it's
Speaker:such a
Speaker:simple word.
Speaker:Uh, this is like
Speaker:the blind,
Speaker:in the blind.
Speaker:Relapse, relapse,
Speaker:relapse.
Speaker:Gosh, it's just
Speaker:the simplest
Speaker:words, right?
Speaker:It's just funny.
Speaker:So it resulted,
Speaker:this is what
Speaker:happens off the
Speaker:COVID, right?
Speaker:It's like all the
Speaker:complex words, no
Speaker:problem, but the
Speaker:simple things of
Speaker:joining krumjags
Speaker:is like really
Speaker:the word you
Speaker:wanna...
Speaker:And perhaps I've
Speaker:blocked it out of
Speaker:my psyche, to
Speaker:some
Speaker:extent, as well.
Speaker:Yeah, this is
Speaker:where you just
Speaker:eat all the urode
Speaker:monophosphate and
Speaker:just pray, yeah,
Speaker:and I can
Speaker:understand that.
Speaker:(Laughing) So anyway, it
Speaker:resulted in a
Speaker:relapse.
Speaker:And in that
Speaker:relapse, I had
Speaker:to, once again,
Speaker:revisit what it
Speaker:was that I had
Speaker:not been
Speaker:addressing.
Speaker:And I think as
Speaker:many men, from
Speaker:our generation at
Speaker:least, and
Speaker:generations
Speaker:prior, we were
Speaker:taught to pretty
Speaker:much suppress the
Speaker:expression of
Speaker:emotions and to
Speaker:just
Speaker:tough it out.
Speaker:Blood-swayed
Speaker:interiors is the
Speaker:motto of our
Speaker:generation.
Speaker:So yeah, with
Speaker:that, just the
Speaker:avoidance sets
Speaker:in, right?
Speaker:So you'll find
Speaker:elaborate ways to
Speaker:avoid what's
Speaker:actually going on
Speaker:within yourself,
Speaker:particularly by
Speaker:way of expression
Speaker:of ego, which
Speaker:didn't help much,
Speaker:I'm grateful for
Speaker:my body, which
Speaker:that's
Speaker:like I have.
Speaker:But in being able
Speaker:to build muscle
Speaker:quite quickly, I
Speaker:was able to build
Speaker:up a persona and
Speaker:ego to avoid a
Speaker:lot of things
Speaker:really
Speaker:easily as well.
Speaker:(Laughing) So, and see
Speaker:whether the
Speaker:relapse happened,
Speaker:came out of that,
Speaker:and things then
Speaker:really started to
Speaker:settle for me,
Speaker:like really
Speaker:started to shift.
Speaker:The foundation
Speaker:started to shift
Speaker:into a whole new
Speaker:dimension of
Speaker:self-experience.
Speaker:And then
Speaker:subsequently, I
Speaker:was doing really
Speaker:well, and then
Speaker:literally six
Speaker:months
Speaker:thereafter, yet
Speaker:another layer of
Speaker:complexity.
Speaker:The universe is
Speaker:like, okay, you
Speaker:ready for the
Speaker:next test?
Speaker:You ready for the
Speaker:next test?
Speaker:You ready for the
Speaker:next test?
Speaker:And then I
Speaker:developed
Speaker:Polymalgeoromatica.
Speaker:Now this is an
Speaker:autoimmune
Speaker:disease that
Speaker:mostly afflicts
Speaker:people over the
Speaker:age of 55.
Speaker:It's an extreme
Speaker:debilitating
Speaker:autoimmune
Speaker:condition, this
Speaker:chronic low grade
Speaker:inflammation that
Speaker:impacts not only
Speaker:pain in the body,
Speaker:but also causes a
Speaker:lot of
Speaker:neuroinflammatory
Speaker:outcomes and
Speaker:symptoms.
Speaker:So I went to
Speaker:every specialist,
Speaker:I mean, I spent
Speaker:money that I
Speaker:didn't have to
Speaker:try and get into
Speaker:the best
Speaker:specialist.
Speaker:And 12th of the
Speaker:best specialists
Speaker:in the country
Speaker:later, I was told
Speaker:it's all
Speaker:psychosomatic.
Speaker:Now, I mean, the
Speaker:intensity of the
Speaker:pain was so bad
Speaker:that I literally
Speaker:couldn't sleep
Speaker:for three or five
Speaker:days at a time.
Speaker:So it had three
Speaker:or five days of
Speaker:perpetual
Speaker:insomnia.
Speaker:Long story short,
Speaker:this sounds like
Speaker:a big dramatic
Speaker:narrative, and I
Speaker:would actually
Speaker:cut it short
Speaker:because it's not
Speaker:about that.
Speaker:It's about what
Speaker:it actually
Speaker:taught me.
Speaker:And what it
Speaker:taught me is
Speaker:that, no matter
Speaker:how good the
Speaker:intention of the
Speaker:person, because I
Speaker:don't believe any
Speaker:of these
Speaker:specialists, and
Speaker:this is where the
Speaker:polarity of
Speaker:fitness
Speaker:communities or
Speaker:biohacking
Speaker:communities or
Speaker:precision
Speaker:medicine or
Speaker:functional
Speaker:medicine
Speaker:communities can
Speaker:really lead
Speaker:people astray.
Speaker:Doctors are not
Speaker:at fault.
Speaker:I'm gonna make
Speaker:the statement
Speaker:right there.
Speaker:Doctors are not
Speaker:at fault.
Speaker:Like to get into
Speaker:medical school,
Speaker:do you know how
Speaker:much discipline
Speaker:and dedication it
Speaker:requires?
Speaker:Literally
Speaker:finishing it.
Speaker:It's not the
Speaker:intention of
Speaker:these individuals
Speaker:to not
Speaker:help people.
Speaker:It's actually the
Speaker:intention to be
Speaker:of service.
Speaker:It's the
Speaker:institution that
Speaker:is the problem.
Speaker:And the
Speaker:institution has
Speaker:led people astray
Speaker:into
Speaker:compartmentalizing
Speaker:their health.
Speaker:And because I
Speaker:wasn't able to be
Speaker:fit in, because
Speaker:they weren't able
Speaker:to fit me
Speaker:into a box.
Speaker:Paradigm, yeah.
Speaker:Into a paradigm,
Speaker:I became the
Speaker:psychosomatic
Speaker:patient.
Speaker:Despite all the
Speaker:symptoms that
Speaker:we're saying
Speaker:otherwise.
Speaker:Yes, most
Speaker:certainly there
Speaker:is some truth to
Speaker:that as well.
Speaker:I won't say that
Speaker:they were
Speaker:entirely wrong.
Speaker:There is most
Speaker:certainly some
Speaker:truth to it.
Speaker:But the truth
Speaker:came in that,
Speaker:yes, there were
Speaker:some psycho,
Speaker:there were many,
Speaker:not some, there
Speaker:were many
Speaker:psychological
Speaker:traumas that were
Speaker:coming up to the
Speaker:surface, which
Speaker:were expressing
Speaker:themselves
Speaker:on my body.
Speaker:I didn't know
Speaker:this at the time.
Speaker:I mean, this is
Speaker:like, you know, I
Speaker:was a bodybuilder
Speaker:two years prior
Speaker:to that.
Speaker:Competing, sorry,
Speaker:a year
Speaker:prior to that.
Speaker:I had done my
Speaker:last
Speaker:bodybuilding show.
Speaker:So I was in that
Speaker:whole fitness
Speaker:community, like,
Speaker:you know, Grant
Speaker:Go, Grant and Go,
Speaker:5am Club, you
Speaker:know, Hell's
Speaker:Bells, off
Speaker:your squat.
Speaker:So I don't really
Speaker:know like, you
Speaker:know, like the
Speaker:somatic impact
Speaker:that can happen
Speaker:from emotional
Speaker:response.
Speaker:I mean, I heard
Speaker:of it, but I kind
Speaker:of, to be honest
Speaker:with you, I
Speaker:thought it was a
Speaker:bit of a hogwash.
Speaker:I thought it was
Speaker:like, it's the
Speaker:things that
Speaker:esoteric believe
Speaker:in kind of
Speaker:thing, right?
Speaker:But a little bit,
Speaker:I know how
Speaker:truthful that
Speaker:actually was.
Speaker:So much
Speaker:truth to it.
Speaker:So it went wrong
Speaker:that it was part,
Speaker:it had
Speaker:psychosomatic,
Speaker:there was certain
Speaker:elements of
Speaker:psychosomatic
Speaker:contribution
Speaker:toward my state.
Speaker:But this is where
Speaker:like, again, in
Speaker:the human
Speaker:dualistic
Speaker:perceptive
Speaker:paradigm, we
Speaker:separate things.
Speaker:We forget that
Speaker:there's actually
Speaker:continuity in
Speaker:everything.
Speaker:And this is where
Speaker:one of my
Speaker:favorite writings
Speaker:of all time, it's
Speaker:actually an
Speaker:essay, it's not a
Speaker:book by Antoine
Speaker:Fabre de la Vie,
Speaker:and he wrote his
Speaker:essay in the
Speaker:late 1700s.
Speaker:And the essay is
Speaker:entitled, "The
Speaker:Metaphysical and
Speaker:Intellectual
Speaker:Constitution
Speaker:of Man."
Speaker:Within this
Speaker:essay, he has a
Speaker:graphical
Speaker:depiction of the
Speaker:intersection.
Speaker:Within his
Speaker:semantics, he
Speaker:doesn't use mind,
Speaker:body and soul, he
Speaker:uses soul, spirit
Speaker:and body.
Speaker:But basically
Speaker:they depict what
Speaker:we understand to
Speaker:be mind, body and
Speaker:soul, and the
Speaker:difference of
Speaker:emotional
Speaker:intersect that
Speaker:can happen
Speaker:depending upon
Speaker:where we are in
Speaker:our state of
Speaker:consciousness,
Speaker:whether it is
Speaker:more so in the
Speaker:anima, the
Speaker:animus, or
Speaker:whether it's more
Speaker:in God
Speaker:consciousness and
Speaker:everything in
Speaker:between.
Speaker:So in looking at
Speaker:that model,
Speaker:knowing that
Speaker:whatever happens
Speaker:to the mind
Speaker:happens to the
Speaker:body, certainly,
Speaker:but whatever's
Speaker:happening to the
Speaker:body can
Speaker:perpetuate what's
Speaker:happening in the
Speaker:mind as well.
Speaker:And this is one
Speaker:of the first big
Speaker:pieces of the
Speaker:puzzle that came
Speaker:together.
Speaker:I had probably,
Speaker:I had done it on
Speaker:my own, because I
Speaker:didn't
Speaker:have any help.
Speaker:I went to
Speaker:everybody and
Speaker:they put me on
Speaker:pregnancy zone
Speaker:and they put me
Speaker:on
Speaker:anti-psychotics
Speaker:and everything
Speaker:else, which just
Speaker:made me worse.
Speaker:Yeah, so as I was
Speaker:saying, so I
Speaker:didn't have
Speaker:pretty much any
Speaker:help from the
Speaker:specialists,
Speaker:although they had
Speaker:good attention,
Speaker:they weren't able
Speaker:to fit me into a
Speaker:model, into
Speaker:like a mold.
Speaker:So I had to
Speaker:pretty much
Speaker:figure myself
Speaker:out, which was
Speaker:quite
Speaker:frustrating,
Speaker:because you look
Speaker:into my
Speaker:historical
Speaker:education behind
Speaker:biochemistry,
Speaker:which I had a
Speaker:very basic
Speaker:biochemical, I
Speaker:mean, it was
Speaker:self-taught in
Speaker:the early part of
Speaker:my, I later on
Speaker:got degrees, in
Speaker:my thirties
Speaker:subsequently
Speaker:after this, I got
Speaker:foundation
Speaker:degrees and then
Speaker:I got a
Speaker:bachelor's and so
Speaker:on at Biochem.
Speaker:But in my
Speaker:twenties, it's
Speaker:very basic.
Speaker:And I thought I
Speaker:had to basically
Speaker:start my whole
Speaker:journey in
Speaker:front of it.
Speaker:But anyway, long
Speaker:story short, when
Speaker:the student is
Speaker:ready, the
Speaker:teacher will
Speaker:appear, and along
Speaker:my journey, I
Speaker:started to be, I
Speaker:was introduced to
Speaker:certain function
Speaker:medicine doctors,
Speaker:integrated
Speaker:medicine doctors,
Speaker:all of which
Speaker:actually provided
Speaker:educational
Speaker:resources as
Speaker:well, which I put
Speaker:myself through,
Speaker:when I had the
Speaker:financial reasons
Speaker:to do so, which
Speaker:was quite tough.
Speaker:I mean, as you
Speaker:probably are
Speaker:aware of, having
Speaker:had long haul
Speaker:COVID-19 for two
Speaker:years, it's
Speaker:really difficult
Speaker:to manage earning
Speaker:a living whilst
Speaker:being chronically
Speaker:fatigued, right?
Speaker:And brain fog to
Speaker:boot on top of
Speaker:that, let alone
Speaker:the physical pain
Speaker:that can also
Speaker:sporadically
Speaker:creep in when
Speaker:there's not
Speaker:enough cortisol
Speaker:to mitigate the
Speaker:inflammation.
Speaker:So I did what I
Speaker:could, and it was
Speaker:a journey.
Speaker:It was probably
Speaker:the best PhD I've
Speaker:ever earned in
Speaker:life going
Speaker:through that
Speaker:journey,
Speaker:which birthed the
Speaker:opportunity to
Speaker:start autonomic
Speaker:coaching.
Speaker:And autonomic
Speaker:coaching is a
Speaker:conceptual birth
Speaker:child of mine,
Speaker:within which I
Speaker:truly am trying
Speaker:to continue to
Speaker:expand a honest
Speaker:interdisciplinary
Speaker:approach.
Speaker:Because again, I
Speaker:just wanna
Speaker:emphasize,
Speaker:doctors are not
Speaker:at fault.
Speaker:You can't blame,
Speaker:it's like putting
Speaker:somebody in a
Speaker:label and saying
Speaker:because they put
Speaker:11 years of their
Speaker:life into
Speaker:educating
Speaker:themselves to do
Speaker:a certain
Speaker:discipline, now
Speaker:they're evil.
Speaker:Like where's the
Speaker:logic of that?
Speaker:They're
Speaker:not at fault.
Speaker:It's just that
Speaker:there are many
Speaker:other ways apart
Speaker:from allopathy as
Speaker:to how one can
Speaker:approach
Speaker:remedying for
Speaker:health, okay?
Speaker:And this is where
Speaker:autonomic
Speaker:coaching comes
Speaker:in, and we
Speaker:provide
Speaker:allopathic
Speaker:support, we
Speaker:provide
Speaker:naturopathic
Speaker:support, we
Speaker:provide
Speaker:psychological
Speaker:support, we
Speaker:provide lifestyle
Speaker:coaching as well.
Speaker:So it's the whole
Speaker:kitchen computer,
Speaker:the whole
Speaker:paradigm to
Speaker:support the
Speaker:individual.
Speaker:This is where
Speaker:inductive
Speaker:reasoning is, we
Speaker:are able to
Speaker:enable inductive
Speaker:reasoning within
Speaker:this paradigm.
Speaker:You know,
Speaker:evidence-based
Speaker:medicine is based
Speaker:on the reductive
Speaker:model so that one
Speaker:can take
Speaker:deductive
Speaker:outcomes from it,
Speaker:which is great
Speaker:for the populace,
Speaker:for the masses.
Speaker:But there's a
Speaker:shortfall within
Speaker:the outliers of
Speaker:those who don't
Speaker:fit into
Speaker:the mold.
Speaker:And this is where
Speaker:inductive
Speaker:reasoning
Speaker:comes in.
Speaker:So most of the
Speaker:people that come
Speaker:to see us,
Speaker:come to see us
Speaker:after they've
Speaker:been to many
Speaker:different
Speaker:practitioners,
Speaker:alternative as
Speaker:well as
Speaker:conventional, and
Speaker:they just haven't
Speaker:gotten
Speaker:the result.
Speaker:That they, well,
Speaker:they haven't been
Speaker:given their
Speaker:life back.
Speaker:Do we help, are
Speaker:we successful
Speaker:with all of those
Speaker:we help?
Speaker:No, we're not,
Speaker:but are we
Speaker:successful with the
Speaker:majority of them?
Speaker:Yes, we are.
Speaker:And those who
Speaker:we're not
Speaker:successful with,
Speaker:we have got an
Speaker:extensive network
Speaker:that we are able
Speaker:to get solutions
Speaker:to people.
Speaker:And this is, the
Speaker:reason why I'm
Speaker:also putting this
Speaker:out there is to
Speaker:not allude anyone
Speaker:to the idea that
Speaker:we are the
Speaker:holy grail.
Speaker:Okay, there is no
Speaker:such thing.
Speaker:If something
Speaker:doesn't work with
Speaker:a certain
Speaker:specialist or a
Speaker:certain thought
Speaker:process, don't
Speaker:give up.
Speaker:That's the
Speaker:message I'm
Speaker:trying to
Speaker:put out there.
Speaker:If anybody is
Speaker:growing through a
Speaker:tough time and
Speaker:they've tried
Speaker:everything, which
Speaker:is impossible, is
Speaker:to try everything
Speaker:you need multiple
Speaker:lifetimes.
Speaker:Okay,
Speaker:don't give up.
Speaker:Like, have faith
Speaker:and truly like
Speaker:the power of, I'm
Speaker:not religious,
Speaker:but I'm very
Speaker:spiritual.
Speaker:And whether you
Speaker:are or you're
Speaker:not, I think it's
Speaker:irrelevant to the
Speaker:question.
Speaker:Sometimes this
Speaker:process is a
Speaker:process of
Speaker:positive
Speaker:introspection,
Speaker:positive
Speaker:psychology can
Speaker:really shift the
Speaker:narrative of
Speaker:where it is that
Speaker:you're willing to
Speaker:invest your
Speaker:energy into.
Speaker:So yes, we
Speaker:help most.
Speaker:Do we help
Speaker:everyone know?
Speaker:But that doesn't
Speaker:mean that there
Speaker:isn't a solution
Speaker:for everybody.
Speaker:And I think as a
Speaker:community of
Speaker:professionals,
Speaker:health
Speaker:professionals,
Speaker:we're making, as
Speaker:we are coming
Speaker:together more and
Speaker:more so, like
Speaker:every year I see
Speaker:that there's
Speaker:better
Speaker:cooperation and
Speaker:less competition
Speaker:happening.
Speaker:And the stronger
Speaker:that we can
Speaker:create
Speaker:cooperation, the
Speaker:more likely that
Speaker:we can do away
Speaker:with states such
Speaker:as
Speaker:neurodiversity,
Speaker:or at least
Speaker:reduce the degree
Speaker:in the percentile
Speaker:of those who are
Speaker:neurodivergent in
Speaker:the populace,
Speaker:which is, I mean,
Speaker:just that, that
Speaker:label alone, that
Speaker:category needs so
Speaker:much new
Speaker:care, right?
Speaker:Because the
Speaker:levels of autism
Speaker:have rise, the
Speaker:level of
Speaker:depression
Speaker:has rise.
Speaker:You know, despite
Speaker:the fact that
Speaker:Western medical
Speaker:technologies have
Speaker:been approved
Speaker:upon, we're still
Speaker:having an influx
Speaker:of these
Speaker:particular
Speaker:states, which
Speaker:need not be if we
Speaker:can come together
Speaker:and unify our
Speaker:skill sets within
Speaker:a paradigm that's
Speaker:truly holistic.
Speaker:That's holistic.
Speaker:You know, there's
Speaker:that word thrown
Speaker:around, way too
Speaker:easily has been
Speaker:thrown around for
Speaker:decades, but what
Speaker:does it
Speaker:really mean?
Speaker:You know, and
Speaker:what I believe
Speaker:means is simply
Speaker:the embodiment of
Speaker:cooperation
Speaker:throughout
Speaker:different
Speaker:disciplines.
Speaker:That's holistic.
Speaker:It's not one
Speaker:discipline,
Speaker:during many
Speaker:different things
Speaker:in the body, is
Speaker:many disciplines
Speaker:supporting the
Speaker:complexity
Speaker:of the body.
Speaker:So that's where I
Speaker:came, and that's
Speaker:where the
Speaker:business is here.
Speaker:(Laughing) That's
Speaker:incredible.
Speaker:And I think
Speaker:you've already
Speaker:answered most of
Speaker:my follow-ups.
Speaker:What I really
Speaker:want to sort of
Speaker:just jump back at
Speaker:you on is just
Speaker:sort of your
Speaker:thoughts on the
Speaker:education model,
Speaker:because when it
Speaker:comes to sort of
Speaker:traditional
Speaker:medicine, and I'm
Speaker:definitely not
Speaker:qualified or also
Speaker:smart enough to
Speaker:make a judgment
Speaker:call on the way
Speaker:medicines talk,
Speaker:but I have a
Speaker:feeling you are,
Speaker:or at least you
Speaker:have some
Speaker:insights
Speaker:into the system.
Speaker:And the way I
Speaker:view it is
Speaker:exactly the way
Speaker:you view it, to
Speaker:an extent.
Speaker:I think that
Speaker:physicians have
Speaker:the best
Speaker:intentions at
Speaker:heart, but they
Speaker:put into this
Speaker:mold, they put
Speaker:this state of
Speaker:having to
Speaker:function based on
Speaker:a set of
Speaker:guidelines and a
Speaker:set of
Speaker:principles, and
Speaker:that's
Speaker:very myopic.
Speaker:And it causes
Speaker:this very sort of
Speaker:siloed approach
Speaker:to healthcare,
Speaker:which just
Speaker:doesn't work.
Speaker:And I've said
Speaker:this before on
Speaker:the podcast, I'm
Speaker:sure you've said
Speaker:it before on
Speaker:others, but I do
Speaker:think it
Speaker:needs to change.
Speaker:If you were, this
Speaker:is a bit of a hot
Speaker:take, but if you
Speaker:were sort of
Speaker:given carte
Speaker:blanche as to how
Speaker:you would
Speaker:potentially
Speaker:re-engineer the
Speaker:way medicines
Speaker:talk, what would
Speaker:you put more an
Speaker:emphasis on,
Speaker:excuse me?
Speaker:What would you
Speaker:sort of take an
Speaker:emphasis off?
Speaker:How would you
Speaker:sort of, briefly,
Speaker:because I mean,
Speaker:this could take
Speaker:us down to a
Speaker:whole other
Speaker:rabbit hole, but
Speaker:how would you
Speaker:sort of recreate
Speaker:medicine to
Speaker:become from a
Speaker:model standpoint,
Speaker:to be more
Speaker:effective and to
Speaker:help more people?
Speaker:Move away from a
Speaker:predominant
Speaker:statistical
Speaker:machine at the
Speaker:ideology.
Speaker:Evidence-based
Speaker:medicine, now
Speaker:we're talking
Speaker:about
Speaker:conventional
Speaker:Western medicine.
Speaker:We're not talking
Speaker:about alternative
Speaker:medicine, such as
Speaker:Chinese medicine
Speaker:and naturopathy
Speaker:or homeopathy,
Speaker:but we're talking
Speaker:about Western
Speaker:medicine, and it
Speaker:really started
Speaker:off really well.
Speaker:And being the
Speaker:known illusion,
Speaker:pharmacology is
Speaker:not the demon.
