Podchaser Logo Rate on Podchaser

Episode 32

full
Published on:

6th Jul 2025

#032 Justin Maguire - Everything to know about Immunometabolism and the Cell Danger Response

Justin Maguire is a multidisciplinary practitioner and educator with a rich background in biochemistry, physiology, psychology and precision nutrition. 

Specialising in complex health conditions such as chronic fatigue, PCOS, and neuroinflammatory disorders, Justin integrates cutting-edge research with genetic functional testing to craft highly personalised protocols for his clients. His work is deeply informed by systems biology and principles of psychoneuroimmunology, offering clients both clarity and practical tools for transformation.

Justin has shared his expertise as a speaker at international health summits, including the Health Optimisation Summit in 2022 and 2023. He also appeared at BodyPower in 2014 and 2015, engaging with audiences on topics related to health and wellness. Additionally, Justin has made guest appearances on various health and wellness podcasts, discussing topics pertinent to his field. As an accomplished author, he has published works that delve into his areas of specialization, further contributing to the broader discourse on health optimisation.

 > During our discussion, you’ll discover:

(00:03:55) Justin's Journey: From Fitness to Integrative Health

(00:09:50) The Impact of Emotional Health on Physical Well-being

(00:13:00) Navigating Long-Haul COVID and Autonomic Coaching

(00:16:00) The Need for Holistic Healthcare

(00:21:18) Community-Centric Healthcare

(00:27:52) Understanding the Immune System

(00:35:07) Immunometabolism Explained

(00:53:36) Understanding Cell Danger Response (CDR) States

(00:58:38) The Impact of Modern Stressors on Health

(01:14:32) Exploring CDR2 and Its Pathological Associations

(01:32:05) Understanding Estrogen Dominance and Histamine Activity

(01:35:40) The Role of Gut Health in Immune Dysfunction

(01:48:52) The Barker Hypothesis and Lifespan Health

(01:52:29) Psychological Stress and Metabolic Dysfunction

(02:01:13) Rapid Fire Questions and Key Nutritional Insights



The vP life Podcast is brought to you by vitalityPRO, a supplement company based in the UK that provides you with the latest in health, anti-ageing and longevity supplementation. What makes vitalityPRO unique is that it third-party tests every product batch for quality, purity, heavy metals and other contaminants. vitalityPRO’s mission is simple: provide you with confidence in the quality and effectiveness of your longevity supplements that focus on restoring your cellular health.

To save on your first order, navigate to the home page and sign up for the newsletter to receive 10% off your first order.

Research Links:

Transcript
Speaker:

Welcome to the VP

Speaker:

Live podcast, the

Speaker:

show where we

Speaker:

bring you

Speaker:

actionable health

Speaker:

advice for

Speaker:

revealing minds.

Speaker:

I'm your

Speaker:

host, Rob.

Speaker:

My guest today is

Speaker:

Justin McGuire, a

Speaker:

South

Speaker:

African-based

Speaker:

holistic health

Speaker:

and performance

Speaker:

coach who works

Speaker:

with clients to

Speaker:

help them

Speaker:

optimize all

Speaker:

aspects of their

Speaker:

health and lives.

Speaker:

Today's

Speaker:

conversation

Speaker:

centers around

Speaker:

how the immune

Speaker:

system ultimately

Speaker:

governs

Speaker:

metabolism.

Speaker:

And while we

Speaker:

certainly get

Speaker:

into the weeds

Speaker:

today, I really

Speaker:

encourage you to

Speaker:

listen through,

Speaker:

as the

Speaker:

information

Speaker:

Justin provides

Speaker:

is nothing short

Speaker:

of pure gold.

Speaker:

Expect to learn

Speaker:

how the immune

Speaker:

system actually

Speaker:

operates, why

Speaker:

chronic

Speaker:

inflammation

Speaker:

might actually be

Speaker:

the cause of

Speaker:

weight gain in so

Speaker:

many populations,

Speaker:

and Justin's top

Speaker:

picks for

Speaker:

nutrients that

Speaker:

help to improve

Speaker:

immune system

Speaker:

function.

Speaker:

Now, on to the

Speaker:

conversation with

Speaker:

Justin McGuire.

Speaker:

Hey, Justin,

Speaker:

thanks for

Speaker:

being here.

Speaker:

We've rubbed

Speaker:

shoulders over

Speaker:

the years, but

Speaker:

we've never

Speaker:

really sat down

Speaker:

to have a

Speaker:

conversation

Speaker:

as such.

Speaker:

So I'm excited to

Speaker:

have this

Speaker:

opportunity to

Speaker:

pick your brain

Speaker:

on this topic,

Speaker:

which is

Speaker:

something I'm

Speaker:

becoming more and

Speaker:

more passionate

Speaker:

about by the day.

Speaker:

And that's this

Speaker:

concept of

Speaker:

immunomatabolism.

Speaker:

The idea, loosely

Speaker:

speaking, that

Speaker:

the metabolism is

Speaker:

mediated, to some

Speaker:

degree, by the

Speaker:

immune system and

Speaker:

vice versa.

Speaker:

And again, just

Speaker:

the idea that

Speaker:

subsequently a

Speaker:

lot of disease

Speaker:

can be viewed

Speaker:

through this lens

Speaker:

and potentially

Speaker:

solved through

Speaker:

this lens

Speaker:

as well.

Speaker:

I know for the

Speaker:

listeners that

Speaker:

that probably

Speaker:

sounds pretty

Speaker:

convoluted, but I

Speaker:

promise we'll

Speaker:

break it down

Speaker:

shortly.

Speaker:

First, though,

Speaker:

I'd love to learn

Speaker:

a little more

Speaker:

about you.

Speaker:

I know through

Speaker:

something of your

Speaker:

story, through

Speaker:

our mutual friend

Speaker:

Ben Law, that

Speaker:

beyond that, I'm

Speaker:

ashamed to say I

Speaker:

don't actually

Speaker:

know too much

Speaker:

about your

Speaker:

backstory, but

Speaker:

I'd love to

Speaker:

understand a bit

Speaker:

more about how

Speaker:

you ended up in

Speaker:

this sort of

Speaker:

integrative

Speaker:

health and

Speaker:

performance

Speaker:

space.

Speaker:

It's good

Speaker:

to be here.

Speaker:

Thank you, Rob.

Speaker:

Looking forward

Speaker:

to sharing some

Speaker:

insight.

Speaker:

So my story is an

Speaker:

interesting one.

Speaker:

I just actually

Speaker:

had a

Speaker:

conversation with

Speaker:

one of my

Speaker:

metaphysicians.

Speaker:

And yes, I'm

Speaker:

probably the most

Speaker:

hippie scientist

Speaker:

you're ever going

Speaker:

to come across.

Speaker:

And in our

Speaker:

conversation this

Speaker:

morning, it was

Speaker:

the fact that

Speaker:

I've literally

Speaker:

gone through four

Speaker:

major personas

Speaker:

just during this

Speaker:

one single

Speaker:

lifetime itself.

Speaker:

So my previous

Speaker:

persona narrative

Speaker:

was very

Speaker:

different as

Speaker:

opposed to whom I

Speaker:

am now today.

Speaker:

And I think this

Speaker:

can, many people,

Speaker:

not many, but

Speaker:

some may attest

Speaker:

to having

Speaker:

experienced the

Speaker:

contrast of self.

Speaker:

So my former life

Speaker:

in my 20s and my

Speaker:

teens, I was

Speaker:

competitive in

Speaker:

the fitness world

Speaker:

and bodybuilding

Speaker:

and martial arts

Speaker:

and so on.

Speaker:

I was a personal

Speaker:

trainer.

Speaker:

And it served

Speaker:

purpose

Speaker:

for a while.

Speaker:

However, it

Speaker:

didn't provide me

Speaker:

with the mental

Speaker:

stimulus that I

Speaker:

inherently was

Speaker:

craving.

Speaker:

Suffice to say,

Speaker:

like a soul,

Speaker:

well, again,

Speaker:

maybe not like a

Speaker:

soul, these

Speaker:

definitive

Speaker:

statements really

Speaker:

get me sometimes.

Speaker:

And the more

Speaker:

conscious you

Speaker:

become, the more

Speaker:

aware you are of

Speaker:

the words you

Speaker:

choose to use.

Speaker:

For some of us,

Speaker:

we go through

Speaker:

dark nights of

Speaker:

assault, some of

Speaker:

which are

Speaker:

self-inflicted in

Speaker:

terms of the

Speaker:

sequence of

Speaker:

events that

Speaker:

lead to it.

Speaker:

Others are

Speaker:

inflicted

Speaker:

upon us.

Speaker:

But for whatever

Speaker:

reason it is that

Speaker:

we, or however it

Speaker:

is that we end up

Speaker:

there, we go

Speaker:

through a moment

Speaker:

of reflection.

Speaker:

So that happened

Speaker:

in my 30th and

Speaker:

31st year,

Speaker:

between the 30

Speaker:

and the 31st year

Speaker:

of my life.

Speaker:

And then shortly

Speaker:

thereafter,

Speaker:

having gone

Speaker:

through that very

Speaker:

extreme moment in

Speaker:

my life, of which

Speaker:

the majority of

Speaker:

it was actually

Speaker:

impacted by my

Speaker:

own poor

Speaker:

decisions,

Speaker:

admittedly.

Speaker:

But not knowing

Speaker:

as to, at that

Speaker:

time in my life,

Speaker:

not knowing as to

Speaker:

why it is that I

Speaker:

had a propensity

Speaker:

to create, to

Speaker:

have, to choose

Speaker:

wrongly.

Speaker:

And only later on

Speaker:

that I started to

Speaker:

discover that

Speaker:

there were so

Speaker:

many more layers

Speaker:

into the

Speaker:

complexity of

Speaker:

life,

Speaker:

particularly our

Speaker:

lives, that can

Speaker:

influence one's

Speaker:

perception and

Speaker:

thus one's own

Speaker:

personal

Speaker:

identity.

Speaker:

And when we are

Speaker:

in a state of

Speaker:

water pilot, and

Speaker:

particularly if

Speaker:

we're not

Speaker:

self-conscious,

Speaker:

we're not

Speaker:

conscious of

Speaker:

self, not

Speaker:

self-conscious,

Speaker:

we're not

Speaker:

conscious of

Speaker:

self, it can lead

Speaker:

us astray.

Speaker:

So in any case, I

Speaker:

would let myself

Speaker:

astray based upon

Speaker:

a whole lot of

Speaker:

variables that

Speaker:

are unnecessary

Speaker:

to divulge into,

Speaker:

because it's not

Speaker:

about what led

Speaker:

you there, it's

Speaker:

the fact that it

Speaker:

happened, and

Speaker:

what are you

Speaker:

gonna do

Speaker:

about it?

Speaker:

Where taking

Speaker:

responsibility

Speaker:

requires letting

Speaker:

go of things that

Speaker:

got you there,

Speaker:

but taking full

Speaker:

hold of what it

Speaker:

is that you were,

Speaker:

or what it is

Speaker:

that you are, and

Speaker:

wanting to

Speaker:

change, unless

Speaker:

you don't

Speaker:

want to change.

Speaker:

And if life is

Speaker:

going the right

Speaker:

direction, I want

Speaker:

me to keep on

Speaker:

doing what it is

Speaker:

that you feel

Speaker:

necessary, but

Speaker:

mine wasn't.

Speaker:

And I was

Speaker:

confronted with

Speaker:

an opportunity to

Speaker:

either pass away,

Speaker:

because

Speaker:

literally, that's

Speaker:

how thin my

Speaker:

lifeline was, or

Speaker:

to make a change.

Speaker:

And I made a

Speaker:

change, and

Speaker:

subsequently

Speaker:

making a change,

Speaker:

and the universe

Speaker:

really threw a

Speaker:

spanner into the

Speaker:

works and

Speaker:

challenged me to

Speaker:

yet

Speaker:

another degree.

Speaker:

And about 18

Speaker:

months after I'd

Speaker:

made a change,

Speaker:

I went through a

Speaker:

bit of a depth,

Speaker:

an emotional

Speaker:

depth that

Speaker:

resulted in a...

Speaker:

What happens when

Speaker:

you've been

Speaker:

sober, and then

Speaker:

you slip up?

Speaker:

Oh, come on, it's

Speaker:

such a

Speaker:

simple word.

Speaker:

Uh, this is like

Speaker:

the blind,

Speaker:

in the blind.

Speaker:

Relapse, relapse,

Speaker:

relapse.

Speaker:

Gosh, it's just

Speaker:

the simplest

Speaker:

words, right?

Speaker:

It's just funny.

Speaker:

So it resulted,

Speaker:

this is what

Speaker:

happens off the

Speaker:

COVID, right?

Speaker:

It's like all the

Speaker:

complex words, no

Speaker:

problem, but the

Speaker:

simple things of

Speaker:

joining krumjags

Speaker:

is like really

Speaker:

the word you

Speaker:

wanna...

Speaker:

And perhaps I've

Speaker:

blocked it out of

Speaker:

my psyche, to

Speaker:

some

Speaker:

extent, as well.

Speaker:

Yeah, this is

Speaker:

where you just

Speaker:

eat all the urode

Speaker:

monophosphate and

Speaker:

just pray, yeah,

Speaker:

and I can

Speaker:

understand that.

Speaker:

(Laughing) So anyway, it

Speaker:

resulted in a

Speaker:

relapse.

Speaker:

And in that

Speaker:

relapse, I had

Speaker:

to, once again,

Speaker:

revisit what it

Speaker:

was that I had

Speaker:

not been

Speaker:

addressing.

Speaker:

And I think as

Speaker:

many men, from

Speaker:

our generation at

Speaker:

least, and

Speaker:

generations

Speaker:

prior, we were

Speaker:

taught to pretty

Speaker:

much suppress the

Speaker:

expression of

Speaker:

emotions and to

Speaker:

just

Speaker:

tough it out.

Speaker:

Blood-swayed

Speaker:

interiors is the

Speaker:

motto of our

Speaker:

generation.

Speaker:

So yeah, with

Speaker:

that, just the

Speaker:

avoidance sets

Speaker:

in, right?

Speaker:

So you'll find

Speaker:

elaborate ways to

Speaker:

avoid what's

Speaker:

actually going on

Speaker:

within yourself,

Speaker:

particularly by

Speaker:

way of expression

Speaker:

of ego, which

Speaker:

didn't help much,

Speaker:

I'm grateful for

Speaker:

my body, which

Speaker:

that's

Speaker:

like I have.

Speaker:

But in being able

Speaker:

to build muscle

Speaker:

quite quickly, I

Speaker:

was able to build

Speaker:

up a persona and

Speaker:

ego to avoid a

Speaker:

lot of things

Speaker:

really

Speaker:

easily as well.

Speaker:

(Laughing) So, and see

Speaker:

whether the

Speaker:

relapse happened,

Speaker:

came out of that,

Speaker:

and things then

Speaker:

really started to

Speaker:

settle for me,

Speaker:

like really

Speaker:

started to shift.

Speaker:

The foundation

Speaker:

started to shift

Speaker:

into a whole new

Speaker:

dimension of

Speaker:

self-experience.

Speaker:

And then

Speaker:

subsequently, I

Speaker:

was doing really

Speaker:

well, and then

Speaker:

literally six

Speaker:

months

Speaker:

thereafter, yet

Speaker:

another layer of

Speaker:

complexity.

Speaker:

The universe is

Speaker:

like, okay, you

Speaker:

ready for the

Speaker:

next test?

Speaker:

You ready for the

Speaker:

next test?

Speaker:

You ready for the

Speaker:

next test?

Speaker:

And then I

Speaker:

developed

Speaker:

Polymalgeoromatica.

Speaker:

Now this is an

Speaker:

autoimmune

Speaker:

disease that

Speaker:

mostly afflicts

Speaker:

people over the

Speaker:

age of 55.

Speaker:

It's an extreme

Speaker:

debilitating

Speaker:

autoimmune

Speaker:

condition, this

Speaker:

chronic low grade

Speaker:

inflammation that

Speaker:

impacts not only

Speaker:

pain in the body,

Speaker:

but also causes a

Speaker:

lot of

Speaker:

neuroinflammatory

Speaker:

outcomes and

Speaker:

symptoms.

Speaker:

So I went to

Speaker:

every specialist,

Speaker:

I mean, I spent

Speaker:

money that I

Speaker:

didn't have to

Speaker:

try and get into

Speaker:

the best

Speaker:

specialist.

Speaker:

And 12th of the

Speaker:

best specialists

Speaker:

in the country

Speaker:

later, I was told

Speaker:

it's all

Speaker:

psychosomatic.

Speaker:

Now, I mean, the

Speaker:

intensity of the

Speaker:

pain was so bad

Speaker:

that I literally

Speaker:

couldn't sleep

Speaker:

for three or five

Speaker:

days at a time.

Speaker:

So it had three

Speaker:

or five days of

Speaker:

perpetual

Speaker:

insomnia.

Speaker:

Long story short,

Speaker:

this sounds like

Speaker:

a big dramatic

Speaker:

narrative, and I

Speaker:

would actually

Speaker:

cut it short

Speaker:

because it's not

Speaker:

about that.

Speaker:

It's about what

Speaker:

it actually

Speaker:

taught me.

Speaker:

And what it

Speaker:

taught me is

Speaker:

that, no matter

Speaker:

how good the

Speaker:

intention of the

Speaker:

person, because I

Speaker:

don't believe any

Speaker:

of these

Speaker:

specialists, and

Speaker:

this is where the

Speaker:

polarity of

Speaker:

fitness

Speaker:

communities or

Speaker:

biohacking

Speaker:

communities or

Speaker:

precision

Speaker:

medicine or

Speaker:

functional

Speaker:

medicine

Speaker:

communities can

Speaker:

really lead

Speaker:

people astray.

Speaker:

Doctors are not

Speaker:

at fault.

Speaker:

I'm gonna make

Speaker:

the statement

Speaker:

right there.

Speaker:

Doctors are not

Speaker:

at fault.

Speaker:

Like to get into

Speaker:

medical school,

Speaker:

do you know how

Speaker:

much discipline

Speaker:

and dedication it

Speaker:

requires?

Speaker:

Literally

Speaker:

finishing it.

Speaker:

It's not the

Speaker:

intention of

Speaker:

these individuals

Speaker:

to not

Speaker:

help people.

Speaker:

It's actually the

Speaker:

intention to be

Speaker:

of service.

Speaker:

It's the

Speaker:

institution that

Speaker:

is the problem.

Speaker:

And the

Speaker:

institution has

Speaker:

led people astray

Speaker:

into

Speaker:

compartmentalizing

Speaker:

their health.

Speaker:

And because I

Speaker:

wasn't able to be

Speaker:

fit in, because

Speaker:

they weren't able

Speaker:

to fit me

Speaker:

into a box.

Speaker:

Paradigm, yeah.

Speaker:

Into a paradigm,

Speaker:

I became the

Speaker:

psychosomatic

Speaker:

patient.

Speaker:

Despite all the

Speaker:

symptoms that

Speaker:

we're saying

Speaker:

otherwise.

Speaker:

Yes, most

Speaker:

certainly there

Speaker:

is some truth to

Speaker:

that as well.

Speaker:

I won't say that

Speaker:

they were

Speaker:

entirely wrong.

Speaker:

There is most

Speaker:

certainly some

Speaker:

truth to it.

Speaker:

But the truth

Speaker:

came in that,

Speaker:

yes, there were

Speaker:

some psycho,

Speaker:

there were many,

Speaker:

not some, there

Speaker:

were many

Speaker:

psychological

Speaker:

traumas that were

Speaker:

coming up to the

Speaker:

surface, which

Speaker:

were expressing

Speaker:

themselves

Speaker:

on my body.

Speaker:

I didn't know

Speaker:

this at the time.

Speaker:

I mean, this is

Speaker:

like, you know, I

Speaker:

was a bodybuilder

Speaker:

two years prior

Speaker:

to that.

Speaker:

Competing, sorry,

Speaker:

a year

Speaker:

prior to that.

Speaker:

I had done my

Speaker:

last

Speaker:

bodybuilding show.

Speaker:

So I was in that

Speaker:

whole fitness

Speaker:

community, like,

Speaker:

you know, Grant

Speaker:

Go, Grant and Go,

Speaker:

5am Club, you

Speaker:

know, Hell's

Speaker:

Bells, off

Speaker:

your squat.

Speaker:

So I don't really

Speaker:

know like, you

Speaker:

know, like the

Speaker:

somatic impact

Speaker:

that can happen

Speaker:

from emotional

Speaker:

response.

Speaker:

I mean, I heard

Speaker:

of it, but I kind

Speaker:

of, to be honest

Speaker:

with you, I

Speaker:

thought it was a

Speaker:

bit of a hogwash.

Speaker:

I thought it was

Speaker:

like, it's the

Speaker:

things that

Speaker:

esoteric believe

Speaker:

in kind of

Speaker:

thing, right?

Speaker:

But a little bit,

Speaker:

I know how

Speaker:

truthful that

Speaker:

actually was.

Speaker:

So much

Speaker:

truth to it.

Speaker:

So it went wrong

Speaker:

that it was part,

Speaker:

it had

Speaker:

psychosomatic,

Speaker:

there was certain

Speaker:

elements of

Speaker:

psychosomatic

Speaker:

contribution

Speaker:

toward my state.

Speaker:

But this is where

Speaker:

like, again, in

Speaker:

the human

Speaker:

dualistic

Speaker:

perceptive

Speaker:

paradigm, we

Speaker:

separate things.

Speaker:

We forget that

Speaker:

there's actually

Speaker:

continuity in

Speaker:

everything.

Speaker:

And this is where

Speaker:

one of my

Speaker:

favorite writings

Speaker:

of all time, it's

Speaker:

actually an

Speaker:

essay, it's not a

Speaker:

book by Antoine

Speaker:

Fabre de la Vie,

Speaker:

and he wrote his

Speaker:

essay in the

Speaker:

late 1700s.

Speaker:

And the essay is

Speaker:

entitled, "The

Speaker:

Metaphysical and

Speaker:

Intellectual

Speaker:

Constitution

Speaker:

of Man."

Speaker:

Within this

Speaker:

essay, he has a

Speaker:

graphical

Speaker:

depiction of the

Speaker:

intersection.

Speaker:

Within his

Speaker:

semantics, he

Speaker:

doesn't use mind,

Speaker:

body and soul, he

Speaker:

uses soul, spirit

Speaker:

and body.