Speaker:It's just a
Speaker:prayer of use,
Speaker:that's the
Speaker:problem.
Speaker:As an example, if
Speaker:you wanted the
Speaker:word to be given
Speaker:in excess of
Speaker:belladonna,
Speaker:that's also not
Speaker:gonna be to any
Speaker:benefit of
Speaker:continuity
Speaker:of health.
Speaker:So it really is
Speaker:like you can't
Speaker:shout, "Oh, it's
Speaker:a big farmer that
Speaker:wants to
Speaker:kill us all."
Speaker:Well, no, a big
Speaker:farmer is only a
Speaker:cooperation,
Speaker:okay?
Speaker:A cooperation, a
Speaker:cooperation.
Speaker:It's a
Speaker:cooperation.
Speaker:And in being a
Speaker:cooperation, it
Speaker:has its profit
Speaker:margins that it
Speaker:needs to attain,
Speaker:like any other
Speaker:business.
Speaker:But it's not,
Speaker:it's like saying
Speaker:BMW is to blame
Speaker:for the road
Speaker:accidents,
Speaker:right?
Speaker:All the deaths on
Speaker:the road.
Speaker:No, no, and you
Speaker:can say, well,
Speaker:you know, they
Speaker:market their
Speaker:drugs and they
Speaker:try to get, they
Speaker:push the
Speaker:likelihood of
Speaker:sale onto doctors
Speaker:and so on.
Speaker:But what else are
Speaker:they meant to do?
Speaker:If they didn't do
Speaker:that, those
Speaker:medicines
Speaker:wouldn't also
Speaker:reach people that
Speaker:actually
Speaker:do need it.
Speaker:And this is where
Speaker:the discernment
Speaker:and improvement
Speaker:of the sermon is
Speaker:required with the
Speaker:end health
Speaker:practitioner,
Speaker:meaning the
Speaker:doctor, the
Speaker:GP, right?
Speaker:Everybody goes
Speaker:and sees.
Speaker:But the way in
Speaker:which,
Speaker:particularly when
Speaker:it comes to like
Speaker:socialistic
Speaker:countries like
Speaker:England or like
Speaker:France, where the
Speaker:healthcare is
Speaker:free, right?
Speaker:It's very much a
Speaker:conveyor
Speaker:belt system.
Speaker:I have a friend
Speaker:of mine who's a
Speaker:doctor based in
Speaker:Germany and
Speaker:before he went
Speaker:into private
Speaker:practice, he said
Speaker:that he had to
Speaker:see 2,000 people
Speaker:a month in order
Speaker:to make, I think
Speaker:it was like 8,000
Speaker:euro a month.
Speaker:2,000 people to
Speaker:make 8,000
Speaker:euro a month.
Speaker:So it's like 10,
Speaker:15 minutes, five
Speaker:sometimes minute
Speaker:consultations and
Speaker:it's just in and
Speaker:out, in and out.
Speaker:So what are you
Speaker:gonna do?
Speaker:Like, I can't do
Speaker:anything in 10
Speaker:minutes.
Speaker:Like I can have a
Speaker:conversation with
Speaker:somebody, but,
Speaker:and if I look at
Speaker:a lab report, I'm
Speaker:probably gonna
Speaker:look at like, you
Speaker:know, single
Speaker:markers and see
Speaker:if there's
Speaker:anything that
Speaker:really
Speaker:stands out.
Speaker:I'm not gonna
Speaker:have time to look
Speaker:at correlation or
Speaker:create a
Speaker:correlation
Speaker:analysis
Speaker:by it all.
Speaker:No way, because
Speaker:there's no time.
Speaker:And that design
Speaker:at least, there
Speaker:isn't any time.
Speaker:So I think the
Speaker:way in which to
Speaker:nonetheless
Speaker:support
Speaker:organizational
Speaker:construct in
Speaker:terms of
Speaker:financial
Speaker:resources,
Speaker:because we also
Speaker:have to think
Speaker:here, it's not
Speaker:just about giving
Speaker:everybody the
Speaker:equal opportunity
Speaker:of health.
Speaker:That's a great, I
Speaker:mean, that's a
Speaker:wonderful,
Speaker:wonderful
Speaker:sentiment and
Speaker:idea, but the
Speaker:reality is in
Speaker:order to do that,
Speaker:we also have to
Speaker:consider the
Speaker:economics
Speaker:of it all.
Speaker:Okay, and the
Speaker:economics of it
Speaker:all mean that we
Speaker:need to create
Speaker:organizational
Speaker:structures that
Speaker:can provide a
Speaker:personalized
Speaker:service to some
Speaker:degree, to a
Speaker:greater degree
Speaker:than is what
Speaker:currently given,
Speaker:but at the same
Speaker:time, not
Speaker:overburden the
Speaker:financial
Speaker:constraints of
Speaker:these
Speaker:organizations
Speaker:that have been
Speaker:set up by
Speaker:different
Speaker:governmental
Speaker:organizations
Speaker:across the world.
Speaker:And I think the
Speaker:way in which you
Speaker:can do this is
Speaker:by, biohacking is
Speaker:most certainly,
Speaker:it's not the
Speaker:foolproof
Speaker:structure, but it
Speaker:definitely has
Speaker:increased
Speaker:consciousness
Speaker:around wellness
Speaker:for many
Speaker:a people.
Speaker:And one can also
Speaker:argue that there
Speaker:are gonna be
Speaker:goods and bads to
Speaker:everything, okay?
Speaker:But however, if
Speaker:we just take the
Speaker:average, what
Speaker:happens when the
Speaker:person involved,
Speaker:it gets involved
Speaker:in a greater
Speaker:state of
Speaker:awareness of
Speaker:what's going on
Speaker:within
Speaker:themselves, they
Speaker:start to read
Speaker:articles.
Speaker:They start to
Speaker:watch
Speaker:YouTube videos.
Speaker:They start to
Speaker:engage with what
Speaker:it is that's
Speaker:actually going on
Speaker:within
Speaker:themselves.
Speaker:Now, if we can
Speaker:somewhat merge
Speaker:that community
Speaker:element, such as
Speaker:what's happening
Speaker:in biohacking
Speaker:into a greater
Speaker:community,
Speaker:thereby not
Speaker:creating the
Speaker:necessity of
Speaker:tribal mentality,
Speaker:but doing away
Speaker:with that tribal
Speaker:mentality, but
Speaker:still keeping the
Speaker:underlying
Speaker:positive premise
Speaker:of it all, then
Speaker:you can have one
Speaker:doctor, for
Speaker:example,
Speaker:that has,
Speaker:you know, somehow
Speaker:a doctor manages
Speaker:a particular
Speaker:county in
Speaker:England,
Speaker:or say a
Speaker:particular
Speaker:village, not a
Speaker:county, but a
Speaker:particular
Speaker:village in
Speaker:England.
Speaker:That doctor in
Speaker:the current
Speaker:construct of how
Speaker:the NHS is set
Speaker:up, patient eats
Speaker:a book, comes and
Speaker:sees a doctor on
Speaker:a one-to-one.
Speaker:But a one-to-one
Speaker:is 10
Speaker:minutes long.
Speaker:But it doesn't,
Speaker:you can't get
Speaker:anywhere
Speaker:with that.
Speaker:So what about,
Speaker:instead of having
Speaker:this design,
Speaker:you're having
Speaker:single
Speaker:consultation, you
Speaker:have a group
Speaker:model whereby the
Speaker:doctor becomes
Speaker:more proactively
Speaker:involved in the
Speaker:ongoing health of
Speaker:the community,
Speaker:right?
Speaker:It sets certain
Speaker:objectives, sets
Speaker:certain
Speaker:incentives for
Speaker:the community to
Speaker:elevate their
Speaker:health together.
Speaker:The biggest issue
Speaker:that I see in
Speaker:modern-day
Speaker:psychological
Speaker:health, at least,
Speaker:is the separation
Speaker:from man, from
Speaker:man's self, is
Speaker:isolation.
Speaker:We live in a
Speaker:world that's more
Speaker:populated now
Speaker:than ever before,
Speaker:yet we are more
Speaker:lonely than
Speaker:ever before.
Speaker:And that, just by
Speaker:that on its own,
Speaker:births many, many
Speaker:a disease.
Speaker:Okay, we're
Speaker:beings, we're a
Speaker:species that
Speaker:needs embrace.
Speaker:Okay, we're not
Speaker:learned
Speaker:creatures.
Speaker:No matter what
Speaker:anybody says,
Speaker:this warrior
Speaker:mentality, and go
Speaker:sit on top of a
Speaker:mountain and
Speaker:meditate for
Speaker:weeks or months
Speaker:or years on end,
Speaker:there may be,
Speaker:there are a few
Speaker:that have done
Speaker:it, they can do
Speaker:it, but whether
Speaker:or not it's
Speaker:healthy for a
Speaker:person or not,
Speaker:that's up
Speaker:for debate.
Speaker:And I don't
Speaker:think,
Speaker:personally, and
Speaker:again, I'm not
Speaker:omnipotent or
Speaker:omnipresent
Speaker:whatsoever, thank
Speaker:God for that,
Speaker:excuse the irony,
Speaker:of what I just
Speaker:said, but I do
Speaker:believe that
Speaker:humanity needs
Speaker:more compassion,
Speaker:and the only way
Speaker:in which we can
Speaker:improve upon the
Speaker:medical system is
Speaker:by implementing
Speaker:consideration for
Speaker:others in a
Speaker:community
Speaker:construct, really
Speaker:bring the
Speaker:community back
Speaker:together.
Speaker:So when something
Speaker:happens, it's not
Speaker:left to the nth
Speaker:degree when
Speaker:somebody's
Speaker:completely
Speaker:derailed, and
Speaker:then they're
Speaker:trying to have a
Speaker:10 minute
Speaker:consultation with
Speaker:the doctor
Speaker:to fix that.
Speaker:Because this
Speaker:faces it, things
Speaker:don't just happen
Speaker:overnight, unless
Speaker:you catch like
Speaker:typhoid fever,
Speaker:by the way, most
Speaker:deaths actually
Speaker:occur from
Speaker:non-communicable
Speaker:diseases,
Speaker:non-communicable
Speaker:diseases.
Speaker:78%, I think it
Speaker:was in 86, I
Speaker:can't remember,
Speaker:but it's between
Speaker:78 or 86, that
Speaker:was the number
Speaker:that I last saw
Speaker:on the steps of
Speaker:global
Speaker:deaths, right?
Speaker:Non-communicable
Speaker:diseases is
Speaker:responsible for
Speaker:the majority of
Speaker:deaths worldwide.
Speaker:And by that you
Speaker:mean things like
Speaker:AOCVD, heart
Speaker:disease, cancer,
Speaker:et cetera.
Speaker:Yeah, any disease
Speaker:that's not caused
Speaker:directly by a
Speaker:pathogen assault.
Speaker:Yeah.
Speaker:So, methylene
Speaker:blue, recovering
Speaker:from COVID.
Speaker:Not to be used
Speaker:perpetually, but
Speaker:the use of sort
Speaker:of circumstances,
Speaker:we had a
Speaker:conversation
Speaker:about this in the
Speaker:second, as well.
Speaker:We didn't need--
Speaker:So things like
Speaker:this, like you
Speaker:know, certain
Speaker:remedies, like
Speaker:methylene blue,
Speaker:that can be
Speaker:destructive,
Speaker:it most certainly
Speaker:can cause harm if
Speaker:it's used in the
Speaker:wrong construct,
Speaker:right?
Speaker:But it most
Speaker:certainly can
Speaker:alleviate harm if
Speaker:it's used in the
Speaker:right construct.
Speaker:But how do people
Speaker:know this?
Speaker:Like, I mean,
Speaker:I've got degrees
Speaker:in
Speaker:biochemistry, right?
Speaker:I've got degrees
Speaker:in nutritional
Speaker:science, but not
Speaker:everybody has a
Speaker:degree in
Speaker:biochemistry and
Speaker:nutritional
Speaker:science, so now,
Speaker:you know, you've
Speaker:got the media
Speaker:mention about its
Speaker:potential
Speaker:benefit, and
Speaker:there are
Speaker:incredible
Speaker:benefits behind
Speaker:this molecule.
Speaker:It truly is a
Speaker:molecule.
Speaker:But we need more
Speaker:of a community
Speaker:for people to be
Speaker:able to use these
Speaker:remedies that
Speaker:don't require a
Speaker:script
Speaker:successfully,
Speaker:rather than use
Speaker:it and feel
Speaker:like crap.
Speaker:Feel worse often
Speaker:than they did
Speaker:prior to
Speaker:using it.
Speaker:And this requires
Speaker:more of a
Speaker:community aspect.
Speaker:And I think this
Speaker:is the only way
Speaker:in which we'll be
Speaker:able to change
Speaker:the trajectory of
Speaker:modern-day
Speaker:medicine.
Speaker:When it comes to
Speaker:like the
Speaker:educational
Speaker:component of it,
Speaker:which is another
Speaker:part of the
Speaker:question
Speaker:that you asked,
Speaker:I think medical
Speaker:school starts off
Speaker:very well, but it
Speaker:ends terribly.
Speaker:(Laughs)
Speaker:Sort of, yeah,
Speaker:you sort of have
Speaker:this sort of,
Speaker:this base of
Speaker:biochemistry or
Speaker:physiology, and
Speaker:then you slowly
Speaker:sort of become a
Speaker:trained
Speaker:pharmacologist
Speaker:where you start
Speaker:to associate any
Speaker:disease outcome
Speaker:with a drug, and
Speaker:that's
Speaker:where you stop.
Speaker:That seems to be
Speaker:my take on it to
Speaker:a large extent.
Speaker:Well, the shame
Speaker:in it all is that
Speaker:it's even worse
Speaker:so than that,
Speaker:because it'd be
Speaker:great if they had
Speaker:more, most GPs
Speaker:have six months
Speaker:to maybe a year,
Speaker:depending upon
Speaker:which school you
Speaker:go to, in
Speaker:exposure to
Speaker:pharmacological
Speaker:studies.
Speaker:Do you know this?
Speaker:It's six months
Speaker:to a year.
Speaker:No, I didn't.
Speaker:Maximum year.
Speaker:Maximum year.
Speaker:That's
Speaker:incredible.
Speaker:Which is crazy,
Speaker:because if you
Speaker:think about it, a
Speaker:pharmacist, most,
Speaker:unless you do,
Speaker:some pharmacists
Speaker:are able to write
Speaker:scripts, but you
Speaker:have to go
Speaker:through extensive
Speaker:post-grad
Speaker:certification
Speaker:processes, very
Speaker:few of
Speaker:them have it.
Speaker:Yet, all doctors
Speaker:are able to write
Speaker:a script that
Speaker:have less
Speaker:knowledge than
Speaker:the pharmacist
Speaker:does on what it
Speaker:is that they're
Speaker:prescribing.
Speaker:That's
Speaker:disconcerting to
Speaker:say the least.
Speaker:And again, it's
Speaker:not the fault of the
Speaker:physician, is it?
Speaker:No, it's not.
Speaker:Definitely not
Speaker:the fault of the
Speaker:physician.
Speaker:Yeah.
Speaker:That was just a
Speaker:perfect podcast
Speaker:in
Speaker:itself, Justin.
Speaker:And I sort of, I
Speaker:love the way you
Speaker:took that, the
Speaker:fact that we sort
Speaker:of really sort
Speaker:of, and I should
Speaker:probably send
Speaker:this to my father
Speaker:because he was
Speaker:involved in
Speaker:community
Speaker:development for
Speaker:years, but it's
Speaker:almost like we've
Speaker:got to sort of
Speaker:rethink the
Speaker:paradigm
Speaker:completely and
Speaker:sort of place
Speaker:more emphasis on
Speaker:the community.
Speaker:How you then go
Speaker:about educating
Speaker:the masses, for
Speaker:the want of
Speaker:better word, is
Speaker:probably another
Speaker:question best
Speaker:left to
Speaker:another day.
Speaker:But it does
Speaker:make sense,
Speaker:bringing the
Speaker:awareness of
Speaker:health to the
Speaker:individual, and
Speaker:almost from a
Speaker:preventative
Speaker:standpoint.
Speaker:So encouraging
Speaker:people to take,
Speaker:how do I
Speaker:put this?
Speaker:Encouraging
Speaker:people to take
Speaker:responsibility
Speaker:for their own
Speaker:health and
Speaker:creating
Speaker:messaging
Speaker:around that.
Speaker:And I think
Speaker:that's where the
Speaker:biohacking
Speaker:community is
Speaker:effective.
Speaker:I think it does
Speaker:get a bit lost in
Speaker:the weeds in
Speaker:terms of maybe
Speaker:focusing on the
Speaker:minutiae more
Speaker:often than the
Speaker:actual needle
Speaker:movers, which
Speaker:just aren't sexy
Speaker:at the end of the
Speaker:day, are they?
Speaker:Nobody wants to
Speaker:necessarily sort
Speaker:of go to bed when
Speaker:it gets dark and
Speaker:wake up when it
Speaker:gets light.
Speaker:They want to sort
Speaker:of play around
Speaker:with the red
Speaker:light and the
Speaker:$10,000 coin
Speaker:plunge or
Speaker:whatever it is.
Speaker:So how you get
Speaker:around that one?
Speaker:It is
Speaker:TVT.
Speaker:Well, I want to come back down to
Speaker:leadership
Speaker:authority, and we
Speaker:look into
Speaker:different social
Speaker:constructs and
Speaker:theories around
Speaker:that as well,
Speaker:which begs the
Speaker:question of like,
Speaker:how much
Speaker:authority are we
Speaker:as a collective
Speaker:giving those who
Speaker:have voices?
Speaker:And what are
Speaker:their intentions?
Speaker:Like, obviously
Speaker:we all need to
Speaker:make money in
Speaker:this lifetime.
Speaker:There's nothing
Speaker:wrong with making
Speaker:money, but I
Speaker:think it's really
Speaker:easy for me at
Speaker:least, and maybe
Speaker:this is a vouch
Speaker:of advice for
Speaker:anybody that may
Speaker:consider
Speaker:reviewing what it
Speaker:is that they're
Speaker:hearing.
Speaker:Any moment when
Speaker:an influencer of
Speaker:any split in the
Speaker:biohacking or policing
Speaker:especially comes
Speaker:with a polarized
Speaker:view, I stop
Speaker:listening
Speaker:to them.
Speaker:I stop listening
Speaker:to them.
Speaker:This is good for
Speaker:you, this is bad
Speaker:for you, blah,
Speaker:blah, blah, blah,
Speaker:blah, blah,
Speaker:blah, blah.
Speaker:Like, you know,
Speaker:again, like for
Speaker:example,
Speaker:palm oil, palm
Speaker:oil, okay, it's
Speaker:terrible, but it
Speaker:is terrible, but
Speaker:it also has
Speaker:certain potential
Speaker:applications
Speaker:outside of the
Speaker:food industry.
Speaker:Okay, so it's not
Speaker:all bad.
Speaker:Yes, there is
Speaker:obviously an
Speaker:impact that has
Speaker:on nature, but
Speaker:tell me what
Speaker:doesn't have an
Speaker:impact on nature
Speaker:given the
Speaker:technological
Speaker:construct of
Speaker:humanity.
Speaker:You know, so
Speaker:there are ways in
Speaker:which we need to
Speaker:mitigate that for
Speaker:sure, but
Speaker:nothing,
Speaker:everything needs
Speaker:to be considered
Speaker:in content and
Speaker:context and
Speaker:content.
Speaker:And a polarized
Speaker:view often comes
Speaker:with a bit of a
Speaker:buy-in or a sale
Speaker:for the person to
Speaker:buy into, okay.
Speaker:I'm not gonna
Speaker:name any names,
Speaker:but not too long
Speaker:ago, there was a
Speaker:very well-known
Speaker:influencer in the
Speaker:space who had
Speaker:everything to say
Speaker:about melatonin
Speaker:and how it can
Speaker:induce the
Speaker:likelihood of an
Speaker:increase of
Speaker:myocardial
Speaker:infarction.
Speaker:And he cited
Speaker:certain studies,
Speaker:but anybody that
Speaker:doesn't know how
Speaker:to read studies
Speaker:will just take
Speaker:what he said for
Speaker:face value, but
Speaker:anybody that does
Speaker:know how to read
Speaker:a study will
Speaker:actually look
Speaker:into the
Speaker:demographic of
Speaker:which was
Speaker:utilized for the
Speaker:study and realize
Speaker:that a lot of
Speaker:these people
Speaker:actually had
Speaker:pre-existing
Speaker:heart conditions
Speaker:in the
Speaker:first place.
Speaker:These are not
Speaker:healthy
Speaker:individuals.
Speaker:Yeah, no, it's
Speaker:just so
Speaker:context-dependent
Speaker:at the end of the
Speaker:day, isn't it?
Speaker:And I love the
Speaker:nutrition and
Speaker:energy too.
Speaker:It's ultimately
Speaker:comes back to
Speaker:sort of finding
Speaker:that middle
Speaker:ground, because
Speaker:ultimately I feel
Speaker:that we're all on
Speaker:the bell curve
Speaker:and obviously
Speaker:you're going to
Speaker:have extreme
Speaker:outliers at
Speaker:either end,
Speaker:people who are
Speaker:going to thrive
Speaker:just caring for
Speaker:this energy on a
Speaker:carnival diet and
Speaker:people who are
Speaker:gonna thrive
Speaker:maybe on a vegan
Speaker:diet on the
Speaker:other end.
Speaker:But yeah, I think
Speaker:ultimately we do
Speaker:all sort of fall
Speaker:somewhere in the
Speaker:middle, don't we?
Speaker:And it's
Speaker:interesting to
Speaker:see many of the
Speaker:influences in
Speaker:this space.
Speaker:You're Paul
Speaker:Saladinas of the
Speaker:world, for
Speaker:example, who sort
Speaker:of started out
Speaker:and maybe, I'm
Speaker:not sure how many
Speaker:people are aware
Speaker:of this, but he
Speaker:started out
Speaker:vegan, then he
Speaker:went fully
Speaker:carnival.
Speaker:And then he sort
Speaker:of ended up
Speaker:essentially an
Speaker:omnivore in
Speaker:the middle.
Speaker:So I do think it
Speaker:speaks to your
Speaker:point in that
Speaker:respect.
Speaker:Anyway,
Speaker:Justin, I think
Speaker:we've already
Speaker:been going for 14
Speaker:minutes and
Speaker:technically we
Speaker:haven't even
Speaker:started his
Speaker:conversation.
Speaker:So taking all
Speaker:that into
Speaker:account, and that
Speaker:was truly the
Speaker:most interesting
Speaker:introduction to
Speaker:Paul Saladinas,
Speaker:so thank you.
Speaker:Let's dive into
Speaker:this concept of
Speaker:immunometabolism.
Speaker:Now, I think when
Speaker:going into a
Speaker:topic as complex,
Speaker:potentially as
Speaker:complex as this,
Speaker:it's great to
Speaker:have a baseline
Speaker:and understanding
Speaker:of the basic
Speaker:physiology, the
Speaker:basic
Speaker:biochemistry.
Speaker:So to start off
Speaker:with, would you
Speaker:mind breaking
Speaker:down for the
Speaker:listeners what
Speaker:the immune system
Speaker:fundamentally is?