Speaker:

But basically

Speaker:

they depict what

Speaker:

we understand to

Speaker:

be mind, body and

Speaker:

soul, and the

Speaker:

difference of

Speaker:

emotional

Speaker:

intersect that

Speaker:

can happen

Speaker:

depending upon

Speaker:

where we are in

Speaker:

our state of

Speaker:

consciousness,

Speaker:

whether it is

Speaker:

more so in the

Speaker:

anima, the

Speaker:

animus, or

Speaker:

whether it's more

Speaker:

in God

Speaker:

consciousness and

Speaker:

everything in

Speaker:

between.

Speaker:

So in looking at

Speaker:

that model,

Speaker:

knowing that

Speaker:

whatever happens

Speaker:

to the mind

Speaker:

happens to the

Speaker:

body, certainly,

Speaker:

but whatever's

Speaker:

happening to the

Speaker:

body can

Speaker:

perpetuate what's

Speaker:

happening in the

Speaker:

mind as well.

Speaker:

And this is one

Speaker:

of the first big

Speaker:

pieces of the

Speaker:

puzzle that came

Speaker:

together.

Speaker:

I had probably,

Speaker:

I had done it on

Speaker:

my own, because I

Speaker:

didn't

Speaker:

have any help.

Speaker:

I went to

Speaker:

everybody and

Speaker:

they put me on

Speaker:

pregnancy zone

Speaker:

and they put me

Speaker:

on

Speaker:

anti-psychotics

Speaker:

and everything

Speaker:

else, which just

Speaker:

made me worse.

Speaker:

Yeah, so as I was

Speaker:

saying, so I

Speaker:

didn't have

Speaker:

pretty much any

Speaker:

help from the

Speaker:

specialists,

Speaker:

although they had

Speaker:

good attention,

Speaker:

they weren't able

Speaker:

to fit me into a

Speaker:

model, into

Speaker:

like a mold.

Speaker:

So I had to

Speaker:

pretty much

Speaker:

figure myself

Speaker:

out, which was

Speaker:

quite

Speaker:

frustrating,

Speaker:

because you look

Speaker:

into my

Speaker:

historical

Speaker:

education behind

Speaker:

biochemistry,

Speaker:

which I had a

Speaker:

very basic

Speaker:

biochemical, I

Speaker:

mean, it was

Speaker:

self-taught in

Speaker:

the early part of

Speaker:

my, I later on

Speaker:

got degrees, in

Speaker:

my thirties

Speaker:

subsequently

Speaker:

after this, I got

Speaker:

foundation

Speaker:

degrees and then

Speaker:

I got a

Speaker:

bachelor's and so

Speaker:

on at Biochem.

Speaker:

But in my

Speaker:

twenties, it's

Speaker:

very basic.

Speaker:

And I thought I

Speaker:

had to basically

Speaker:

start my whole

Speaker:

journey in

Speaker:

front of it.

Speaker:

But anyway, long

Speaker:

story short, when

Speaker:

the student is

Speaker:

ready, the

Speaker:

teacher will

Speaker:

appear, and along

Speaker:

my journey, I

Speaker:

started to be, I

Speaker:

was introduced to

Speaker:

certain function

Speaker:

medicine doctors,

Speaker:

integrated

Speaker:

medicine doctors,

Speaker:

all of which

Speaker:

actually provided

Speaker:

educational

Speaker:

resources as

Speaker:

well, which I put

Speaker:

myself through,

Speaker:

when I had the

Speaker:

financial reasons

Speaker:

to do so, which

Speaker:

was quite tough.

Speaker:

I mean, as you

Speaker:

probably are

Speaker:

aware of, having

Speaker:

had long haul

Speaker:

COVID-19 for two

Speaker:

years, it's

Speaker:

really difficult

Speaker:

to manage earning

Speaker:

a living whilst

Speaker:

being chronically

Speaker:

fatigued, right?

Speaker:

And brain fog to

Speaker:

boot on top of

Speaker:

that, let alone

Speaker:

the physical pain

Speaker:

that can also

Speaker:

sporadically

Speaker:

creep in when

Speaker:

there's not

Speaker:

enough cortisol

Speaker:

to mitigate the

Speaker:

inflammation.

Speaker:

So I did what I

Speaker:

could, and it was

Speaker:

a journey.

Speaker:

It was probably

Speaker:

the best PhD I've

Speaker:

ever earned in

Speaker:

life going

Speaker:

through that

Speaker:

journey,

Speaker:

which birthed the

Speaker:

opportunity to

Speaker:

start autonomic

Speaker:

coaching.

Speaker:

And autonomic

Speaker:

coaching is a

Speaker:

conceptual birth

Speaker:

child of mine,

Speaker:

within which I

Speaker:

truly am trying

Speaker:

to continue to

Speaker:

expand a honest

Speaker:

interdisciplinary

Speaker:

approach.

Speaker:

Because again, I

Speaker:

just wanna

Speaker:

emphasize,

Speaker:

doctors are not

Speaker:

at fault.

Speaker:

You can't blame,

Speaker:

it's like putting

Speaker:

somebody in a

Speaker:

label and saying

Speaker:

because they put

Speaker:

11 years of their

Speaker:

life into

Speaker:

educating

Speaker:

themselves to do

Speaker:

a certain

Speaker:

discipline, now

Speaker:

they're evil.

Speaker:

Like where's the

Speaker:

logic of that?

Speaker:

They're

Speaker:

not at fault.

Speaker:

It's just that

Speaker:

there are many

Speaker:

other ways apart

Speaker:

from allopathy as

Speaker:

to how one can

Speaker:

approach

Speaker:

remedying for

Speaker:

health, okay?

Speaker:

And this is where

Speaker:

autonomic

Speaker:

coaching comes

Speaker:

in, and we

Speaker:

provide

Speaker:

allopathic

Speaker:

support, we

Speaker:

provide

Speaker:

naturopathic

Speaker:

support, we

Speaker:

provide

Speaker:

psychological

Speaker:

support, we

Speaker:

provide lifestyle

Speaker:

coaching as well.

Speaker:

So it's the whole

Speaker:

kitchen computer,

Speaker:

the whole

Speaker:

paradigm to

Speaker:

support the

Speaker:

individual.

Speaker:

This is where

Speaker:

inductive

Speaker:

reasoning is, we

Speaker:

are able to

Speaker:

enable inductive

Speaker:

reasoning within

Speaker:

this paradigm.

Speaker:

You know,

Speaker:

evidence-based

Speaker:

medicine is based

Speaker:

on the reductive

Speaker:

model so that one

Speaker:

can take

Speaker:

deductive

Speaker:

outcomes from it,

Speaker:

which is great

Speaker:

for the populace,

Speaker:

for the masses.

Speaker:

But there's a

Speaker:

shortfall within

Speaker:

the outliers of

Speaker:

those who don't

Speaker:

fit into

Speaker:

the mold.

Speaker:

And this is where

Speaker:

inductive

Speaker:

reasoning

Speaker:

comes in.

Speaker:

So most of the

Speaker:

people that come

Speaker:

to see us,

Speaker:

come to see us

Speaker:

after they've

Speaker:

been to many

Speaker:

different

Speaker:

practitioners,

Speaker:

alternative as

Speaker:

well as

Speaker:

conventional, and

Speaker:

they just haven't

Speaker:

gotten

Speaker:

the result.

Speaker:

That they, well,

Speaker:

they haven't been

Speaker:

given their

Speaker:

life back.

Speaker:

Do we help, are

Speaker:

we successful

Speaker:

with all of those

Speaker:

we help?

Speaker:

No, we're not,

Speaker:

but are we

Speaker:

successful with the

Speaker:

majority of them?

Speaker:

Yes, we are.

Speaker:

And those who

Speaker:

we're not

Speaker:

successful with,

Speaker:

we have got an

Speaker:

extensive network

Speaker:

that we are able

Speaker:

to get solutions

Speaker:

to people.

Speaker:

And this is, the

Speaker:

reason why I'm

Speaker:

also putting this

Speaker:

out there is to

Speaker:

not allude anyone

Speaker:

to the idea that

Speaker:

we are the

Speaker:

holy grail.

Speaker:

Okay, there is no

Speaker:

such thing.

Speaker:

If something

Speaker:

doesn't work with

Speaker:

a certain

Speaker:

specialist or a

Speaker:

certain thought

Speaker:

process, don't

Speaker:

give up.

Speaker:

That's the

Speaker:

message I'm

Speaker:

trying to

Speaker:

put out there.

Speaker:

If anybody is

Speaker:

growing through a

Speaker:

tough time and

Speaker:

they've tried

Speaker:

everything, which

Speaker:

is impossible, is

Speaker:

to try everything

Speaker:

you need multiple

Speaker:

lifetimes.

Speaker:

Okay,

Speaker:

don't give up.

Speaker:

Like, have faith

Speaker:

and truly like

Speaker:

the power of, I'm

Speaker:

not religious,

Speaker:

but I'm very

Speaker:

spiritual.

Speaker:

And whether you

Speaker:

are or you're

Speaker:

not, I think it's

Speaker:

irrelevant to the

Speaker:

question.

Speaker:

Sometimes this

Speaker:

process is a

Speaker:

process of

Speaker:

positive

Speaker:

introspection,

Speaker:

positive

Speaker:

psychology can

Speaker:

really shift the

Speaker:

narrative of

Speaker:

where it is that

Speaker:

you're willing to

Speaker:

invest your

Speaker:

energy into.

Speaker:

So yes, we

Speaker:

help most.

Speaker:

Do we help

Speaker:

everyone know?

Speaker:

But that doesn't

Speaker:

mean that there

Speaker:

isn't a solution

Speaker:

for everybody.

Speaker:

And I think as a

Speaker:

community of

Speaker:

professionals,

Speaker:

health

Speaker:

professionals,

Speaker:

we're making, as

Speaker:

we are coming

Speaker:

together more and

Speaker:

more so, like

Speaker:

every year I see

Speaker:

that there's

Speaker:

better

Speaker:

cooperation and

Speaker:

less competition

Speaker:

happening.

Speaker:

And the stronger

Speaker:

that we can

Speaker:

create

Speaker:

cooperation, the

Speaker:

more likely that

Speaker:

we can do away

Speaker:

with states such

Speaker:

as

Speaker:

neurodiversity,

Speaker:

or at least

Speaker:

reduce the degree

Speaker:

in the percentile

Speaker:

of those who are

Speaker:

neurodivergent in

Speaker:

the populace,

Speaker:

which is, I mean,

Speaker:

just that, that

Speaker:

label alone, that

Speaker:

category needs so

Speaker:

much new

Speaker:

care, right?

Speaker:

Because the

Speaker:

levels of autism

Speaker:

have rise, the

Speaker:

level of

Speaker:

depression

Speaker:

has rise.

Speaker:

You know, despite

Speaker:

the fact that

Speaker:

Western medical

Speaker:

technologies have

Speaker:

been approved

Speaker:

upon, we're still

Speaker:

having an influx

Speaker:

of these

Speaker:

particular

Speaker:

states, which

Speaker:

need not be if we

Speaker:

can come together

Speaker:

and unify our

Speaker:

skill sets within

Speaker:

a paradigm that's

Speaker:

truly holistic.

Speaker:

That's holistic.

Speaker:

You know, there's

Speaker:

that word thrown

Speaker:

around, way too

Speaker:

easily has been

Speaker:

thrown around for

Speaker:

decades, but what

Speaker:

does it

Speaker:

really mean?

Speaker:

You know, and

Speaker:

what I believe

Speaker:

means is simply

Speaker:

the embodiment of

Speaker:

cooperation

Speaker:

throughout

Speaker:

different

Speaker:

disciplines.

Speaker:

That's holistic.

Speaker:

It's not one

Speaker:

discipline,

Speaker:

during many

Speaker:

different things

Speaker:

in the body, is

Speaker:

many disciplines

Speaker:

supporting the

Speaker:

complexity

Speaker:

of the body.

Speaker:

So that's where I

Speaker:

came, and that's

Speaker:

where the

Speaker:

business is here.

Speaker:

(Laughing) That's

Speaker:

incredible.

Speaker:

And I think

Speaker:

you've already

Speaker:

answered most of

Speaker:

my follow-ups.

Speaker:

What I really

Speaker:

want to sort of

Speaker:

just jump back at

Speaker:

you on is just

Speaker:

sort of your

Speaker:

thoughts on the

Speaker:

education model,

Speaker:

because when it

Speaker:

comes to sort of

Speaker:

traditional

Speaker:

medicine, and I'm

Speaker:

definitely not

Speaker:

qualified or also

Speaker:

smart enough to

Speaker:

make a judgment

Speaker:

call on the way

Speaker:

medicines talk,

Speaker:

but I have a

Speaker:

feeling you are,

Speaker:

or at least you

Speaker:

have some

Speaker:

insights

Speaker:

into the system.

Speaker:

And the way I

Speaker:

view it is

Speaker:

exactly the way

Speaker:

you view it, to

Speaker:

an extent.

Speaker:

I think that

Speaker:

physicians have

Speaker:

the best

Speaker:

intentions at

Speaker:

heart, but they

Speaker:

put into this

Speaker:

mold, they put

Speaker:

this state of

Speaker:

having to

Speaker:

function based on

Speaker:

a set of

Speaker:

guidelines and a

Speaker:

set of

Speaker:

principles, and

Speaker:

that's

Speaker:

very myopic.

Speaker:

And it causes

Speaker:

this very sort of

Speaker:

siloed approach

Speaker:

to healthcare,

Speaker:

which just

Speaker:

doesn't work.

Speaker:

And I've said

Speaker:

this before on

Speaker:

the podcast, I'm

Speaker:

sure you've said

Speaker:

it before on

Speaker:

others, but I do

Speaker:

think it

Speaker:

needs to change.

Speaker:

If you were, this

Speaker:

is a bit of a hot

Speaker:

take, but if you

Speaker:

were sort of

Speaker:

given carte

Speaker:

blanche as to how

Speaker:

you would

Speaker:

potentially

Speaker:

re-engineer the

Speaker:

way medicines

Speaker:

talk, what would

Speaker:

you put more an

Speaker:

emphasis on,

Speaker:

excuse me?

Speaker:

What would you

Speaker:

sort of take an

Speaker:

emphasis off?

Speaker:

How would you

Speaker:

sort of, briefly,

Speaker:

because I mean,

Speaker:

this could take

Speaker:

us down to a

Speaker:

whole other

Speaker:

rabbit hole, but

Speaker:

how would you

Speaker:

sort of recreate

Speaker:

medicine to

Speaker:

become from a

Speaker:

model standpoint,

Speaker:

to be more

Speaker:

effective and to

Speaker:

help more people?

Speaker:

Move away from a

Speaker:

predominant

Speaker:

statistical

Speaker:

machine at the

Speaker:

ideology.

Speaker:

Evidence-based

Speaker:

medicine, now

Speaker:

we're talking

Speaker:

about

Speaker:

conventional

Speaker:

Western medicine.

Speaker:

We're not talking

Speaker:

about alternative

Speaker:

medicine, such as

Speaker:

Chinese medicine

Speaker:

and naturopathy

Speaker:

or homeopathy,

Speaker:

but we're talking

Speaker:

about Western

Speaker:

medicine, and it

Speaker:

really started

Speaker:

off really well.

Speaker:

And being the

Speaker:

known illusion,

Speaker:

pharmacology is

Speaker:

not the demon.

Speaker:

It's just a

Speaker:

prayer of use,

Speaker:

that's the

Speaker:

problem.

Speaker:

As an example, if

Speaker:

you wanted the

Speaker:

word to be given

Speaker:

in excess of

Speaker:

belladonna,

Speaker:

that's also not

Speaker:

gonna be to any

Speaker:

benefit of

Speaker:

continuity

Speaker:

of health.

Speaker:

So it really is

Speaker:

like you can't

Speaker:

shout, "Oh, it's

Speaker:

a big farmer that

Speaker:

wants to

Speaker:

kill us all."

Speaker:

Well, no, a big

Speaker:

farmer is only a

Speaker:

cooperation,

Speaker:

okay?

Speaker:

A cooperation, a

Speaker:

cooperation.

Speaker:

It's a

Speaker:

cooperation.

Speaker:

And in being a

Speaker:

cooperation, it

Speaker:

has its profit

Speaker:

margins that it

Speaker:

needs to attain,

Speaker:

like any other

Speaker:

business.

Speaker:

But it's not,

Speaker:

it's like saying

Speaker:

BMW is to blame

Speaker:

for the road

Speaker:

accidents,

Speaker:

right?

Speaker:

All the deaths on

Speaker:

the road.

Speaker:

No, no, and you

Speaker:

can say, well,

Speaker:

you know, they

Speaker:

market their

Speaker:

drugs and they

Speaker:

try to get, they

Speaker:

push the

Speaker:

likelihood of

Speaker:

sale onto doctors

Speaker:

and so on.

Speaker:

But what else are

Speaker:

they meant to do?

Speaker:

If they didn't do

Speaker:

that, those

Speaker:

medicines

Speaker:

wouldn't also

Speaker:

reach people that

Speaker:

actually

Speaker:

do need it.

Speaker:

And this is where

Speaker:

the discernment

Speaker:

and improvement

Speaker:

of the sermon is

Speaker:

required with the

Speaker:

end health

Speaker:

practitioner,

Speaker:

meaning the

Speaker:

doctor, the

Speaker:

GP, right?

Speaker:

Everybody goes

Speaker:

and sees.

Speaker:

But the way in

Speaker:

which,

Speaker:

particularly when

Speaker:

it comes to like

Speaker:

socialistic

Speaker:

countries like

Speaker:

England or like

Speaker:

France, where the

Speaker:

healthcare is

Speaker:

free, right?

Speaker:

It's very much a

Speaker:

conveyor

Speaker:

belt system.

Speaker:

I have a friend

Speaker:

of mine who's a

Speaker:

doctor based in

Speaker:

Germany and

Speaker:

before he went

Speaker:

into private

Speaker:

practice, he said

Speaker:

that he had to

Speaker:

see 2,000 people

Speaker:

a month in order

Speaker:

to make, I think

Speaker:

it was like 8,000

Speaker:

euro a month.

Speaker:

2,000 people to

Speaker:

make 8,000

Speaker:

euro a month.

Speaker:

So it's like 10,

Speaker:

15 minutes, five

Speaker:

sometimes minute

Speaker:

consultations and

Speaker:

it's just in and

Speaker:

out, in and out.

Speaker:

So what are you

Speaker:

gonna do?

Speaker:

Like, I can't do

Speaker:

anything in 10

Speaker:

minutes.

Speaker:

Like I can have a

Speaker:

conversation with

Speaker:

somebody, but,

Speaker:

and if I look at

Speaker:

a lab report, I'm

Speaker:

probably gonna

Speaker:

look at like, you

Speaker:

know, single

Speaker:

markers and see

Speaker:

if there's

Speaker:

anything that

Speaker:

really

Speaker:

stands out.

Speaker:

I'm not gonna

Speaker:

have time to look

Speaker:

at correlation or

Speaker:

create a

Speaker:

correlation

Speaker:

analysis

Speaker:

by it all.

Speaker:

No way, because

Speaker:

there's no time.

Speaker:

And that design

Speaker:

at least, there

Speaker:

isn't any time.

Speaker:

So I think the

Speaker:

way in which to

Speaker:

nonetheless

Speaker:

support

Speaker:

organizational

Speaker:

construct in

Speaker:

terms of

Speaker:

financial

Speaker:

resources,

Speaker:

because we also

Speaker:

have to think

Speaker:

here, it's not

Speaker:

just about giving

Speaker:

everybody the

Speaker:

equal opportunity

Speaker:

of health.

Speaker:

That's a great, I

Speaker:

mean, that's a

Speaker:

wonderful,

Speaker:

wonderful

Speaker:

sentiment and

Speaker:

idea, but the

Speaker:

reality is in

Speaker:

order to do that,

Speaker:

we also have to

Speaker:

consider the

Speaker:

economics

Speaker:

of it all.

Speaker:

Okay, and the

Speaker:

economics of it

Speaker:

all mean that we

Speaker:

need to create

Speaker:

organizational

Speaker:

structures that

Speaker:

can provide a

Speaker:

personalized

Speaker:

service to some

Speaker:

degree, to a

Speaker:

greater degree

Speaker:

than is what

Speaker:

currently given,

Speaker:

but at the same

Speaker:

time, not

Speaker:

overburden the

Speaker:

financial

Speaker:

constraints of

Speaker:

these

Speaker:

organizations

Speaker:

that have been

Speaker:

set up by

Speaker:

different

Speaker:

governmental

Speaker:

organizations

Speaker:

across the world.

Speaker:

And I think the

Speaker:

way in which you

Speaker:

can do this is

Speaker:

by, biohacking is

Speaker:

most certainly,

Speaker:

it's not the

Speaker:

foolproof

Speaker:

structure, but it

Speaker:

definitely has

Speaker:

increased

Speaker:

consciousness

Speaker:

around wellness

Speaker:

for many

Speaker:

a people.

Speaker:

And one can also

Speaker:

argue that there

Speaker:

are gonna be

Speaker:

goods and bads to

Speaker:

everything, okay?

Speaker:

But however, if

Speaker:

we just take the

Speaker:

average, what

Speaker:

happens when the

Speaker:

person involved,

Speaker:

it gets involved

Speaker:

in a greater

Speaker:

state of

Speaker:

awareness of

Speaker:

what's going on

Speaker:

within

Speaker:

themselves, they

Speaker:

start to read

Speaker:

articles.

Speaker:

They start to

Speaker:

watch

Speaker:

YouTube videos.

Speaker:

They start to

Speaker:

engage with what

Speaker:

it is that's

Speaker:

actually going on

Speaker:

within

Speaker:

themselves.

Speaker:

Now, if we can

Speaker:

somewhat merge

Speaker:

that community

Speaker:

element, such as

Speaker:

what's happening

Speaker:

in biohacking

Speaker:

into a greater

Speaker:

community,

Speaker:

thereby not

Speaker:

creating the

Speaker:

necessity of

Speaker:

tribal mentality,

Speaker:

but doing away

Speaker:

with that tribal

Speaker:

mentality, but

Speaker:

still keeping the

Speaker:

underlying

Speaker:

positive premise

Speaker:

of it all, then

Speaker:

you can have one

Speaker:

doctor, for

Speaker:

example,

Speaker:

that has,

Speaker:

you know, somehow

Speaker:

a doctor manages

Speaker:

a particular

Speaker:

county in

Speaker:

England,

Speaker:

or say a

Speaker:

particular

Speaker:

village, not a

Speaker:

county, but a

Speaker:

particular

Speaker:

village in

Speaker:

England.

Speaker:

That doctor in

Speaker:

the current

Speaker:

construct of how

Speaker:

the NHS is set

Speaker:

up, patient eats

Speaker:

a book, comes and

Speaker:

sees a doctor on

Speaker:

a one-to-one.