Speaker:And then we could
Speaker:maybe branch into
Speaker:more discussion
Speaker:about how that
Speaker:relates to
Speaker:metabolism.
Speaker:But yeah,
Speaker:immunology 101,
Speaker:as it were, would
Speaker:you mind just
Speaker:sort of providing
Speaker:us with a
Speaker:breakdown of the
Speaker:concepts there?
Speaker:It's an
Speaker:environmental
Speaker:foreman.
Speaker:Let me explain.
Speaker:So I was like,
Speaker:what do you mean
Speaker:environment
Speaker:foreman?
Speaker:It pretty much
Speaker:directs what
Speaker:needs to happen
Speaker:between two
Speaker:different
Speaker:environment, well
Speaker:within an
Speaker:environment based
Speaker:upon two
Speaker:different
Speaker:environments.
Speaker:We live in an
Speaker:environment, like
Speaker:there is a
Speaker:microcosm to the
Speaker:macrocosm.
Speaker:So we live in the
Speaker:world, and the
Speaker:world is a part
Speaker:of the solar
Speaker:system, and the
Speaker:solar system is
Speaker:part of the
Speaker:galaxy, and the
Speaker:galaxy is part of
Speaker:the universe, and
Speaker:there are
Speaker:probably multiple
Speaker:universes.
Speaker:Maybe, maybe not.
Speaker:I don't know, I'm
Speaker:not a quantum
Speaker:physicist, but I
Speaker:would assume that
Speaker:they are.
Speaker:So within we take
Speaker:the macro to the
Speaker:macrocosm,
Speaker:everything has
Speaker:the potential of
Speaker:symbiosis, or
Speaker:conflict to that
Speaker:symbiosis.
Speaker:Now when conflict
Speaker:exists to that
Speaker:symbiosis, we
Speaker:have to consider
Speaker:what is it
Speaker:between the two
Speaker:environments
Speaker:that's acting in
Speaker:opposition to one
Speaker:another.
Speaker:And this is where
Speaker:the immune system
Speaker:comes in, because
Speaker:it tries to sort
Speaker:out the
Speaker:oppositional
Speaker:activities
Speaker:between our
Speaker:internal
Speaker:environment as to
Speaker:what's happening
Speaker:outside of
Speaker:ourselves.
Speaker:So in the immune
Speaker:system, the
Speaker:immune system
Speaker:itself, from a
Speaker:scientific
Speaker:perspective, you
Speaker:have two major
Speaker:components.
Speaker:You have the
Speaker:adaptive and the
Speaker:innate
Speaker:immune system.
Speaker:The innate immune
Speaker:system has been
Speaker:around for a
Speaker:lot longer.
Speaker:The adaptive
Speaker:immune system
Speaker:came about
Speaker:subsequently
Speaker:thereafter.
Speaker:The innate immune
Speaker:system comprises
Speaker:elements such as
Speaker:macrophage, such
Speaker:as neutrophils,
Speaker:such as natural
Speaker:killer cells and
Speaker:granular
Speaker:cytoplasmophils
Speaker:and basophils.
Speaker:They have less
Speaker:specificity in
Speaker:order to address
Speaker:whatever burden
Speaker:might be plaguing
Speaker:the body, but
Speaker:they have more
Speaker:immediate
Speaker:reactions.
Speaker:And then in their
Speaker:immediate
Speaker:reaction,
Speaker:particularly
Speaker:dendritic cells,
Speaker:they create what
Speaker:they call
Speaker:presentation.
Speaker:They they
Speaker:optimize.
Speaker:Basically they
Speaker:decorate what,
Speaker:like for example,
Speaker:a pathogen,
Speaker:enabling the
Speaker:adaptive immune
Speaker:players, which
Speaker:are your B and
Speaker:your T
Speaker:lymphocytes, to
Speaker:come in and say,
Speaker:okay, cool, these
Speaker:guys
Speaker:shouldn't be here.
Speaker:And the B and the
Speaker:T lymphocytes are
Speaker:initially your
Speaker:artillery,
Speaker:because when we
Speaker:get into the
Speaker:solid danger
Speaker:response part of
Speaker:the discussion,
Speaker:I'll explain it a
Speaker:little bit more,
Speaker:initially you
Speaker:proliferate
Speaker:T cells.
Speaker:So the innate
Speaker:immune system
Speaker:will launch of
Speaker:its defense.
Speaker:And in doing so,
Speaker:create APC and
Speaker:then in that, the
Speaker:body will create
Speaker:a reaction in
Speaker:releasing a lot
Speaker:of naive or
Speaker:increasing the
Speaker:production of
Speaker:your
Speaker:naive T cells.
Speaker:Then over time,
Speaker:with the APC is
Speaker:coming into
Speaker:contact with
Speaker:these particular
Speaker:lymph node
Speaker:points, then the
Speaker:specific type of
Speaker:T cells will
Speaker:proliferate.
Speaker:You have two
Speaker:subsets in my T
Speaker:helper cells, T
Speaker:regulatory cells,
Speaker:and then
Speaker:cytotoxic
Speaker:lymphocytes.
Speaker:And then you also
Speaker:have your
Speaker:antibodies, the
Speaker:cell that's
Speaker:within your B
Speaker:cell complexes,
Speaker:your IgMs, your
Speaker:IgGs, IgAs
Speaker:and IgEs.
Speaker:Depending upon
Speaker:what it is,
Speaker:that's within
Speaker:those particular
Speaker:antibodies and
Speaker:that those
Speaker:particular T cell
Speaker:responses will
Speaker:come into
Speaker:the mix.
Speaker:Now it's very
Speaker:important that a
Speaker:response is
Speaker:calibrated to a
Speaker:point where it
Speaker:doesn't cause
Speaker:self-autoreactivity
Speaker:in the body.
Speaker:Otherwise you
Speaker:have a state of
Speaker:perpetual assault
Speaker:that the immune
Speaker:system perceives
Speaker:that it is
Speaker:required to
Speaker:facilitate, even
Speaker:though there
Speaker:isn't a
Speaker:continual threat.
Speaker:Or there is no
Speaker:longer the degree
Speaker:of threat that it
Speaker:perceives that it
Speaker:actually has.
Speaker:So it's very much
Speaker:a concert.
Speaker:And it's very
Speaker:much like a
Speaker:football game,
Speaker:whereby the ball
Speaker:is passed into
Speaker:specific players
Speaker:depending upon
Speaker:the certain
Speaker:sequence of how
Speaker:the game is
Speaker:playing out.
Speaker:So those are your
Speaker:two major
Speaker:components that
Speaker:you've been
Speaker:using, the innate
Speaker:and the adaptive
Speaker:and obviously the
Speaker:players.
Speaker:What's very
Speaker:interesting in
Speaker:the innate immune
Speaker:system is that
Speaker:the stem cells
Speaker:that produce most
Speaker:of the innate
Speaker:immune players
Speaker:are lymphoid
Speaker:stem cells.
Speaker:Sorry, I'm sorry,
Speaker:myeloid
Speaker:stem cells.
Speaker:Whereas the stem
Speaker:cells that
Speaker:produce most of
Speaker:the adaptive
Speaker:immune players
Speaker:are lymphoid,
Speaker:except albeit for
Speaker:or natural
Speaker:killer cells.
Speaker:And this is
Speaker:highly relevant
Speaker:because your
Speaker:natural killer
Speaker:cells have the
Speaker:greatest degree
Speaker:of specificity in
Speaker:contrast to the
Speaker:other innate
Speaker:immune players in
Speaker:being able to
Speaker:detect faulty
Speaker:mutations.
Speaker:So when you have
Speaker:a lower natural
Speaker:killer cells,
Speaker:your risk of
Speaker:cancer increases,
Speaker:your body's
Speaker:ability to resist
Speaker:things like
Speaker:perpetual cell
Speaker:wall deficient
Speaker:attacks such as
Speaker:Lyme disease
Speaker:reduces, your
Speaker:body's ability to
Speaker:mitigate
Speaker:expression of
Speaker:chronic envelope
Speaker:based viruses
Speaker:like
Speaker:Epstein-Bach,
Speaker:cyclo-mekovirus
Speaker:decreases.
Speaker:So when you have
Speaker:lower natural
Speaker:killer cells, you
Speaker:become
Speaker:vulnerable.
Speaker:And what happens
Speaker:is when you
Speaker:become
Speaker:vulnerable, the
Speaker:other innate
Speaker:players try to
Speaker:step in because
Speaker:there's a
Speaker:deficiency of one
Speaker:of their
Speaker:teammates.
Speaker:They try to come
Speaker:in and help where
Speaker:their teammates
Speaker:not able to take
Speaker:on the workload.
Speaker:But in them doing
Speaker:that, because of
Speaker:their degree of
Speaker:specificity isn't
Speaker:as targeted as to
Speaker:what natural
Speaker:killer cells, and
Speaker:it's also by way
Speaker:of the stem cells
Speaker:that they
Speaker:originate from as
Speaker:to why, this
Speaker:creates a
Speaker:likelihood of
Speaker:perpetual,
Speaker:chronic,
Speaker:low-grade
Speaker:inflammation.
Speaker:Now, this
Speaker:low-grade
Speaker:inflammation can
Speaker:also further
Speaker:exhaust the
Speaker:adaptive immune
Speaker:system over time.
Speaker:And HIV is a
Speaker:classical
Speaker:example.
Speaker:You know, it's an
Speaker:extreme example,
Speaker:but it's a
Speaker:classical example
Speaker:of this whereby
Speaker:HIV hijacks
Speaker:certain
Speaker:CD4 cells.
Speaker:The CD4 cells
Speaker:present
Speaker:themselves along
Speaker:the lymph nodes.
Speaker:The innate immune
Speaker:system launches
Speaker:in a fence, but
Speaker:meanwhile it's
Speaker:launching in the
Speaker:fence in the
Speaker:wrong areas,
Speaker:thereby reducing
Speaker:the adaptive
Speaker:capacity to
Speaker:launch a
Speaker:cytotoxic
Speaker:lymphocyte
Speaker:response at the
Speaker:point where the
Speaker:immune system
Speaker:exhausts itself
Speaker:and then you
Speaker:develop eight.
Speaker:Okay.
Speaker:Would this be a,
Speaker:excuse me, would
Speaker:this be a point
Speaker:where something
Speaker:like a cytokine
Speaker:resistance of
Speaker:sorts would
Speaker:develop,
Speaker:potentially where
Speaker:you've got an
Speaker:anti-inflammatory
Speaker:cytokin coming
Speaker:into the mix, or
Speaker:am I a bit off
Speaker:base there?
Speaker:I'm just trying
Speaker:to piece this
Speaker:together as you
Speaker:go with regards
Speaker:to the natural
Speaker:killer cells.
Speaker:Cytokin
Speaker:resistance,
Speaker:you're talking
Speaker:about like
Speaker:interleukin-10 as
Speaker:a predominant
Speaker:anti-cytokin.
Speaker:Yes and no, and it's contextual,
Speaker:because it
Speaker:depends upon the
Speaker:quantitative
Speaker:release of other
Speaker:cytokines in
Speaker:ratio to that
Speaker:interleukin-10
Speaker:response.
Speaker:As an example, if
Speaker:you have a lot of
Speaker:interleukin-4
Speaker:being expressed
Speaker:at the same time
Speaker:as
Speaker:interleukin-10,
Speaker:and subsequently
Speaker:you also might
Speaker:have an
Speaker:interleukin-13
Speaker:activity
Speaker:happening in
Speaker:conjunction with
Speaker:interleukin-4,
Speaker:this may
Speaker:propagate a
Speaker:neutrophilic
Speaker:response.
Speaker:And the
Speaker:neutrophilic
Speaker:response can
Speaker:increase the,
Speaker:exacerbate a
Speaker:release of
Speaker:hydrogen
Speaker:peroxide, which
Speaker:is what they do.
Speaker:That's where
Speaker:hydrogen peroxide
Speaker:is actually part
Speaker:of the
Speaker:immune system.
Speaker:Immune system
Speaker:actually release
Speaker:hydrogen peroxide
Speaker:as a form of very
Speaker:strong
Speaker:anti-microbial.
Speaker:This is why, like
Speaker:if you've had
Speaker:hydrogen peroxide
Speaker:IDs and so on,
Speaker:it's because it's
Speaker:supporting an
Speaker:exhausted immune
Speaker:system, this FYI.
Speaker:Interesting.
Speaker:Yeah, no, that's
Speaker:a tip that I do
Speaker:not know.
Speaker:So with this
Speaker:whole paradigm,
Speaker:it's not just
Speaker:about like, okay,
Speaker:interleukin-10 is
Speaker:there, we're
Speaker:still having
Speaker:information.
Speaker:Well, no, it's,
Speaker:it's looking at
Speaker:it as doing what
Speaker:it needs to do,
Speaker:but what else is
Speaker:going on in this
Speaker:whole paradigm?
Speaker:And this is where
Speaker:like measuring a
Speaker:cytokine map
Speaker:provides to be
Speaker:incredibly useful
Speaker:when you're
Speaker:seeing the
Speaker:complex activity
Speaker:of the entire
Speaker:immune system.
Speaker:You know, two
Speaker:tests that I
Speaker:always, not
Speaker:always, but that
Speaker:I enjoy running
Speaker:because I get so
Speaker:much insight from
Speaker:them,
Speaker:particularly in
Speaker:cases of chronic
Speaker:fatigue, not
Speaker:necessarily
Speaker:always long walk
Speaker:over, just
Speaker:chronic fatigue
Speaker:cases, because in
Speaker:my clinical
Speaker:experience, in
Speaker:supporting those
Speaker:with chronic
Speaker:fatigue, 90% of
Speaker:the time it has
Speaker:an association
Speaker:with a exhausted
Speaker:natural killer
Speaker:cell response and
Speaker:subsequently a
Speaker:perpetuated
Speaker:monocyte
Speaker:inflammatory
Speaker:response.
Speaker:So in these
Speaker:cases, they
Speaker:always, no matter
Speaker:how much iron or
Speaker:iron-rich foods
Speaker:they eat, they
Speaker:always have low
Speaker:serum iron.
Speaker:If this is you,
Speaker:and I'm speaking
Speaker:to the audience
Speaker:now, if you eat a
Speaker:lot of red meat,
Speaker:you're taking
Speaker:trimethylglycine
Speaker:to help with
Speaker:hyperchloridea in
Speaker:case you may have
Speaker:that and try to
Speaker:absorb
Speaker:iron better.
Speaker:And yet your
Speaker:serum iron
Speaker:concentration is
Speaker:always on the low
Speaker:side or maybe
Speaker:even deficient,
Speaker:despite the fact
Speaker:that you might be
Speaker:eating it's a
Speaker:kilogram of
Speaker:steak a day.
Speaker:Whether you are
Speaker:or you're not, if
Speaker:it is that you're
Speaker:full of this
Speaker:paradigm and yet
Speaker:no matter what
Speaker:you do, albeit
Speaker:from maybe direct
Speaker:super
Speaker:thermal iron,
Speaker:your iron levels
Speaker:are always
Speaker:suppressed.
Speaker:Consider the fact
Speaker:that your
Speaker:monocytes are
Speaker:microphage on a
Speaker:state of
Speaker:perpetual
Speaker:reactivation.
Speaker:Okay, they're in
Speaker:a state of M1,
Speaker:microphage,
Speaker:immunotype.
Speaker:And this is
Speaker:really elusive
Speaker:because like, if
Speaker:you just look
Speaker:into a white
Speaker:blood salt
Speaker:differential to
Speaker:try and determine
Speaker:whether or not
Speaker:this is
Speaker:happening,
Speaker:it doesn't always
Speaker:show itself on a
Speaker:standard white
Speaker:blood salt
Speaker:differential
Speaker:because unless
Speaker:you're gonna do
Speaker:immunological
Speaker:survey every day
Speaker:for a period of
Speaker:seven days, in
Speaker:these particular
Speaker:cases, you're not
Speaker:always
Speaker:necessarily gonna
Speaker:get the window
Speaker:within which the
Speaker:immune systems
Speaker:are compromised,
Speaker:showing the true
Speaker:effect of what
Speaker:isn't or what is
Speaker:actually
Speaker:going on.
Speaker:So this is where
Speaker:running a
Speaker:lymphocyte flow
Speaker:cytometry as well
Speaker:as a cytokine
Speaker:map, proves to be
Speaker:incredibly
Speaker:insightful
Speaker:because this
Speaker:gives more of the
Speaker:specificity in
Speaker:terms of like
Speaker:microphage
Speaker:inflammatory
Speaker:proteins and so
Speaker:on and other side
Speaker:of kinds of that
Speaker:nature that could
Speaker:be expressed in
Speaker:the background,
Speaker:actually
Speaker:impacting anemia,
Speaker:iron-based
Speaker:anemia.
Speaker:Again, despite
Speaker:the fact of any
Speaker:supplementation
Speaker:or nutritional
Speaker:augmentation,
Speaker:when one is
Speaker:experiencing
Speaker:perpetual
Speaker:iron-based
Speaker:anemia,
Speaker:especially in
Speaker:situations where
Speaker:they have
Speaker:supplements, that
Speaker:comes to consider
Speaker:that there is an
Speaker:immunological or
Speaker:an immunological
Speaker:distorted
Speaker:perception
Speaker:going on.
Speaker:And I think
Speaker:that's really
Speaker:important is
Speaker:that, yes, the
Speaker:immune system can
Speaker:exhaust itself,
Speaker:however, it's not
Speaker:always the point,
Speaker:it's like the
Speaker:whole concept
Speaker:behind adrenal
Speaker:exhaustion.
Speaker:Do the adrenal
Speaker:glands really
Speaker:exhaust
Speaker:themselves or is
Speaker:it the receptor
Speaker:makeup that
Speaker:actually starts
Speaker:to lose the
Speaker:sensitivity to
Speaker:the effect of the
Speaker:glucocorticoids?
Speaker:Or is it the fact
Speaker:that it redirects
Speaker:your other
Speaker:catecholamines or
Speaker:other hormone
Speaker:specifically to
Speaker:try and maintain
Speaker:the state of pH
Speaker:in the body?
Speaker:The organic
Speaker:gradient
Speaker:in the body.
Speaker:So again, the
Speaker:immune system is
Speaker:the same, is
Speaker:that, I guess, in
Speaker:most only you can
Speaker:get exhausted and
Speaker:certain
Speaker:components of the
Speaker:immune system can
Speaker:tire, but you
Speaker:have to ask
Speaker:yourself why?
Speaker:Why is the immune
Speaker:system exhausted
Speaker:in its cytotoxic
Speaker:effect, for
Speaker:example?
Speaker:And often the
Speaker:answer is because
Speaker:there's an
Speaker:imbalance between
Speaker:its innate and
Speaker:adaptive
Speaker:components.
Speaker:Yeah, that was
Speaker:truly, I could
Speaker:have used all of
Speaker:that when
Speaker:prepping for this
Speaker:episode, that
Speaker:would have made
Speaker:life a lot easier
Speaker:instead of trying
Speaker:to sort of figure
Speaker:out the
Speaker:immunology from
Speaker:scratch, which I
Speaker:will fully admit,
Speaker:I am not that
Speaker:proficient in.
Speaker:So I will for one
Speaker:will be relisting
Speaker:to all of that
Speaker:because
Speaker:truthfully I'm
Speaker:talking about 80%
Speaker:of it, some of it
Speaker:was beyond me,
Speaker:however, that was
Speaker:incredible,
Speaker:thank you.
Speaker:And the audience
Speaker:listening, you
Speaker:may be a bit
Speaker:flummoxed by
Speaker:that, but I think
Speaker:if you were to
Speaker:give it a second
Speaker:listen after
Speaker:having listened
Speaker:to the rest of
Speaker:the episode, of
Speaker:course, you will
Speaker:pick up on a lot
Speaker:of what Justin
Speaker:just said.
Speaker:And I know going
Speaker:forwards, that's
Speaker:going to really
Speaker:help the rest of
Speaker:the discussion
Speaker:that we're going
Speaker:to have about the
Speaker:sort of concept
Speaker:of
Speaker:immunomatabolism,
Speaker:which really is a
Speaker:perfect segue
Speaker:into that, into
Speaker:this concept of
Speaker:immunomatabolism.
Speaker:And the way I
Speaker:understand it,
Speaker:sort of at a very
Speaker:layman's
Speaker:level is that
Speaker:the immune system
Speaker:obviously at
Speaker:higher levels,
Speaker:what controls the
Speaker:inflammatory
Speaker:response
Speaker:in the body.
Speaker:And when that
Speaker:inflammatory
Speaker:response is out
Speaker:of control, then
Speaker:there's a strong
Speaker:carry over to
Speaker:what is
Speaker:colloquially
Speaker:known as
Speaker:metabolism.
Speaker:That being the
Speaker:result or the
Speaker:collection of
Speaker:various organ
Speaker:systems
Speaker:throughout the
Speaker:body, everything
Speaker:from thyroid to
Speaker:pancreatic and
Speaker:insulin function,
Speaker:et cetera.
Speaker:And I'd love to
Speaker:sort of chat
Speaker:about those
Speaker:upstream
Speaker:triggers points
Speaker:in a bit.
Speaker:But to start off
Speaker:with, would you
Speaker:sort of mind
Speaker:breaking down the
Speaker:way you see
Speaker:immunomatabolism?
Speaker:Because I think
Speaker:I've got the gist
Speaker:of it, but not
Speaker:entirely.
Speaker:So would you
Speaker:provide the
Speaker:audience with a
Speaker:breakdown of this
Speaker:term and then we
Speaker:can discuss it in
Speaker:a bit more depth
Speaker:from there.
Speaker:Well, I've got to
Speaker:give credit to
Speaker:Professor
Speaker:Robert Naviou.
Speaker:You know, that's
Speaker:the cornerstone
Speaker:of my
Speaker:understanding
Speaker:behind this
Speaker:concept.
Speaker:There are others
Speaker:that definitely
Speaker:contributed
Speaker:toward it.
Speaker:But by far he's
Speaker:being the most
Speaker:influential in
Speaker:alluding to my
Speaker:understanding as
Speaker:to what this
Speaker:paradigm actually
Speaker:entails.
Speaker:I mentioned
Speaker:Albert Zangorgi
Speaker:before when I was
Speaker:talking about
Speaker:methylene blue.
Speaker:He also went into
Speaker:this prior
Speaker:to Naviou.
Speaker:And prior to that
Speaker:generation was
Speaker:John Beard back
Speaker:in the early part
Speaker:of the 1900s, who
Speaker:was the first to
Speaker:treat cancer by
Speaker:injecting
Speaker:digestive enzymes
Speaker:into tumors.
Speaker:So this whole
Speaker:paradigm is
Speaker:actually started
Speaker:by looking at
Speaker:cancer as a
Speaker:physiological
Speaker:process, right?
Speaker:And then
Speaker:determining what
Speaker:was going on
Speaker:within cancer.
Speaker:But then
Speaker:obviously then as
Speaker:time went on, it
Speaker:actually was made
Speaker:apparent
Speaker:that the rate of
Speaker:respiratory chain
Speaker:activity has a
Speaker:dramatic impact
Speaker:over the
Speaker:availability of
Speaker:ATP, but not only
Speaker:the availability
Speaker:of ATP, it's
Speaker:potential
Speaker:oxidative
Speaker:byproducts.