Speaker:

But a one-to-one

Speaker:

is 10

Speaker:

minutes long.

Speaker:

But it doesn't,

Speaker:

you can't get

Speaker:

anywhere

Speaker:

with that.

Speaker:

So what about,

Speaker:

instead of having

Speaker:

this design,

Speaker:

you're having

Speaker:

single

Speaker:

consultation, you

Speaker:

have a group

Speaker:

model whereby the

Speaker:

doctor becomes

Speaker:

more proactively

Speaker:

involved in the

Speaker:

ongoing health of

Speaker:

the community,

Speaker:

right?

Speaker:

It sets certain

Speaker:

objectives, sets

Speaker:

certain

Speaker:

incentives for

Speaker:

the community to

Speaker:

elevate their

Speaker:

health together.

Speaker:

The biggest issue

Speaker:

that I see in

Speaker:

modern-day

Speaker:

psychological

Speaker:

health, at least,

Speaker:

is the separation

Speaker:

from man, from

Speaker:

man's self, is

Speaker:

isolation.

Speaker:

We live in a

Speaker:

world that's more

Speaker:

populated now

Speaker:

than ever before,

Speaker:

yet we are more

Speaker:

lonely than

Speaker:

ever before.

Speaker:

And that, just by

Speaker:

that on its own,

Speaker:

births many, many

Speaker:

a disease.

Speaker:

Okay, we're

Speaker:

beings, we're a

Speaker:

species that

Speaker:

needs embrace.

Speaker:

Okay, we're not

Speaker:

learned

Speaker:

creatures.

Speaker:

No matter what

Speaker:

anybody says,

Speaker:

this warrior

Speaker:

mentality, and go

Speaker:

sit on top of a

Speaker:

mountain and

Speaker:

meditate for

Speaker:

weeks or months

Speaker:

or years on end,

Speaker:

there may be,

Speaker:

there are a few

Speaker:

that have done

Speaker:

it, they can do

Speaker:

it, but whether

Speaker:

or not it's

Speaker:

healthy for a

Speaker:

person or not,

Speaker:

that's up

Speaker:

for debate.

Speaker:

And I don't

Speaker:

think,

Speaker:

personally, and

Speaker:

again, I'm not

Speaker:

omnipotent or

Speaker:

omnipresent

Speaker:

whatsoever, thank

Speaker:

God for that,

Speaker:

excuse the irony,

Speaker:

of what I just

Speaker:

said, but I do

Speaker:

believe that

Speaker:

humanity needs

Speaker:

more compassion,

Speaker:

and the only way

Speaker:

in which we can

Speaker:

improve upon the

Speaker:

medical system is

Speaker:

by implementing

Speaker:

consideration for

Speaker:

others in a

Speaker:

community

Speaker:

construct, really

Speaker:

bring the

Speaker:

community back

Speaker:

together.

Speaker:

So when something

Speaker:

happens, it's not

Speaker:

left to the nth

Speaker:

degree when

Speaker:

somebody's

Speaker:

completely

Speaker:

derailed, and

Speaker:

then they're

Speaker:

trying to have a

Speaker:

10 minute

Speaker:

consultation with

Speaker:

the doctor

Speaker:

to fix that.

Speaker:

Because this

Speaker:

faces it, things

Speaker:

don't just happen

Speaker:

overnight, unless

Speaker:

you catch like

Speaker:

typhoid fever,

Speaker:

by the way, most

Speaker:

deaths actually

Speaker:

occur from

Speaker:

non-communicable

Speaker:

diseases,

Speaker:

non-communicable

Speaker:

diseases.

Speaker:

78%, I think it

Speaker:

was in 86, I

Speaker:

can't remember,

Speaker:

but it's between

Speaker:

78 or 86, that

Speaker:

was the number

Speaker:

that I last saw

Speaker:

on the steps of

Speaker:

global

Speaker:

deaths, right?

Speaker:

Non-communicable

Speaker:

diseases is

Speaker:

responsible for

Speaker:

the majority of

Speaker:

deaths worldwide.

Speaker:

And by that you

Speaker:

mean things like

Speaker:

AOCVD, heart

Speaker:

disease, cancer,

Speaker:

et cetera.

Speaker:

Yeah, any disease

Speaker:

that's not caused

Speaker:

directly by a

Speaker:

pathogen assault.

Speaker:

Yeah.

Speaker:

So, methylene

Speaker:

blue, recovering

Speaker:

from COVID.

Speaker:

Not to be used

Speaker:

perpetually, but

Speaker:

the use of sort

Speaker:

of circumstances,

Speaker:

we had a

Speaker:

conversation

Speaker:

about this in the

Speaker:

second, as well.

Speaker:

We didn't need--

Speaker:

So things like

Speaker:

this, like you

Speaker:

know, certain

Speaker:

remedies, like

Speaker:

methylene blue,

Speaker:

that can be

Speaker:

destructive,

Speaker:

it most certainly

Speaker:

can cause harm if

Speaker:

it's used in the

Speaker:

wrong construct,

Speaker:

right?

Speaker:

But it most

Speaker:

certainly can

Speaker:

alleviate harm if

Speaker:

it's used in the

Speaker:

right construct.

Speaker:

But how do people

Speaker:

know this?

Speaker:

Like, I mean,

Speaker:

I've got degrees

Speaker:

in

Speaker:

biochemistry, right?

Speaker:

I've got degrees

Speaker:

in nutritional

Speaker:

science, but not

Speaker:

everybody has a

Speaker:

degree in

Speaker:

biochemistry and

Speaker:

nutritional

Speaker:

science, so now,

Speaker:

you know, you've

Speaker:

got the media

Speaker:

mention about its

Speaker:

potential

Speaker:

benefit, and

Speaker:

there are

Speaker:

incredible

Speaker:

benefits behind

Speaker:

this molecule.

Speaker:

It truly is a

Speaker:

molecule.

Speaker:

But we need more

Speaker:

of a community

Speaker:

for people to be

Speaker:

able to use these

Speaker:

remedies that

Speaker:

don't require a

Speaker:

script

Speaker:

successfully,

Speaker:

rather than use

Speaker:

it and feel

Speaker:

like crap.

Speaker:

Feel worse often

Speaker:

than they did

Speaker:

prior to

Speaker:

using it.

Speaker:

And this requires

Speaker:

more of a

Speaker:

community aspect.

Speaker:

And I think this

Speaker:

is the only way

Speaker:

in which we'll be

Speaker:

able to change

Speaker:

the trajectory of

Speaker:

modern-day

Speaker:

medicine.

Speaker:

When it comes to

Speaker:

like the

Speaker:

educational

Speaker:

component of it,

Speaker:

which is another

Speaker:

part of the

Speaker:

question

Speaker:

that you asked,

Speaker:

I think medical

Speaker:

school starts off

Speaker:

very well, but it

Speaker:

ends terribly.

Speaker:

(Laughs)

Speaker:

Sort of, yeah,

Speaker:

you sort of have

Speaker:

this sort of,

Speaker:

this base of

Speaker:

biochemistry or

Speaker:

physiology, and

Speaker:

then you slowly

Speaker:

sort of become a

Speaker:

trained

Speaker:

pharmacologist

Speaker:

where you start

Speaker:

to associate any

Speaker:

disease outcome

Speaker:

with a drug, and

Speaker:

that's

Speaker:

where you stop.

Speaker:

That seems to be

Speaker:

my take on it to

Speaker:

a large extent.

Speaker:

Well, the shame

Speaker:

in it all is that

Speaker:

it's even worse

Speaker:

so than that,

Speaker:

because it'd be

Speaker:

great if they had

Speaker:

more, most GPs

Speaker:

have six months

Speaker:

to maybe a year,

Speaker:

depending upon

Speaker:

which school you

Speaker:

go to, in

Speaker:

exposure to

Speaker:

pharmacological

Speaker:

studies.

Speaker:

Do you know this?

Speaker:

It's six months

Speaker:

to a year.

Speaker:

No, I didn't.

Speaker:

Maximum year.

Speaker:

Maximum year.

Speaker:

That's

Speaker:

incredible.

Speaker:

Which is crazy,

Speaker:

because if you

Speaker:

think about it, a

Speaker:

pharmacist, most,

Speaker:

unless you do,

Speaker:

some pharmacists

Speaker:

are able to write

Speaker:

scripts, but you

Speaker:

have to go

Speaker:

through extensive

Speaker:

post-grad

Speaker:

certification

Speaker:

processes, very

Speaker:

few of

Speaker:

them have it.

Speaker:

Yet, all doctors

Speaker:

are able to write

Speaker:

a script that

Speaker:

have less

Speaker:

knowledge than

Speaker:

the pharmacist

Speaker:

does on what it

Speaker:

is that they're

Speaker:

prescribing.

Speaker:

That's

Speaker:

disconcerting to

Speaker:

say the least.

Speaker:

And again, it's

Speaker:

not the fault of the

Speaker:

physician, is it?

Speaker:

No, it's not.

Speaker:

Definitely not

Speaker:

the fault of the

Speaker:

physician.

Speaker:

Yeah.

Speaker:

That was just a

Speaker:

perfect podcast

Speaker:

in

Speaker:

itself, Justin.

Speaker:

And I sort of, I

Speaker:

love the way you

Speaker:

took that, the

Speaker:

fact that we sort

Speaker:

of really sort

Speaker:

of, and I should

Speaker:

probably send

Speaker:

this to my father

Speaker:

because he was

Speaker:

involved in

Speaker:

community

Speaker:

development for

Speaker:

years, but it's

Speaker:

almost like we've

Speaker:

got to sort of

Speaker:

rethink the

Speaker:

paradigm

Speaker:

completely and

Speaker:

sort of place

Speaker:

more emphasis on

Speaker:

the community.

Speaker:

How you then go

Speaker:

about educating

Speaker:

the masses, for

Speaker:

the want of

Speaker:

better word, is

Speaker:

probably another

Speaker:

question best

Speaker:

left to

Speaker:

another day.

Speaker:

But it does

Speaker:

make sense,

Speaker:

bringing the

Speaker:

awareness of

Speaker:

health to the

Speaker:

individual, and

Speaker:

almost from a

Speaker:

preventative

Speaker:

standpoint.

Speaker:

So encouraging

Speaker:

people to take,

Speaker:

how do I

Speaker:

put this?

Speaker:

Encouraging

Speaker:

people to take

Speaker:

responsibility

Speaker:

for their own

Speaker:

health and

Speaker:

creating

Speaker:

messaging

Speaker:

around that.

Speaker:

And I think

Speaker:

that's where the

Speaker:

biohacking

Speaker:

community is

Speaker:

effective.

Speaker:

I think it does

Speaker:

get a bit lost in

Speaker:

the weeds in

Speaker:

terms of maybe

Speaker:

focusing on the

Speaker:

minutiae more

Speaker:

often than the

Speaker:

actual needle

Speaker:

movers, which

Speaker:

just aren't sexy

Speaker:

at the end of the

Speaker:

day, are they?

Speaker:

Nobody wants to

Speaker:

necessarily sort

Speaker:

of go to bed when

Speaker:

it gets dark and

Speaker:

wake up when it

Speaker:

gets light.

Speaker:

They want to sort

Speaker:

of play around

Speaker:

with the red

Speaker:

light and the

Speaker:

$10,000 coin

Speaker:

plunge or

Speaker:

whatever it is.

Speaker:

So how you get

Speaker:

around that one?

Speaker:

It is

Speaker:

TVT.

Speaker:

Well, I want to come back down to

Speaker:

leadership

Speaker:

authority, and we

Speaker:

look into

Speaker:

different social

Speaker:

constructs and

Speaker:

theories around

Speaker:

that as well,

Speaker:

which begs the

Speaker:

question of like,

Speaker:

how much

Speaker:

authority are we

Speaker:

as a collective

Speaker:

giving those who

Speaker:

have voices?

Speaker:

And what are

Speaker:

their intentions?

Speaker:

Like, obviously

Speaker:

we all need to

Speaker:

make money in

Speaker:

this lifetime.

Speaker:

There's nothing

Speaker:

wrong with making

Speaker:

money, but I

Speaker:

think it's really

Speaker:

easy for me at

Speaker:

least, and maybe

Speaker:

this is a vouch

Speaker:

of advice for

Speaker:

anybody that may

Speaker:

consider

Speaker:

reviewing what it

Speaker:

is that they're

Speaker:

hearing.

Speaker:

Any moment when

Speaker:

an influencer of

Speaker:

any split in the

Speaker:

biohacking or policing

Speaker:

especially comes

Speaker:

with a polarized

Speaker:

view, I stop

Speaker:

listening

Speaker:

to them.

Speaker:

I stop listening

Speaker:

to them.

Speaker:

This is good for

Speaker:

you, this is bad

Speaker:

for you, blah,

Speaker:

blah, blah, blah,

Speaker:

blah, blah,

Speaker:

blah, blah.

Speaker:

Like, you know,

Speaker:

again, like for

Speaker:

example,

Speaker:

palm oil, palm

Speaker:

oil, okay, it's

Speaker:

terrible, but it

Speaker:

is terrible, but

Speaker:

it also has

Speaker:

certain potential

Speaker:

applications

Speaker:

outside of the

Speaker:

food industry.

Speaker:

Okay, so it's not

Speaker:

all bad.

Speaker:

Yes, there is

Speaker:

obviously an

Speaker:

impact that has

Speaker:

on nature, but

Speaker:

tell me what

Speaker:

doesn't have an

Speaker:

impact on nature

Speaker:

given the

Speaker:

technological

Speaker:

construct of

Speaker:

humanity.

Speaker:

You know, so

Speaker:

there are ways in

Speaker:

which we need to

Speaker:

mitigate that for

Speaker:

sure, but

Speaker:

nothing,

Speaker:

everything needs

Speaker:

to be considered

Speaker:

in content and

Speaker:

context and

Speaker:

content.

Speaker:

And a polarized

Speaker:

view often comes

Speaker:

with a bit of a

Speaker:

buy-in or a sale

Speaker:

for the person to

Speaker:

buy into, okay.

Speaker:

I'm not gonna

Speaker:

name any names,

Speaker:

but not too long

Speaker:

ago, there was a

Speaker:

very well-known

Speaker:

influencer in the

Speaker:

space who had

Speaker:

everything to say

Speaker:

about melatonin

Speaker:

and how it can

Speaker:

induce the

Speaker:

likelihood of an

Speaker:

increase of

Speaker:

myocardial

Speaker:

infarction.

Speaker:

And he cited

Speaker:

certain studies,

Speaker:

but anybody that

Speaker:

doesn't know how

Speaker:

to read studies

Speaker:

will just take

Speaker:

what he said for

Speaker:

face value, but

Speaker:

anybody that does

Speaker:

know how to read

Speaker:

a study will

Speaker:

actually look

Speaker:

into the

Speaker:

demographic of

Speaker:

which was

Speaker:

utilized for the

Speaker:

study and realize

Speaker:

that a lot of

Speaker:

these people

Speaker:

actually had

Speaker:

pre-existing

Speaker:

heart conditions

Speaker:

in the

Speaker:

first place.

Speaker:

These are not

Speaker:

healthy

Speaker:

individuals.

Speaker:

Yeah, no, it's

Speaker:

just so

Speaker:

context-dependent

Speaker:

at the end of the

Speaker:

day, isn't it?

Speaker:

And I love the

Speaker:

nutrition and

Speaker:

energy too.

Speaker:

It's ultimately

Speaker:

comes back to

Speaker:

sort of finding

Speaker:

that middle

Speaker:

ground, because

Speaker:

ultimately I feel

Speaker:

that we're all on

Speaker:

the bell curve

Speaker:

and obviously

Speaker:

you're going to

Speaker:

have extreme

Speaker:

outliers at

Speaker:

either end,

Speaker:

people who are

Speaker:

going to thrive

Speaker:

just caring for

Speaker:

this energy on a

Speaker:

carnival diet and

Speaker:

people who are

Speaker:

gonna thrive

Speaker:

maybe on a vegan

Speaker:

diet on the

Speaker:

other end.

Speaker:

But yeah, I think

Speaker:

ultimately we do

Speaker:

all sort of fall

Speaker:

somewhere in the

Speaker:

middle, don't we?

Speaker:

And it's

Speaker:

interesting to

Speaker:

see many of the

Speaker:

influences in

Speaker:

this space.

Speaker:

You're Paul

Speaker:

Saladinas of the

Speaker:

world, for

Speaker:

example, who sort

Speaker:

of started out

Speaker:

and maybe, I'm

Speaker:

not sure how many

Speaker:

people are aware

Speaker:

of this, but he

Speaker:

started out

Speaker:

vegan, then he

Speaker:

went fully

Speaker:

carnival.

Speaker:

And then he sort

Speaker:

of ended up

Speaker:

essentially an

Speaker:

omnivore in

Speaker:

the middle.

Speaker:

So I do think it

Speaker:

speaks to your

Speaker:

point in that

Speaker:

respect.

Speaker:

Anyway,

Speaker:

Justin, I think

Speaker:

we've already

Speaker:

been going for 14

Speaker:

minutes and

Speaker:

technically we

Speaker:

haven't even

Speaker:

started his

Speaker:

conversation.

Speaker:

So taking all

Speaker:

that into

Speaker:

account, and that

Speaker:

was truly the

Speaker:

most interesting

Speaker:

introduction to

Speaker:

Paul Saladinas,

Speaker:

so thank you.

Speaker:

Let's dive into

Speaker:

this concept of

Speaker:

immunometabolism.

Speaker:

Now, I think when

Speaker:

going into a

Speaker:

topic as complex,

Speaker:

potentially as

Speaker:

complex as this,

Speaker:

it's great to

Speaker:

have a baseline

Speaker:

and understanding

Speaker:

of the basic

Speaker:

physiology, the

Speaker:

basic

Speaker:

biochemistry.

Speaker:

So to start off

Speaker:

with, would you

Speaker:

mind breaking

Speaker:

down for the

Speaker:

listeners what

Speaker:

the immune system

Speaker:

fundamentally is?

Speaker:

And then we could

Speaker:

maybe branch into

Speaker:

more discussion

Speaker:

about how that

Speaker:

relates to

Speaker:

metabolism.

Speaker:

But yeah,

Speaker:

immunology 101,

Speaker:

as it were, would

Speaker:

you mind just

Speaker:

sort of providing

Speaker:

us with a

Speaker:

breakdown of the

Speaker:

concepts there?

Speaker:

It's an

Speaker:

environmental

Speaker:

foreman.

Speaker:

Let me explain.

Speaker:

So I was like,

Speaker:

what do you mean

Speaker:

environment

Speaker:

foreman?

Speaker:

It pretty much

Speaker:

directs what

Speaker:

needs to happen

Speaker:

between two

Speaker:

different

Speaker:

environment, well

Speaker:

within an

Speaker:

environment based

Speaker:

upon two

Speaker:

different

Speaker:

environments.

Speaker:

We live in an

Speaker:

environment, like

Speaker:

there is a

Speaker:

microcosm to the

Speaker:

macrocosm.

Speaker:

So we live in the

Speaker:

world, and the

Speaker:

world is a part

Speaker:

of the solar

Speaker:

system, and the

Speaker:

solar system is

Speaker:

part of the

Speaker:

galaxy, and the

Speaker:

galaxy is part of

Speaker:

the universe, and

Speaker:

there are

Speaker:

probably multiple

Speaker:

universes.

Speaker:

Maybe, maybe not.

Speaker:

I don't know, I'm

Speaker:

not a quantum

Speaker:

physicist, but I

Speaker:

would assume that

Speaker:

they are.

Speaker:

So within we take

Speaker:

the macro to the

Speaker:

macrocosm,

Speaker:

everything has

Speaker:

the potential of

Speaker:

symbiosis, or

Speaker:

conflict to that

Speaker:

symbiosis.

Speaker:

Now when conflict

Speaker:

exists to that

Speaker:

symbiosis, we

Speaker:

have to consider

Speaker:

what is it

Speaker:

between the two

Speaker:

environments

Speaker:

that's acting in

Speaker:

opposition to one

Speaker:

another.

Speaker:

And this is where

Speaker:

the immune system

Speaker:

comes in, because

Speaker:

it tries to sort

Speaker:

out the

Speaker:

oppositional

Speaker:

activities

Speaker:

between our

Speaker:

internal

Speaker:

environment as to

Speaker:

what's happening

Speaker:

outside of

Speaker:

ourselves.

Speaker:

So in the immune

Speaker:

system, the

Speaker:

immune system

Speaker:

itself, from a

Speaker:

scientific

Speaker:

perspective, you

Speaker:

have two major

Speaker:

components.

Speaker:

You have the

Speaker:

adaptive and the

Speaker:

innate

Speaker:

immune system.

Speaker:

The innate immune

Speaker:

system has been

Speaker:

around for a

Speaker:

lot longer.

Speaker:

The adaptive

Speaker:

immune system

Speaker:

came about

Speaker:

subsequently

Speaker:

thereafter.

Speaker:

The innate immune

Speaker:

system comprises

Speaker:

elements such as

Speaker:

macrophage, such

Speaker:

as neutrophils,

Speaker:

such as natural

Speaker:

killer cells and

Speaker:

granular

Speaker:

cytoplasmophils

Speaker:

and basophils.

Speaker:

They have less

Speaker:

specificity in

Speaker:

order to address

Speaker:

whatever burden

Speaker:

might be plaguing

Speaker:

the body, but

Speaker:

they have more

Speaker:

immediate

Speaker:

reactions.

Speaker:

And then in their

Speaker:

immediate

Speaker:

reaction,

Speaker:

particularly

Speaker:

dendritic cells,

Speaker:

they create what

Speaker:

they call

Speaker:

presentation.

Speaker:

They they

Speaker:

optimize.

Speaker:

Basically they

Speaker:

decorate what,

Speaker:

like for example,

Speaker:

a pathogen,

Speaker:

enabling the

Speaker:

adaptive immune

Speaker:

players, which

Speaker:

are your B and

Speaker:

your T

Speaker:

lymphocytes, to

Speaker:

come in and say,

Speaker:

okay, cool, these

Speaker:

guys

Speaker:

shouldn't be here.

Speaker:

And the B and the

Speaker:

T lymphocytes are

Speaker:

initially your

Speaker:

artillery,

Speaker:

because when we

Speaker:

get into the

Speaker:

solid danger

Speaker:

response part of

Speaker:

the discussion,

Speaker:

I'll explain it a

Speaker:

little bit more,

Speaker:

initially you

Speaker:

proliferate

Speaker:

T cells.

Speaker:

So the innate

Speaker:

immune system

Speaker:

will launch of

Speaker:

its defense.