Speaker:So mitochondria
Speaker:produce a lot of
Speaker:oxidants because
Speaker:they produce a
Speaker:lot of energy,
Speaker:which means that
Speaker:their membranes
Speaker:are highly
Speaker:susceptible to
Speaker:oxidative stress
Speaker:if they're not
Speaker:maintained in a
Speaker:neutral anhydrous
Speaker:state, okay?
Speaker:Like a battery.
Speaker:You have to think
Speaker:of your
Speaker:mitochondria like
Speaker:a battery.
Speaker:If the polarity
Speaker:or the ion
Speaker:exchange is not
Speaker:in well balanced
Speaker:within
Speaker:mitochondria,
Speaker:that battery gets
Speaker:hot, okay?
Speaker:And what can
Speaker:induce this if we
Speaker:do not, or if our
Speaker:mitochondria
Speaker:don't have the
Speaker:capacity to
Speaker:readily shift
Speaker:from different
Speaker:energy dynamics,
Speaker:meaning from
Speaker:something as
Speaker:immediate as the
Speaker:creatine
Speaker:phosphate system
Speaker:to the
Speaker:glycolysis, to
Speaker:triclobolic acid,
Speaker:to electron
Speaker:transport chain
Speaker:and shifting.
Speaker:Because the thing
Speaker:is you shouldn't
Speaker:just do one.
Speaker:Like there is a
Speaker:flow of them all
Speaker:happening
Speaker:simultaneously
Speaker:but to varying
Speaker:degrees.
Speaker:But when there's
Speaker:a requirement in
Speaker:the shift to take
Speaker:place into a more
Speaker:predominant state
Speaker:of respiratory
Speaker:chain activity,
Speaker:energy
Speaker:production, and
Speaker:that shift can't
Speaker:take place
Speaker:effectively, then
Speaker:what happens is
Speaker:these
Speaker:mitochondria
Speaker:become highly
Speaker:radical.
Speaker:So they start to
Speaker:not only damage
Speaker:their own DNA but
Speaker:they start to
Speaker:damage DNA within
Speaker:proximity from
Speaker:expression from
Speaker:the nucleus of
Speaker:the cell.
Speaker:And this is where
Speaker:over time you can
Speaker:start to have
Speaker:mutations occur
Speaker:as well.
Speaker:Albeit that even
Speaker:prior to these
Speaker:mutations
Speaker:occurring an
Speaker:increase in the
Speaker:likelihood of a
Speaker:concept called
Speaker:immunological
Speaker:citizens may take
Speaker:place as well.
Speaker:So metabolism,
Speaker:immunology, what
Speaker:was the term?
Speaker:How did you
Speaker:connect
Speaker:those two terms?
Speaker:The idea of sort
Speaker:of
Speaker:immunomatabolism.
Speaker:Immunomatabolism
Speaker:of our, see the
Speaker:moments of the
Speaker:light
Speaker:dislikes here.
Speaker:Immunomatabolism
Speaker:really is, as you
Speaker:mentioned, the
Speaker:segue between how
Speaker:the internal
Speaker:environment of
Speaker:our physiology is
Speaker:responding to
Speaker:stimuli from our
Speaker:external
Speaker:environment.
Speaker:And subsequently
Speaker:within that
Speaker:response, how
Speaker:well we are
Speaker:managing the
Speaker:production as
Speaker:well as recycling
Speaker:of energy.
Speaker:So going back to
Speaker:Professor
Speaker:Navia's work,
Speaker:there he created
Speaker:a concept called
Speaker:the cell danger
Speaker:response state,
Speaker:which involves
Speaker:different states
Speaker:of respiratory
Speaker:chain activity in
Speaker:the mitochondria,
Speaker:going from a
Speaker:neutral, or I'm
Speaker:gonna say a
Speaker:neutral state, a
Speaker:energetically
Speaker:efficient state.
Speaker:So think of your
Speaker:mitochondria when
Speaker:they're like
Speaker:nuclear power
Speaker:plants, meaning
Speaker:they produce a
Speaker:lot of energy
Speaker:with a high
Speaker:energy yield, but
Speaker:a low
Speaker:energy cost.
Speaker:That's when
Speaker:they're in their
Speaker:energetic,
Speaker:optimized state.
Speaker:Okay, so they are
Speaker:nuclear
Speaker:power plants.
Speaker:That would be CDR3.
Speaker:No, no, that's a
Speaker:neutral CDR.
Speaker:That's CDR0,
Speaker:think about it.
Speaker:Okay, all right.
Speaker:That's your, the
Speaker:top part of
Speaker:the wheel.
Speaker:And then what
Speaker:happens is when
Speaker:you initially
Speaker:have a threat, it
Speaker:doesn't have to
Speaker:be a
Speaker:pathogenic threat.
Speaker:It can be a
Speaker:toxin, it can be
Speaker:a heavy metal, it
Speaker:could be
Speaker:psychological
Speaker:threats, it could
Speaker:be persistent
Speaker:organic
Speaker:pollutants.
Speaker:You name it.
Speaker:When there's an
Speaker:initial threat of
Speaker:which the immune
Speaker:system perceives
Speaker:that it needs to
Speaker:create a specific
Speaker:response to, then
Speaker:the mitochondria
Speaker:shift into a
Speaker:CDR1 state.
Speaker:This is where
Speaker:they become more
Speaker:glycolytically
Speaker:dominant.
Speaker:Now, which is
Speaker:very natural, and
Speaker:just by the way,
Speaker:the mitochondria
Speaker:are continually
Speaker:shifting in and
Speaker:out of these
Speaker:different cell
Speaker:danger
Speaker:response states.
Speaker:But it's
Speaker:important that
Speaker:they're able to
Speaker:shift and they
Speaker:don't get stuck.
Speaker:Okay, the reason
Speaker:as to why they
Speaker:get stuck is
Speaker:very, are very
Speaker:complex, because
Speaker:now we're looking
Speaker:at an interplay
Speaker:between endocrine
Speaker:and neurological,
Speaker:immunological,
Speaker:which actually
Speaker:there's Leo
Speaker:Prambro, of which
Speaker:we both know of.
Speaker:He also created a
Speaker:category
Speaker:entitled
Speaker:psychoneuroimmunology,
Speaker:which pretty much
Speaker:embodies a lot of
Speaker:this work
Speaker:as well.
Speaker:But he puts it
Speaker:into a construct
Speaker:of not only that
Speaker:of apparent
Speaker:physiology, but
Speaker:also
Speaker:psychological,
Speaker:even spiritual
Speaker:processes, which
Speaker:I'm very much
Speaker:aligned into his
Speaker:theories as well.
Speaker:Yet, we go back
Speaker:to Navio's work,
Speaker:the cell danger
Speaker:one is when you
Speaker:become more
Speaker:glycolytically
Speaker:dominant.
Speaker:So what happens
Speaker:here is that the
Speaker:mitochondria are
Speaker:going to be more
Speaker:readily engaged,
Speaker:augmented,
Speaker:responsive, are
Speaker:gonna be more
Speaker:responsive to
Speaker:within the use of
Speaker:glucose as an
Speaker:energy fuel
Speaker:source, right?
Speaker:Glucose and
Speaker:pyruvate and so
Speaker:on, rather than
Speaker:being able to
Speaker:utilize a vast
Speaker:degree of
Speaker:precursors to
Speaker:pyruvate, such as
Speaker:fats and
Speaker:amino acids.
Speaker:So what happens
Speaker:here is that you
Speaker:create a
Speaker:maladaptive
Speaker:response if you
Speaker:get stuck in the
Speaker:CDR1 state,
Speaker:whereby the
Speaker:mitochondria are
Speaker:like, okay, we
Speaker:need glucose, we
Speaker:need glucose, and
Speaker:you start having
Speaker:increased sugar
Speaker:cravings.
Speaker:And subsequently,
Speaker:this is where it
Speaker:starts, right?
Speaker:And then the
Speaker:increase of sugar
Speaker:cravings can also
Speaker:have an impact on
Speaker:driving down
Speaker:methylation
Speaker:because sugar
Speaker:depletes
Speaker:methyl donors.
Speaker:And this is where
Speaker:it can really
Speaker:become a storm.
Speaker:Not only a
Speaker:cytokine storm,
Speaker:but also a storm
Speaker:on your
Speaker:neurotransmitter
Speaker:makeup.
Speaker:So you start to
Speaker:be able to
Speaker:produce less
Speaker:dopamine, you
Speaker:start to have
Speaker:dysregulated
Speaker:production of
Speaker:serotonin, you
Speaker:start to have
Speaker:exacerbated
Speaker:expression of
Speaker:extracellular
Speaker:glutamate, not
Speaker:intracellular,
Speaker:extracellular
Speaker:glutamate.
Speaker:You start to
Speaker:downregulate your
Speaker:gamma-minipituric
Speaker:acid receptor
Speaker:sensitivity
Speaker:because you're
Speaker:not producing
Speaker:enough of it
Speaker:because the
Speaker:extracellular
Speaker:glutamate is
Speaker:preventing you
Speaker:from doing so.
Speaker:And these are all
Speaker:the unfortunate
Speaker:consequences that
Speaker:occur with
Speaker:habitual excess
Speaker:of sugar intake.
Speaker:Now, this state
Speaker:CDR1 is also
Speaker:associated to an
Speaker:immunological
Speaker:phenotype called
Speaker:TH2 dominant, of
Speaker:which I've just
Speaker:written a
Speaker:book about.
Speaker:And it's a book
Speaker:that will be
Speaker:facing for
Speaker:practitioners as
Speaker:well as for
Speaker:the laymen.
Speaker:So we'll have all
Speaker:the complex words
Speaker:that I've thrown
Speaker:around today.
Speaker:We'll have some
Speaker:words that people
Speaker:understand.
Speaker:And the book for
Speaker:the laymen is
Speaker:entitled
Speaker:"Responsible
Speaker:Living, Moving
Speaker:Away From
Speaker:Reactivity."
Speaker:And this is
Speaker:really important
Speaker:because our
Speaker:bodies have
Speaker:veered into
Speaker:states of
Speaker:reactivity
Speaker:without us even
Speaker:realizing it.
Speaker:And the CDR1,
Speaker:when we get stuck
Speaker:here, we also
Speaker:propensiate the
Speaker:release of
Speaker:histamine, which
Speaker:creates fibrosis,
Speaker:which causes poor
Speaker:microvasculature,
Speaker:which does not
Speaker:enable things
Speaker:such as an
Speaker:example, thyroid
Speaker:hormone, from
Speaker:being able to
Speaker:reach certain
Speaker:receptors in the
Speaker:mitochondrial
Speaker:space to induce
Speaker:support of
Speaker:oxidant-phosphorylated
Speaker:pathways, which
Speaker:thyroid hormone
Speaker:is highly
Speaker:responsible
Speaker:for doing.
Speaker:Start protein
Speaker:expression and
Speaker:all of that.
Speaker:Exactly right,
Speaker:exactly right.
Speaker:So this is CDR1.
Speaker:And often people
Speaker:get stuck here
Speaker:because, again,
Speaker:when we're young
Speaker:and our DNA can
Speaker:replicate at a
Speaker:quicker pace, we
Speaker:can recover.
Speaker:But as soon as we
Speaker:get to like 33,
Speaker:that varies from
Speaker:person to person.
Speaker:That's the first
Speaker:switch that
Speaker:occurs as to when
Speaker:our DNA
Speaker:replication
Speaker:starts to
Speaker:slow down.
Speaker:And this is where
Speaker:we have an
Speaker:increase of
Speaker:senescence
Speaker:starting
Speaker:to come up.
Speaker:And then
Speaker:obviously that
Speaker:proliferates as
Speaker:we get over the
Speaker:age of 55, it
Speaker:really
Speaker:proliferates.
Speaker:So in our current
Speaker:time, when you're
Speaker:young, 20s and
Speaker:you're a
Speaker:youngster, you
Speaker:don't feel it as
Speaker:much, but without
Speaker:a doubt, you're
Speaker:being exposed to
Speaker:it and you'll
Speaker:start to
Speaker:feel it later.
Speaker:And it's been
Speaker:reported that
Speaker:those who were
Speaker:born in our
Speaker:generation may
Speaker:not even live as
Speaker:long as our
Speaker:parents'
Speaker:generation,
Speaker:right?
Speaker:Despite the
Speaker:medical
Speaker:advancements.
Speaker:And there's
Speaker:obviously, it's a
Speaker:polarized
Speaker:perspective,
Speaker:again, the
Speaker:courses of
Speaker:polarity,
Speaker:but it does make
Speaker:consideration as
Speaker:to where it is.
Speaker:And these
Speaker:suggestive
Speaker:probabilities
Speaker:that would come
Speaker:about just by
Speaker:opinion, that
Speaker:came about from
Speaker:actually looking
Speaker:into the increase
Speaker:of
Speaker:non-conventional
Speaker:disease and the
Speaker:subsequent
Speaker:shortening of
Speaker:lifespan,
Speaker:depending
Speaker:upon that.
Speaker:And also
Speaker:financial
Speaker:constraints that
Speaker:come about with
Speaker:non-conventional
Speaker:disease, because
Speaker:it's one thing to
Speaker:have medical
Speaker:advancements, but
Speaker:it's another
Speaker:thing to
Speaker:look at, right?
Speaker:So we're actually
Speaker:living in a very
Speaker:interesting time
Speaker:where we have a
Speaker:lot of
Speaker:innovation, but
Speaker:yet we're still
Speaker:exposed to the
Speaker:onslaught of
Speaker:continual stress.
Speaker:Now, one of the
Speaker:bigger stressors
Speaker:that I think is
Speaker:not considered
Speaker:are the unseen
Speaker:stressors
Speaker:like EMF.
Speaker:Without a doubt,
Speaker:non-native EMF is
Speaker:by far the
Speaker:biggest toxin of
Speaker:our age, by far.
Speaker:Without a doubt,
Speaker:there's a-- Ooh,
Speaker:there's a
Speaker:decisive
Speaker:statement.
Speaker:Yeah, absolutely.
Speaker:And I'm also,
Speaker:like I mentioned
Speaker:before, be
Speaker:careful when you
Speaker:have people
Speaker:saying, decisive
Speaker:statements in
Speaker:this instance,
Speaker:and I'm very,
Speaker:very, very
Speaker:critical of being
Speaker:objective.
Speaker:But in this
Speaker:instance, I am
Speaker:passionately
Speaker:committed to the
Speaker:statement that
Speaker:non-native EMF is
Speaker:by far the
Speaker:greatest toxin of
Speaker:our age.
Speaker:The influx of
Speaker:patients
Speaker:struggling with
Speaker:chronic fatigue,
Speaker:struggling with
Speaker:different forms
Speaker:of neurodiversity
Speaker:since the
Speaker:introduction of
Speaker:5G towers is very
Speaker:apparent.
Speaker:Not only in my
Speaker:practice, but
Speaker:many other
Speaker:doctors and
Speaker:physicians, which
Speaker:I work in
Speaker:community with,
Speaker:have also
Speaker:experienced the
Speaker:same thing.
Speaker:So in essence,
Speaker:not to go down
Speaker:that rabbit hole,
Speaker:because Alice is
Speaker:waiting with a
Speaker:mad hatcher to
Speaker:really go down
Speaker:the tangent.
Speaker:So just to avoid
Speaker:that tangent, and
Speaker:the point I'm
Speaker:trying to make is
Speaker:we live in a time
Speaker:where we are
Speaker:perpetually
Speaker:exposed to many
Speaker:stressors, more
Speaker:so than what we
Speaker:actually might
Speaker:give credit to,
Speaker:and may give
Speaker:awareness to.
Speaker:And because of
Speaker:this, it is by
Speaker:natural default,
Speaker:because I mean,
Speaker:evolution takes a
Speaker:lot longer than
Speaker:technological
Speaker:evolution
Speaker:has taken.
Speaker:So the
Speaker:mitochondria have
Speaker:adapted pretty
Speaker:well, very
Speaker:quickly, but they
Speaker:still haven't
Speaker:adapted to what
Speaker:it is we expose
Speaker:them to in our
Speaker:current daily
Speaker:basis,
Speaker:current times.
Speaker:So what we're
Speaker:finding, what
Speaker:I've found, and
Speaker:other
Speaker:practitioners as
Speaker:well, is that
Speaker:people can
Speaker:momentarily move
Speaker:out of these
Speaker:states, you know,
Speaker:if they implement
Speaker:all the biohacks
Speaker:and they change
Speaker:their lifestyle
Speaker:and so on, but
Speaker:the older that
Speaker:they get, the
Speaker:more inclined
Speaker:they are to stay
Speaker:stuck in the CDR1
Speaker:state, okay?
Speaker:Which is very
Speaker:closely
Speaker:associated to
Speaker:chronic low grade
Speaker:information.
Speaker:And again, in
Speaker:influencing
Speaker:metabolic
Speaker:resistance,
Speaker:because when the
Speaker:mitochondria
Speaker:become more
Speaker:glycolytically
Speaker:dominant, they
Speaker:can look for
Speaker:glucose.
Speaker:They're not gonna
Speaker:utilize fat
Speaker:effectively.
Speaker:So beta-oxidation
Speaker:goes down, which
Speaker:means you have
Speaker:extracellular
Speaker:ketones
Speaker:propagating,
Speaker:which also causes
Speaker:more lipid
Speaker:peroxidation, and
Speaker:other cumulative
Speaker:issues between
Speaker:cells comes into
Speaker:the equation.
Speaker:So it's quite an
Speaker:intense paradigm,
Speaker:to understand,
Speaker:but it's an
Speaker:important concept
Speaker:to understand.
Speaker:When we get into
Speaker:cell danger two
Speaker:response state,
Speaker:this is where we
Speaker:have a
Speaker:proliferated
Speaker:mTOR.
Speaker:Just one question
Speaker:before we jump
Speaker:into CD2, if
Speaker:that's okay.
Speaker:You mentioned
Speaker:earlier that
Speaker:isolation is
Speaker:potentially,
Speaker:aside from
Speaker:non-native EMFs,
Speaker:of course, is
Speaker:potentially one
Speaker:of the biggest
Speaker:triggers of the
Speaker:slow grade
Speaker:inflammation.
Speaker:Do you think, and
Speaker:I'm just thinking
Speaker:of myself,
Speaker:subjectively from
Speaker:this, when saying
Speaker:this, but when I
Speaker:was younger, I
Speaker:was definitely
Speaker:more able, and
Speaker:this speaks to
Speaker:what you were
Speaker:saying earlier
Speaker:about us really
Speaker:being more
Speaker:gregarious than
Speaker:we think we are,
Speaker:I was really able
Speaker:to function more
Speaker:in a sort of an
Speaker:isolated
Speaker:capacity.
Speaker:I found I wasn't
Speaker:that being
Speaker:isolated, I
Speaker:wasn't subject to
Speaker:feeling the way I
Speaker:do now, which as
Speaker:we talked about,
Speaker:I'm going through
Speaker:some, my own sort
Speaker:of
Speaker:post-phylophoty
Speaker:with COVID,
Speaker:et cetera.
Speaker:And maybe that is
Speaker:a mitigating
Speaker:factor thereof,
Speaker:but sort of
Speaker:almost
Speaker:independently of
Speaker:that, and maybe
Speaker:prior to COVID, I
Speaker:found that the
Speaker:more time I
Speaker:spent alone,
Speaker:as I got older, I
Speaker:would, yeah, I
Speaker:would definitely
Speaker:become more
Speaker:systemically
Speaker:inflamed.
Speaker:My HRV would tend
Speaker:to drop,
Speaker:et cetera.
Speaker:Do you think that
Speaker:there's a sort of
Speaker:a direct, well,
Speaker:that social
Speaker:isolation is
Speaker:going to fuel
Speaker:that CDR1
Speaker:response as well,
Speaker:or at least as we
Speaker:get older, is it
Speaker:going to
Speaker:exacerbate it?
Speaker:I think it's a
Speaker:question of
Speaker:correlation,
Speaker:perpetuating
Speaker:causation.
Speaker:So I don't think
Speaker:it's causation,
Speaker:and it's, I don't
Speaker:think it's a
Speaker:direct causation,
Speaker:but I think it
Speaker:most certainly
Speaker:has a correlate
Speaker:to perpetuating
Speaker:this misaligned
Speaker:immunological
Speaker:expression.
Speaker:So as you
Speaker:mentioned before,
Speaker:when you were
Speaker:younger, being
Speaker:able to be within
Speaker:your own space
Speaker:and be in a state
Speaker:of, I won't say
Speaker:isolation, but in
Speaker:a solitary state,
Speaker:a solitude, that
Speaker:is solitude.
Speaker:That's a better
Speaker:way, because
Speaker:isolation kind of
Speaker:sounds like
Speaker:you're
Speaker:self-flagellating,
Speaker:right?
Speaker:But solitude
Speaker:sounds a
Speaker:lot better.
Speaker:Yeah,
Speaker:it's better.
Speaker:So when you're
Speaker:younger, you're
Speaker:able to stay at a
Speaker:state, well, you
Speaker:may have been
Speaker:able, not
Speaker:everybody, but in
Speaker:your case, you
Speaker:may have stayed
Speaker:at a state of
Speaker:solitude, but yet
Speaker:you're not
Speaker:dealing with
Speaker:spike protein.
Speaker:You're not
Speaker:dealing with
Speaker:possible
Speaker:associated
Speaker:re-expressions of
Speaker:envelope-based
Speaker:viruses.
Speaker:As you get older,
Speaker:by way of being
Speaker:exposed to heavy
Speaker:metals, which we
Speaker:all are, and a
Speaker:patient asked me
Speaker:the other day,
Speaker:"Where did I have
Speaker:exposure to heavy
Speaker:metals?"
Speaker:I'm like, "Where
Speaker:did you not?"
Speaker:Why do you not
Speaker:have exposure to
Speaker:heavy metals in
Speaker:the day which we
Speaker:live in?
Speaker:They're
Speaker:accumulates,
Speaker:they're
Speaker:accumulates.
Speaker:So as we get
Speaker:older, we
Speaker:accumulate
Speaker:toxins, the body
Speaker:accumulates
Speaker:toxins,
Speaker:particularly if
Speaker:we're not in the
Speaker:nurse, how to
Speaker:remove them, and
Speaker:to have,
Speaker:it's super
Speaker:important to be
Speaker:responsible, and
Speaker:at word
Speaker:responsible,
Speaker:meaning the
Speaker:ability to
Speaker:respond to it in
Speaker:today's
Speaker:current times.
Speaker:And what I'm
Speaker:referring to here
Speaker:is taking
Speaker:strategies in and
Speaker:into an habitual
Speaker:aspect, affording
Speaker:the body to be
Speaker:lightened from
Speaker:its environmental
Speaker:toxin load.
Speaker:Things like Epsom
Speaker:salts, baths,
Speaker:things like
Speaker:sauna, okay?
Speaker:And obviously, it
Speaker:is also need to
Speaker:come with certain
Speaker:considerations,
Speaker:not everybody
Speaker:should be doing
Speaker:them either.
Speaker:That's why I'm
Speaker:not making a
Speaker:blanket statement
Speaker:that sauna is the
Speaker:holy grail for
Speaker:everybody.
Speaker:Some were to go
Speaker:into a sauna,
Speaker:particularly
Speaker:those who have a
Speaker:perpetuated
Speaker:CDR1 state.