Speaker:

And in doing so,

Speaker:

create APC and

Speaker:

then in that, the

Speaker:

body will create

Speaker:

a reaction in

Speaker:

releasing a lot

Speaker:

of naive or

Speaker:

increasing the

Speaker:

production of

Speaker:

your

Speaker:

naive T cells.

Speaker:

Then over time,

Speaker:

with the APC is

Speaker:

coming into

Speaker:

contact with

Speaker:

these particular

Speaker:

lymph node

Speaker:

points, then the

Speaker:

specific type of

Speaker:

T cells will

Speaker:

proliferate.

Speaker:

You have two

Speaker:

subsets in my T

Speaker:

helper cells, T

Speaker:

regulatory cells,

Speaker:

and then

Speaker:

cytotoxic

Speaker:

lymphocytes.

Speaker:

And then you also

Speaker:

have your

Speaker:

antibodies, the

Speaker:

cell that's

Speaker:

within your B

Speaker:

cell complexes,

Speaker:

your IgMs, your

Speaker:

IgGs, IgAs

Speaker:

and IgEs.

Speaker:

Depending upon

Speaker:

what it is,

Speaker:

that's within

Speaker:

those particular

Speaker:

antibodies and

Speaker:

that those

Speaker:

particular T cell

Speaker:

responses will

Speaker:

come into

Speaker:

the mix.

Speaker:

Now it's very

Speaker:

important that a

Speaker:

response is

Speaker:

calibrated to a

Speaker:

point where it

Speaker:

doesn't cause

Speaker:

self-autoreactivity

Speaker:

in the body.

Speaker:

Otherwise you

Speaker:

have a state of

Speaker:

perpetual assault

Speaker:

that the immune

Speaker:

system perceives

Speaker:

that it is

Speaker:

required to

Speaker:

facilitate, even

Speaker:

though there

Speaker:

isn't a

Speaker:

continual threat.

Speaker:

Or there is no

Speaker:

longer the degree

Speaker:

of threat that it

Speaker:

perceives that it

Speaker:

actually has.

Speaker:

So it's very much

Speaker:

a concert.

Speaker:

And it's very

Speaker:

much like a

Speaker:

football game,

Speaker:

whereby the ball

Speaker:

is passed into

Speaker:

specific players

Speaker:

depending upon

Speaker:

the certain

Speaker:

sequence of how

Speaker:

the game is

Speaker:

playing out.

Speaker:

So those are your

Speaker:

two major

Speaker:

components that

Speaker:

you've been

Speaker:

using, the innate

Speaker:

and the adaptive

Speaker:

and obviously the

Speaker:

players.

Speaker:

What's very

Speaker:

interesting in

Speaker:

the innate immune

Speaker:

system is that

Speaker:

the stem cells

Speaker:

that produce most

Speaker:

of the innate

Speaker:

immune players

Speaker:

are lymphoid

Speaker:

stem cells.

Speaker:

Sorry, I'm sorry,

Speaker:

myeloid

Speaker:

stem cells.

Speaker:

Whereas the stem

Speaker:

cells that

Speaker:

produce most of

Speaker:

the adaptive

Speaker:

immune players

Speaker:

are lymphoid,

Speaker:

except albeit for

Speaker:

or natural

Speaker:

killer cells.

Speaker:

And this is

Speaker:

highly relevant

Speaker:

because your

Speaker:

natural killer

Speaker:

cells have the

Speaker:

greatest degree

Speaker:

of specificity in

Speaker:

contrast to the

Speaker:

other innate

Speaker:

immune players in

Speaker:

being able to

Speaker:

detect faulty

Speaker:

mutations.

Speaker:

So when you have

Speaker:

a lower natural

Speaker:

killer cells,

Speaker:

your risk of

Speaker:

cancer increases,

Speaker:

your body's

Speaker:

ability to resist

Speaker:

things like

Speaker:

perpetual cell

Speaker:

wall deficient

Speaker:

attacks such as

Speaker:

Lyme disease

Speaker:

reduces, your

Speaker:

body's ability to

Speaker:

mitigate

Speaker:

expression of

Speaker:

chronic envelope

Speaker:

based viruses

Speaker:

like

Speaker:

Epstein-Bach,

Speaker:

cyclo-mekovirus

Speaker:

decreases.

Speaker:

So when you have

Speaker:

lower natural

Speaker:

killer cells, you

Speaker:

become

Speaker:

vulnerable.

Speaker:

And what happens

Speaker:

is when you

Speaker:

become

Speaker:

vulnerable, the

Speaker:

other innate

Speaker:

players try to

Speaker:

step in because

Speaker:

there's a

Speaker:

deficiency of one

Speaker:

of their

Speaker:

teammates.

Speaker:

They try to come

Speaker:

in and help where

Speaker:

their teammates

Speaker:

not able to take

Speaker:

on the workload.

Speaker:

But in them doing

Speaker:

that, because of

Speaker:

their degree of

Speaker:

specificity isn't

Speaker:

as targeted as to

Speaker:

what natural

Speaker:

killer cells, and

Speaker:

it's also by way

Speaker:

of the stem cells

Speaker:

that they

Speaker:

originate from as

Speaker:

to why, this

Speaker:

creates a

Speaker:

likelihood of

Speaker:

perpetual,

Speaker:

chronic,

Speaker:

low-grade

Speaker:

inflammation.

Speaker:

Now, this

Speaker:

low-grade

Speaker:

inflammation can

Speaker:

also further

Speaker:

exhaust the

Speaker:

adaptive immune

Speaker:

system over time.

Speaker:

And HIV is a

Speaker:

classical

Speaker:

example.

Speaker:

You know, it's an

Speaker:

extreme example,

Speaker:

but it's a

Speaker:

classical example

Speaker:

of this whereby

Speaker:

HIV hijacks

Speaker:

certain

Speaker:

CD4 cells.

Speaker:

The CD4 cells

Speaker:

present

Speaker:

themselves along

Speaker:

the lymph nodes.

Speaker:

The innate immune

Speaker:

system launches

Speaker:

in a fence, but

Speaker:

meanwhile it's

Speaker:

launching in the

Speaker:

fence in the

Speaker:

wrong areas,

Speaker:

thereby reducing

Speaker:

the adaptive

Speaker:

capacity to

Speaker:

launch a

Speaker:

cytotoxic

Speaker:

lymphocyte

Speaker:

response at the

Speaker:

point where the

Speaker:

immune system

Speaker:

exhausts itself

Speaker:

and then you

Speaker:

develop eight.

Speaker:

Okay.

Speaker:

Would this be a,

Speaker:

excuse me, would

Speaker:

this be a point

Speaker:

where something

Speaker:

like a cytokine

Speaker:

resistance of

Speaker:

sorts would

Speaker:

develop,

Speaker:

potentially where

Speaker:

you've got an

Speaker:

anti-inflammatory

Speaker:

cytokin coming

Speaker:

into the mix, or

Speaker:

am I a bit off

Speaker:

base there?

Speaker:

I'm just trying

Speaker:

to piece this

Speaker:

together as you

Speaker:

go with regards

Speaker:

to the natural

Speaker:

killer cells.

Speaker:

Cytokin

Speaker:

resistance,

Speaker:

you're talking

Speaker:

about like

Speaker:

interleukin-10 as

Speaker:

a predominant

Speaker:

anti-cytokin.

Speaker:

Yes and no, and it's contextual,

Speaker:

because it

Speaker:

depends upon the

Speaker:

quantitative

Speaker:

release of other

Speaker:

cytokines in

Speaker:

ratio to that

Speaker:

interleukin-10

Speaker:

response.

Speaker:

As an example, if

Speaker:

you have a lot of

Speaker:

interleukin-4

Speaker:

being expressed

Speaker:

at the same time

Speaker:

as

Speaker:

interleukin-10,

Speaker:

and subsequently

Speaker:

you also might

Speaker:

have an

Speaker:

interleukin-13

Speaker:

activity

Speaker:

happening in

Speaker:

conjunction with

Speaker:

interleukin-4,

Speaker:

this may

Speaker:

propagate a

Speaker:

neutrophilic

Speaker:

response.

Speaker:

And the

Speaker:

neutrophilic

Speaker:

response can

Speaker:

increase the,

Speaker:

exacerbate a

Speaker:

release of

Speaker:

hydrogen

Speaker:

peroxide, which

Speaker:

is what they do.

Speaker:

That's where

Speaker:

hydrogen peroxide

Speaker:

is actually part

Speaker:

of the

Speaker:

immune system.

Speaker:

Immune system

Speaker:

actually release

Speaker:

hydrogen peroxide

Speaker:

as a form of very

Speaker:

strong

Speaker:

anti-microbial.

Speaker:

This is why, like

Speaker:

if you've had

Speaker:

hydrogen peroxide

Speaker:

IDs and so on,

Speaker:

it's because it's

Speaker:

supporting an

Speaker:

exhausted immune

Speaker:

system, this FYI.

Speaker:

Interesting.

Speaker:

Yeah, no, that's

Speaker:

a tip that I do

Speaker:

not know.

Speaker:

So with this

Speaker:

whole paradigm,

Speaker:

it's not just

Speaker:

about like, okay,

Speaker:

interleukin-10 is

Speaker:

there, we're

Speaker:

still having

Speaker:

information.

Speaker:

Well, no, it's,

Speaker:

it's looking at

Speaker:

it as doing what

Speaker:

it needs to do,

Speaker:

but what else is

Speaker:

going on in this

Speaker:

whole paradigm?

Speaker:

And this is where

Speaker:

like measuring a

Speaker:

cytokine map

Speaker:

provides to be

Speaker:

incredibly useful

Speaker:

when you're

Speaker:

seeing the

Speaker:

complex activity

Speaker:

of the entire

Speaker:

immune system.

Speaker:

You know, two

Speaker:

tests that I

Speaker:

always, not

Speaker:

always, but that

Speaker:

I enjoy running

Speaker:

because I get so

Speaker:

much insight from

Speaker:

them,

Speaker:

particularly in

Speaker:

cases of chronic

Speaker:

fatigue, not

Speaker:

necessarily

Speaker:

always long walk

Speaker:

over, just

Speaker:

chronic fatigue

Speaker:

cases, because in

Speaker:

my clinical

Speaker:

experience, in

Speaker:

supporting those

Speaker:

with chronic

Speaker:

fatigue, 90% of

Speaker:

the time it has

Speaker:

an association

Speaker:

with a exhausted

Speaker:

natural killer

Speaker:

cell response and

Speaker:

subsequently a

Speaker:

perpetuated

Speaker:

monocyte

Speaker:

inflammatory

Speaker:

response.

Speaker:

So in these

Speaker:

cases, they

Speaker:

always, no matter

Speaker:

how much iron or

Speaker:

iron-rich foods

Speaker:

they eat, they

Speaker:

always have low

Speaker:

serum iron.

Speaker:

If this is you,

Speaker:

and I'm speaking

Speaker:

to the audience

Speaker:

now, if you eat a

Speaker:

lot of red meat,

Speaker:

you're taking

Speaker:

trimethylglycine

Speaker:

to help with

Speaker:

hyperchloridea in

Speaker:

case you may have

Speaker:

that and try to

Speaker:

absorb

Speaker:

iron better.

Speaker:

And yet your

Speaker:

serum iron

Speaker:

concentration is

Speaker:

always on the low

Speaker:

side or maybe

Speaker:

even deficient,

Speaker:

despite the fact

Speaker:

that you might be

Speaker:

eating it's a

Speaker:

kilogram of

Speaker:

steak a day.

Speaker:

Whether you are

Speaker:

or you're not, if

Speaker:

it is that you're

Speaker:

full of this

Speaker:

paradigm and yet

Speaker:

no matter what

Speaker:

you do, albeit

Speaker:

from maybe direct

Speaker:

super

Speaker:

thermal iron,

Speaker:

your iron levels

Speaker:

are always

Speaker:

suppressed.

Speaker:

Consider the fact

Speaker:

that your

Speaker:

monocytes are

Speaker:

microphage on a

Speaker:

state of

Speaker:

perpetual

Speaker:

reactivation.

Speaker:

Okay, they're in

Speaker:

a state of M1,

Speaker:

microphage,

Speaker:

immunotype.

Speaker:

And this is

Speaker:

really elusive

Speaker:

because like, if

Speaker:

you just look

Speaker:

into a white

Speaker:

blood salt

Speaker:

differential to

Speaker:

try and determine

Speaker:

whether or not

Speaker:

this is

Speaker:

happening,

Speaker:

it doesn't always

Speaker:

show itself on a

Speaker:

standard white

Speaker:

blood salt

Speaker:

differential

Speaker:

because unless

Speaker:

you're gonna do

Speaker:

immunological

Speaker:

survey every day

Speaker:

for a period of

Speaker:

seven days, in

Speaker:

these particular

Speaker:

cases, you're not

Speaker:

always

Speaker:

necessarily gonna

Speaker:

get the window

Speaker:

within which the

Speaker:

immune systems

Speaker:

are compromised,

Speaker:

showing the true

Speaker:

effect of what

Speaker:

isn't or what is

Speaker:

actually

Speaker:

going on.

Speaker:

So this is where

Speaker:

running a

Speaker:

lymphocyte flow

Speaker:

cytometry as well

Speaker:

as a cytokine

Speaker:

map, proves to be

Speaker:

incredibly

Speaker:

insightful

Speaker:

because this

Speaker:

gives more of the

Speaker:

specificity in

Speaker:

terms of like

Speaker:

microphage

Speaker:

inflammatory

Speaker:

proteins and so

Speaker:

on and other side

Speaker:

of kinds of that

Speaker:

nature that could

Speaker:

be expressed in

Speaker:

the background,

Speaker:

actually

Speaker:

impacting anemia,

Speaker:

iron-based

Speaker:

anemia.

Speaker:

Again, despite

Speaker:

the fact of any

Speaker:

supplementation

Speaker:

or nutritional

Speaker:

augmentation,

Speaker:

when one is

Speaker:

experiencing

Speaker:

perpetual

Speaker:

iron-based

Speaker:

anemia,

Speaker:

especially in

Speaker:

situations where

Speaker:

they have

Speaker:

supplements, that

Speaker:

comes to consider

Speaker:

that there is an

Speaker:

immunological or

Speaker:

an immunological

Speaker:

distorted

Speaker:

perception

Speaker:

going on.

Speaker:

And I think

Speaker:

that's really

Speaker:

important is

Speaker:

that, yes, the

Speaker:

immune system can

Speaker:

exhaust itself,

Speaker:

however, it's not

Speaker:

always the point,

Speaker:

it's like the

Speaker:

whole concept

Speaker:

behind adrenal

Speaker:

exhaustion.

Speaker:

Do the adrenal

Speaker:

glands really

Speaker:

exhaust

Speaker:

themselves or is

Speaker:

it the receptor

Speaker:

makeup that

Speaker:

actually starts

Speaker:

to lose the

Speaker:

sensitivity to

Speaker:

the effect of the

Speaker:

glucocorticoids?

Speaker:

Or is it the fact

Speaker:

that it redirects

Speaker:

your other

Speaker:

catecholamines or

Speaker:

other hormone

Speaker:

specifically to

Speaker:

try and maintain

Speaker:

the state of pH

Speaker:

in the body?

Speaker:

The organic

Speaker:

gradient

Speaker:

in the body.

Speaker:

So again, the

Speaker:

immune system is

Speaker:

the same, is

Speaker:

that, I guess, in

Speaker:

most only you can

Speaker:

get exhausted and

Speaker:

certain

Speaker:

components of the

Speaker:

immune system can

Speaker:

tire, but you

Speaker:

have to ask

Speaker:

yourself why?

Speaker:

Why is the immune

Speaker:

system exhausted

Speaker:

in its cytotoxic

Speaker:

effect, for

Speaker:

example?

Speaker:

And often the

Speaker:

answer is because

Speaker:

there's an

Speaker:

imbalance between

Speaker:

its innate and

Speaker:

adaptive

Speaker:

components.

Speaker:

Yeah, that was

Speaker:

truly, I could

Speaker:

have used all of

Speaker:

that when

Speaker:

prepping for this

Speaker:

episode, that

Speaker:

would have made

Speaker:

life a lot easier

Speaker:

instead of trying

Speaker:

to sort of figure

Speaker:

out the

Speaker:

immunology from

Speaker:

scratch, which I

Speaker:

will fully admit,

Speaker:

I am not that

Speaker:

proficient in.

Speaker:

So I will for one

Speaker:

will be relisting

Speaker:

to all of that

Speaker:

because

Speaker:

truthfully I'm

Speaker:

talking about 80%

Speaker:

of it, some of it

Speaker:

was beyond me,

Speaker:

however, that was

Speaker:

incredible,

Speaker:

thank you.

Speaker:

And the audience

Speaker:

listening, you

Speaker:

may be a bit

Speaker:

flummoxed by

Speaker:

that, but I think

Speaker:

if you were to

Speaker:

give it a second

Speaker:

listen after

Speaker:

having listened

Speaker:

to the rest of

Speaker:

the episode, of

Speaker:

course, you will

Speaker:

pick up on a lot

Speaker:

of what Justin

Speaker:

just said.

Speaker:

And I know going

Speaker:

forwards, that's

Speaker:

going to really

Speaker:

help the rest of

Speaker:

the discussion

Speaker:

that we're going

Speaker:

to have about the

Speaker:

sort of concept

Speaker:

of

Speaker:

immunomatabolism,

Speaker:

which really is a

Speaker:

perfect segue

Speaker:

into that, into

Speaker:

this concept of

Speaker:

immunomatabolism.

Speaker:

And the way I

Speaker:

understand it,

Speaker:

sort of at a very

Speaker:

layman's

Speaker:

level is that

Speaker:

the immune system

Speaker:

obviously at

Speaker:

higher levels,

Speaker:

what controls the

Speaker:

inflammatory

Speaker:

response

Speaker:

in the body.

Speaker:

And when that

Speaker:

inflammatory

Speaker:

response is out

Speaker:

of control, then

Speaker:

there's a strong

Speaker:

carry over to

Speaker:

what is

Speaker:

colloquially

Speaker:

known as

Speaker:

metabolism.

Speaker:

That being the

Speaker:

result or the

Speaker:

collection of

Speaker:

various organ

Speaker:

systems

Speaker:

throughout the

Speaker:

body, everything

Speaker:

from thyroid to

Speaker:

pancreatic and

Speaker:

insulin function,

Speaker:

et cetera.

Speaker:

And I'd love to

Speaker:

sort of chat

Speaker:

about those

Speaker:

upstream

Speaker:

triggers points

Speaker:

in a bit.

Speaker:

But to start off

Speaker:

with, would you

Speaker:

sort of mind

Speaker:

breaking down the

Speaker:

way you see

Speaker:

immunomatabolism?

Speaker:

Because I think

Speaker:

I've got the gist

Speaker:

of it, but not

Speaker:

entirely.

Speaker:

So would you

Speaker:

provide the

Speaker:

audience with a

Speaker:

breakdown of this

Speaker:

term and then we

Speaker:

can discuss it in

Speaker:

a bit more depth

Speaker:

from there.

Speaker:

Well, I've got to

Speaker:

give credit to

Speaker:

Professor

Speaker:

Robert Naviou.

Speaker:

You know, that's

Speaker:

the cornerstone

Speaker:

of my

Speaker:

understanding

Speaker:

behind this

Speaker:

concept.

Speaker:

There are others

Speaker:

that definitely

Speaker:

contributed

Speaker:

toward it.

Speaker:

But by far he's

Speaker:

being the most

Speaker:

influential in

Speaker:

alluding to my

Speaker:

understanding as

Speaker:

to what this

Speaker:

paradigm actually

Speaker:

entails.

Speaker:

I mentioned

Speaker:

Albert Zangorgi

Speaker:

before when I was

Speaker:

talking about

Speaker:

methylene blue.

Speaker:

He also went into

Speaker:

this prior

Speaker:

to Naviou.

Speaker:

And prior to that

Speaker:

generation was

Speaker:

John Beard back

Speaker:

in the early part

Speaker:

of the 1900s, who

Speaker:

was the first to

Speaker:

treat cancer by

Speaker:

injecting

Speaker:

digestive enzymes

Speaker:

into tumors.

Speaker:

So this whole

Speaker:

paradigm is

Speaker:

actually started

Speaker:

by looking at

Speaker:

cancer as a

Speaker:

physiological

Speaker:

process, right?

Speaker:

And then

Speaker:

determining what

Speaker:

was going on

Speaker:

within cancer.

Speaker:

But then

Speaker:

obviously then as

Speaker:

time went on, it

Speaker:

actually was made

Speaker:

apparent

Speaker:

that the rate of

Speaker:

respiratory chain

Speaker:

activity has a

Speaker:

dramatic impact

Speaker:

over the

Speaker:

availability of

Speaker:

ATP, but not only

Speaker:

the availability

Speaker:

of ATP, it's

Speaker:

potential

Speaker:

oxidative

Speaker:

byproducts.

Speaker:

So mitochondria

Speaker:

produce a lot of

Speaker:

oxidants because

Speaker:

they produce a

Speaker:

lot of energy,

Speaker:

which means that

Speaker:

their membranes

Speaker:

are highly

Speaker:

susceptible to

Speaker:

oxidative stress

Speaker:

if they're not

Speaker:

maintained in a

Speaker:

neutral anhydrous

Speaker:

state, okay?

Speaker:

Like a battery.

Speaker:

You have to think

Speaker:

of your

Speaker:

mitochondria like

Speaker:

a battery.

Speaker:

If the polarity

Speaker:

or the ion

Speaker:

exchange is not

Speaker:

in well balanced

Speaker:

within

Speaker:

mitochondria,

Speaker:

that battery gets

Speaker:

hot, okay?

Speaker:

And what can

Speaker:

induce this if we

Speaker:

do not, or if our

Speaker:

mitochondria

Speaker:

don't have the

Speaker:

capacity to

Speaker:

readily shift

Speaker:

from different

Speaker:

energy dynamics,

Speaker:

meaning from

Speaker:

something as

Speaker:

immediate as the

Speaker:

creatine

Speaker:

phosphate system

Speaker:

to the

Speaker:

glycolysis, to

Speaker:

triclobolic acid,

Speaker:

to electron

Speaker:

transport chain

Speaker:

and shifting.

Speaker:

Because the thing

Speaker:

is you shouldn't

Speaker:

just do one.

Speaker:

Like there is a

Speaker:

flow of them all

Speaker:

happening

Speaker:

simultaneously

Speaker:

but to varying

Speaker:

degrees.

Speaker:

But when there's

Speaker:

a requirement in

Speaker:

the shift to take

Speaker:

place into a more

Speaker:

predominant state

Speaker:

of respiratory

Speaker:

chain activity,

Speaker:

energy

Speaker:

production, and

Speaker:

that shift can't

Speaker:

take place

Speaker:

effectively, then

Speaker:

what happens is

Speaker:

these

Speaker:

mitochondria

Speaker:

become highly

Speaker:

radical.

Speaker:

So they start to

Speaker:

not only damage

Speaker:

their own DNA but

Speaker:

they start to

Speaker:

damage DNA within

Speaker:

proximity from

Speaker:

expression from

Speaker:

the nucleus of

Speaker:

the cell.

Speaker:

And this is where

Speaker:

over time you can

Speaker:

start to have

Speaker:

mutations occur

Speaker:

as well.

Speaker:

Albeit that even

Speaker:

prior to these

Speaker:

mutations

Speaker:

occurring an

Speaker:

increase in the

Speaker:

likelihood of a

Speaker:

concept called

Speaker:

immunological

Speaker:

citizens may take

Speaker:

place as well.

Speaker:

So metabolism,

Speaker:

immunology, what

Speaker:

was the term?

Speaker:

How did you

Speaker:

connect

Speaker:

those two terms?

Speaker:

The idea of sort

Speaker:

of

Speaker:

immunomatabolism.

Speaker:

Immunomatabolism

Speaker:

of our, see the

Speaker:

moments of the

Speaker:

light

Speaker:

dislikes here.

Speaker:

Immunomatabolism

Speaker:

really is, as you

Speaker:

mentioned, the

Speaker:

segue between how

Speaker:

the internal

Speaker:

environment of

Speaker:

our physiology is

Speaker:

responding to

Speaker:

stimuli from our

Speaker:

external

Speaker:

environment.

Speaker:

And subsequently

Speaker:

within that

Speaker:

response, how

Speaker:

well we are

Speaker:

managing the

Speaker:

production as

Speaker:

well as recycling

Speaker:

of energy.

Speaker:

So going back to

Speaker:

Professor

Speaker:

Navia's work,

Speaker:

there he created

Speaker:

a concept called

Speaker:

the cell danger

Speaker:

response state,

Speaker:

which involves

Speaker:

different states

Speaker:

of respiratory

Speaker:

chain activity in

Speaker:

the mitochondria,

Speaker:

going from a

Speaker:

neutral, or I'm

Speaker:

gonna say a

Speaker:

neutral state, a

Speaker:

energetically

Speaker:

efficient state.

Speaker:

So think of your

Speaker:

mitochondria when

Speaker:

they're like

Speaker:

nuclear power

Speaker:

plants, meaning

Speaker:

they produce a

Speaker:

lot of energy

Speaker:

with a high

Speaker:

energy yield, but

Speaker:

a low

Speaker:

energy cost.

Speaker:

That's when

Speaker:

they're in their

Speaker:

energetic,

Speaker:

optimized state.

Speaker:

Okay, so they are

Speaker:

nuclear

Speaker:

power plants.

Speaker:

That would be CDR3.

Speaker:

No, no, that's a

Speaker:

neutral CDR.

Speaker:

That's CDR0,

Speaker:

think about it.

Speaker:

Okay, all right.

Speaker:

That's your, the

Speaker:

top part of

Speaker:

the wheel.

Speaker:

And then what

Speaker:

happens is when

Speaker:

you initially

Speaker:

have a threat, it

Speaker:

doesn't have to

Speaker:

be a

Speaker:

pathogenic threat.

Speaker:

It can be a

Speaker:

toxin, it can be

Speaker:

a heavy metal, it

Speaker:

could be

Speaker:

psychological

Speaker:

threats, it could

Speaker:

be persistent

Speaker:

organic

Speaker:

pollutants.

Speaker:

You name it.

Speaker:

When there's an

Speaker:

initial threat of

Speaker:

which the immune

Speaker:

system perceives

Speaker:

that it needs to

Speaker:

create a specific

Speaker:

response to, then

Speaker:

the mitochondria

Speaker:

shift into a

Speaker:

CDR1 state.

Speaker:

This is where

Speaker:

they become more

Speaker:

glycolytically

Speaker:

dominant.

Speaker:

Now, which is

Speaker:

very natural, and

Speaker:

just by the way,

Speaker:

the mitochondria

Speaker:

are continually

Speaker:

shifting in and

Speaker:

out of these

Speaker:

different cell

Speaker:

danger

Speaker:

response states.

Speaker:

But it's

Speaker:

important that

Speaker:

they're able to

Speaker:

shift and they

Speaker:

don't get stuck.

Speaker:

Okay, the reason

Speaker:

as to why they

Speaker:

get stuck is

Speaker:

very, are very

Speaker:

complex, because

Speaker:

now we're looking

Speaker:

at an interplay

Speaker:

between endocrine

Speaker:

and neurological,

Speaker:

immunological,

Speaker:

which actually

Speaker:

there's Leo

Speaker:

Prambro, of which

Speaker:

we both know of.

Speaker:

He also created a

Speaker:

category

Speaker:

entitled

Speaker:

psychoneuroimmunology,

Speaker:

which pretty much

Speaker:

embodies a lot of

Speaker:

this work

Speaker:

as well.

Speaker:

But he puts it

Speaker:

into a construct

Speaker:

of not only that

Speaker:

of apparent

Speaker:

physiology, but

Speaker:

also

Speaker:

psychological,

Speaker:

even spiritual

Speaker:

processes, which

Speaker:

I'm very much

Speaker:

aligned into his

Speaker:

theories as well.

Speaker:

Yet, we go back

Speaker:

to Navio's work,

Speaker:

the cell danger

Speaker:

one is when you

Speaker:

become more

Speaker:

glycolytically

Speaker:

dominant.

Speaker:

So what happens

Speaker:

here is that the

Speaker:

mitochondria are

Speaker:

going to be more

Speaker:

readily engaged,

Speaker:

augmented,

Speaker:

responsive, are

Speaker:

gonna be more

Speaker:

responsive to

Speaker:

within the use of

Speaker:

glucose as an

Speaker:

energy fuel

Speaker:

source, right?

Speaker:

Glucose and

Speaker:

pyruvate and so

Speaker:

on, rather than

Speaker:

being able to

Speaker:

utilize a vast

Speaker:

degree of

Speaker:

precursors to

Speaker:

pyruvate, such as

Speaker:

fats and

Speaker:

amino acids.

Speaker:

So what happens

Speaker:

here is that you

Speaker:

create a

Speaker:

maladaptive

Speaker:

response if you

Speaker:

get stuck in the

Speaker:

CDR1 state,

Speaker:

whereby the

Speaker:

mitochondria are

Speaker:

like, okay, we

Speaker:

need glucose, we

Speaker:

need glucose, and

Speaker:

you start having

Speaker:

increased sugar

Speaker:

cravings.

Speaker:

And subsequently,

Speaker:

this is where it

Speaker:

starts, right?

Speaker:

And then the

Speaker:

increase of sugar

Speaker:

cravings can also

Speaker:

have an impact on

Speaker:

driving down

Speaker:

methylation

Speaker:

because sugar

Speaker:

depletes

Speaker:

methyl donors.

Speaker:

And this is where

Speaker:

it can really

Speaker:

become a storm.

Speaker:

Not only a

Speaker:

cytokine storm,

Speaker:

but also a storm

Speaker:

on your

Speaker:

neurotransmitter

Speaker:

makeup.

Speaker:

So you start to

Speaker:

be able to

Speaker:

produce less

Speaker:

dopamine, you

Speaker:

start to have

Speaker:

dysregulated

Speaker:

production of

Speaker:

serotonin, you

Speaker:

start to have

Speaker:

exacerbated

Speaker:

expression of

Speaker:

extracellular

Speaker:

glutamate, not

Speaker:

intracellular,

Speaker:

extracellular

Speaker:

glutamate.

Speaker:

You start to

Speaker:

downregulate your

Speaker:

gamma-minipituric

Speaker:

acid receptor

Speaker:

sensitivity

Speaker:

because you're

Speaker:

not producing

Speaker:

enough of it

Speaker:

because the

Speaker:

extracellular

Speaker:

glutamate is

Speaker:

preventing you

Speaker:

from doing so.

Speaker:

And these are all

Speaker:

the unfortunate

Speaker:

consequences that

Speaker:

occur with

Speaker:

habitual excess

Speaker:

of sugar intake.

Speaker:

Now, this state

Speaker:

CDR1 is also

Speaker:

associated to an

Speaker:

immunological

Speaker:

phenotype called

Speaker:

TH2 dominant, of

Speaker:

which I've just

Speaker:

written a

Speaker:

book about.

Speaker:

And it's a book

Speaker:

that will be

Speaker:

facing for

Speaker:

practitioners as

Speaker:

well as for

Speaker:

the laymen.

Speaker:

So we'll have all

Speaker:

the complex words

Speaker:

that I've thrown

Speaker:

around today.

Speaker:

We'll have some

Speaker:

words that people

Speaker:

understand.

Speaker:

And the book for

Speaker:

the laymen is

Speaker:

entitled

Speaker:

"Responsible

Speaker:

Living, Moving

Speaker:

Away From

Speaker:

Reactivity."

Speaker:

And this is

Speaker:

really important

Speaker:

because our

Speaker:

bodies have

Speaker:

veered into

Speaker:

states of

Speaker:

reactivity

Speaker:

without us even

Speaker:

realizing it.

Speaker:

And the CDR1,

Speaker:

when we get stuck

Speaker:

here, we also

Speaker:

propensiate the

Speaker:

release of

Speaker:

histamine, which

Speaker:

creates fibrosis,

Speaker:

which causes poor

Speaker:

microvasculature,

Speaker:

which does not

Speaker:

enable things

Speaker:

such as an

Speaker:

example, thyroid

Speaker:

hormone, from

Speaker:

being able to

Speaker:

reach certain

Speaker:

receptors in the

Speaker:

mitochondrial

Speaker:

space to induce

Speaker:

support of

Speaker:

oxidant-phosphorylated

Speaker:

pathways, which

Speaker:

thyroid hormone

Speaker:

is highly

Speaker:

responsible

Speaker:

for doing.

Speaker:

Start protein

Speaker:

expression and

Speaker:

all of that.

Speaker:

Exactly right,

Speaker:

exactly right.

Speaker:

So this is CDR1.

Speaker:

And often people

Speaker:

get stuck here

Speaker:

because, again,

Speaker:

when we're young

Speaker:

and our DNA can

Speaker:

replicate at a

Speaker:

quicker pace, we

Speaker:

can recover.

Speaker:

But as soon as we

Speaker:

get to like 33,

Speaker:

that varies from

Speaker:

person to person.

Speaker:

That's the first

Speaker:

switch that

Speaker:

occurs as to when

Speaker:

our DNA

Speaker:

replication

Speaker:

starts to

Speaker:

slow down.

Speaker:

And this is where

Speaker:

we have an

Speaker:

increase of

Speaker:

senescence

Speaker:

starting

Speaker:

to come up.

Speaker:

And then

Speaker:

obviously that

Speaker:

proliferates as

Speaker:

we get over the

Speaker:

age of 55, it

Speaker:

really

Speaker:

proliferates.

Speaker:

So in our current

Speaker:

time, when you're

Speaker:

young, 20s and

Speaker:

you're a

Speaker:

youngster, you

Speaker:

don't feel it as

Speaker:

much, but without

Speaker:

a doubt, you're

Speaker:

being exposed to

Speaker:

it and you'll

Speaker:

start to

Speaker:

feel it later.

Speaker:

And it's been

Speaker:

reported that

Speaker:

those who were

Speaker:

born in our

Speaker:

generation may

Speaker:

not even live as

Speaker:

long as our

Speaker:

parents'

Speaker:

generation,

Speaker:

right?

Speaker:

Despite the

Speaker:

medical

Speaker:

advancements.

Speaker:

And there's

Speaker:

obviously, it's a

Speaker:

polarized

Speaker:

perspective,

Speaker:

again, the

Speaker:

courses of

Speaker:

polarity,

Speaker:

but it does make

Speaker:

consideration as

Speaker:

to where it is.

Speaker:

And these

Speaker:

suggestive

Speaker:

probabilities

Speaker:

that would come

Speaker:

about just by

Speaker:

opinion, that

Speaker:

came about from

Speaker:

actually looking

Speaker:

into the increase

Speaker:

of

Speaker:

non-conventional

Speaker:

disease and the

Speaker:

subsequent

Speaker:

shortening of

Speaker:

lifespan,

Speaker:

depending

Speaker:

upon that.

Speaker:

And also

Speaker:

financial

Speaker:

constraints that

Speaker:

come about with

Speaker:

non-conventional

Speaker:

disease, because

Speaker:

it's one thing to

Speaker:

have medical

Speaker:

advancements, but

Speaker:

it's another

Speaker:

thing to

Speaker:

look at, right?

Speaker:

So we're actually

Speaker:

living in a very

Speaker:

interesting time

Speaker:

where we have a

Speaker:

lot of

Speaker:

innovation, but

Speaker:

yet we're still

Speaker:

exposed to the

Speaker:

onslaught of

Speaker:

continual stress.

Speaker:

Now, one of the

Speaker:

bigger stressors

Speaker:

that I think is

Speaker:

not considered

Speaker:

are the unseen

Speaker:

stressors

Speaker:

like EMF.

Speaker:

Without a doubt,

Speaker:

non-native EMF is

Speaker:

by far the

Speaker:

biggest toxin of

Speaker:

our age, by far.

Speaker:

Without a doubt,

Speaker:

there's a-- Ooh,

Speaker:

there's a

Speaker:

decisive

Speaker:

statement.

Speaker:

Yeah, absolutely.

Speaker:

And I'm also,

Speaker:

like I mentioned

Speaker:

before, be

Speaker:

careful when you

Speaker:

have people

Speaker:

saying, decisive

Speaker:

statements in

Speaker:

this instance,

Speaker:

and I'm very,

Speaker:

very, very

Speaker:

critical of being

Speaker:

objective.

Speaker:

But in this

Speaker:

instance, I am

Speaker:

passionately

Speaker:

committed to the

Speaker:

statement that

Speaker:

non-native EMF is

Speaker:

by far the

Speaker:

greatest toxin of

Speaker:

our age.

Speaker:

The influx of

Speaker:

patients

Speaker:

struggling with

Speaker:

chronic fatigue,

Speaker:

struggling with

Speaker:

different forms

Speaker:

of neurodiversity

Speaker:

since the

Speaker:

introduction of

Speaker:

5G towers is very

Speaker:

apparent.

Speaker:

Not only in my

Speaker:

practice, but

Speaker:

many other

Speaker:

doctors and

Speaker:

physicians, which

Speaker:

I work in

Speaker:

community with,

Speaker:

have also

Speaker:

experienced the

Speaker:

same thing.

Speaker:

So in essence,

Speaker:

not to go down

Speaker:

that rabbit hole,

Speaker:

because Alice is

Speaker:

waiting with a

Speaker:

mad hatcher to

Speaker:

really go down

Speaker:

the tangent.

Speaker:

So just to avoid

Speaker:

that tangent, and

Speaker:

the point I'm

Speaker:

trying to make is

Speaker:

we live in a time

Speaker:

where we are

Speaker:

perpetually

Speaker:

exposed to many

Speaker:

stressors, more

Speaker:

so than what we

Speaker:

actually might

Speaker:

give credit to,

Speaker:

and may give

Speaker:

awareness to.

Speaker:

And because of

Speaker:

this, it is by

Speaker:

natural default,

Speaker:

because I mean,

Speaker:

evolution takes a

Speaker:

lot longer than

Speaker:

technological

Speaker:

evolution

Speaker:

has taken.

Speaker:

So the

Speaker:

mitochondria have

Speaker:

adapted pretty

Speaker:

well, very

Speaker:

quickly, but they

Speaker:

still haven't

Speaker:

adapted to what

Speaker:

it is we expose

Speaker:

them to in our

Speaker:

current daily

Speaker:

basis,

Speaker:

current times.

Speaker:

So what we're

Speaker:

finding, what

Speaker:

I've found, and

Speaker:

other

Speaker:

practitioners as

Speaker:

well, is that

Speaker:

people can

Speaker:

momentarily move

Speaker:

out of these

Speaker:

states, you know,

Speaker:

if they implement

Speaker:

all the biohacks

Speaker:

and they change

Speaker:

their lifestyle

Speaker:

and so on, but

Speaker:

the older that

Speaker:

they get, the

Speaker:

more inclined

Speaker:

they are to stay

Speaker:

stuck in the CDR1

Speaker:

state, okay?

Speaker:

Which is very

Speaker:

closely

Speaker:

associated to

Speaker:

chronic low grade

Speaker:

information.

Speaker:

And again, in

Speaker:

influencing

Speaker:

metabolic

Speaker:

resistance,

Speaker:

because when the

Speaker:

mitochondria

Speaker:

become more

Speaker:

glycolytically

Speaker:

dominant, they

Speaker:

can look for

Speaker:

glucose.

Speaker:

They're not gonna

Speaker:

utilize fat

Speaker:

effectively.

Speaker:

So beta-oxidation

Speaker:

goes down, which

Speaker:

means you have

Speaker:

extracellular

Speaker:

ketones

Speaker:

propagating,

Speaker:

which also causes

Speaker:

more lipid

Speaker:

peroxidation, and

Speaker:

other cumulative

Speaker:

issues between

Speaker:

cells comes into

Speaker:

the equation.

Speaker:

So it's quite an

Speaker:

intense paradigm,

Speaker:

to understand,

Speaker:

but it's an

Speaker:

important concept

Speaker:

to understand.

Speaker:

When we get into

Speaker:

cell danger two

Speaker:

response state,

Speaker:

this is where we

Speaker:

have a

Speaker:

proliferated

Speaker:

mTOR.

Speaker:

Just one question

Speaker:

before we jump

Speaker:

into CD2, if

Speaker:

that's okay.

Speaker:

You mentioned

Speaker:

earlier that

Speaker:

isolation is

Speaker:

potentially,

Speaker:

aside from

Speaker:

non-native EMFs,

Speaker:

of course, is

Speaker:

potentially one

Speaker:

of the biggest

Speaker:

triggers of the

Speaker:

slow grade

Speaker:

inflammation.

Speaker:

Do you think, and

Speaker:

I'm just thinking

Speaker:

of myself,

Speaker:

subjectively from

Speaker:

this, when saying

Speaker:

this, but when I

Speaker:

was younger, I

Speaker:

was definitely

Speaker:

more able, and

Speaker:

this speaks to

Speaker:

what you were

Speaker:

saying earlier

Speaker:

about us really

Speaker:

being more

Speaker:

gregarious than

Speaker:

we think we are,

Speaker:

I was really able

Speaker:

to function more

Speaker:

in a sort of an

Speaker:

isolated

Speaker:

capacity.

Speaker:

I found I wasn't

Speaker:

that being

Speaker:

isolated, I

Speaker:

wasn't subject to

Speaker:

feeling the way I

Speaker:

do now, which as

Speaker:

we talked about,

Speaker:

I'm going through

Speaker:

some, my own sort

Speaker:

of

Speaker:

post-phylophoty

Speaker:

with COVID,

Speaker:

et cetera.

Speaker:

And maybe that is

Speaker:

a mitigating

Speaker:

factor thereof,

Speaker:

but sort of

Speaker:

almost

Speaker:

independently of

Speaker:

that, and maybe

Speaker:

prior to COVID, I

Speaker:

found that the

Speaker:

more time I

Speaker:

spent alone,

Speaker:

as I got older, I

Speaker:

would, yeah, I

Speaker:

would definitely

Speaker:

become more

Speaker:

systemically

Speaker:

inflamed.

Speaker:

My HRV would tend

Speaker:

to drop,

Speaker:

et cetera.

Speaker:

Do you think that

Speaker:

there's a sort of

Speaker:

a direct, well,

Speaker:

that social

Speaker:

isolation is

Speaker:

going to fuel

Speaker:

that CDR1

Speaker:

response as well,

Speaker:

or at least as we

Speaker:

get older, is it

Speaker:

going to

Speaker:

exacerbate it?

Speaker:

I think it's a

Speaker:

question of

Speaker:

correlation,

Speaker:

perpetuating

Speaker:

causation.

Speaker:

So I don't think

Speaker:

it's causation,

Speaker:

and it's, I don't

Speaker:

think it's a

Speaker:

direct causation,

Speaker:

but I think it

Speaker:

most certainly

Speaker:

has a correlate

Speaker:

to perpetuating

Speaker:

this misaligned

Speaker:

immunological

Speaker:

expression.

Speaker:

So as you

Speaker:

mentioned before,

Speaker:

when you were

Speaker:

younger, being

Speaker:

able to be within

Speaker:

your own space

Speaker:

and be in a state

Speaker:

of, I won't say

Speaker:

isolation, but in

Speaker:

a solitary state,

Speaker:

a solitude, that

Speaker:

is solitude.

Speaker:

That's a better

Speaker:

way, because

Speaker:

isolation kind of

Speaker:

sounds like

Speaker:

you're

Speaker:

self-flagellating,

Speaker:

right?

Speaker:

But solitude

Speaker:

sounds a

Speaker:

lot better.

Speaker:

Yeah,

Speaker:

it's better.

Speaker:

So when you're

Speaker:

younger, you're

Speaker:

able to stay at a

Speaker:

state, well, you

Speaker:

may have been

Speaker:

able, not

Speaker:

everybody, but in

Speaker:

your case, you

Speaker:

may have stayed

Speaker:

at a state of

Speaker:

solitude, but yet

Speaker:

you're not

Speaker:

dealing with

Speaker:

spike protein.

Speaker:

You're not

Speaker:

dealing with

Speaker:

possible

Speaker:

associated

Speaker:

re-expressions of

Speaker:

envelope-based

Speaker:

viruses.

Speaker:

As you get older,

Speaker:

by way of being

Speaker:

exposed to heavy

Speaker:

metals, which we

Speaker:

all are, and a

Speaker:

patient asked me

Speaker:

the other day,

Speaker:

"Where did I have

Speaker:

exposure to heavy

Speaker:

metals?"

Speaker:

I'm like, "Where

Speaker:

did you not?"

Speaker:

Why do you not

Speaker:

have exposure to

Speaker:

heavy metals in

Speaker:

the day which we

Speaker:

live in?

Speaker:

They're

Speaker:

accumulates,

Speaker:

they're

Speaker:

accumulates.