Speaker:It's just going
Speaker:to, it's going to
Speaker:exacerbate your
Speaker:muscle
Speaker:response, okay?
Speaker:So you need to
Speaker:like, it's
Speaker:contextual, but
Speaker:regardless, those
Speaker:are the instates.
Speaker:When we get to
Speaker:the point where
Speaker:we become highly
Speaker:reactive, we
Speaker:wanna prevent
Speaker:people from
Speaker:getting to that
Speaker:point, okay?
Speaker:When you are at
Speaker:that point, it is
Speaker:likely that
Speaker:you're gonna need
Speaker:a practitioner
Speaker:like myself or my
Speaker:team to come in
Speaker:and guide the
Speaker:process because
Speaker:it's complex,
Speaker:it's very
Speaker:complex.
Speaker:But we don't want
Speaker:you to get there.
Speaker:Like, I don't
Speaker:want to see a
Speaker:billion people.
Speaker:You know, I'd
Speaker:rather see less
Speaker:people, ill and
Speaker:support more
Speaker:people being
Speaker:healthy.
Speaker:Yeah,
Speaker:preventative,
Speaker:okay.
Speaker:So habitual detox
Speaker:needs to be part
Speaker:of every modern
Speaker:day man's
Speaker:routine.
Speaker:We do not, we're
Speaker:not, the society
Speaker:is not going to
Speaker:reduce its toxic
Speaker:assault on us.
Speaker:So long as
Speaker:technology
Speaker:affords a payoff,
Speaker:we're gonna
Speaker:continue to have
Speaker:more toxins.
Speaker:Just make peace
Speaker:with that.
Speaker:Yes, I'm hopeful
Speaker:that humanity's
Speaker:future will
Speaker:afford better
Speaker:practices, but in
Speaker:the meantime,
Speaker:let's not negate
Speaker:the reality of
Speaker:corporations and
Speaker:the effect that
Speaker:they have on the
Speaker:economy, okay?
Speaker:And also that
Speaker:effect in which
Speaker:it has in
Speaker:providing
Speaker:employment across
Speaker:the globe.
Speaker:So we can't
Speaker:discredit all
Speaker:these things.
Speaker:We have to
Speaker:consider these
Speaker:things, and which
Speaker:means that we
Speaker:need to be
Speaker:malleable in what
Speaker:it is that we
Speaker:contribute to our
Speaker:own health.
Speaker:Bringing back
Speaker:again the
Speaker:community
Speaker:consciousness
Speaker:around
Speaker:health, right?
Speaker:Yeah, so now your
Speaker:tolerance in that
Speaker:isolated state in
Speaker:contrast to when
Speaker:you're younger is
Speaker:also fueled not
Speaker:only by the fact
Speaker:that you should
Speaker:be around people,
Speaker:because obviously
Speaker:your spirit is
Speaker:telling you this
Speaker:such, but it's
Speaker:also fueled by
Speaker:the fact that
Speaker:there's certain
Speaker:energetic bodies
Speaker:that we exist
Speaker:within, not only
Speaker:the
Speaker:physical state.
Speaker:And I say that, I
Speaker:think it was
Speaker:Wayne Dyer that
Speaker:mentioned one of
Speaker:his audio books.
Speaker:He had a friend
Speaker:that was a
Speaker:neurologist, and
Speaker:they had to, he
Speaker:went to his home
Speaker:for dinner, and
Speaker:they got into
Speaker:conversation
Speaker:about God, okay?
Speaker:And obviously
Speaker:that word has a
Speaker:lot of meaning
Speaker:for
Speaker:different people,
Speaker:or has meaning
Speaker:for, yeah, has
Speaker:difference of
Speaker:meaning for
Speaker:many people.
Speaker:In any case, so
Speaker:his friend was an
Speaker:atheist, and he
Speaker:said, "No, I
Speaker:don't believe in
Speaker:anything, "but I
Speaker:cannot quantify."
Speaker:See, so he's
Speaker:like, "Okay, so
Speaker:Tommy, "when you
Speaker:open up a man's
Speaker:brain, or the
Speaker:skull, "when you
Speaker:look into the
Speaker:brain, "have you
Speaker:ever witnessed
Speaker:consciousness?"
Speaker:That alone is
Speaker:such a profound
Speaker:realization, and
Speaker:the entire human
Speaker:body regenerates
Speaker:itself every
Speaker:seven, well, over
Speaker:a period of
Speaker:seven years.
Speaker:Okay, so the
Speaker:cellular
Speaker:construct changes
Speaker:every seven
Speaker:years, and yet
Speaker:consciousness--
Speaker:Heart included.
Speaker:Blooded.
Speaker:Cardiac muscle
Speaker:included?
Speaker:Now you're asking
Speaker:me a question, I
Speaker:think so.
Speaker:From my
Speaker:understanding, I
Speaker:think all cells
Speaker:actually
Speaker:recycle over a
Speaker:period of
Speaker:seven years.
Speaker:Cardiac cells, I
Speaker:think actually
Speaker:have a quicker
Speaker:recycling
Speaker:capacity more so
Speaker:than others.
Speaker:Liver and cardiac
Speaker:cells have
Speaker:couldn't actually
Speaker:repair quite
Speaker:quickly,
Speaker:but now you're
Speaker:asking me, I need
Speaker:to look back into
Speaker:my physiology.
Speaker:(Laughing) Yeah, no.
Speaker:Don't remember
Speaker:everything of
Speaker:heart, but
Speaker:nonetheless, all
Speaker:cells, the
Speaker:entire, like some
Speaker:cells, like
Speaker:they're repaired
Speaker:slower than
Speaker:others, but all
Speaker:cells over a
Speaker:seven year period
Speaker:would have
Speaker:changed, would
Speaker:have actually
Speaker:changed.
Speaker:(Laughing) Would have been
Speaker:recycled,
Speaker:regenerated,
Speaker:regenerated,
Speaker:that's what I was
Speaker:looking for,
Speaker:regenerated.
Speaker:So just have that
Speaker:concept in your
Speaker:mind, if your
Speaker:entire construct
Speaker:is gonna be
Speaker:different in
Speaker:seven years from
Speaker:now, which it is,
Speaker:but yet your
Speaker:consciousness is
Speaker:transferred
Speaker:into your new
Speaker:construct.
Speaker:What does
Speaker:that depict?
Speaker:What does
Speaker:that mean?
Speaker:Does it mean that
Speaker:Newtonian concept
Speaker:of physical
Speaker:reality of
Speaker:physics is very
Speaker:much a small
Speaker:vantage point of
Speaker:a greater
Speaker:paradigm?
Speaker:Are we looking
Speaker:now to the realm
Speaker:of quantum?
Speaker:What are we, in
Speaker:essence, in the
Speaker:realm of quantum?
Speaker:We're the space
Speaker:between spaces.
Speaker:What does
Speaker:that mean?
Speaker:We're a thought,
Speaker:we're an idea.
Speaker:And this is when
Speaker:you start to
Speaker:think of your, in
Speaker:this type of
Speaker:manner, and you
Speaker:start to see a
Speaker:human, not as a
Speaker:physical body,
Speaker:but as a spirit
Speaker:having a human
Speaker:experience, you
Speaker:start to see that
Speaker:the spirit comes
Speaker:into experience
Speaker:by way of its
Speaker:desire of
Speaker:education.
Speaker:And it is
Speaker:important that
Speaker:when you start to
Speaker:see a person
Speaker:going through a
Speaker:period of
Speaker:struggle, that
Speaker:you support their
Speaker:education, that
Speaker:you don't try to
Speaker:have them avoid
Speaker:their education,
Speaker:which is where
Speaker:opioids can come
Speaker:into the equation
Speaker:otherwise.
Speaker:And I'm not
Speaker:saying opioids
Speaker:are always wrong,
Speaker:there are
Speaker:instances where
Speaker:they're helpful,
Speaker:but definitely
Speaker:not to the degree
Speaker:of which they're
Speaker:being abused.
Speaker:And this is where
Speaker:the ego, now
Speaker:we're going to
Speaker:the realm of
Speaker:psychology, has
Speaker:the part in
Speaker:trying to
Speaker:captivate its
Speaker:falsehood in
Speaker:your belief
Speaker:in being your
Speaker:God, in being
Speaker:your reality.
Speaker:And in essence,
Speaker:the ego is just a
Speaker:program that we
Speaker:adopt for
Speaker:survival in the
Speaker:physical
Speaker:construct, but it
Speaker:most certainly
Speaker:does not need to
Speaker:define us.
Speaker:And when you
Speaker:don't let it
Speaker:define you,
Speaker:because the ego
Speaker:is also manifest
Speaker:by cultural,
Speaker:societal, and
Speaker:belief
Speaker:systems, right?
Speaker:Which get
Speaker:impressed upon us
Speaker:from the day in
Speaker:which we
Speaker:were born.
Speaker:So it begs the
Speaker:question is what
Speaker:is us and what
Speaker:isn't us?
Speaker:Like are we the
Speaker:narrative that we
Speaker:have adopted?
Speaker:Are we more?
Speaker:And I believe
Speaker:that we're more,
Speaker:I believe in the
Speaker:latter, but it is
Speaker:important to
Speaker:nurse a person's
Speaker:experience so
Speaker:that they can
Speaker:have the life of
Speaker:an elevated life
Speaker:where they're not
Speaker:impacted by the
Speaker:burden of disease
Speaker:and so on, which
Speaker:means that
Speaker:sometimes when
Speaker:somebody's going
Speaker:through shit,
Speaker:it's because they
Speaker:are meant to go
Speaker:through shit.
Speaker:They're meant not
Speaker:to just stay
Speaker:there, but
Speaker:they're meant to
Speaker:go through it.
Speaker:Now you can't go
Speaker:through something
Speaker:if you avoid it.
Speaker:It's like having
Speaker:a tunnel.
Speaker:It's like you're
Speaker:being on a main
Speaker:road and there's
Speaker:a tunnel
Speaker:coming up.
Speaker:And you gotta go
Speaker:through the
Speaker:tunnel to get to
Speaker:the other side
Speaker:and see the
Speaker:daylight again.
Speaker:But you get to
Speaker:the tunnel and
Speaker:instead of going
Speaker:through the
Speaker:tunnel, you just
Speaker:put on all your
Speaker:lights in the car
Speaker:so that you could
Speaker:have some light,
Speaker:but you blind
Speaker:yourself and then
Speaker:you try to go
Speaker:through the
Speaker:tunnel, but you
Speaker:keep on crashing
Speaker:because you have
Speaker:too much light
Speaker:going on in your
Speaker:car because
Speaker:you're not
Speaker:willing to
Speaker:experience a
Speaker:brevity of
Speaker:darkness.
Speaker:Yeah, that
Speaker:makes sense.
Speaker:I think that
Speaker:there's a lot
Speaker:there to unpack.
Speaker:And yeah, it is
Speaker:interesting how
Speaker:we sort of
Speaker:managed to link
Speaker:CDR one up with
Speaker:almost this sort
Speaker:of pseudo concept
Speaker:of free will.
Speaker:I guess.
Speaker:But yeah, getting
Speaker:back to sort of
Speaker:the cell danger
Speaker:response just to
Speaker:sort of tie up
Speaker:this section of
Speaker:the conversation.
Speaker:CDR two
Speaker:specifically, you
Speaker:sort of
Speaker:elucidated that
Speaker:CDR one is where
Speaker:there's a lot of
Speaker:sort of disparity
Speaker:in fuel sources
Speaker:being used and
Speaker:this cell becomes
Speaker:sort of almost
Speaker:more glycolytic
Speaker:and sort of more
Speaker:dependent on
Speaker:those fuel
Speaker:sources and less
Speaker:able to maybe
Speaker:utilize fatty
Speaker:acids if you're,
Speaker:which I think is
Speaker:quite interesting
Speaker:because you
Speaker:oftentimes see
Speaker:people who are
Speaker:unable to fast,
Speaker:unable to sort of
Speaker:utilize ketogenic
Speaker:diets
Speaker:effectively.
Speaker:They're often in
Speaker:this state.
Speaker:Now, it then
Speaker:obviously
Speaker:progresses as you
Speaker:alluded
Speaker:to CDR two.
Speaker:Would you sort of
Speaker:mind sort of
Speaker:carrying on the
Speaker:conversation
Speaker:from there?
Speaker:Yeah, absolutely.
Speaker:So CDR two from a
Speaker:pathological
Speaker:perspective has
Speaker:high association
Speaker:with cancer and
Speaker:PCOS and
Speaker:endometriosis.
Speaker:In essence, where
Speaker:replication or
Speaker:cell cycle arrest
Speaker:starts to become
Speaker:somewhat
Speaker:compromised.
Speaker:So CDR two is
Speaker:when it is a
Speaker:predominant mTOR
Speaker:state and not
Speaker:enough of an AMPK
Speaker:reactive state.
Speaker:So this is where
Speaker:mitochondria
Speaker:become highly
Speaker:saturated.
Speaker:Okay, so if one
Speaker:is stuck in a CDR
Speaker:two, let's
Speaker:understand from
Speaker:the natural way
Speaker:in which this
Speaker:whole sequence of
Speaker:events is meant
Speaker:to unfold is that
Speaker:when you
Speaker:initially have a
Speaker:threat, you
Speaker:induce
Speaker:inflammation,
Speaker:which by way of
Speaker:increasing the
Speaker:activity of
Speaker:glycolysis,
Speaker:you're gonna
Speaker:increase
Speaker:extracellular ATP
Speaker:quite rapidly.
Speaker:That
Speaker:extracellular ATP
Speaker:fills the
Speaker:response of the
Speaker:innate system,
Speaker:but also then
Speaker:triggers the
Speaker:adaptive immune
Speaker:system to create
Speaker:replication,
Speaker:plonal
Speaker:replication,
Speaker:okay.
Speaker:And then you get
Speaker:into the CDR two.
Speaker:Now the CDR two,
Speaker:you have again,
Speaker:it's glycolysis
Speaker:as well as your
Speaker:oxidase or
Speaker:phosphorylated
Speaker:systems that
Speaker:start to kick in.
Speaker:But they kick in
Speaker:in a more of a
Speaker:predominance mTOR
Speaker:fashion for
Speaker:recovery, okay,
Speaker:for recovery
Speaker:because CDR one,
Speaker:inflammation
Speaker:damages tissue.
Speaker:CDR two, the
Speaker:recovery of that
Speaker:damaged tissue
Speaker:needs to take
Speaker:place, okay.
Speaker:And then CDR
Speaker:three, if you're
Speaker:there, this is
Speaker:when you're
Speaker:nucleotide, your
Speaker:production of
Speaker:NAD, FAD, this
Speaker:starts to ramp up
Speaker:to support
Speaker:electron
Speaker:transport chain.
Speaker:Okay, but if you
Speaker:get stuck in a
Speaker:CDR three, it's
Speaker:because there is
Speaker:compromise in the
Speaker:phosphate
Speaker:systems.
Speaker:Not to support
Speaker:the electron
Speaker:transport chain.
Speaker:So this is
Speaker:where like,
Speaker:that autism is
Speaker:indicative
Speaker:of CDR three.
Speaker:Okay, so you have
Speaker:optimal oxidative
Speaker:phosphorylation,
Speaker:but you don't
Speaker:have enough of
Speaker:the spark because
Speaker:your glycolysis
Speaker:lights that
Speaker:bonfire to keep
Speaker:the mitochondria
Speaker:in an anhydrous
Speaker:state,
Speaker:catabolic state.
Speaker:If you don't have
Speaker:enough of that
Speaker:glycolytic
Speaker:reaction
Speaker:occurring, then
Speaker:the mitochondria,
Speaker:although their
Speaker:nucleotide
Speaker:reactions can be
Speaker:optimal through
Speaker:oxidative
Speaker:phosphorylation,
Speaker:subsequent
Speaker:availability of
Speaker:things like NAD
Speaker:would be
Speaker:massively
Speaker:declined because
Speaker:sequence of in
Speaker:the production of
Speaker:NAD is also
Speaker:highly reliant on
Speaker:glycolysis
Speaker:as well.
Speaker:And this is where
Speaker:something like
Speaker:the thylene blue
Speaker:would come in as
Speaker:an electron dolib
Speaker:because it's
Speaker:obviously able to
Speaker:bypass some of
Speaker:those complexes
Speaker:that are being
Speaker:blocked, is that
Speaker:correct?
Speaker:In part, yes, but
Speaker:most certainly
Speaker:the first and the
Speaker:third complexes,
Speaker:but it also can
Speaker:come into
Speaker:the CDR one.
Speaker:Let me
Speaker:explain why.
Speaker:So the CDR one
Speaker:will trigger a
Speaker:macrophage to
Speaker:induce a
Speaker:hepcidin, an
Speaker:increase of
Speaker:hepcidin
Speaker:activity, which
Speaker:basically affords
Speaker:their consumption
Speaker:of iron, thereby
Speaker:increasing their
Speaker:nature from an
Speaker:anti-inflammatory
Speaker:state to a
Speaker:radical state, in
Speaker:perpetuating
Speaker:their
Speaker:pro-inflammatory
Speaker:activity in the
Speaker:body, which by
Speaker:means of
Speaker:increasing
Speaker:attraction toward
Speaker:a particular site
Speaker:is highly
Speaker:feasible and also
Speaker:productive.
Speaker:So the macrophage
Speaker:in compromising,
Speaker:so by
Speaker:compromising
Speaker:iron,
Speaker:by creating an
Speaker:excess of
Speaker:extracellular
Speaker:iron as well not
Speaker:being made
Speaker:available for the
Speaker:health of red
Speaker:blood cells and
Speaker:so on, has a
Speaker:negative knock-on
Speaker:impact onto the
Speaker:pentose phosphate
Speaker:cycle, which also
Speaker:has a depleto
Speaker:factor on NADPH
Speaker:availability.
Speaker:So in these
Speaker:instances, iron
Speaker:is incredibly
Speaker:important for
Speaker:oxidative
Speaker:phosphorylation,
Speaker:incredibly,
Speaker:particularly with
Speaker:those particular
Speaker:oxidative
Speaker:phosphorylated
Speaker:points,
Speaker:those stages.
Speaker:So methylene blue
Speaker:comes into the
Speaker:equation by
Speaker:firstly reducing
Speaker:the release of
Speaker:hepcidin, also by
Speaker:neutralizing the
Speaker:reactivity of
Speaker:these monocytes,
Speaker:all the while
Speaker:even in an
Speaker:iron-depleted
Speaker:state, which most
Speaker:viral incidences
Speaker:can actually
Speaker:induce, it still
Speaker:supports the
Speaker:mechanisms of
Speaker:which get shut
Speaker:down when one
Speaker:goes into a
Speaker:predominant
Speaker:glycolytic state.
Speaker:So methylene blue
Speaker:can, most
Speaker:certainly, it's a
Speaker:versatile
Speaker:molecule that can
Speaker:be utilized in
Speaker:multiple CDR
Speaker:states, but
Speaker:specifically CDR1
Speaker:and CDR3, it is
Speaker:highly beneficial
Speaker:to incorporate
Speaker:its use.
Speaker:Okay, and just
Speaker:one follow-up
Speaker:from that, and
Speaker:I've just been
Speaker:going through
Speaker:this, trying to
Speaker:understand this
Speaker:concept of
Speaker:ferroptosis,
Speaker:sort of
Speaker:pre-programmed,
Speaker:form of
Speaker:pre-programmed
Speaker:cell death that
Speaker:is driven by sort
Speaker:of, I believe,
Speaker:characterized by
Speaker:iron-dependent
Speaker:accumulation in
Speaker:lipid peroxides.
Speaker:Now,
Speaker:loosely with
Speaker:methylene blue,
Speaker:and I'm just
Speaker:trying to link
Speaker:this together on
Speaker:the fly here, so
Speaker:I might be
Speaker:completely
Speaker:off base,
Speaker:would you
Speaker:potentially
Speaker:utilize methylene
Speaker:blue when there's
Speaker:this sort of
Speaker:heightened
Speaker:presence of
Speaker:ferroptosis?
Speaker:Absolutely, it
Speaker:would propensiate
Speaker:it, for sure.
Speaker:Actually, it
Speaker:propensiates ever
Speaker:more, so it
Speaker:wouldn't
Speaker:inhibit it.
Speaker:It would actually
Speaker:propensiate that
Speaker:particular
Speaker:activity of
Speaker:ferroptosis, for sure.
Speaker:Okay.
Speaker:Yeah.
Speaker:All right,
Speaker:okay, good.
Speaker:I'm glad I
Speaker:vaguely got
Speaker:something
Speaker:right today.
Speaker:Yep, we have to
Speaker:ask stuff, what
Speaker:is the process of
Speaker:ferroptosis
Speaker:actually
Speaker:inducing?
Speaker:A form of
Speaker:apoptosis or a
Speaker:necrosis.
Speaker:Exactly,
Speaker:apoptosis,
Speaker:hopefully not
Speaker:necrosis, but
Speaker:apoptosis,
Speaker:for sure.
Speaker:And what
Speaker:methylene blue
Speaker:will actually do
Speaker:is fuel that
Speaker:process of
Speaker:autophagy to
Speaker:occur by way in
Speaker:which it actually
Speaker:modulates
Speaker:oxidative
Speaker:phosphorylated
Speaker:pathways to
Speaker:ensure the
Speaker:continual supply
Speaker:of energy that's
Speaker:required during
Speaker:processes of
Speaker:autophagy.
Speaker:Okay, I think
Speaker:I've got that.
Speaker:That's, yeah,
Speaker:I've got it good.
Speaker:If you think
Speaker:about the
Speaker:difference
Speaker:between
Speaker:catecholamine,
Speaker:dorbicorticoids,
Speaker:and
Speaker:insulin, okay.
Speaker:So insulin brings
Speaker:things into the
Speaker:cell,
Speaker:dorbicorticoids,
Speaker:catecholamine
Speaker:release things
Speaker:from the cell.
Speaker:Okay, so when we
Speaker:are looking to,
Speaker:(Laughs)
Speaker:I'm trying to
Speaker:simplify
Speaker:something very
Speaker:complex.
Speaker:(Laughs) Sorry, sorry,
Speaker:this is
Speaker:completely
Speaker:my fault.
Speaker:We've gone off on
Speaker:a tangent.
Speaker:No, not at all,
Speaker:not at all.
Speaker:When we are
Speaker:looking to break
Speaker:particles down,
Speaker:we need somewhat
Speaker:of a catalytic
Speaker:reaction to
Speaker:occur, okay.
Speaker:In order for a
Speaker:catalytic action
Speaker:to occur, we need
Speaker:availability
Speaker:of ATP.
Speaker:So we need to be able to do that
Speaker:in the most
Speaker:basic sense.
Speaker:So in an increase
Speaker:of ferroptosis,
Speaker:you're most
Speaker:certainly
Speaker:inducing an
Speaker:oxidative state
Speaker:in the
Speaker:body, okay.
Speaker:That's pretty
Speaker:much what it
Speaker:does, and from
Speaker:that, apoptosis
Speaker:shouldn't ensue.
Speaker:And high dose
Speaker:vitamin C by way
Speaker:is a way of
Speaker:inducing
Speaker:ferroptosis.