Speaker:

So as we get

Speaker:

older, we

Speaker:

accumulate

Speaker:

toxins, the body

Speaker:

accumulates

Speaker:

toxins,

Speaker:

particularly if

Speaker:

we're not in the

Speaker:

nurse, how to

Speaker:

remove them, and

Speaker:

to have,

Speaker:

it's super

Speaker:

important to be

Speaker:

responsible, and

Speaker:

at word

Speaker:

responsible,

Speaker:

meaning the

Speaker:

ability to

Speaker:

respond to it in

Speaker:

today's

Speaker:

current times.

Speaker:

And what I'm

Speaker:

referring to here

Speaker:

is taking

Speaker:

strategies in and

Speaker:

into an habitual

Speaker:

aspect, affording

Speaker:

the body to be

Speaker:

lightened from

Speaker:

its environmental

Speaker:

toxin load.

Speaker:

Things like Epsom

Speaker:

salts, baths,

Speaker:

things like

Speaker:

sauna, okay?

Speaker:

And obviously, it

Speaker:

is also need to

Speaker:

come with certain

Speaker:

considerations,

Speaker:

not everybody

Speaker:

should be doing

Speaker:

them either.

Speaker:

That's why I'm

Speaker:

not making a

Speaker:

blanket statement

Speaker:

that sauna is the

Speaker:

holy grail for

Speaker:

everybody.

Speaker:

Some were to go

Speaker:

into a sauna,

Speaker:

particularly

Speaker:

those who have a

Speaker:

perpetuated

Speaker:

CDR1 state.

Speaker:

It's just going

Speaker:

to, it's going to

Speaker:

exacerbate your

Speaker:

muscle

Speaker:

response, okay?

Speaker:

So you need to

Speaker:

like, it's

Speaker:

contextual, but

Speaker:

regardless, those

Speaker:

are the instates.

Speaker:

When we get to

Speaker:

the point where

Speaker:

we become highly

Speaker:

reactive, we

Speaker:

wanna prevent

Speaker:

people from

Speaker:

getting to that

Speaker:

point, okay?

Speaker:

When you are at

Speaker:

that point, it is

Speaker:

likely that

Speaker:

you're gonna need

Speaker:

a practitioner

Speaker:

like myself or my

Speaker:

team to come in

Speaker:

and guide the

Speaker:

process because

Speaker:

it's complex,

Speaker:

it's very

Speaker:

complex.

Speaker:

But we don't want

Speaker:

you to get there.

Speaker:

Like, I don't

Speaker:

want to see a

Speaker:

billion people.

Speaker:

You know, I'd

Speaker:

rather see less

Speaker:

people, ill and

Speaker:

support more

Speaker:

people being

Speaker:

healthy.

Speaker:

Yeah,

Speaker:

preventative,

Speaker:

okay.

Speaker:

So habitual detox

Speaker:

needs to be part

Speaker:

of every modern

Speaker:

day man's

Speaker:

routine.

Speaker:

We do not, we're

Speaker:

not, the society

Speaker:

is not going to

Speaker:

reduce its toxic

Speaker:

assault on us.

Speaker:

So long as

Speaker:

technology

Speaker:

affords a payoff,

Speaker:

we're gonna

Speaker:

continue to have

Speaker:

more toxins.

Speaker:

Just make peace

Speaker:

with that.

Speaker:

Yes, I'm hopeful

Speaker:

that humanity's

Speaker:

future will

Speaker:

afford better

Speaker:

practices, but in

Speaker:

the meantime,

Speaker:

let's not negate

Speaker:

the reality of

Speaker:

corporations and

Speaker:

the effect that

Speaker:

they have on the

Speaker:

economy, okay?

Speaker:

And also that

Speaker:

effect in which

Speaker:

it has in

Speaker:

providing

Speaker:

employment across

Speaker:

the globe.

Speaker:

So we can't

Speaker:

discredit all

Speaker:

these things.

Speaker:

We have to

Speaker:

consider these

Speaker:

things, and which

Speaker:

means that we

Speaker:

need to be

Speaker:

malleable in what

Speaker:

it is that we

Speaker:

contribute to our

Speaker:

own health.

Speaker:

Bringing back

Speaker:

again the

Speaker:

community

Speaker:

consciousness

Speaker:

around

Speaker:

health, right?

Speaker:

Yeah, so now your

Speaker:

tolerance in that

Speaker:

isolated state in

Speaker:

contrast to when

Speaker:

you're younger is

Speaker:

also fueled not

Speaker:

only by the fact

Speaker:

that you should

Speaker:

be around people,

Speaker:

because obviously

Speaker:

your spirit is

Speaker:

telling you this

Speaker:

such, but it's

Speaker:

also fueled by

Speaker:

the fact that

Speaker:

there's certain

Speaker:

energetic bodies

Speaker:

that we exist

Speaker:

within, not only

Speaker:

the

Speaker:

physical state.

Speaker:

And I say that, I

Speaker:

think it was

Speaker:

Wayne Dyer that

Speaker:

mentioned one of

Speaker:

his audio books.

Speaker:

He had a friend

Speaker:

that was a

Speaker:

neurologist, and

Speaker:

they had to, he

Speaker:

went to his home

Speaker:

for dinner, and

Speaker:

they got into

Speaker:

conversation

Speaker:

about God, okay?

Speaker:

And obviously

Speaker:

that word has a

Speaker:

lot of meaning

Speaker:

for

Speaker:

different people,

Speaker:

or has meaning

Speaker:

for, yeah, has

Speaker:

difference of

Speaker:

meaning for

Speaker:

many people.

Speaker:

In any case, so

Speaker:

his friend was an

Speaker:

atheist, and he

Speaker:

said, "No, I

Speaker:

don't believe in

Speaker:

anything, "but I

Speaker:

cannot quantify."

Speaker:

See, so he's

Speaker:

like, "Okay, so

Speaker:

Tommy, "when you

Speaker:

open up a man's

Speaker:

brain, or the

Speaker:

skull, "when you

Speaker:

look into the

Speaker:

brain, "have you

Speaker:

ever witnessed

Speaker:

consciousness?"

Speaker:

That alone is

Speaker:

such a profound

Speaker:

realization, and

Speaker:

the entire human

Speaker:

body regenerates

Speaker:

itself every

Speaker:

seven, well, over

Speaker:

a period of

Speaker:

seven years.

Speaker:

Okay, so the

Speaker:

cellular

Speaker:

construct changes

Speaker:

every seven

Speaker:

years, and yet

Speaker:

consciousness--

Speaker:

Heart included.

Speaker:

Blooded.

Speaker:

Cardiac muscle

Speaker:

included?

Speaker:

Now you're asking

Speaker:

me a question, I

Speaker:

think so.

Speaker:

From my

Speaker:

understanding, I

Speaker:

think all cells

Speaker:

actually

Speaker:

recycle over a

Speaker:

period of

Speaker:

seven years.

Speaker:

Cardiac cells, I

Speaker:

think actually

Speaker:

have a quicker

Speaker:

recycling

Speaker:

capacity more so

Speaker:

than others.

Speaker:

Liver and cardiac

Speaker:

cells have

Speaker:

couldn't actually

Speaker:

repair quite

Speaker:

quickly,

Speaker:

but now you're

Speaker:

asking me, I need

Speaker:

to look back into

Speaker:

my physiology.

Speaker:

(Laughing) Yeah, no.

Speaker:

Don't remember

Speaker:

everything of

Speaker:

heart, but

Speaker:

nonetheless, all

Speaker:

cells, the

Speaker:

entire, like some

Speaker:

cells, like

Speaker:

they're repaired

Speaker:

slower than

Speaker:

others, but all

Speaker:

cells over a

Speaker:

seven year period

Speaker:

would have

Speaker:

changed, would

Speaker:

have actually

Speaker:

changed.

Speaker:

(Laughing) Would have been

Speaker:

recycled,

Speaker:

regenerated,

Speaker:

regenerated,

Speaker:

that's what I was

Speaker:

looking for,

Speaker:

regenerated.

Speaker:

So just have that

Speaker:

concept in your

Speaker:

mind, if your

Speaker:

entire construct

Speaker:

is gonna be

Speaker:

different in

Speaker:

seven years from

Speaker:

now, which it is,

Speaker:

but yet your

Speaker:

consciousness is

Speaker:

transferred

Speaker:

into your new

Speaker:

construct.

Speaker:

What does

Speaker:

that depict?

Speaker:

What does

Speaker:

that mean?

Speaker:

Does it mean that

Speaker:

Newtonian concept

Speaker:

of physical

Speaker:

reality of

Speaker:

physics is very

Speaker:

much a small

Speaker:

vantage point of

Speaker:

a greater

Speaker:

paradigm?

Speaker:

Are we looking

Speaker:

now to the realm

Speaker:

of quantum?

Speaker:

What are we, in

Speaker:

essence, in the

Speaker:

realm of quantum?

Speaker:

We're the space

Speaker:

between spaces.

Speaker:

What does

Speaker:

that mean?

Speaker:

We're a thought,

Speaker:

we're an idea.

Speaker:

And this is when

Speaker:

you start to

Speaker:

think of your, in

Speaker:

this type of

Speaker:

manner, and you

Speaker:

start to see a

Speaker:

human, not as a

Speaker:

physical body,

Speaker:

but as a spirit

Speaker:

having a human

Speaker:

experience, you

Speaker:

start to see that

Speaker:

the spirit comes

Speaker:

into experience

Speaker:

by way of its

Speaker:

desire of

Speaker:

education.

Speaker:

And it is

Speaker:

important that

Speaker:

when you start to

Speaker:

see a person

Speaker:

going through a

Speaker:

period of

Speaker:

struggle, that

Speaker:

you support their

Speaker:

education, that

Speaker:

you don't try to

Speaker:

have them avoid

Speaker:

their education,

Speaker:

which is where

Speaker:

opioids can come

Speaker:

into the equation

Speaker:

otherwise.

Speaker:

And I'm not

Speaker:

saying opioids

Speaker:

are always wrong,

Speaker:

there are

Speaker:

instances where

Speaker:

they're helpful,

Speaker:

but definitely

Speaker:

not to the degree

Speaker:

of which they're

Speaker:

being abused.

Speaker:

And this is where

Speaker:

the ego, now

Speaker:

we're going to

Speaker:

the realm of

Speaker:

psychology, has

Speaker:

the part in

Speaker:

trying to

Speaker:

captivate its

Speaker:

falsehood in

Speaker:

your belief

Speaker:

in being your

Speaker:

God, in being

Speaker:

your reality.

Speaker:

And in essence,

Speaker:

the ego is just a

Speaker:

program that we

Speaker:

adopt for

Speaker:

survival in the

Speaker:

physical

Speaker:

construct, but it

Speaker:

most certainly

Speaker:

does not need to

Speaker:

define us.

Speaker:

And when you

Speaker:

don't let it

Speaker:

define you,

Speaker:

because the ego

Speaker:

is also manifest

Speaker:

by cultural,

Speaker:

societal, and

Speaker:

belief

Speaker:

systems, right?

Speaker:

Which get

Speaker:

impressed upon us

Speaker:

from the day in

Speaker:

which we

Speaker:

were born.

Speaker:

So it begs the

Speaker:

question is what

Speaker:

is us and what

Speaker:

isn't us?

Speaker:

Like are we the

Speaker:

narrative that we

Speaker:

have adopted?

Speaker:

Are we more?

Speaker:

And I believe

Speaker:

that we're more,

Speaker:

I believe in the

Speaker:

latter, but it is

Speaker:

important to

Speaker:

nurse a person's

Speaker:

experience so

Speaker:

that they can

Speaker:

have the life of

Speaker:

an elevated life

Speaker:

where they're not

Speaker:

impacted by the

Speaker:

burden of disease

Speaker:

and so on, which

Speaker:

means that

Speaker:

sometimes when

Speaker:

somebody's going

Speaker:

through shit,

Speaker:

it's because they

Speaker:

are meant to go

Speaker:

through shit.

Speaker:

They're meant not

Speaker:

to just stay

Speaker:

there, but

Speaker:

they're meant to

Speaker:

go through it.

Speaker:

Now you can't go

Speaker:

through something

Speaker:

if you avoid it.

Speaker:

It's like having

Speaker:

a tunnel.

Speaker:

It's like you're

Speaker:

being on a main

Speaker:

road and there's

Speaker:

a tunnel

Speaker:

coming up.

Speaker:

And you gotta go

Speaker:

through the

Speaker:

tunnel to get to

Speaker:

the other side

Speaker:

and see the

Speaker:

daylight again.

Speaker:

But you get to

Speaker:

the tunnel and

Speaker:

instead of going

Speaker:

through the

Speaker:

tunnel, you just

Speaker:

put on all your

Speaker:

lights in the car

Speaker:

so that you could

Speaker:

have some light,

Speaker:

but you blind

Speaker:

yourself and then

Speaker:

you try to go

Speaker:

through the

Speaker:

tunnel, but you

Speaker:

keep on crashing

Speaker:

because you have

Speaker:

too much light

Speaker:

going on in your

Speaker:

car because

Speaker:

you're not

Speaker:

willing to

Speaker:

experience a

Speaker:

brevity of

Speaker:

darkness.

Speaker:

Yeah, that

Speaker:

makes sense.

Speaker:

I think that

Speaker:

there's a lot

Speaker:

there to unpack.

Speaker:

And yeah, it is

Speaker:

interesting how

Speaker:

we sort of

Speaker:

managed to link

Speaker:

CDR one up with

Speaker:

almost this sort

Speaker:

of pseudo concept

Speaker:

of free will.

Speaker:

I guess.

Speaker:

But yeah, getting

Speaker:

back to sort of

Speaker:

the cell danger

Speaker:

response just to

Speaker:

sort of tie up

Speaker:

this section of

Speaker:

the conversation.

Speaker:

CDR two

Speaker:

specifically, you

Speaker:

sort of

Speaker:

elucidated that

Speaker:

CDR one is where

Speaker:

there's a lot of

Speaker:

sort of disparity

Speaker:

in fuel sources

Speaker:

being used and

Speaker:

this cell becomes

Speaker:

sort of almost

Speaker:

more glycolytic

Speaker:

and sort of more

Speaker:

dependent on

Speaker:

those fuel

Speaker:

sources and less

Speaker:

able to maybe

Speaker:

utilize fatty

Speaker:

acids if you're,

Speaker:

which I think is

Speaker:

quite interesting

Speaker:

because you

Speaker:

oftentimes see

Speaker:

people who are

Speaker:

unable to fast,

Speaker:

unable to sort of

Speaker:

utilize ketogenic

Speaker:

diets

Speaker:

effectively.

Speaker:

They're often in

Speaker:

this state.

Speaker:

Now, it then

Speaker:

obviously

Speaker:

progresses as you

Speaker:

alluded

Speaker:

to CDR two.

Speaker:

Would you sort of

Speaker:

mind sort of

Speaker:

carrying on the

Speaker:

conversation

Speaker:

from there?

Speaker:

Yeah, absolutely.

Speaker:

So CDR two from a

Speaker:

pathological

Speaker:

perspective has

Speaker:

high association

Speaker:

with cancer and

Speaker:

PCOS and

Speaker:

endometriosis.

Speaker:

In essence, where

Speaker:

replication or

Speaker:

cell cycle arrest

Speaker:

starts to become

Speaker:

somewhat

Speaker:

compromised.

Speaker:

So CDR two is

Speaker:

when it is a

Speaker:

predominant mTOR

Speaker:

state and not

Speaker:

enough of an AMPK

Speaker:

reactive state.

Speaker:

So this is where

Speaker:

mitochondria

Speaker:

become highly

Speaker:

saturated.

Speaker:

Okay, so if one

Speaker:

is stuck in a CDR

Speaker:

two, let's

Speaker:

understand from

Speaker:

the natural way

Speaker:

in which this

Speaker:

whole sequence of

Speaker:

events is meant

Speaker:

to unfold is that

Speaker:

when you

Speaker:

initially have a

Speaker:

threat, you

Speaker:

induce

Speaker:

inflammation,

Speaker:

which by way of

Speaker:

increasing the

Speaker:

activity of

Speaker:

glycolysis,

Speaker:

you're gonna

Speaker:

increase

Speaker:

extracellular ATP

Speaker:

quite rapidly.

Speaker:

That

Speaker:

extracellular ATP

Speaker:

fills the

Speaker:

response of the

Speaker:

innate system,

Speaker:

but also then

Speaker:

triggers the

Speaker:

adaptive immune

Speaker:

system to create

Speaker:

replication,

Speaker:

plonal

Speaker:

replication,

Speaker:

okay.

Speaker:

And then you get

Speaker:

into the CDR two.

Speaker:

Now the CDR two,

Speaker:

you have again,

Speaker:

it's glycolysis

Speaker:

as well as your

Speaker:

oxidase or

Speaker:

phosphorylated

Speaker:

systems that

Speaker:

start to kick in.

Speaker:

But they kick in

Speaker:

in a more of a

Speaker:

predominance mTOR

Speaker:

fashion for

Speaker:

recovery, okay,

Speaker:

for recovery

Speaker:

because CDR one,

Speaker:

inflammation

Speaker:

damages tissue.

Speaker:

CDR two, the

Speaker:

recovery of that

Speaker:

damaged tissue

Speaker:

needs to take

Speaker:

place, okay.

Speaker:

And then CDR

Speaker:

three, if you're

Speaker:

there, this is

Speaker:

when you're

Speaker:

nucleotide, your

Speaker:

production of

Speaker:

NAD, FAD, this

Speaker:

starts to ramp up

Speaker:

to support

Speaker:

electron

Speaker:

transport chain.

Speaker:

Okay, but if you

Speaker:

get stuck in a

Speaker:

CDR three, it's

Speaker:

because there is

Speaker:

compromise in the

Speaker:

phosphate

Speaker:

systems.

Speaker:

Not to support

Speaker:

the electron

Speaker:

transport chain.

Speaker:

So this is

Speaker:

where like,

Speaker:

that autism is

Speaker:

indicative

Speaker:

of CDR three.

Speaker:

Okay, so you have

Speaker:

optimal oxidative

Speaker:

phosphorylation,

Speaker:

but you don't

Speaker:

have enough of

Speaker:

the spark because

Speaker:

your glycolysis

Speaker:

lights that

Speaker:

bonfire to keep

Speaker:

the mitochondria

Speaker:

in an anhydrous

Speaker:

state,

Speaker:

catabolic state.

Speaker:

If you don't have

Speaker:

enough of that

Speaker:

glycolytic

Speaker:

reaction

Speaker:

occurring, then

Speaker:

the mitochondria,

Speaker:

although their

Speaker:

nucleotide

Speaker:

reactions can be

Speaker:

optimal through

Speaker:

oxidative

Speaker:

phosphorylation,

Speaker:

subsequent

Speaker:

availability of

Speaker:

things like NAD

Speaker:

would be

Speaker:

massively

Speaker:

declined because

Speaker:

sequence of in

Speaker:

the production of

Speaker:

NAD is also

Speaker:

highly reliant on

Speaker:

glycolysis

Speaker:

as well.

Speaker:

And this is where

Speaker:

something like

Speaker:

the thylene blue

Speaker:

would come in as

Speaker:

an electron dolib

Speaker:

because it's

Speaker:

obviously able to

Speaker:

bypass some of

Speaker:

those complexes

Speaker:

that are being

Speaker:

blocked, is that

Speaker:

correct?

Speaker:

In part, yes, but

Speaker:

most certainly

Speaker:

the first and the

Speaker:

third complexes,

Speaker:

but it also can

Speaker:

come into

Speaker:

the CDR one.

Speaker:

Let me

Speaker:

explain why.

Speaker:

So the CDR one

Speaker:

will trigger a

Speaker:

macrophage to

Speaker:

induce a

Speaker:

hepcidin, an

Speaker:

increase of

Speaker:

hepcidin

Speaker:

activity, which

Speaker:

basically affords

Speaker:

their consumption

Speaker:

of iron, thereby

Speaker:

increasing their

Speaker:

nature from an

Speaker:

anti-inflammatory

Speaker:

state to a

Speaker:

radical state, in

Speaker:

perpetuating

Speaker:

their

Speaker:

pro-inflammatory

Speaker:

activity in the

Speaker:

body, which by

Speaker:

means of

Speaker:

increasing

Speaker:

attraction toward

Speaker:

a particular site

Speaker:

is highly

Speaker:

feasible and also

Speaker:

productive.

Speaker:

So the macrophage

Speaker:

in compromising,

Speaker:

so by

Speaker:

compromising

Speaker:

iron,

Speaker:

by creating an

Speaker:

excess of

Speaker:

extracellular

Speaker:

iron as well not

Speaker:

being made

Speaker:

available for the

Speaker:

health of red

Speaker:

blood cells and

Speaker:

so on, has a

Speaker:

negative knock-on

Speaker:

impact onto the

Speaker:

pentose phosphate

Speaker:

cycle, which also

Speaker:

has a depleto

Speaker:

factor on NADPH

Speaker:

availability.

Speaker:

So in these

Speaker:

instances, iron

Speaker:

is incredibly

Speaker:

important for

Speaker:

oxidative

Speaker:

phosphorylation,

Speaker:

incredibly,

Speaker:

particularly with

Speaker:

those particular

Speaker:

oxidative

Speaker:

phosphorylated

Speaker:

points,

Speaker:

those stages.

Speaker:

So methylene blue

Speaker:

comes into the

Speaker:

equation by

Speaker:

firstly reducing

Speaker:

the release of

Speaker:

hepcidin, also by

Speaker:

neutralizing the

Speaker:

reactivity of

Speaker:

these monocytes,

Speaker:

all the while

Speaker:

even in an

Speaker:

iron-depleted

Speaker:

state, which most

Speaker:

viral incidences

Speaker:

can actually

Speaker:

induce, it still

Speaker:

supports the

Speaker:

mechanisms of

Speaker:

which get shut

Speaker:

down when one

Speaker:

goes into a

Speaker:

predominant

Speaker:

glycolytic state.

Speaker:

So methylene blue

Speaker:

can, most

Speaker:

certainly, it's a

Speaker:

versatile

Speaker:

molecule that can

Speaker:

be utilized in

Speaker:

multiple CDR

Speaker:

states, but

Speaker:

specifically CDR1

Speaker:

and CDR3, it is

Speaker:

highly beneficial

Speaker:

to incorporate

Speaker:

its use.

Speaker:

Okay, and just

Speaker:

one follow-up

Speaker:

from that, and

Speaker:

I've just been

Speaker:

going through

Speaker:

this, trying to

Speaker:

understand this

Speaker:

concept of

Speaker:

ferroptosis,

Speaker:

sort of

Speaker:

pre-programmed,

Speaker:

form of

Speaker:

pre-programmed

Speaker:

cell death that

Speaker:

is driven by sort

Speaker:

of, I believe,

Speaker:

characterized by

Speaker:

iron-dependent

Speaker:

accumulation in

Speaker:

lipid peroxides.

Speaker:

Now,

Speaker:

loosely with

Speaker:

methylene blue,

Speaker:

and I'm just

Speaker:

trying to link

Speaker:

this together on

Speaker:

the fly here, so

Speaker:

I might be

Speaker:

completely

Speaker:

off base,

Speaker:

would you

Speaker:

potentially

Speaker:

utilize methylene

Speaker:

blue when there's

Speaker:

this sort of

Speaker:

heightened

Speaker:

presence of

Speaker:

ferroptosis?

Speaker:

Absolutely, it

Speaker:

would propensiate

Speaker:

it, for sure.

Speaker:

Actually, it

Speaker:

propensiates ever

Speaker:

more, so it

Speaker:

wouldn't

Speaker:

inhibit it.

Speaker:

It would actually

Speaker:

propensiate that

Speaker:

particular

Speaker:

activity of

Speaker:

ferroptosis, for sure.

Speaker:

Okay.

Speaker:

Yeah.

Speaker:

All right,

Speaker:

okay, good.

Speaker:

I'm glad I

Speaker:

vaguely got

Speaker:

something

Speaker:

right today.

Speaker:

Yep, we have to

Speaker:

ask stuff, what

Speaker:

is the process of

Speaker:

ferroptosis

Speaker:

actually

Speaker:

inducing?

Speaker:

A form of

Speaker:

apoptosis or a

Speaker:

necrosis.

Speaker:

Exactly,

Speaker:

apoptosis,

Speaker:

hopefully not

Speaker:

necrosis, but

Speaker:

apoptosis,

Speaker:

for sure.

Speaker:

And what

Speaker:

methylene blue

Speaker:

will actually do

Speaker:

is fuel that

Speaker:

process of

Speaker:

autophagy to

Speaker:

occur by way in

Speaker:

which it actually

Speaker:

modulates

Speaker:

oxidative

Speaker:

phosphorylated

Speaker:

pathways to

Speaker:

ensure the

Speaker:

continual supply

Speaker:

of energy that's

Speaker:

required during

Speaker:

processes of

Speaker:

autophagy.

Speaker:

Okay, I think

Speaker:

I've got that.

Speaker:

That's, yeah,

Speaker:

I've got it good.

Speaker:

If you think

Speaker:

about the

Speaker:

difference

Speaker:

between

Speaker:

catecholamine,

Speaker:

dorbicorticoids,

Speaker:

and

Speaker:

insulin, okay.

Speaker:

So insulin brings

Speaker:

things into the

Speaker:

cell,

Speaker:

dorbicorticoids,

Speaker:

catecholamine

Speaker:

release things

Speaker:

from the cell.

Speaker:

Okay, so when we

Speaker:

are looking to,

Speaker:

(Laughs)

Speaker:

I'm trying to

Speaker:

simplify

Speaker:

something very

Speaker:

complex.

Speaker:

(Laughs) Sorry, sorry,

Speaker:

this is

Speaker:

completely

Speaker:

my fault.

Speaker:

We've gone off on

Speaker:

a tangent.

Speaker:

No, not at all,

Speaker:

not at all.

Speaker:

When we are

Speaker:

looking to break

Speaker:

particles down,

Speaker:

we need somewhat

Speaker:

of a catalytic

Speaker:

reaction to

Speaker:

occur, okay.

Speaker:

In order for a

Speaker:

catalytic action

Speaker:

to occur, we need

Speaker:

availability

Speaker:

of ATP.

Speaker:

So we need to be able to do that

Speaker:

in the most

Speaker:

basic sense.

Speaker:

So in an increase

Speaker:

of ferroptosis,

Speaker:

you're most

Speaker:

certainly

Speaker:

inducing an

Speaker:

oxidative state

Speaker:

in the

Speaker:

body, okay.

Speaker:

That's pretty

Speaker:

much what it

Speaker:

does, and from

Speaker:

that, apoptosis

Speaker:

shouldn't ensue.

Speaker:

And high dose

Speaker:

vitamin C by way

Speaker:

is a way of

Speaker:

inducing

Speaker:

ferroptosis.

Speaker:

Yeah, that's one

Speaker:

of the, that's

Speaker:

one of, and

Speaker:

people didn't

Speaker:

realize this for

Speaker:

such a long time

Speaker:

when they were

Speaker:

like, you know,

Speaker:

using high dose

Speaker:

vitamin C and was

Speaker:

working

Speaker:

for cancer.

Speaker:

It's actually

Speaker:

because it

Speaker:

induces an

Speaker:

oxidative state

Speaker:

in order for the

Speaker:

body to

Speaker:

upregulate

Speaker:

certain regions

Speaker:

of lymphocyte

Speaker:

response.

Speaker:

This is why it

Speaker:

regenerates

Speaker:

lymphocytes.

Speaker:

Vitamin C is well

Speaker:

known to

Speaker:

regenerate such

Speaker:

toxic lymphocytes

Speaker:

that have become

Speaker:

exhausted, high

Speaker:

dose vitamin C.

Speaker:

And it's by way,

Speaker:

in part, by way

Speaker:

of this oxidative

Speaker:

process through

Speaker:

ferroptosis that

Speaker:

this occurs.

Speaker:

So in order for

Speaker:

this to continue

Speaker:

to provide

Speaker:

its process of

Speaker:

apoptosis

Speaker:

support, there is

Speaker:

a needed

Speaker:

availability of

Speaker:

energy that comes

Speaker:

into the

Speaker:

equation, not

Speaker:

only to fuel

Speaker:

this, but also to

Speaker:

mitigate the

Speaker:

excess of

Speaker:

radicals that can

Speaker:

also create an

Speaker:

unwanted effect

Speaker:

onto neighboring

Speaker:

tissues, which

Speaker:

whereby, if this

Speaker:

wasn't there, the

Speaker:

likelihood of

Speaker:

necrosis would be

Speaker:

a greater

Speaker:

probability.

Speaker:

So we don't want,

Speaker:

you know,

Speaker:

necrotic tissue

Speaker:

to accumulate.

Speaker:

We want the

Speaker:

breakdown and the

Speaker:

regeneration, the

Speaker:

optimal cell

Speaker:

cycle arrest or a

Speaker:

cyclo-renewal

Speaker:

state to come

Speaker:

into the, to into

Speaker:

expression.

Speaker:

This is where

Speaker:

methylene blue,

Speaker:

in specific

Speaker:

cases, most

Speaker:

certainly can

Speaker:

improve upon the

Speaker:

likelihood of

Speaker:

this actually

Speaker:

occurring.

Speaker:

The consideration

Speaker:

to methylene blue

Speaker:

is the

Speaker:

availability

Speaker:

to NADPH.

Speaker:

Okay.

Speaker:

If there is an

Speaker:

insufficient

Speaker:

availability of

Speaker:

NADPH, which is

Speaker:

predominantly

Speaker:

fueled through

Speaker:

the activity of

Speaker:

the

Speaker:

pentose-phosphate

Speaker:

pathway, then

Speaker:

you're going to

Speaker:

have an excess of

Speaker:

extracellular

Speaker:

methylene blue,

Speaker:

not leukolucalene

Speaker:

blue, but

Speaker:

extracellular

Speaker:

methylene blue

Speaker:

accumulate, which

Speaker:

again-- It's the

Speaker:

thiamine.

Speaker:

Yeah, the

Speaker:

thiamine, the

Speaker:

thiamine supports

Speaker:

the

Speaker:

pentose-phosphate

Speaker:

pathway.

Speaker:

There are other

Speaker:

elements that do

Speaker:

as well.

Speaker:

There are a lot,

Speaker:

but the thiamine,

Speaker:

as far as a focal

Speaker:

point is

Speaker:

concerned,

Speaker:

propensiates a

Speaker:

lot of the PPP

Speaker:

activity.

Speaker:

So in these

Speaker:

constructs

Speaker:

between the

Speaker:

pentose-phosphate

Speaker:

pathway NADPH,

Speaker:

NAD, when there

Speaker:

isn't enough

Speaker:

NADPH to

Speaker:

complement the

Speaker:

activity of NAD,

Speaker:

then leukocytes

Speaker:

lose their

Speaker:

capacity to

Speaker:

integrate from a

Speaker:

metabolomic level

Speaker:

methylene blue

Speaker:

into their

Speaker:

construct, which

Speaker:

is mostly the

Speaker:

reason as to

Speaker:

where, as a

Speaker:

dichromatic

Speaker:

material,

Speaker:

methylene blue

Speaker:

provides

Speaker:

antioxidant

Speaker:

support.

Speaker:

So it's both an

Speaker:

oxidative

Speaker:

potentiator as

Speaker:

well as an

Speaker:

antioxidant

Speaker:

potentiator.

Speaker:

And in order for

Speaker:

it to be

Speaker:

balanced, in

Speaker:

order for it to

Speaker:

have a modulated

Speaker:

effect on the

Speaker:

body, the

Speaker:

subsequent

Speaker:

availability of

Speaker:

NADPH is highly,

Speaker:

highly, highly

Speaker:

important.

Speaker:

And this is

Speaker:

something like

Speaker:

anybody that's

Speaker:

going through

Speaker:

like CDO1 or

Speaker:

CDO3, that's

Speaker:

looking to, considering

Speaker:

utilizing

Speaker:

methylene blue,

Speaker:

really first

Speaker:

thing is to look

Speaker:

into the state of

Speaker:

their spleen,

Speaker:

their specific

Speaker:

markers that can

Speaker:

give you

Speaker:

indication of

Speaker:

that MPV, ESR.

Speaker:

When there's

Speaker:

instance of

Speaker:

splenic

Speaker:

insufficiency,

Speaker:

first, make sure

Speaker:

that at the same

Speaker:

time that you are

Speaker:

supplementing

Speaker:

with methylene

Speaker:

blue, that you're

Speaker:

supporting the

Speaker:

PPP with

Speaker:

necessary

Speaker:

co-factors.

Speaker:

And then this

Speaker:

will help to

Speaker:

mitigate the

Speaker:

likelihood of

Speaker:

unwanted side

Speaker:

effect through

Speaker:

the use of

Speaker:

methylene blue.

Speaker:

It's the same

Speaker:

thing with ozone

Speaker:

therapy.

Speaker:

Ozone therapy is

Speaker:

incredible.

Speaker:

It most

Speaker:

certainly, I

Speaker:

mean, it does so

Speaker:

many things.

Speaker:

I'm just trying

Speaker:

to say

Speaker:

what it does.

Speaker:

It's like, I will

Speaker:

take another

Speaker:

podcast.

Speaker:

Yet, if you were

Speaker:

to administer

Speaker:

ozone therapy,

Speaker:

eventually, I

Speaker:

mean, there are

Speaker:

certain instances

Speaker:

where it requires

Speaker:

more application,

Speaker:

like for example,

Speaker:

Lyme disease

Speaker:

and cancer.

Speaker:

But that's also

Speaker:

because the

Speaker:

metabolic state

Speaker:

thus deems its

Speaker:

necessity based

Speaker:

upon what these

Speaker:

particular

Speaker:

constructs do to

Speaker:

immunomatabolism.

Speaker:

In situations

Speaker:

outside of that

Speaker:

construct, if you

Speaker:

were to use ozone

Speaker:

therapy every

Speaker:

day, it's not

Speaker:

gonna be very

Speaker:

healthy for you.

Speaker:

It's the same

Speaker:

with

Speaker:

methylene blue.

Speaker:

Same with

Speaker:

methylene blue.

Speaker:

It most certainly

Speaker:

can be utilized

Speaker:

on a daily basis

Speaker:

depending upon

Speaker:

the content,

Speaker:

sorry, the

Speaker:

context, the

Speaker:

context as to

Speaker:

where you're

Speaker:

using the

Speaker:

methylene blue

Speaker:

content

Speaker:

within, right?

Speaker:

So I'm going off

Speaker:

on the tangent of

Speaker:

methylene blue,

Speaker:

but it does bring

Speaker:

you to what it

Speaker:

was talking

Speaker:

about,

Speaker:

immunomatabolism

Speaker:

and dichromatic

Speaker:

materials.

Speaker:

Kirkman is

Speaker:

another

Speaker:

dichromatic

Speaker:

material, by the

Speaker:

way, but also

Speaker:

plays incredible

Speaker:

vantage role in

Speaker:

mitigating

Speaker:

astrogliosis in

Speaker:

the brain,

Speaker:

thus reducing the

Speaker:

potential buildup

Speaker:

of amyloid

Speaker:

plaques as well

Speaker:

as modulating

Speaker:

cineclic protein,

Speaker:

ensuring that the

Speaker:

misfolding of

Speaker:

those proteins

Speaker:

don't ensue

Speaker:

within the

Speaker:

certain regions

Speaker:

of the brain.

Speaker:

So these are all,

Speaker:

these dichromatic

Speaker:

materials are

Speaker:

credible, but too

Speaker:

much Kirkman in

Speaker:

certain

Speaker:

individuals that

Speaker:

have compromised

Speaker:

in their modamine

Speaker:

oxidase activity

Speaker:

or in their

Speaker:

phenol breakdown,

Speaker:

which has a lot

Speaker:

to do actually

Speaker:

with gluten

Speaker:

intolerance.

Speaker:

So those who have

Speaker:

like severe

Speaker:

gluten

Speaker:

intolerance, if

Speaker:

you give them a

Speaker:

high dose of

Speaker:

Kirkman, there's

Speaker:

a likelihood that

Speaker:

the phenol load

Speaker:

in the Kirkman

Speaker:

may cause

Speaker:

anxiety.

Speaker:

Just on Kirkman

Speaker:

quickly, have you

Speaker:

ever seen any

Speaker:

issues,

Speaker:

particularly with

Speaker:

Kirkman and

Speaker:

overly inhibiting

Speaker:

5-alpha

Speaker:

reductase?

Speaker:

Obviously that's

Speaker:

another tangent

Speaker:

of the rabbit

Speaker:

hole, but some

Speaker:

people are going

Speaker:

to be more

Speaker:

sensitive to the

Speaker:

inhibition of

Speaker:

that enzyme than

Speaker:

say others.

Speaker:

Do you think, and

Speaker:

the whole

Speaker:

post-menastride

Speaker:

argument is a

Speaker:

completely

Speaker:

different

Speaker:

conversation, I

Speaker:

apologize to the

Speaker:

audience because

Speaker:

we've now gone on

Speaker:

rabbit holes, but

Speaker:

rabbit holes.

Speaker:

However, do you

Speaker:

think

Speaker:

some of these

Speaker:

nutrients to call

Speaker:

compounds,

Speaker:

high dose

Speaker:

riboflavin, zinc,

Speaker:

et cetera, what

Speaker:

are the other

Speaker:

ones, the lion's

Speaker:

mane, can

Speaker:

potentiate some

Speaker:

of these issues

Speaker:

that the same

Speaker:

class of drug

Speaker:

acting on the

Speaker:

same receptor

Speaker:

can, or do you

Speaker:

not see that to

Speaker:

be an issue

Speaker:

clinically

Speaker:

speaking?

Speaker:

I guess the

Speaker:

Kirkman,

Speaker:

resveratrol,

Speaker:

there are a

Speaker:

couple of others

Speaker:

that have an

Speaker:

impact on 5-alpha

Speaker:

reductase.

Speaker:

Some have also

Speaker:

reported that it

Speaker:

can have an

Speaker:

impact on free

Speaker:

androgen levels

Speaker:

as well in that

Speaker:

activity.

Speaker:

When you look

Speaker:

into the pharma

Speaker:

dynamics,

Speaker:

you'll see that

Speaker:

it really is

Speaker:

dependent upon

Speaker:

specific genetic

Speaker:

probabilities

Speaker:

into enzyme

Speaker:

function as to

Speaker:

how the person

Speaker:

breaks down these

Speaker:

particular

Speaker:

molecules, which

Speaker:

is quite

Speaker:

interesting

Speaker:

because those who

Speaker:

have a propensity

Speaker:

for a slower

Speaker:

caffeine

Speaker:

metabolism as an

Speaker:

example, which

Speaker:

also has certain

Speaker:

similarity of

Speaker:

enzymatic

Speaker:

interaction as to

Speaker:

how the liver

Speaker:

breaks down

Speaker:

Kirkman or

Speaker:

resveratrol.

Speaker:

In these

Speaker:

instances, these

Speaker:

people also have

Speaker:

a greater

Speaker:

tendency for

Speaker:

estrogen

Speaker:

dominance, not

Speaker:

always, but they

Speaker:

generally have,

Speaker:

sorry, they often

Speaker:

have a propensity

Speaker:

for more estrogen

Speaker:

dominance.

Speaker:

So it begs the

Speaker:

question of

Speaker:

what's going on

Speaker:

within certain

Speaker:

methylation

Speaker:

sequences

Speaker:

depending upon

Speaker:

the individual,

Speaker:

and as to what

Speaker:

impact this is

Speaker:

having on

Speaker:

modification

Speaker:

rates and the

Speaker:

different

Speaker:

modification

Speaker:

rates as well.

Speaker:

So it's

Speaker:

contextual, and

Speaker:

this is where the

Speaker:

incorporation of

Speaker:

inductive

Speaker:

reasoning is

Speaker:

highly, highly

Speaker:

important because

Speaker:

when we take a

Speaker:

deductive

Speaker:

paradigm,

Speaker:

Kirkman's great

Speaker:

for everybody.

Speaker:

Let's see, is it

Speaker:

for neural

Speaker:

formation?

Speaker:

Well, no, it

Speaker:

might be good for

Speaker:

a lot because

Speaker:

even in

Speaker:

longitudinal

Speaker:

studies, the

Speaker:

majority of

Speaker:

people had to

Speaker:

respond

Speaker:

positively to

Speaker:

Kirkman, but the

Speaker:

majority is not

Speaker:

everyone.

Speaker:

So you can't make

Speaker:

this definitive

Speaker:

statement and a

Speaker:

blanket statement

Speaker:

saying, "You

Speaker:

know, Kirkman,

Speaker:

you're good for

Speaker:

everybody."

Speaker:

And it can

Speaker:

actually backfire

Speaker:

because in

Speaker:

Kirkman's

Speaker:

activity in

Speaker:

mitigating

Speaker:

astrogliosis,

Speaker:

as well as

Speaker:

expressing more

Speaker:

sirtuin activity,

Speaker:

there are many

Speaker:

things as to what

Speaker:

kookanoids do in

Speaker:

the body and for

Speaker:

the

Speaker:

immune system.

Speaker:

One of the things

Speaker:

in which it does

Speaker:

is also inhibit

Speaker:

C-X-C-L

Speaker:

complexes, C-C-L

Speaker:

complexes,

Speaker:

which are also

Speaker:

sort of chemokine

Speaker:

subsets within

Speaker:

the immune

Speaker:

system itself.

Speaker:

And in doing so,

Speaker:

it can actually

Speaker:

reduce this

Speaker:

auto-reactivity

Speaker:

of monocytes that

Speaker:

I spoke about

Speaker:

before in the way

Speaker:

in which they

Speaker:

hijack our iron,

Speaker:

thereby becoming

Speaker:

super-sproxidated

Speaker:

radicals.

Speaker:

So Kirkman can

Speaker:

actually mitigate

Speaker:

that from

Speaker:

happening, but in

Speaker:

instances whereby

Speaker:

it can compromise

Speaker:

through the

Speaker:

antigen to

Speaker:

estrogen ratio

Speaker:

availability, and

Speaker:

this is very

Speaker:

much, it's not

Speaker:

the, I just have

Speaker:

to make this

Speaker:

statement, is

Speaker:

that we're not

Speaker:

dealing with a

Speaker:

majority here.

Speaker:

In this

Speaker:

statement, we are

Speaker:

dealing with

Speaker:

outliers, but

Speaker:

outliers

Speaker:

also matter.

Speaker:

So generally,

Speaker:

most people

Speaker:

respond very well

Speaker:

to Kirkman and it

Speaker:

helps immune

Speaker:

system

Speaker:

multi-levels, but

Speaker:

those whom do

Speaker:

have a disparity

Speaker:

or do develop a

Speaker:

disparity in the

Speaker:

ratio between

Speaker:

testosterone and

Speaker:

estrogen

Speaker:

through its use

Speaker:

can also actually

Speaker:

thereby

Speaker:

propensiate more

Speaker:

histamine release

Speaker:

because estrogen

Speaker:

out of all our

Speaker:

sex hormones is

Speaker:

the hormone that

Speaker:

propensiates

Speaker:

histamine release

Speaker:

more so than any

Speaker:

other hormone.

Speaker:

And this is also

Speaker:

a reason why

Speaker:

estrogen is more,

Speaker:

I don't like to

Speaker:

use the word

Speaker:

important,

Speaker:

has more of an

Speaker:

active role,

Speaker:

there we go.

Speaker:

You can see I

Speaker:

don't like

Speaker:

hierarchy.

Speaker:

(Laughs)

Speaker:

I try to avoid

Speaker:

these words at

Speaker:

all costs.

Speaker:

It's good, it

Speaker:

challenges my

Speaker:

vocabulary.

Speaker:

So it has more of

Speaker:

an active role in

Speaker:

modulating one's

Speaker:

libido, more so

Speaker:

in testosterone,

Speaker:

because people

Speaker:

aren't

Speaker:

aware of this.

Speaker:

Most people think

Speaker:

testosterone is

Speaker:

the hormone that

Speaker:

actually is

Speaker:

estrogen.

Speaker:

And the reason is

Speaker:

to, one of the

Speaker:

reasons as to why

Speaker:

estrogen, it

Speaker:

propensiates

Speaker:

histamine

Speaker:

receptors

Speaker:

in the brain

Speaker:

by way of its

Speaker:

impact in causing

Speaker:

the release of

Speaker:

histamine,

Speaker:

propensiating the

Speaker:

release of

Speaker:

histamine

Speaker:

as well.

Speaker:

So if you are in

Speaker:

a CDR1 state and

Speaker:

you histamine

Speaker:

prone, which is

Speaker:

what CH2

Speaker:

dominance, and

Speaker:

there are

Speaker:

multiple

Speaker:

contributory

Speaker:

factors that can

Speaker:

actually reduce a

Speaker:

CH2 dominant

Speaker:

state or CDR1

Speaker:

state, which

Speaker:

we'll go to

Speaker:

in a moment.

Speaker:

But if you are in

Speaker:

the state, you

Speaker:

really wanna take

Speaker:

as much

Speaker:

precaution

Speaker:

within avoiding

Speaker:

an estrogen

Speaker:

dominant state.