Speaker:Yeah, that's one
Speaker:of the, that's
Speaker:one of, and
Speaker:people didn't
Speaker:realize this for
Speaker:such a long time
Speaker:when they were
Speaker:like, you know,
Speaker:using high dose
Speaker:vitamin C and was
Speaker:working
Speaker:for cancer.
Speaker:It's actually
Speaker:because it
Speaker:induces an
Speaker:oxidative state
Speaker:in order for the
Speaker:body to
Speaker:upregulate
Speaker:certain regions
Speaker:of lymphocyte
Speaker:response.
Speaker:This is why it
Speaker:regenerates
Speaker:lymphocytes.
Speaker:Vitamin C is well
Speaker:known to
Speaker:regenerate such
Speaker:toxic lymphocytes
Speaker:that have become
Speaker:exhausted, high
Speaker:dose vitamin C.
Speaker:And it's by way,
Speaker:in part, by way
Speaker:of this oxidative
Speaker:process through
Speaker:ferroptosis that
Speaker:this occurs.
Speaker:So in order for
Speaker:this to continue
Speaker:to provide
Speaker:its process of
Speaker:apoptosis
Speaker:support, there is
Speaker:a needed
Speaker:availability of
Speaker:energy that comes
Speaker:into the
Speaker:equation, not
Speaker:only to fuel
Speaker:this, but also to
Speaker:mitigate the
Speaker:excess of
Speaker:radicals that can
Speaker:also create an
Speaker:unwanted effect
Speaker:onto neighboring
Speaker:tissues, which
Speaker:whereby, if this
Speaker:wasn't there, the
Speaker:likelihood of
Speaker:necrosis would be
Speaker:a greater
Speaker:probability.
Speaker:So we don't want,
Speaker:you know,
Speaker:necrotic tissue
Speaker:to accumulate.
Speaker:We want the
Speaker:breakdown and the
Speaker:regeneration, the
Speaker:optimal cell
Speaker:cycle arrest or a
Speaker:cyclo-renewal
Speaker:state to come
Speaker:into the, to into
Speaker:expression.
Speaker:This is where
Speaker:methylene blue,
Speaker:in specific
Speaker:cases, most
Speaker:certainly can
Speaker:improve upon the
Speaker:likelihood of
Speaker:this actually
Speaker:occurring.
Speaker:The consideration
Speaker:to methylene blue
Speaker:is the
Speaker:availability
Speaker:to NADPH.
Speaker:Okay.
Speaker:If there is an
Speaker:insufficient
Speaker:availability of
Speaker:NADPH, which is
Speaker:predominantly
Speaker:fueled through
Speaker:the activity of
Speaker:the
Speaker:pentose-phosphate
Speaker:pathway, then
Speaker:you're going to
Speaker:have an excess of
Speaker:extracellular
Speaker:methylene blue,
Speaker:not leukolucalene
Speaker:blue, but
Speaker:extracellular
Speaker:methylene blue
Speaker:accumulate, which
Speaker:again-- It's the
Speaker:thiamine.
Speaker:Yeah, the
Speaker:thiamine, the
Speaker:thiamine supports
Speaker:the
Speaker:pentose-phosphate
Speaker:pathway.
Speaker:There are other
Speaker:elements that do
Speaker:as well.
Speaker:There are a lot,
Speaker:but the thiamine,
Speaker:as far as a focal
Speaker:point is
Speaker:concerned,
Speaker:propensiates a
Speaker:lot of the PPP
Speaker:activity.
Speaker:So in these
Speaker:constructs
Speaker:between the
Speaker:pentose-phosphate
Speaker:pathway NADPH,
Speaker:NAD, when there
Speaker:isn't enough
Speaker:NADPH to
Speaker:complement the
Speaker:activity of NAD,
Speaker:then leukocytes
Speaker:lose their
Speaker:capacity to
Speaker:integrate from a
Speaker:metabolomic level
Speaker:methylene blue
Speaker:into their
Speaker:construct, which
Speaker:is mostly the
Speaker:reason as to
Speaker:where, as a
Speaker:dichromatic
Speaker:material,
Speaker:methylene blue
Speaker:provides
Speaker:antioxidant
Speaker:support.
Speaker:So it's both an
Speaker:oxidative
Speaker:potentiator as
Speaker:well as an
Speaker:antioxidant
Speaker:potentiator.
Speaker:And in order for
Speaker:it to be
Speaker:balanced, in
Speaker:order for it to
Speaker:have a modulated
Speaker:effect on the
Speaker:body, the
Speaker:subsequent
Speaker:availability of
Speaker:NADPH is highly,
Speaker:highly, highly
Speaker:important.
Speaker:And this is
Speaker:something like
Speaker:anybody that's
Speaker:going through
Speaker:like CDO1 or
Speaker:CDO3, that's
Speaker:looking to, considering
Speaker:utilizing
Speaker:methylene blue,
Speaker:really first
Speaker:thing is to look
Speaker:into the state of
Speaker:their spleen,
Speaker:their specific
Speaker:markers that can
Speaker:give you
Speaker:indication of
Speaker:that MPV, ESR.
Speaker:When there's
Speaker:instance of
Speaker:splenic
Speaker:insufficiency,
Speaker:first, make sure
Speaker:that at the same
Speaker:time that you are
Speaker:supplementing
Speaker:with methylene
Speaker:blue, that you're
Speaker:supporting the
Speaker:PPP with
Speaker:necessary
Speaker:co-factors.
Speaker:And then this
Speaker:will help to
Speaker:mitigate the
Speaker:likelihood of
Speaker:unwanted side
Speaker:effect through
Speaker:the use of
Speaker:methylene blue.
Speaker:It's the same
Speaker:thing with ozone
Speaker:therapy.
Speaker:Ozone therapy is
Speaker:incredible.
Speaker:It most
Speaker:certainly, I
Speaker:mean, it does so
Speaker:many things.
Speaker:I'm just trying
Speaker:to say
Speaker:what it does.
Speaker:It's like, I will
Speaker:take another
Speaker:podcast.
Speaker:Yet, if you were
Speaker:to administer
Speaker:ozone therapy,
Speaker:eventually, I
Speaker:mean, there are
Speaker:certain instances
Speaker:where it requires
Speaker:more application,
Speaker:like for example,
Speaker:Lyme disease
Speaker:and cancer.
Speaker:But that's also
Speaker:because the
Speaker:metabolic state
Speaker:thus deems its
Speaker:necessity based
Speaker:upon what these
Speaker:particular
Speaker:constructs do to
Speaker:immunomatabolism.
Speaker:In situations
Speaker:outside of that
Speaker:construct, if you
Speaker:were to use ozone
Speaker:therapy every
Speaker:day, it's not
Speaker:gonna be very
Speaker:healthy for you.
Speaker:It's the same
Speaker:with
Speaker:methylene blue.
Speaker:Same with
Speaker:methylene blue.
Speaker:It most certainly
Speaker:can be utilized
Speaker:on a daily basis
Speaker:depending upon
Speaker:the content,
Speaker:sorry, the
Speaker:context, the
Speaker:context as to
Speaker:where you're
Speaker:using the
Speaker:methylene blue
Speaker:content
Speaker:within, right?
Speaker:So I'm going off
Speaker:on the tangent of
Speaker:methylene blue,
Speaker:but it does bring
Speaker:you to what it
Speaker:was talking
Speaker:about,
Speaker:immunomatabolism
Speaker:and dichromatic
Speaker:materials.
Speaker:Kirkman is
Speaker:another
Speaker:dichromatic
Speaker:material, by the
Speaker:way, but also
Speaker:plays incredible
Speaker:vantage role in
Speaker:mitigating
Speaker:astrogliosis in
Speaker:the brain,
Speaker:thus reducing the
Speaker:potential buildup
Speaker:of amyloid
Speaker:plaques as well
Speaker:as modulating
Speaker:cineclic protein,
Speaker:ensuring that the
Speaker:misfolding of
Speaker:those proteins
Speaker:don't ensue
Speaker:within the
Speaker:certain regions
Speaker:of the brain.
Speaker:So these are all,
Speaker:these dichromatic
Speaker:materials are
Speaker:credible, but too
Speaker:much Kirkman in
Speaker:certain
Speaker:individuals that
Speaker:have compromised
Speaker:in their modamine
Speaker:oxidase activity
Speaker:or in their
Speaker:phenol breakdown,
Speaker:which has a lot
Speaker:to do actually
Speaker:with gluten
Speaker:intolerance.
Speaker:So those who have
Speaker:like severe
Speaker:gluten
Speaker:intolerance, if
Speaker:you give them a
Speaker:high dose of
Speaker:Kirkman, there's
Speaker:a likelihood that
Speaker:the phenol load
Speaker:in the Kirkman
Speaker:may cause
Speaker:anxiety.
Speaker:Just on Kirkman
Speaker:quickly, have you
Speaker:ever seen any
Speaker:issues,
Speaker:particularly with
Speaker:Kirkman and
Speaker:overly inhibiting
Speaker:5-alpha
Speaker:reductase?
Speaker:Obviously that's
Speaker:another tangent
Speaker:of the rabbit
Speaker:hole, but some
Speaker:people are going
Speaker:to be more
Speaker:sensitive to the
Speaker:inhibition of
Speaker:that enzyme than
Speaker:say others.
Speaker:Do you think, and
Speaker:the whole
Speaker:post-menastride
Speaker:argument is a
Speaker:completely
Speaker:different
Speaker:conversation, I
Speaker:apologize to the
Speaker:audience because
Speaker:we've now gone on
Speaker:rabbit holes, but
Speaker:rabbit holes.
Speaker:However, do you
Speaker:think
Speaker:some of these
Speaker:nutrients to call
Speaker:compounds,
Speaker:high dose
Speaker:riboflavin, zinc,
Speaker:et cetera, what
Speaker:are the other
Speaker:ones, the lion's
Speaker:mane, can
Speaker:potentiate some
Speaker:of these issues
Speaker:that the same
Speaker:class of drug
Speaker:acting on the
Speaker:same receptor
Speaker:can, or do you
Speaker:not see that to
Speaker:be an issue
Speaker:clinically
Speaker:speaking?
Speaker:I guess the
Speaker:Kirkman,
Speaker:resveratrol,
Speaker:there are a
Speaker:couple of others
Speaker:that have an
Speaker:impact on 5-alpha
Speaker:reductase.
Speaker:Some have also
Speaker:reported that it
Speaker:can have an
Speaker:impact on free
Speaker:androgen levels
Speaker:as well in that
Speaker:activity.
Speaker:When you look
Speaker:into the pharma
Speaker:dynamics,
Speaker:you'll see that
Speaker:it really is
Speaker:dependent upon
Speaker:specific genetic
Speaker:probabilities
Speaker:into enzyme
Speaker:function as to
Speaker:how the person
Speaker:breaks down these
Speaker:particular
Speaker:molecules, which
Speaker:is quite
Speaker:interesting
Speaker:because those who
Speaker:have a propensity
Speaker:for a slower
Speaker:caffeine
Speaker:metabolism as an
Speaker:example, which
Speaker:also has certain
Speaker:similarity of
Speaker:enzymatic
Speaker:interaction as to
Speaker:how the liver
Speaker:breaks down
Speaker:Kirkman or
Speaker:resveratrol.
Speaker:In these
Speaker:instances, these
Speaker:people also have
Speaker:a greater
Speaker:tendency for
Speaker:estrogen
Speaker:dominance, not
Speaker:always, but they
Speaker:generally have,
Speaker:sorry, they often
Speaker:have a propensity
Speaker:for more estrogen
Speaker:dominance.
Speaker:So it begs the
Speaker:question of
Speaker:what's going on
Speaker:within certain
Speaker:methylation
Speaker:sequences
Speaker:depending upon
Speaker:the individual,
Speaker:and as to what
Speaker:impact this is
Speaker:having on
Speaker:modification
Speaker:rates and the
Speaker:different
Speaker:modification
Speaker:rates as well.
Speaker:So it's
Speaker:contextual, and
Speaker:this is where the
Speaker:incorporation of
Speaker:inductive
Speaker:reasoning is
Speaker:highly, highly
Speaker:important because
Speaker:when we take a
Speaker:deductive
Speaker:paradigm,
Speaker:Kirkman's great
Speaker:for everybody.
Speaker:Let's see, is it
Speaker:for neural
Speaker:formation?
Speaker:Well, no, it
Speaker:might be good for
Speaker:a lot because
Speaker:even in
Speaker:longitudinal
Speaker:studies, the
Speaker:majority of
Speaker:people had to
Speaker:respond
Speaker:positively to
Speaker:Kirkman, but the
Speaker:majority is not
Speaker:everyone.
Speaker:So you can't make
Speaker:this definitive
Speaker:statement and a
Speaker:blanket statement
Speaker:saying, "You
Speaker:know, Kirkman,
Speaker:you're good for
Speaker:everybody."
Speaker:And it can
Speaker:actually backfire
Speaker:because in
Speaker:Kirkman's
Speaker:activity in
Speaker:mitigating
Speaker:astrogliosis,
Speaker:as well as
Speaker:expressing more
Speaker:sirtuin activity,
Speaker:there are many
Speaker:things as to what
Speaker:kookanoids do in
Speaker:the body and for
Speaker:the
Speaker:immune system.
Speaker:One of the things
Speaker:in which it does
Speaker:is also inhibit
Speaker:C-X-C-L
Speaker:complexes, C-C-L
Speaker:complexes,
Speaker:which are also
Speaker:sort of chemokine
Speaker:subsets within
Speaker:the immune
Speaker:system itself.
Speaker:And in doing so,
Speaker:it can actually
Speaker:reduce this
Speaker:auto-reactivity
Speaker:of monocytes that
Speaker:I spoke about
Speaker:before in the way
Speaker:in which they
Speaker:hijack our iron,
Speaker:thereby becoming
Speaker:super-sproxidated
Speaker:radicals.
Speaker:So Kirkman can
Speaker:actually mitigate
Speaker:that from
Speaker:happening, but in
Speaker:instances whereby
Speaker:it can compromise
Speaker:through the
Speaker:antigen to
Speaker:estrogen ratio
Speaker:availability, and
Speaker:this is very
Speaker:much, it's not
Speaker:the, I just have
Speaker:to make this
Speaker:statement, is
Speaker:that we're not
Speaker:dealing with a
Speaker:majority here.
Speaker:In this
Speaker:statement, we are
Speaker:dealing with
Speaker:outliers, but
Speaker:outliers
Speaker:also matter.
Speaker:So generally,
Speaker:most people
Speaker:respond very well
Speaker:to Kirkman and it
Speaker:helps immune
Speaker:system
Speaker:multi-levels, but
Speaker:those whom do
Speaker:have a disparity
Speaker:or do develop a
Speaker:disparity in the
Speaker:ratio between
Speaker:testosterone and
Speaker:estrogen
Speaker:through its use
Speaker:can also actually
Speaker:thereby
Speaker:propensiate more
Speaker:histamine release
Speaker:because estrogen
Speaker:out of all our
Speaker:sex hormones is
Speaker:the hormone that
Speaker:propensiates
Speaker:histamine release
Speaker:more so than any
Speaker:other hormone.
Speaker:And this is also
Speaker:a reason why
Speaker:estrogen is more,
Speaker:I don't like to
Speaker:use the word
Speaker:important,
Speaker:has more of an
Speaker:active role,
Speaker:there we go.
Speaker:You can see I
Speaker:don't like
Speaker:hierarchy.
Speaker:(Laughs)
Speaker:I try to avoid
Speaker:these words at
Speaker:all costs.
Speaker:It's good, it
Speaker:challenges my
Speaker:vocabulary.
Speaker:So it has more of
Speaker:an active role in
Speaker:modulating one's
Speaker:libido, more so
Speaker:in testosterone,
Speaker:because people
Speaker:aren't
Speaker:aware of this.
Speaker:Most people think
Speaker:testosterone is
Speaker:the hormone that
Speaker:actually is
Speaker:estrogen.
Speaker:And the reason is
Speaker:to, one of the
Speaker:reasons as to why
Speaker:estrogen, it
Speaker:propensiates
Speaker:histamine
Speaker:receptors
Speaker:in the brain
Speaker:by way of its
Speaker:impact in causing
Speaker:the release of
Speaker:histamine,
Speaker:propensiating the
Speaker:release of
Speaker:histamine
Speaker:as well.
Speaker:So if you are in
Speaker:a CDR1 state and
Speaker:you histamine
Speaker:prone, which is
Speaker:what CH2
Speaker:dominance, and
Speaker:there are
Speaker:multiple
Speaker:contributory
Speaker:factors that can
Speaker:actually reduce a
Speaker:CH2 dominant
Speaker:state or CDR1
Speaker:state, which
Speaker:we'll go to
Speaker:in a moment.
Speaker:But if you are in
Speaker:the state, you
Speaker:really wanna take
Speaker:as much
Speaker:precaution
Speaker:within avoiding
Speaker:an estrogen
Speaker:dominant state.
Speaker:Because that
Speaker:estrogen
Speaker:dominance can
Speaker:actually just
Speaker:fuel more of the
Speaker:histamine
Speaker:activity and
Speaker:histamine
Speaker:dominance, and
Speaker:thereby impact
Speaker:other subsequent
Speaker:endocrine
Speaker:systems, such as
Speaker:the thyroid
Speaker:mitochondrial
Speaker:axis as well.
Speaker:So yeah, again,
Speaker:this contextual,
Speaker:the particular
Speaker:genome in
Speaker:question, or the
Speaker:CYP enzyme in
Speaker:question.
Speaker:1A2.
Speaker:Yes, correct,
Speaker:correct.
Speaker:Yeah, Justin,
Speaker:that was again,
Speaker:amazing.
Speaker:I think we're
Speaker:definitely gonna
Speaker:have to have part
Speaker:one, two, and
Speaker:potentially three
Speaker:to this podcast,
Speaker:but it's been an
Speaker:incredible
Speaker:conversation so
Speaker:far, thank you.
Speaker:You're welcome.
Speaker:Okay, I think
Speaker:that really wraps
Speaker:up this whole
Speaker:concept of
Speaker:immunomentabolism.
Speaker:And again, I
Speaker:apologize to the
Speaker:audience.
Speaker:We went on an
Speaker:unknown number of
Speaker:tangents, but I
Speaker:hope it's of some
Speaker:value to you.
Speaker:And in any case,
Speaker:it's definitely
Speaker:been a
Speaker:treat for me.
Speaker:Maybe this is
Speaker:just a selfish
Speaker:reason to
Speaker:podcast.
Speaker:I don't know that
Speaker:I've loved this.
Speaker:Well, happy
Speaker:to oblige.
Speaker:It's been an
Speaker:awesome
Speaker:opportunity to be
Speaker:able to have
Speaker:reciprocity of
Speaker:knowledge share,
Speaker:within
Speaker:knowledge share.
Speaker:Well, I was about
Speaker:to say, you're
Speaker:too kind, and
Speaker:we'll discuss
Speaker:that later.
Speaker:Anyway,
Speaker:so upstream of
Speaker:what causes this
Speaker:dysfunction, you
Speaker:obviously have
Speaker:various systems.
Speaker:And I think the
Speaker:two I'd like to
Speaker:maybe touch on
Speaker:are the gut,
Speaker:because I think
Speaker:it's relatable
Speaker:too for most of
Speaker:the audience,
Speaker:especially people
Speaker:coming from this
Speaker:from a
Speaker:traditional
Speaker:functional
Speaker:medicine
Speaker:standpoint,
Speaker:should we say.
Speaker:I mean, most
Speaker:people view gut
Speaker:dysfunction from
Speaker:the point of
Speaker:lipopolysaccharide
Speaker:ingress, or these
Speaker:so-called
Speaker:endotoxins that
Speaker:create this
Speaker:phenomenon called
Speaker:leaky gut.
Speaker:Actually, I
Speaker:almost got that
Speaker:word right.
Speaker:On test on
Speaker:permeability,
Speaker:whereby these
Speaker:foreign
Speaker:molecules, just
Speaker:broadly speaking,
Speaker:get into
Speaker:circulation
Speaker:through the
Speaker:smaller intestine
Speaker:and drive a lot
Speaker:of inflammation.
Speaker:Now, there's a
Speaker:lot more
Speaker:biochemistry
Speaker:there, obviously,
Speaker:and that's going
Speaker:to sort of
Speaker:subsequently
Speaker:drive a lot of,
Speaker:as you alluded to
Speaker:earlier, HPA-axis
Speaker:dysfunction,
Speaker:which is then
Speaker:going to have
Speaker:this downstream
Speaker:consequence on
Speaker:the immune
Speaker:system, or
Speaker:potentially
Speaker:vice versa.
Speaker:I think you could
Speaker:definitely
Speaker:explain this
Speaker:better than I
Speaker:could, but would
Speaker:you mind just
Speaker:maybe talking us
Speaker:through why this
Speaker:potentially can start off in the
Speaker:gut, this sort of
Speaker:immune
Speaker:dysfunction,
Speaker:this cell danger
Speaker:response?
Speaker:And then maybe we
Speaker:could also then
Speaker:wrap it up with a
Speaker:short
Speaker:conversation
Speaker:about it from an
Speaker:autonomic nervous
Speaker:system
Speaker:standpoint, too.
Speaker:But yeah, we
Speaker:could start there
Speaker:and then go on.
Speaker:That would
Speaker:be great.
Speaker:Absolutely,
Speaker:absolutely.
Speaker:It's interesting
Speaker:to see the
Speaker:microbiome profiling
Speaker:dependent upon
Speaker:the different
Speaker:stages of one's
Speaker:life and the
Speaker:predominance of
Speaker:different
Speaker:species.
Speaker:It's even more
Speaker:interesting when
Speaker:you overlay that
Speaker:mapping as to
Speaker:what particular
Speaker:species ought to
Speaker:be dominant in
Speaker:contrast to those
Speaker:who may be
Speaker:dominant into
Speaker:certain lifestyle
Speaker:factors as well.
Speaker:And I'm not just
Speaker:talking about
Speaker:blatant
Speaker:infarctions.
Speaker:I'm talking about
Speaker:the subtle
Speaker:infarctions.
Speaker:For example,
Speaker:going through a
Speaker:bereavement.
Speaker:Going through a
Speaker:bereavement most
Speaker:certainly has an
Speaker:impact on the
Speaker:limbic system
Speaker:subsequently
Speaker:impacts the
Speaker:gastrointestinal
Speaker:endocrine system,
Speaker:affording
Speaker:opportunity of
Speaker:change of pH
Speaker:variables.
Speaker:And as you
Speaker:alluded to
Speaker:alluded, well,
Speaker:alluded to
Speaker:before, I love
Speaker:the subtle
Speaker:differences of
Speaker:the difference of
Speaker:meaning between
Speaker:words, but as you
Speaker:alluded to before
Speaker:lipopolysaccharides,
Speaker:I actually just
Speaker:finished the
Speaker:dissertation a
Speaker:few years back on
Speaker:lipopolysaccharides
Speaker:and the impact
Speaker:that they have on
Speaker:major depressive
Speaker:disorder.
Speaker:But in my
Speaker:research, there
Speaker:are multiple
Speaker:different
Speaker:mechanisms
Speaker:in which it
Speaker:induced
Speaker:neurodiversity.
Speaker:And again, the
Speaker:reason why I
Speaker:bring up
Speaker:neurodiversity,
Speaker:histamine
Speaker:dominance, CDR1,
Speaker:and its impact on
Speaker:depleting methyl
Speaker:donors as well as
Speaker:availability of
Speaker:iron, it's very,
Speaker:very apparent.
Speaker:And if you don't
Speaker:have these
Speaker:precursors
Speaker:available,
Speaker:they're looking
Speaker:at HVA levels,
Speaker:looking at 5HIA
Speaker:levels, looking
Speaker:at VMA levels.
Speaker:These are all
Speaker:subsequently
Speaker:always impaired
Speaker:in those who have
Speaker:TH2 dominance, or
Speaker:at least
Speaker:one of them.
Speaker:Those are all
Speaker:organic acids for
Speaker:the
Speaker:autososaccharide.
Speaker:Correct, yeah, so
Speaker:your 5HA is an
Speaker:organic acid
Speaker:marker depicting
Speaker:activity of
Speaker:serotonin,
Speaker:which if it's too
Speaker:high, it's also a
Speaker:problem because
Speaker:you might have an
Speaker:excess of
Speaker:peripheral
Speaker:serotonin, which
Speaker:by its nature can
Speaker:certainly induce
Speaker:peripheral, it
Speaker:fuel peripheral
Speaker:inflammation.
Speaker:I mean parasites
Speaker:feed off of
Speaker:serotonin.
Speaker:There's a reason
Speaker:as to why we have
Speaker:more parasitic
Speaker:activity during
Speaker:the full moon,
Speaker:because there's a
Speaker:compromise in
Speaker:terms of the
Speaker:serotonin being
Speaker:methylated into
Speaker:melatonin during
Speaker:that time.
Speaker:Because this is
Speaker:why a lot of
Speaker:your, again, this
Speaker:is also based
Speaker:upon some
Speaker:science, but also
Speaker:functional
Speaker:paradigm science,
Speaker:which it's like
Speaker:the
Speaker:metaphysicians
Speaker:have been
Speaker:alluding to
Speaker:quantum physics
Speaker:well before the
Speaker:scientists jump
Speaker:on board and then
Speaker:they
Speaker:figure it out.
Speaker:So there is some
Speaker:association, but
Speaker:anyway, going
Speaker:back to 5HA,
Speaker:there's an
Speaker:association with
Speaker:serotonin, too
Speaker:much, really bad,
Speaker:too little, also,
Speaker:it's a question
Speaker:of balance.
Speaker:And then your HVA
Speaker:is your
Speaker:homo-banylic
Speaker:acid, which is an
Speaker:indication of
Speaker:dopamine
Speaker:activity.
Speaker:And you've got
Speaker:Dokpak as well,
Speaker:precursor.
Speaker:And then you've
Speaker:got your VMA,
Speaker:which is an
Speaker:indication of
Speaker:nwopin, a front
Speaker:end of the thing.
Speaker:So there are
Speaker:certain nutrient
Speaker:donors required
Speaker:for these
Speaker:enzymatic
Speaker:reactions to
Speaker:take place.
Speaker:Like for example,
Speaker:the production of
Speaker:dopamine, all
Speaker:dopamine,
Speaker:dopamine, and
Speaker:what that
Speaker:requires from the
Speaker:pateratin cycle
Speaker:as an
Speaker:example, right?
Speaker:And what impact
Speaker:that pateratin
Speaker:cycle has on the
Speaker:folate pathway in
Speaker:relation to
Speaker:acetylsomatini
Speaker:and homocysteine.
Speaker:So there's an
Speaker:interplay in this
Speaker:whole makeup, but
Speaker:essence of CDR1,
Speaker:it creates a
Speaker:compromise to
Speaker:that methylation
Speaker:cycling, those
Speaker:methylation
Speaker:wheels, because
Speaker:of the state of
Speaker:our chronic load
Speaker:rate information
Speaker:causing that
Speaker:compromise in the
Speaker:first place.
Speaker:So when we look
Speaker:into the gut in
Speaker:particular,
Speaker:and we see the
Speaker:impact that
Speaker:lipopolysaccharides
Speaker:or the impact
Speaker:that stress can
Speaker:have an impact on
Speaker:the gut affording
Speaker:opportunity to
Speaker:lipopolysaccharides
Speaker:come through, we
Speaker:often notice a
Speaker:decrease of
Speaker:neurotransmitters
Speaker:or availability
Speaker:of
Speaker:neurotransmitters
Speaker:and an expression
Speaker:of cytokines.
Speaker:And also
Speaker:morphological
Speaker:changes that
Speaker:occur in the
Speaker:brain themselves.
Speaker:So the
Speaker:morphological
Speaker:changes are more
Speaker:likely to occur
Speaker:in a perpetuated
Speaker:state of CDR1 or
Speaker:TH2 dominance, or
Speaker:particularly in
Speaker:the developmental
Speaker:stages of an
Speaker:infant's life,
Speaker:kind of the first
Speaker:seven
Speaker:years of life.
Speaker:So this is why
Speaker:even in the
Speaker:uterine
Speaker:considerations of
Speaker:the mother's
Speaker:stress state is
Speaker:highly important
Speaker:to take into
Speaker:consideration.
Speaker:Too much cortisol
Speaker:can actually
Speaker:cause the
Speaker:depletion of
Speaker:certain enzymes
Speaker:that are within
Speaker:the placenta that
Speaker:are meant to be
Speaker:able to contend
Speaker:with that for
Speaker:immunological
Speaker:purposes, thereby
Speaker:actually
Speaker:resulting in an
Speaker:increase of the
Speaker:exposure to the
Speaker:fetus developing
Speaker:brain to
Speaker:cortisol, thereby
Speaker:actually creating
Speaker:morphological
Speaker:changes before
Speaker:the baby's
Speaker:even born.
Speaker:So the reason why
Speaker:I'm bringing up
Speaker:like intrauterine
Speaker:activity and
Speaker:reason why it was
Speaker:regards to the
Speaker:gut is because
Speaker:it's all
Speaker:interconnected.
Speaker:You know, if
Speaker:there's an
Speaker:imbalance of
Speaker:perception, which
Speaker:by way of
Speaker:depletion of
Speaker:certain
Speaker:neurotransmitters
Speaker:that can be
Speaker:induced, that
Speaker:subsequent
Speaker:imbalance is also
Speaker:gonna create
Speaker:somewhat of a
Speaker:threat
Speaker:perception.
Speaker:Now, if the
Speaker:body's in a state
Speaker:of threat
Speaker:perception, as in
Speaker:these monocytes
Speaker:being
Speaker:professionally
Speaker:activated, to try
Speaker:and re-inoculate
Speaker:the body is
Speaker:incredibly
Speaker:difficult.
Speaker:You can probably
Speaker:take all the
Speaker:probiotics
Speaker:in the world.
Speaker:I even had
Speaker:patients of mine
Speaker:whom decided to
Speaker:take on the
Speaker:advice of doctors
Speaker:that have been
Speaker:around for a lot
Speaker:longer
Speaker:than I had.
Speaker:And I had good
Speaker:intentions in
Speaker:these doctors,
Speaker:but they didn't
Speaker:see this
Speaker:particular
Speaker:sequence of--
Speaker:Phenotab.
Speaker:Yeah, they didn't
Speaker:see this paradigm
Speaker:for what it was,
Speaker:so they couldn't
Speaker:conceptualize
Speaker:what this
Speaker:paradigm meant in
Speaker:their efforts.
Speaker:So anyway, these
Speaker:patients spent a
Speaker:lot of money on
Speaker:fecal matter
Speaker:transplant.
Speaker:I'm talking a lot
Speaker:of money.
Speaker:If anybody knows
Speaker:what FMT is, you
Speaker:know, it's not a
Speaker:cheap affair,
Speaker:especially when
Speaker:you're doing it
Speaker:in a clinic,
Speaker:but one of
Speaker:which-- I was
Speaker:about to say, I
Speaker:think most
Speaker:people, there are
Speaker:lots of people,
Speaker:well, not a lot,
Speaker:but I know a few
Speaker:people who sort
Speaker:of go on the DIY
Speaker:route, one might
Speaker:say, and it's not
Speaker:ended, maybe it's
Speaker:a poor pun, but
Speaker:it has not ended
Speaker:up to be a very
Speaker:pretty, with a
Speaker:very
Speaker:pretty ending.
Speaker:So yeah, it's a
Speaker:complete
Speaker:different
Speaker:wheelhouse, as
Speaker:far as I'm
Speaker:concerned.
Speaker:I wouldn't go
Speaker:anywhere near an
Speaker:FMT without very
Speaker:strict
Speaker:supervision.
Speaker:Yeah, you know, I
Speaker:definitely want
Speaker:to do it in a
Speaker:clinic setting.
Speaker:I think there are
Speaker:suppositories and
Speaker:what have that,
Speaker:they're selling
Speaker:at-home kits.
Speaker:The thing is,
Speaker:it's not about
Speaker:just giving the
Speaker:bacteria, whether
Speaker:or not the body
Speaker:receives it.
Speaker:It's like trying
Speaker:to give an organ
Speaker:transplant to a
Speaker:donor that
Speaker:doesn't
Speaker:match the donor.
Speaker:Sorry, to a
Speaker:recipient that
Speaker:doesn't
Speaker:match the donor.
Speaker:So what we need
Speaker:to do, if you
Speaker:just take that
Speaker:comparative
Speaker:situation in
Speaker:terms of the
Speaker:organ donor, and
Speaker:the organ
Speaker:recipient
Speaker:of the donor,
Speaker:we need to
Speaker:improve upon the
Speaker:receptivity of
Speaker:re-inoculation, in
Speaker:re-inoculation.
Speaker:So in order for
Speaker:probiotics to
Speaker:improve upon the
Speaker:microbiome, the
Speaker:immune system
Speaker:needs to be in a
Speaker:state of
Speaker:coherence,
Speaker:not reactivity.
Speaker:With the bodies
Speaker:in the state of
Speaker:hyper-reactivity,
Speaker:when you try to
Speaker:re-inoculate the
Speaker:gut, it's not
Speaker:gonna take hold.
Speaker:So which means
Speaker:that all the gram
Speaker:negative which
Speaker:are more
Speaker:anaerobic in
Speaker:nature are going
Speaker:to continue to
Speaker:perpetuate
Speaker:because the pH is
Speaker:gonna afford
Speaker:their continual
Speaker:activity.
Speaker:Now, it's very
Speaker:important.
Speaker:I love the fact
Speaker:that you brought
Speaker:up the microbiome
Speaker:in the gut
Speaker:because the
Speaker:microbiome
Speaker:expressed 150
Speaker:times more DNA
Speaker:than what our
Speaker:human cells
Speaker:express.
Speaker:So their profile
Speaker:within our bodies
Speaker:has a direct
Speaker:impact on our
Speaker:metabolic
Speaker:respiratory chain
Speaker:efficiency, as in
Speaker:when we have an
Speaker:excess of
Speaker:lipopolysaccharides,
Speaker:given the fact
Speaker:that they're
Speaker:anaerobic nature,
Speaker:can you see how
Speaker:that can link
Speaker:into predominance
Speaker:of glycolysis?
Speaker:Yes, I can.
Speaker:Just getting to
Speaker:feel that
Speaker:inflammatory
Speaker:process, yeah.
Speaker:So it's a
Speaker:question like,
Speaker:where do we go
Speaker:with this?
Speaker:Like where do we
Speaker:start in order to
Speaker:get people
Speaker:feeling healthy
Speaker:again and not
Speaker:having brain fog,
Speaker:not having
Speaker:autoimmune
Speaker:expressions?
Speaker:Lupus, very
Speaker:closely and
Speaker:intimately
Speaker:connected
Speaker:to CDR1.
Speaker:That's the
Speaker:extremes of CDR1.
Speaker:We're extremes of
Speaker:TH2 dominance.
Speaker:So how do we get
Speaker:people away from
Speaker:the potential
Speaker:expressions of
Speaker:these
Speaker:pathological
Speaker:states?
Speaker:And it really
Speaker:comes into seeing
Speaker:the body from a
Speaker:holistic
Speaker:perspective, not
Speaker:throwing that
Speaker:word around as
Speaker:people have, like
Speaker:really
Speaker:understanding the
Speaker:interplay of
Speaker:multiple
Speaker:physiological
Speaker:systems and
Speaker:specifically
Speaker:immunometabolism.
Speaker:See, I didn't, not
Speaker:metabolimmunism, but
Speaker:immunometabolism.
Speaker:And this is, I
Speaker:feel, not just
Speaker:feel, but I also
Speaker:know through
Speaker:clinical
Speaker:experience, a way
Speaker:in which to take
Speaker:people out of the
Speaker:state of dorsal,
Speaker:vagal dominance,
Speaker:which can also
Speaker:have an impact,
Speaker:which does mean,
Speaker:I mean, there's a
Speaker:bidirectional
Speaker:impact on the
Speaker:nervous system as
Speaker:well as immune
Speaker:system,
Speaker:influencing
Speaker:physiological
Speaker:metabolomics.
Speaker:So the gut, yeah,
Speaker:if you're damp,
Speaker:you're gonna have
Speaker:more elaborate
Speaker:polysaccharides.
Speaker:If you're damp,
Speaker:you're gonna have
Speaker:more fungi,
Speaker:meaning more
Speaker:reoccurring
Speaker:Candiases.
Speaker:And everything
Speaker:that that comes
Speaker:with as well, I
Speaker:mean, like just
Speaker:Candida and its
Speaker:own, one of the
Speaker:things that
Speaker:Candida does, one
Speaker:of the things, an
Speaker:increase of
Speaker:pentociety and
Speaker:what this does to
Speaker:the myelin sheath
Speaker:is quite
Speaker:destructive,
Speaker:okay?
Speaker:Not only does it
Speaker:induce the
Speaker:production of
Speaker:pentociety, which
Speaker:destroys the
Speaker:nerve coding,
Speaker:but also
Speaker:subsequently
Speaker:compromises how
Speaker:well the body can
Speaker:use arginine and
Speaker:lysine in
Speaker:doing so.
Speaker:And if anybody
Speaker:knows the
Speaker:importance of
Speaker:lysine in terms
Speaker:of a white blood
Speaker:selectivity
Speaker:against viral
Speaker:threat, when you
Speaker:compromise that,
Speaker:what are you
Speaker:doing to the
Speaker:adaptive
Speaker:immune system?
Speaker:You're tempering
Speaker:it, not tempering
Speaker:it, sorry, you
Speaker:are
Speaker:compromising it.
Speaker:So- Yeah, it's
Speaker:gonna be fairly
Speaker:dissimated.
Speaker:Well, the gut is
Speaker:incredibly
Speaker:important because
Speaker:if you're damp
Speaker:and you've got
Speaker:Candida, you're
Speaker:gonna compromise
Speaker:the adaptive
Speaker:immune system.
Speaker:You're gonna
Speaker:compromise the
Speaker:liver by way in
Speaker:which it
Speaker:increases acetyl
Speaker:aldehyde
Speaker:concentration in
Speaker:the liver, and
Speaker:subsequently
Speaker:there by further
Speaker:compounding
Speaker:methylation,
Speaker:not depletion,
Speaker:but methylation
Speaker:response,
Speaker:compromising the
Speaker:response of
Speaker:methylation by
Speaker:way of inhibiting
Speaker:methionine
Speaker:synthase, which
Speaker:is what acetyl
Speaker:aldehyde does.
Speaker:So there's so
Speaker:many sequences of
Speaker:the gut, but the
Speaker:gut doesn't one
Speaker:day wake up and
Speaker:it's like, okay,
Speaker:you know, I don't
Speaker:like you anymore.
Speaker:Here you go,
Speaker:enjoy a
Speaker:shitty life.
Speaker:Excuse the pun.
Speaker:(Laughs)
Speaker:It happens, and
Speaker:really one needs
Speaker:to venture into
Speaker:considering the
Speaker:Barker
Speaker:hypothesis.
Speaker:Within the Barker
Speaker:hypothesis, it
Speaker:has been recently
Speaker:expanded upon.
Speaker:This Barker
Speaker:hypothesis was
Speaker:around, I think
Speaker:the 60s or so,
Speaker:and he postulated
Speaker:the impact of a
Speaker:lifetime of
Speaker:exposures to a
Speaker:person's current
Speaker:state of health.
Speaker:And that was
Speaker:expanded upon in,
Speaker:I think it was in
Speaker:2000, or after
Speaker:2000 and late
Speaker:90s, in a new
Speaker:concept, which is
Speaker:again, just the
Speaker:evolution of the
Speaker:Barker hypothesis
Speaker:and the designs
Speaker:of health and
Speaker:disease
Speaker:hypothesis, which
Speaker:pretty much looks
Speaker:at the whole
Speaker:lifespan as to
Speaker:how certain
Speaker:factors may have
Speaker:influenced the
Speaker:person's current
Speaker:state of
Speaker:microbiome.
Speaker:And subsequently
Speaker:what impact that
Speaker:has on immunology
Speaker:and so on
Speaker:and so forth.
Speaker:So yes, but to
Speaker:answer your
Speaker:question, most
Speaker:certainly a
Speaker:compromise
Speaker:gastrointestinal
Speaker:tract.
Speaker:I mean, it's the
Speaker:point of entry
Speaker:that we have,
Speaker:it's the most
Speaker:dramatic point of
Speaker:entry in terms of
Speaker:a perceptive
Speaker:entry that we
Speaker:have to the
Speaker:environment.
Speaker:So yeah, most
Speaker:certainly it can
Speaker:induce a
Speaker:CDR1 state.
Speaker:It's probably one
Speaker:of the greater
Speaker:means in
Speaker:which to do so.
Speaker:It's not
Speaker:the only.
Speaker:One of the other
Speaker:ways is actually
Speaker:by way of simple
Speaker:things, like
Speaker:those of you whom
Speaker:are tattooed, who
Speaker:have a lot of
Speaker:tattoos on
Speaker:the body.
Speaker:I love tattoos
Speaker:for the cosmetic
Speaker:reasons of them,
Speaker:but they're
Speaker:really not good
Speaker:for the
Speaker:immune system.
Speaker:They're really
Speaker:not good for the
Speaker:immune system
Speaker:because it
Speaker:creates a low
Speaker:grade perpetual
Speaker:immune activity
Speaker:based upon the
Speaker:lead that's in
Speaker:these tattoos.
Speaker:And even if you
Speaker:had lead free
Speaker:tattoos, there
Speaker:are other- I was
Speaker:about to ask.
Speaker:Yeah, there are
Speaker:other- 10
Speaker:minutes.
Speaker:Puts within them.
Speaker:They're less
Speaker:impactful, but
Speaker:they're still
Speaker:impactful to
Speaker:some degree.
Speaker:So those who have
Speaker:tattoos, you
Speaker:should always be
Speaker:using chlorella.
Speaker:I'm sorry, you
Speaker:gotta always use
Speaker:chlorella and
Speaker:find a way in
Speaker:which to preserve
Speaker:your iron.
Speaker:Because if you
Speaker:have a lot of
Speaker:tattoos and
Speaker:you're
Speaker:experiencing
Speaker:reoccurring
Speaker:anemia, it ties
Speaker:into what I
Speaker:mentioned to you
Speaker:before about this
Speaker:perpetual
Speaker:monocyte
Speaker:reactivation.
Speaker:That makes total
Speaker:sense as well.
Speaker:Rob, I would love
Speaker:to do a study.
Speaker:Maybe one of your
Speaker:audience can find
Speaker:a way in which we
Speaker:can actually do
Speaker:so efficiently,
Speaker:whereby we
Speaker:actually map the
Speaker:correlation
Speaker:between those
Speaker:whom have
Speaker:tattoos, as well
Speaker:as the extent or
Speaker:the timeframe of
Speaker:chronic viral
Speaker:expression,
Speaker:fatigue, chronic
Speaker:viral expression.
Speaker:And I'm sure, I
Speaker:hypothesize that
Speaker:there is an
Speaker:intimate,
Speaker:nobody's done the
Speaker:study, by
Speaker:the way.
Speaker:That's why I'm
Speaker:putting
Speaker:out there.
Speaker:No one's done the
Speaker:study yet.
Speaker:No one's done the
Speaker:study to see what
Speaker:tattoos, how
Speaker:tattoos increase
Speaker:the vulnerability
Speaker:for post-viral
Speaker:fatigue.
Speaker:No one's done the
Speaker:study yet.
Speaker:Yeah, no, I don't
Speaker:think anyone's
Speaker:ever thought of
Speaker:doing that study.
Speaker:It's definitely novel.
Speaker:I mean, maybe we
Speaker:would have to get
Speaker:this in front of
Speaker:Ben Greenfield,
Speaker:because he's
Speaker:definitely
Speaker:well-to-do and
Speaker:fairly inked up.
Speaker:So maybe he's
Speaker:someone to sort
Speaker:of talk to.
Speaker:You've really
Speaker:alluded to this,
Speaker:Justin, but I
Speaker:think it's a
Speaker:great place to
Speaker:start ending off.
Speaker:But just this
Speaker:idea of the
Speaker:central nervous
Speaker:system and its
Speaker:role in
Speaker:triggering this
Speaker:sort of
Speaker:immunological
Speaker:metabolic
Speaker:dysfunction.
Speaker:Again, me just
Speaker:taking a sort of
Speaker:a very layman's
Speaker:approach to it,
Speaker:but the idea that
Speaker:when the nervous
Speaker:system, when the
Speaker:body is stressed,
Speaker:it's not going to
Speaker:sort of really,
Speaker:it doesn't, okay,
Speaker:it does to an
Speaker:extent, but with
Speaker:stress is
Speaker:perceived
Speaker:as stress.
Speaker:It doesn't matter
Speaker:if it's
Speaker:psychological,
Speaker:broadly speaking,
Speaker:or physiological.
Speaker:You're going to
Speaker:have the sort of
Speaker:the same
Speaker:biological
Speaker:reactions.
Speaker:There's going to
Speaker:be a surge in
Speaker:catecholamines, a
Speaker:surge in
Speaker:hormones.
Speaker:That's going to
Speaker:increase the
Speaker:transcription
Speaker:factors.
Speaker:And then you're
Speaker:going to have
Speaker:this downstream
Speaker:effect again on
Speaker:the immune system
Speaker:and subsequently
Speaker:on the metabolism
Speaker:once again.
Speaker:And we're going
Speaker:to end up in this
Speaker:state of being in
Speaker:CDR1 two or
Speaker:three, which I'm
Speaker:not sure, but I'm
Speaker:sure you can sort
Speaker:of elucidate that
Speaker:more succinctly
Speaker:than I can.
Speaker:Do you think that
Speaker:this theory of,
Speaker:and I suppose it
Speaker:ties into some of
Speaker:Leo Primbok's
Speaker:work, the
Speaker:psychoneuroimmunology,
Speaker:do you think
Speaker:there is merit to
Speaker:this idea that a
Speaker:sort of
Speaker:psychological
Speaker:stress in general
Speaker:can drive this
Speaker:metabolic
Speaker:dysfunction?
Speaker:Or is that sort
Speaker:of more of an
Speaker:edge case?
Speaker:An edge case?
Speaker:Good question.
Speaker:I think again, it
Speaker:is dependent upon
Speaker:the individual as
Speaker:to what the
Speaker:individual had
Speaker:been exposed to
Speaker:over a course of
Speaker:a lifespan.
Speaker:As an example,
Speaker:you know, on a
Speaker:swash leg, I'm
Speaker:going to use him
Speaker:as an example,
Speaker:and he even
Speaker:discusses this in
Speaker:a couple of his
Speaker:documentaries,
Speaker:whereby his, him
Speaker:and his brother
Speaker:were exposed to an
Speaker:abusive father.
Speaker:His brother ended
Speaker:up killing
Speaker:himself in a car
Speaker:crash because
Speaker:whilst he was
Speaker:drunk, whilst he
Speaker:was intoxicated.
Speaker:So, you know, in
Speaker:two
Speaker:circumstances,
Speaker:you have one
Speaker:person utilizing
Speaker:that stress for
Speaker:improvement upon
Speaker:what adaptability
Speaker:to some degree,
Speaker:based upon the
Speaker:circumstances
Speaker:he was in.
Speaker:And the other,
Speaker:where that stress
Speaker:overwhelmed him
Speaker:to the point
Speaker:where he
Speaker:pretty much
Speaker:equated to the
Speaker:state of
Speaker:destruction.
Speaker:So it really,
Speaker:it's not even a
Speaker:question of just
Speaker:genetic.
Speaker:I mean, for sure,
Speaker:genetics do play
Speaker:a role in one's
Speaker:stress tolerance.
Speaker:However, what
Speaker:micron RNA is
Speaker:being expressed
Speaker:to put upon
Speaker:certain sequences
Speaker:of one's life
Speaker:experiences will
Speaker:have also a
Speaker:greater
Speaker:determining
Speaker:epigenetic effect
Speaker:than just that of
Speaker:DNA alone.
Speaker:So yes, is stress
Speaker:a psychological
Speaker:stress
Speaker:contributor
Speaker:for sure.
Speaker:But what does
Speaker:that mean?
Speaker:I think that's
Speaker:the question that
Speaker:you're asking.
Speaker:What does that
Speaker:really mean?
Speaker:Like, how can we
Speaker:quantify this?
Speaker:And the truth is,
Speaker:from an
Speaker:evidence-based
Speaker:paradigm, you
Speaker:can't, you can't,
Speaker:because then
Speaker:you've got to
Speaker:bring it into
Speaker:reductive models
Speaker:and create the
Speaker:ducted reasoning,
Speaker:which doesn't
Speaker:take into account
Speaker:every possible
Speaker:life experience
Speaker:that the
Speaker:individual
Speaker:has had.
Speaker:Now, I don't know
Speaker:two people, even
Speaker:twins, that have
Speaker:had the exact
Speaker:identical life
Speaker:experiences, or
Speaker:at least have not
Speaker:perceived the
Speaker:exact life
Speaker:experiences
Speaker:the same.
Speaker:I think every
Speaker:individual,
Speaker:albeit those who
Speaker:might be a twin
Speaker:or not,
Speaker:experience a life
Speaker:and a individual
Speaker:from an
Speaker:individual
Speaker:perspective.
Speaker:So what
Speaker:does that mean?
Speaker:And now we are
Speaker:venturing into
Speaker:the realm of
Speaker:metaphysics
Speaker:again, like what
Speaker:is consciousness?
Speaker:What is life?
Speaker:What does this
Speaker:all mean?
Speaker:And like, what do
Speaker:we mean in our
Speaker:experience?
Speaker:Not just what
Speaker:does that
Speaker:experience mean
Speaker:to us, what do we
Speaker:mean within the
Speaker:experience?
Speaker:Like, what is our
Speaker:essence in
Speaker:all this?
Speaker:And I think
Speaker:regardless of
Speaker:trying to, once
Speaker:again, put a
Speaker:remedy to a
Speaker:challenge or a scenario
Speaker:or to a category,
Speaker:considering
Speaker:compassionately
Speaker:the individual
Speaker:and as to what it
Speaker:is that they are
Speaker:reporting, they
Speaker:are going
Speaker:through, is
Speaker:incredibly
Speaker:important.
Speaker:Compassion and
Speaker:cooperation is
Speaker:the way, I would
Speaker:love to believe,
Speaker:is the way of the
Speaker:future of
Speaker:medicine.
Speaker:But in order for
Speaker:that to come into
Speaker:complete
Speaker:fruition, we need
Speaker:to change the way
Speaker:in which we
Speaker:perceive or how
Speaker:we perceive
Speaker:others, let alone
Speaker:how we perceive
Speaker:ourselves.
Speaker:I mean, we first
Speaker:can change how we
Speaker:perceive
Speaker:ourselves.
Speaker:That in its own
Speaker:right is a rite
Speaker:of passage, which
Speaker:I think takes
Speaker:multiple
Speaker:lifetimes to do,
Speaker:in all honesty,
Speaker:but there's no
Speaker:reason as to why
Speaker:we cannot
Speaker:simultaneously at
Speaker:least attempt and
Speaker:try to change our
Speaker:perception
Speaker:of others.
Speaker:And also again,
Speaker:just venturing
Speaker:into the
Speaker:metaphysics here,
Speaker:again, Professor
Speaker:Hugh Limb as a
Speaker:professor who was
Speaker:treating the
Speaker:medically, sorry,
Speaker:the criminally
Speaker:insane in Hawaii,
Speaker:and he adopted
Speaker:this Hawaiian
Speaker:prayer called
Speaker:"Upon O'Pono."
Speaker:And there's a lot
Speaker:of obviously
Speaker:rumor around what
Speaker:it had or had not
Speaker:done, but by his
Speaker:own account, he
Speaker:was able to heal
Speaker:the criminally
Speaker:insane by way of
Speaker:changing his
Speaker:perception
Speaker:through this
Speaker:prayer of what it
Speaker:is that he
Speaker:believed these
Speaker:people to be.
Speaker:And perhaps that
Speaker:also ventures
Speaker:into yet another
Speaker:question is that
Speaker:are those we deem
Speaker:to be faulty, are
Speaker:those who we deem
Speaker:to be faulty the
Speaker:construct of our
Speaker:ego, trying to
Speaker:have them fit
Speaker:into a narrative
Speaker:of our own
Speaker:design, or is the
Speaker:construct of our
Speaker:ego and the
Speaker:narrative of our
Speaker:own design the
Speaker:problem
Speaker:over here?
Speaker:And I'm inclined
Speaker:to believe that
Speaker:egoic and
Speaker:identity of which
Speaker:the majority of
Speaker:humanity has
Speaker:adopted over
Speaker:throughout its
Speaker:incarnation,
Speaker:really is at
Speaker:fault in that we
Speaker:have lost, and
Speaker:I'm hoping that
Speaker:we can reemerge
Speaker:the compassionate
Speaker:understanding of
Speaker:our fellow man
Speaker:and what they're
Speaker:going through.
Speaker:Because truly
Speaker:it's only through
Speaker:understanding
Speaker:that we can
Speaker:cultivate
Speaker:patience to see,
Speaker:okay, like the
Speaker:psychology, what
Speaker:this person is
Speaker:experiencing
Speaker:might be trivial
Speaker:to you or to me
Speaker:or to somebody
Speaker:else, but to that
Speaker:person it's
Speaker:detrimental,
Speaker:okay?
Speaker:It's relative.
Speaker:Yeah, exactly,
Speaker:it's relative,
Speaker:incredibly
Speaker:relative.
Speaker:And bringing it
Speaker:back to the
Speaker:theory of
Speaker:relativity here,
Speaker:(Laughs)
Speaker:and the
Speaker:perspective
Speaker:influence that
Speaker:that has on life
Speaker:and the speed of
Speaker:life and
Speaker:everything that
Speaker:that can have
Speaker:from a
Speaker:perspective of
Speaker:physics,
Speaker:biophysics
Speaker:in the body,
Speaker:relative
Speaker:perspective most
Speaker:certainly has an
Speaker:impact on
Speaker:biophysics,
Speaker:undoubtedly.
Speaker:And there are
Speaker:actually some
Speaker:documented
Speaker:studies of this
Speaker:matter as well.
Speaker:And there is the
Speaker:Institute of
Speaker:Noetic Sciences
Speaker:that was founded
Speaker:by an astronaut,
Speaker:his name is Dr.
Speaker:Edgar Mitchell,
Speaker:of which they
Speaker:actually mapped
Speaker:out
Speaker:scientifically
Speaker:the impact of
Speaker:relative
Speaker:consciousness to
Speaker:biophysics, the
Speaker:movement of
Speaker:particles in the
Speaker:body itself.
Speaker:So it's, yes, to
Speaker:answer your
Speaker:question, most
Speaker:certainly it can
Speaker:lead into a CDR1,
Speaker:but as to what
Speaker:measure that, as
Speaker:to what point
Speaker:within a measure
Speaker:it could induce
Speaker:that is variable
Speaker:to the
Speaker:individual.
Speaker:It is not a set
Speaker:standard, it's
Speaker:not a set
Speaker:universal
Speaker:standard that
Speaker:everybody would
Speaker:be
Speaker:susceptible to.
Speaker:There's a varying
Speaker:degree of
Speaker:susceptibility
Speaker:across the board.
Speaker:Yeah, it would
Speaker:probably require
Speaker:a bit more than
Speaker:sort of an HRV
Speaker:intervention, I'd
Speaker:imagine to sort
Speaker:of try and
Speaker:ascertain that
Speaker:level of data.
Speaker:Justin, I think,
Speaker:to be honest,
Speaker:we've been going
Speaker:on for nearly
Speaker:three hours.
Speaker:(Laughs) So what I'd love
Speaker:to- Are you
Speaker:kidding me?
Speaker:Wow, this is
Speaker:incredible,
Speaker:fantastic, good.
Speaker:It's been
Speaker:absolutely
Speaker:amazing,
Speaker:thank you.
Speaker:To end off with,
Speaker:I'd love to ask
Speaker:you a few rapid
Speaker:fire questions,
Speaker:and then, yeah,
Speaker:let's call it a
Speaker:day, and we can
Speaker:then point people
Speaker:to where they can
Speaker:find you.
Speaker:But to start off
Speaker:with, what do you
Speaker:think is the most
Speaker:underrated
Speaker:nutrient from an
Speaker:immunological
Speaker:health
Speaker:standpoint?
Speaker:Most underrated
Speaker:nutrient.
Speaker:I know we had
Speaker:discussed this
Speaker:briefly before,
Speaker:and I wrote
Speaker:garlic, but I'm
Speaker:not sure.
Speaker:It's a really
Speaker:difficult
Speaker:question
Speaker:to answer.
Speaker:Within the
Speaker:context of CDR1,
Speaker:or in the context
Speaker:of, in what
Speaker:context?
Speaker:Let me ask you
Speaker:that, let me ask
Speaker:your question to
Speaker:your question, in
Speaker:what context?
Speaker:Okay.
Speaker:Let's go with,
Speaker:yeah, let's go
Speaker:with CDR1.
Speaker:It's what we've
Speaker:discussed most
Speaker:today, I think,
Speaker:so it's probably
Speaker:most relevant.
Speaker:Contextual,
Speaker:because CDR1 has
Speaker:many contributory
Speaker:factors to it.
Speaker:So I'm gonna go
Speaker:through those
Speaker:factors, and then
Speaker:I'll give you
Speaker:some indication.
Speaker:So if it's a
Speaker:question of
Speaker:compromised
Speaker:histamine
Speaker:intolerance in
Speaker:terms of a
Speaker:dietary histamine
Speaker:intolerance,
Speaker:those whom are
Speaker:able to
Speaker:metabolize
Speaker:sulfur, onion, I
Speaker:mean, works
Speaker:incredibly well,
Speaker:has a natural
Speaker:source of
Speaker:kerstin, and
Speaker:kerstin is the
Speaker:molecule, the
Speaker:nutrient in
Speaker:question, that
Speaker:helps a lot with
Speaker:modulating the
Speaker:mast cells.
Speaker:If it's a
Speaker:question of
Speaker:estrogen
Speaker:dominance that
Speaker:might be fueling
Speaker:the histamine, or
Speaker:perpetuating the
Speaker:histamine
Speaker:response, then
Speaker:broccoli and
Speaker:subsequent indole
Speaker:methane also
Speaker:support the
Speaker:modulation to the
Speaker:CDR1 response.
Speaker:If it's a
Speaker:question of
Speaker:prostate gladdon
Speaker:imbalance, I'm
Speaker:not a big fan of
Speaker:fish roll, but I
Speaker:am a big fan of
Speaker:perzolving
Speaker:mediators.
Speaker:Perzolving
Speaker:mediators.
Speaker:Yeah, so that
Speaker:there is a great,
Speaker:if there's an
Speaker:imbalance of
Speaker:lipid utility,
Speaker:that would be a
Speaker:place to start.
Speaker:If there's
Speaker:imbalance of
Speaker:methylation
Speaker:imbalance, then
Speaker:determining
Speaker:exactly whether
Speaker:or not, if it's a
Speaker:beta oxidative
Speaker:issue, then
Speaker:pantothenin can
Speaker:work
Speaker:incredibly well.
Speaker:If it's a pyrol
Speaker:issue, then
Speaker:pyrolyloxin can
Speaker:work really well.
Speaker:If it is a
Speaker:question of poor
Speaker:glutathione
Speaker:recycling and
Speaker:your GSSG levels
Speaker:being higher,
Speaker:then rubber
Speaker:flabbing can work
Speaker:incredibly well.
Speaker:I think I gave
Speaker:enough examples.
Speaker:I think so.
Speaker:You answered that
Speaker:as only an
Speaker:academic could,
Speaker:is that already
Speaker:possible?
Speaker:Yeah, it's a
Speaker:broad question.
Speaker:It's like, you
Speaker:know, within,
Speaker:even in the
Speaker:subject of CDR1
Speaker:or TH2 dominance,
Speaker:what, you know,
Speaker:there's so many
Speaker:contradictory
Speaker:factors that can
Speaker:have an influence
Speaker:on that.
Speaker:Like, one can
Speaker:even venture into
Speaker:amino acids now,
Speaker:like theanine, to
Speaker:prove a polygonal
Speaker:response, and
Speaker:thereby hopefully
Speaker:mitigating
Speaker:glutamate
Speaker:dominance, which
Speaker:also by way,
Speaker:influences CDR1
Speaker:expression,
Speaker:glutamate
Speaker:dominance.
Speaker:So yeah, which, like
Speaker:polysaccharides
Speaker:have an influence
Speaker:on activating
Speaker:NMDA receptors,
Speaker:which are one of
Speaker:the subsets of,
Speaker:there's two
Speaker:classes of
Speaker:glutamate
Speaker:receptors.
Speaker:It's one of the
Speaker:subsets of the
Speaker:main class of
Speaker:glutamate
Speaker:receptors.
Speaker:So, you know,
Speaker:theanine, green
Speaker:tea, could have
Speaker:sort of
Speaker:contextual
Speaker:importance
Speaker:as well.
Speaker:That's
Speaker:incredible,
Speaker:thank you.
Speaker:Okay, next one.
Speaker:What's one
Speaker:supplement you
Speaker:personally could
Speaker:not go without?
Speaker:Again, another
Speaker:contextual
Speaker:question.
Speaker:Can I not go
Speaker:within which,
Speaker:within which
Speaker:scenario?
Speaker:Just generally,
Speaker:if you got stuck
Speaker:in a desert
Speaker:island with one
Speaker:bottle of
Speaker:something.
Speaker:Yeah, my friend
Speaker:Dominic
Speaker:Nischwitz, he
Speaker:told me to say
Speaker:chlorella.
Speaker:(Laughing)
Speaker:I'm sorry for it.
Speaker:Chlorella,
Speaker:chlorella.
Speaker:Which is right, I
Speaker:think chlorella
Speaker:is incredible
Speaker:compound.
Speaker:Amazing, so many,
Speaker:it's got a great
Speaker:source of iodine,
Speaker:great binder,
Speaker:great B vitamin
Speaker:profile, great
Speaker:selenium profile,
Speaker:really is a
Speaker:super sweet.
Speaker:Supplement, could
Speaker:I not go without?
Speaker:You've got
Speaker:phosphatidylcholine
Speaker:here, I
Speaker:think, PC.
Speaker:Yeah, I think in
Speaker:my particular
Speaker:case, having
Speaker:historically
Speaker:having had issues
Speaker:with bioacid
Speaker:activity,
Speaker:and also
Speaker:subsequent
Speaker:certain cognitive
Speaker:memory recall
Speaker:issues, certain
Speaker:points when I had
Speaker:my water
Speaker:immunity,
Speaker:phosphatidylcholine
Speaker:was certainly
Speaker:mitigated a lot
Speaker:of this.
Speaker:So
Speaker:phosphatidylcholine
Speaker:is different, be
Speaker:on the top
Speaker:of the list.
Speaker:And I also do
Speaker:have certain PEMT
Speaker:genome that makes
Speaker:me more
Speaker:vulnerable to
Speaker:deficiency of
Speaker:cholera,
Speaker:phosphatidylcholine.
Speaker:So let's go with
Speaker:that one, let's
Speaker:go with that one.
Speaker:Okay, perfect.
Speaker:Emerging therapies you're
Speaker:most excited
Speaker:about or therapy?
Speaker:I always forget
Speaker:how, because I
Speaker:always wanted to
Speaker:say
Speaker:ionotrophysis,
Speaker:but it's not how
Speaker:you, it's
Speaker:ionophoresis.
Speaker:That was Newton,
Speaker:I must admit.
Speaker:Yeah, it's quite
Speaker:an interesting
Speaker:technology,
Speaker:almost works like
Speaker:on a battery type
Speaker:of a dark man
Speaker:concept in terms
Speaker:of the positive
Speaker:and
Speaker:negative charge.
Speaker:And what it does
Speaker:by inducing this
Speaker:ionic
Speaker:displacement, it
Speaker:opens up the
Speaker:membranes to be
Speaker:more accepting of
Speaker:nutrient
Speaker:delivery.
Speaker:So it's quite an
Speaker:interesting
Speaker:model.
Speaker:There's a few
Speaker:companies, Ion
Speaker:Layer, and there
Speaker:are others as
Speaker:well, that
Speaker:provide this
Speaker:technology by way
Speaker:of delivering NAD
Speaker:and glutathione.
Speaker:Molecules that
Speaker:are highly
Speaker:susceptible to
Speaker:the gastric
Speaker:environment as an
Speaker:example.
Speaker:So it's quite
Speaker:cool, I'm working
Speaker:with a scientist,
Speaker:his name's also
Speaker:Justin, Justin
Speaker:Kirkland,
Speaker:incredible mind.
Speaker:He's got some
Speaker:real cool
Speaker:innovative
Speaker:technologies that
Speaker:he's busy with at
Speaker:the moment.
Speaker:And I'm hopeful
Speaker:that in due
Speaker:course, majority
Speaker:of the nutrients
Speaker:that we prescribe
Speaker:within our
Speaker:practice can
Speaker:actually be given
Speaker:by way of patch
Speaker:delivery rather
Speaker:than
Speaker:ingesting it.
Speaker:Obviously, albeit
Speaker:things like
Speaker:lipids, I think
Speaker:it would be more
Speaker:difficult to do.
Speaker:And the larger
Speaker:particles might
Speaker:be a little bit
Speaker:more challenging.
Speaker:Binders, we're
Speaker:certainly gonna
Speaker:wanna ingest for
Speaker:the purpose of
Speaker:the need to
Speaker:buy toxins.
Speaker:But yeah, I think
Speaker:it's an
Speaker:interesting tech
Speaker:because it does
Speaker:pave the way and
Speaker:the potential for
Speaker:not to have to
Speaker:consume so many
Speaker:pills, so many
Speaker:capsules and
Speaker:supplements,
Speaker:whilst still
Speaker:getting the
Speaker:benefit in the
Speaker:increase of
Speaker:biological
Speaker:availability.
Speaker:Yeah, no, that's
Speaker:an interesting
Speaker:one and one I'll
Speaker:definitely be
Speaker:exploring.
Speaker:Okay, let's end
Speaker:off with one
Speaker:about the gut.
Speaker:What's the
Speaker:biggest myth
Speaker:about gut health
Speaker:that you
Speaker:regularly
Speaker:encounter?
Speaker:It must be, it
Speaker:must certainly
Speaker:must have to do
Speaker:with fermented
Speaker:fruits,
Speaker:fermented fruits.
Speaker:People have this
Speaker:being told, I
Speaker:mean, it's only
Speaker:natural.
Speaker:Every time you,
Speaker:well, when you
Speaker:used to look at
Speaker:least in social
Speaker:media, it was all
Speaker:about kimchi and
Speaker:sauerkrauts and
Speaker:kefir and
Speaker:everything else.
Speaker:Now I'm not
Speaker:saying these are
Speaker:bad, they come
Speaker:textual again.
Speaker:But particularly
Speaker:in a TH2 dominant
Speaker:state, you do not
Speaker:wanna be
Speaker:consuming a lot
Speaker:of these foods
Speaker:because by nature
Speaker:of them being
Speaker:fermented,
Speaker:they're gonna
Speaker:have a high
Speaker:histamine blow.
Speaker:Okay, so it's
Speaker:really like, it's
Speaker:such a myth like,
Speaker:eat more
Speaker:sauerkraut and
Speaker:you're gonna have
Speaker:healthy
Speaker:microbiome or
Speaker:drink more kefir
Speaker:and you're gonna
Speaker:have healthy
Speaker:microbiome.
Speaker:Or if you have
Speaker:stomach issues,
Speaker:please drink
Speaker:more kefir.
Speaker:No, like if you
Speaker:have stomach
Speaker:issues that it's
Speaker:been instigated
Speaker:by muscle
Speaker:activation
Speaker:syndrome, please
Speaker:do not drink more
Speaker:fucking kefir.
Speaker:Flipping,
Speaker:flipping,
Speaker:kefir, kanao.
Speaker:Like this, yeah,
Speaker:just a context, a
Speaker:context, content
Speaker:and context.
Speaker:Yeah, Justin,
Speaker:those are perfect
Speaker:answers.
Speaker:Thank you again.
Speaker:Answered only as
Speaker:an
Speaker:academic could.
Speaker:I've said this
Speaker:once before, that
Speaker:was to Tyler
Speaker:Pansner, but I
Speaker:think I might be
Speaker:in love with
Speaker:your brain.
Speaker:I really can't
Speaker:thank you enough
Speaker:for your time.
Speaker:You've already
Speaker:alluded to
Speaker:autonomic
Speaker:coaching, but
Speaker:where can people
Speaker:find you if
Speaker:they'd like to
Speaker:connect?
Speaker:autonomic_coaching
Speaker:through our
Speaker:website,
Speaker:www.autonomiccoaching.com.
Speaker:Else you can drop
Speaker:us an email, info
Speaker:at
Speaker:autonomiccoaching.com.
Speaker:Do keep an eye
Speaker:out for my book
Speaker:that is gonna be
Speaker:provisionally
Speaker:going to be
Speaker:launched at the
Speaker:end of September.
Speaker:And within that,
Speaker:there'll be even
Speaker:more details as
Speaker:to how you can
Speaker:connect with us.
Speaker:That's perfect,
Speaker:and we'll be
Speaker:short-linked to
Speaker:all of that in
Speaker:the show notes.
Speaker:Justin, thank you
Speaker:so much for
Speaker:your time.
Speaker:Thank you, Rob.
Speaker:Take care.