Speaker:

Because that

Speaker:

estrogen

Speaker:

dominance can

Speaker:

actually just

Speaker:

fuel more of the

Speaker:

histamine

Speaker:

activity and

Speaker:

histamine

Speaker:

dominance, and

Speaker:

thereby impact

Speaker:

other subsequent

Speaker:

endocrine

Speaker:

systems, such as

Speaker:

the thyroid

Speaker:

mitochondrial

Speaker:

axis as well.

Speaker:

So yeah, again,

Speaker:

this contextual,

Speaker:

the particular

Speaker:

genome in

Speaker:

question, or the

Speaker:

CYP enzyme in

Speaker:

question.

Speaker:

1A2.

Speaker:

Yes, correct,

Speaker:

correct.

Speaker:

Yeah, Justin,

Speaker:

that was again,

Speaker:

amazing.

Speaker:

I think we're

Speaker:

definitely gonna

Speaker:

have to have part

Speaker:

one, two, and

Speaker:

potentially three

Speaker:

to this podcast,

Speaker:

but it's been an

Speaker:

incredible

Speaker:

conversation so

Speaker:

far, thank you.

Speaker:

You're welcome.

Speaker:

Okay, I think

Speaker:

that really wraps

Speaker:

up this whole

Speaker:

concept of

Speaker:

immunomentabolism.

Speaker:

And again, I

Speaker:

apologize to the

Speaker:

audience.

Speaker:

We went on an

Speaker:

unknown number of

Speaker:

tangents, but I

Speaker:

hope it's of some

Speaker:

value to you.

Speaker:

And in any case,

Speaker:

it's definitely

Speaker:

been a

Speaker:

treat for me.

Speaker:

Maybe this is

Speaker:

just a selfish

Speaker:

reason to

Speaker:

podcast.

Speaker:

I don't know that

Speaker:

I've loved this.

Speaker:

Well, happy

Speaker:

to oblige.

Speaker:

It's been an

Speaker:

awesome

Speaker:

opportunity to be

Speaker:

able to have

Speaker:

reciprocity of

Speaker:

knowledge share,

Speaker:

within

Speaker:

knowledge share.

Speaker:

Well, I was about

Speaker:

to say, you're

Speaker:

too kind, and

Speaker:

we'll discuss

Speaker:

that later.

Speaker:

Anyway,

Speaker:

so upstream of

Speaker:

what causes this

Speaker:

dysfunction, you

Speaker:

obviously have

Speaker:

various systems.

Speaker:

And I think the

Speaker:

two I'd like to

Speaker:

maybe touch on

Speaker:

are the gut,

Speaker:

because I think

Speaker:

it's relatable

Speaker:

too for most of

Speaker:

the audience,

Speaker:

especially people

Speaker:

coming from this

Speaker:

from a

Speaker:

traditional

Speaker:

functional

Speaker:

medicine

Speaker:

standpoint,

Speaker:

should we say.

Speaker:

I mean, most

Speaker:

people view gut

Speaker:

dysfunction from

Speaker:

the point of

Speaker:

lipopolysaccharide

Speaker:

ingress, or these

Speaker:

so-called

Speaker:

endotoxins that

Speaker:

create this

Speaker:

phenomenon called

Speaker:

leaky gut.

Speaker:

Actually, I

Speaker:

almost got that

Speaker:

word right.

Speaker:

On test on

Speaker:

permeability,

Speaker:

whereby these

Speaker:

foreign

Speaker:

molecules, just

Speaker:

broadly speaking,

Speaker:

get into

Speaker:

circulation

Speaker:

through the

Speaker:

smaller intestine

Speaker:

and drive a lot

Speaker:

of inflammation.

Speaker:

Now, there's a

Speaker:

lot more

Speaker:

biochemistry

Speaker:

there, obviously,

Speaker:

and that's going

Speaker:

to sort of

Speaker:

subsequently

Speaker:

drive a lot of,

Speaker:

as you alluded to

Speaker:

earlier, HPA-axis

Speaker:

dysfunction,

Speaker:

which is then

Speaker:

going to have

Speaker:

this downstream

Speaker:

consequence on

Speaker:

the immune

Speaker:

system, or

Speaker:

potentially

Speaker:

vice versa.

Speaker:

I think you could

Speaker:

definitely

Speaker:

explain this

Speaker:

better than I

Speaker:

could, but would

Speaker:

you mind just

Speaker:

maybe talking us

Speaker:

through why this

Speaker:

potentially can start off in the

Speaker:

gut, this sort of

Speaker:

immune

Speaker:

dysfunction,

Speaker:

this cell danger

Speaker:

response?

Speaker:

And then maybe we

Speaker:

could also then

Speaker:

wrap it up with a

Speaker:

short

Speaker:

conversation

Speaker:

about it from an

Speaker:

autonomic nervous

Speaker:

system

Speaker:

standpoint, too.

Speaker:

But yeah, we

Speaker:

could start there

Speaker:

and then go on.

Speaker:

That would

Speaker:

be great.

Speaker:

Absolutely,

Speaker:

absolutely.

Speaker:

It's interesting

Speaker:

to see the

Speaker:

microbiome profiling

Speaker:

dependent upon

Speaker:

the different

Speaker:

stages of one's

Speaker:

life and the

Speaker:

predominance of

Speaker:

different

Speaker:

species.

Speaker:

It's even more

Speaker:

interesting when

Speaker:

you overlay that

Speaker:

mapping as to

Speaker:

what particular

Speaker:

species ought to

Speaker:

be dominant in

Speaker:

contrast to those

Speaker:

who may be

Speaker:

dominant into

Speaker:

certain lifestyle

Speaker:

factors as well.

Speaker:

And I'm not just

Speaker:

talking about

Speaker:

blatant

Speaker:

infarctions.

Speaker:

I'm talking about

Speaker:

the subtle

Speaker:

infarctions.

Speaker:

For example,

Speaker:

going through a

Speaker:

bereavement.

Speaker:

Going through a

Speaker:

bereavement most

Speaker:

certainly has an

Speaker:

impact on the

Speaker:

limbic system

Speaker:

subsequently

Speaker:

impacts the

Speaker:

gastrointestinal

Speaker:

endocrine system,

Speaker:

affording

Speaker:

opportunity of

Speaker:

change of pH

Speaker:

variables.

Speaker:

And as you

Speaker:

alluded to

Speaker:

alluded, well,

Speaker:

alluded to

Speaker:

before, I love

Speaker:

the subtle

Speaker:

differences of

Speaker:

the difference of

Speaker:

meaning between

Speaker:

words, but as you

Speaker:

alluded to before

Speaker:

lipopolysaccharides,

Speaker:

I actually just

Speaker:

finished the

Speaker:

dissertation a

Speaker:

few years back on

Speaker:

lipopolysaccharides

Speaker:

and the impact

Speaker:

that they have on

Speaker:

major depressive

Speaker:

disorder.

Speaker:

But in my

Speaker:

research, there

Speaker:

are multiple

Speaker:

different

Speaker:

mechanisms

Speaker:

in which it

Speaker:

induced

Speaker:

neurodiversity.

Speaker:

And again, the

Speaker:

reason why I

Speaker:

bring up

Speaker:

neurodiversity,

Speaker:

histamine

Speaker:

dominance, CDR1,

Speaker:

and its impact on

Speaker:

depleting methyl

Speaker:

donors as well as

Speaker:

availability of

Speaker:

iron, it's very,

Speaker:

very apparent.

Speaker:

And if you don't

Speaker:

have these

Speaker:

precursors

Speaker:

available,

Speaker:

they're looking

Speaker:

at HVA levels,

Speaker:

looking at 5HIA

Speaker:

levels, looking

Speaker:

at VMA levels.

Speaker:

These are all

Speaker:

subsequently

Speaker:

always impaired

Speaker:

in those who have

Speaker:

TH2 dominance, or

Speaker:

at least

Speaker:

one of them.

Speaker:

Those are all

Speaker:

organic acids for

Speaker:

the

Speaker:

autososaccharide.

Speaker:

Correct, yeah, so

Speaker:

your 5HA is an

Speaker:

organic acid

Speaker:

marker depicting

Speaker:

activity of

Speaker:

serotonin,

Speaker:

which if it's too

Speaker:

high, it's also a

Speaker:

problem because

Speaker:

you might have an

Speaker:

excess of

Speaker:

peripheral

Speaker:

serotonin, which

Speaker:

by its nature can

Speaker:

certainly induce

Speaker:

peripheral, it

Speaker:

fuel peripheral

Speaker:

inflammation.

Speaker:

I mean parasites

Speaker:

feed off of

Speaker:

serotonin.

Speaker:

There's a reason

Speaker:

as to why we have

Speaker:

more parasitic

Speaker:

activity during

Speaker:

the full moon,

Speaker:

because there's a

Speaker:

compromise in

Speaker:

terms of the

Speaker:

serotonin being

Speaker:

methylated into

Speaker:

melatonin during

Speaker:

that time.

Speaker:

Because this is

Speaker:

why a lot of

Speaker:

your, again, this

Speaker:

is also based

Speaker:

upon some

Speaker:

science, but also

Speaker:

functional

Speaker:

paradigm science,

Speaker:

which it's like

Speaker:

the

Speaker:

metaphysicians

Speaker:

have been

Speaker:

alluding to

Speaker:

quantum physics

Speaker:

well before the

Speaker:

scientists jump

Speaker:

on board and then

Speaker:

they

Speaker:

figure it out.

Speaker:

So there is some

Speaker:

association, but

Speaker:

anyway, going

Speaker:

back to 5HA,

Speaker:

there's an

Speaker:

association with

Speaker:

serotonin, too

Speaker:

much, really bad,

Speaker:

too little, also,

Speaker:

it's a question

Speaker:

of balance.

Speaker:

And then your HVA

Speaker:

is your

Speaker:

homo-banylic

Speaker:

acid, which is an

Speaker:

indication of

Speaker:

dopamine

Speaker:

activity.

Speaker:

And you've got

Speaker:

Dokpak as well,

Speaker:

precursor.

Speaker:

And then you've

Speaker:

got your VMA,

Speaker:

which is an

Speaker:

indication of

Speaker:

nwopin, a front

Speaker:

end of the thing.

Speaker:

So there are

Speaker:

certain nutrient

Speaker:

donors required

Speaker:

for these

Speaker:

enzymatic

Speaker:

reactions to

Speaker:

take place.

Speaker:

Like for example,

Speaker:

the production of

Speaker:

dopamine, all

Speaker:

dopamine,

Speaker:

dopamine, and

Speaker:

what that

Speaker:

requires from the

Speaker:

pateratin cycle

Speaker:

as an

Speaker:

example, right?

Speaker:

And what impact

Speaker:

that pateratin

Speaker:

cycle has on the

Speaker:

folate pathway in

Speaker:

relation to

Speaker:

acetylsomatini

Speaker:

and homocysteine.

Speaker:

So there's an

Speaker:

interplay in this

Speaker:

whole makeup, but

Speaker:

essence of CDR1,

Speaker:

it creates a

Speaker:

compromise to

Speaker:

that methylation

Speaker:

cycling, those

Speaker:

methylation

Speaker:

wheels, because

Speaker:

of the state of

Speaker:

our chronic load

Speaker:

rate information

Speaker:

causing that

Speaker:

compromise in the

Speaker:

first place.

Speaker:

So when we look

Speaker:

into the gut in

Speaker:

particular,

Speaker:

and we see the

Speaker:

impact that

Speaker:

lipopolysaccharides

Speaker:

or the impact

Speaker:

that stress can

Speaker:

have an impact on

Speaker:

the gut affording

Speaker:

opportunity to

Speaker:

lipopolysaccharides

Speaker:

come through, we

Speaker:

often notice a

Speaker:

decrease of

Speaker:

neurotransmitters

Speaker:

or availability

Speaker:

of

Speaker:

neurotransmitters

Speaker:

and an expression

Speaker:

of cytokines.

Speaker:

And also

Speaker:

morphological

Speaker:

changes that

Speaker:

occur in the

Speaker:

brain themselves.

Speaker:

So the

Speaker:

morphological

Speaker:

changes are more

Speaker:

likely to occur

Speaker:

in a perpetuated

Speaker:

state of CDR1 or

Speaker:

TH2 dominance, or

Speaker:

particularly in

Speaker:

the developmental

Speaker:

stages of an

Speaker:

infant's life,

Speaker:

kind of the first

Speaker:

seven

Speaker:

years of life.

Speaker:

So this is why

Speaker:

even in the

Speaker:

uterine

Speaker:

considerations of

Speaker:

the mother's

Speaker:

stress state is

Speaker:

highly important

Speaker:

to take into

Speaker:

consideration.

Speaker:

Too much cortisol

Speaker:

can actually

Speaker:

cause the

Speaker:

depletion of

Speaker:

certain enzymes

Speaker:

that are within

Speaker:

the placenta that

Speaker:

are meant to be

Speaker:

able to contend

Speaker:

with that for

Speaker:

immunological

Speaker:

purposes, thereby

Speaker:

actually

Speaker:

resulting in an

Speaker:

increase of the

Speaker:

exposure to the

Speaker:

fetus developing

Speaker:

brain to

Speaker:

cortisol, thereby

Speaker:

actually creating

Speaker:

morphological

Speaker:

changes before

Speaker:

the baby's

Speaker:

even born.

Speaker:

So the reason why

Speaker:

I'm bringing up

Speaker:

like intrauterine

Speaker:

activity and

Speaker:

reason why it was

Speaker:

regards to the

Speaker:

gut is because

Speaker:

it's all

Speaker:

interconnected.

Speaker:

You know, if

Speaker:

there's an

Speaker:

imbalance of

Speaker:

perception, which

Speaker:

by way of

Speaker:

depletion of

Speaker:

certain

Speaker:

neurotransmitters

Speaker:

that can be

Speaker:

induced, that

Speaker:

subsequent

Speaker:

imbalance is also

Speaker:

gonna create

Speaker:

somewhat of a

Speaker:

threat

Speaker:

perception.

Speaker:

Now, if the

Speaker:

body's in a state

Speaker:

of threat

Speaker:

perception, as in

Speaker:

these monocytes

Speaker:

being

Speaker:

professionally

Speaker:

activated, to try

Speaker:

and re-inoculate

Speaker:

the body is

Speaker:

incredibly

Speaker:

difficult.

Speaker:

You can probably

Speaker:

take all the

Speaker:

probiotics

Speaker:

in the world.

Speaker:

I even had

Speaker:

patients of mine

Speaker:

whom decided to

Speaker:

take on the

Speaker:

advice of doctors

Speaker:

that have been

Speaker:

around for a lot

Speaker:

longer

Speaker:

than I had.

Speaker:

And I had good

Speaker:

intentions in

Speaker:

these doctors,

Speaker:

but they didn't

Speaker:

see this

Speaker:

particular

Speaker:

sequence of--

Speaker:

Phenotab.

Speaker:

Yeah, they didn't

Speaker:

see this paradigm

Speaker:

for what it was,

Speaker:

so they couldn't

Speaker:

conceptualize

Speaker:

what this

Speaker:

paradigm meant in

Speaker:

their efforts.

Speaker:

So anyway, these

Speaker:

patients spent a

Speaker:

lot of money on

Speaker:

fecal matter

Speaker:

transplant.

Speaker:

I'm talking a lot

Speaker:

of money.

Speaker:

If anybody knows

Speaker:

what FMT is, you

Speaker:

know, it's not a

Speaker:

cheap affair,

Speaker:

especially when

Speaker:

you're doing it

Speaker:

in a clinic,

Speaker:

but one of

Speaker:

which-- I was

Speaker:

about to say, I

Speaker:

think most

Speaker:

people, there are

Speaker:

lots of people,

Speaker:

well, not a lot,

Speaker:

but I know a few

Speaker:

people who sort

Speaker:

of go on the DIY

Speaker:

route, one might

Speaker:

say, and it's not

Speaker:

ended, maybe it's

Speaker:

a poor pun, but

Speaker:

it has not ended

Speaker:

up to be a very

Speaker:

pretty, with a

Speaker:

very

Speaker:

pretty ending.

Speaker:

So yeah, it's a

Speaker:

complete

Speaker:

different

Speaker:

wheelhouse, as

Speaker:

far as I'm

Speaker:

concerned.

Speaker:

I wouldn't go

Speaker:

anywhere near an

Speaker:

FMT without very

Speaker:

strict

Speaker:

supervision.

Speaker:

Yeah, you know, I

Speaker:

definitely want

Speaker:

to do it in a

Speaker:

clinic setting.

Speaker:

I think there are

Speaker:

suppositories and

Speaker:

what have that,

Speaker:

they're selling

Speaker:

at-home kits.

Speaker:

The thing is,

Speaker:

it's not about

Speaker:

just giving the

Speaker:

bacteria, whether

Speaker:

or not the body

Speaker:

receives it.

Speaker:

It's like trying

Speaker:

to give an organ

Speaker:

transplant to a

Speaker:

donor that

Speaker:

doesn't

Speaker:

match the donor.

Speaker:

Sorry, to a

Speaker:

recipient that

Speaker:

doesn't

Speaker:

match the donor.

Speaker:

So what we need

Speaker:

to do, if you

Speaker:

just take that

Speaker:

comparative

Speaker:

situation in

Speaker:

terms of the

Speaker:

organ donor, and

Speaker:

the organ

Speaker:

recipient

Speaker:

of the donor,

Speaker:

we need to

Speaker:

improve upon the

Speaker:

receptivity of

Speaker:

re-inoculation, in

Speaker:

re-inoculation.

Speaker:

So in order for

Speaker:

probiotics to

Speaker:

improve upon the

Speaker:

microbiome, the

Speaker:

immune system

Speaker:

needs to be in a

Speaker:

state of

Speaker:

coherence,

Speaker:

not reactivity.

Speaker:

With the bodies

Speaker:

in the state of

Speaker:

hyper-reactivity,

Speaker:

when you try to

Speaker:

re-inoculate the

Speaker:

gut, it's not

Speaker:

gonna take hold.

Speaker:

So which means

Speaker:

that all the gram

Speaker:

negative which

Speaker:

are more

Speaker:

anaerobic in

Speaker:

nature are going

Speaker:

to continue to

Speaker:

perpetuate

Speaker:

because the pH is

Speaker:

gonna afford

Speaker:

their continual

Speaker:

activity.

Speaker:

Now, it's very

Speaker:

important.

Speaker:

I love the fact

Speaker:

that you brought

Speaker:

up the microbiome

Speaker:

in the gut

Speaker:

because the

Speaker:

microbiome

Speaker:

expressed 150

Speaker:

times more DNA

Speaker:

than what our

Speaker:

human cells

Speaker:

express.

Speaker:

So their profile

Speaker:

within our bodies

Speaker:

has a direct

Speaker:

impact on our

Speaker:

metabolic

Speaker:

respiratory chain

Speaker:

efficiency, as in

Speaker:

when we have an

Speaker:

excess of

Speaker:

lipopolysaccharides,

Speaker:

given the fact

Speaker:

that they're

Speaker:

anaerobic nature,

Speaker:

can you see how

Speaker:

that can link

Speaker:

into predominance

Speaker:

of glycolysis?

Speaker:

Yes, I can.

Speaker:

Just getting to

Speaker:

feel that

Speaker:

inflammatory

Speaker:

process, yeah.

Speaker:

So it's a

Speaker:

question like,

Speaker:

where do we go

Speaker:

with this?

Speaker:

Like where do we

Speaker:

start in order to

Speaker:

get people

Speaker:

feeling healthy

Speaker:

again and not

Speaker:

having brain fog,

Speaker:

not having

Speaker:

autoimmune

Speaker:

expressions?

Speaker:

Lupus, very

Speaker:

closely and

Speaker:

intimately

Speaker:

connected

Speaker:

to CDR1.

Speaker:

That's the

Speaker:

extremes of CDR1.

Speaker:

We're extremes of

Speaker:

TH2 dominance.

Speaker:

So how do we get

Speaker:

people away from

Speaker:

the potential

Speaker:

expressions of

Speaker:

these

Speaker:

pathological

Speaker:

states?

Speaker:

And it really

Speaker:

comes into seeing

Speaker:

the body from a

Speaker:

holistic

Speaker:

perspective, not

Speaker:

throwing that

Speaker:

word around as

Speaker:

people have, like

Speaker:

really

Speaker:

understanding the

Speaker:

interplay of

Speaker:

multiple

Speaker:

physiological

Speaker:

systems and

Speaker:

specifically

Speaker:

immunometabolism.

Speaker:

See, I didn't, not

Speaker:

metabolimmunism, but

Speaker:

immunometabolism.

Speaker:

And this is, I

Speaker:

feel, not just

Speaker:

feel, but I also

Speaker:

know through

Speaker:

clinical

Speaker:

experience, a way

Speaker:

in which to take

Speaker:

people out of the

Speaker:

state of dorsal,

Speaker:

vagal dominance,

Speaker:

which can also

Speaker:

have an impact,

Speaker:

which does mean,

Speaker:

I mean, there's a

Speaker:

bidirectional

Speaker:

impact on the

Speaker:

nervous system as

Speaker:

well as immune

Speaker:

system,

Speaker:

influencing

Speaker:

physiological

Speaker:

metabolomics.

Speaker:

So the gut, yeah,

Speaker:

if you're damp,

Speaker:

you're gonna have

Speaker:

more elaborate

Speaker:

polysaccharides.

Speaker:

If you're damp,

Speaker:

you're gonna have

Speaker:

more fungi,

Speaker:

meaning more

Speaker:

reoccurring

Speaker:

Candiases.

Speaker:

And everything

Speaker:

that that comes

Speaker:

with as well, I

Speaker:

mean, like just

Speaker:

Candida and its

Speaker:

own, one of the

Speaker:

things that

Speaker:

Candida does, one

Speaker:

of the things, an

Speaker:

increase of

Speaker:

pentociety and

Speaker:

what this does to

Speaker:

the myelin sheath

Speaker:

is quite

Speaker:

destructive,

Speaker:

okay?

Speaker:

Not only does it

Speaker:

induce the

Speaker:

production of

Speaker:

pentociety, which

Speaker:

destroys the

Speaker:

nerve coding,

Speaker:

but also

Speaker:

subsequently

Speaker:

compromises how

Speaker:

well the body can

Speaker:

use arginine and

Speaker:

lysine in

Speaker:

doing so.

Speaker:

And if anybody

Speaker:

knows the

Speaker:

importance of

Speaker:

lysine in terms

Speaker:

of a white blood

Speaker:

selectivity

Speaker:

against viral

Speaker:

threat, when you

Speaker:

compromise that,

Speaker:

what are you

Speaker:

doing to the

Speaker:

adaptive

Speaker:

immune system?

Speaker:

You're tempering

Speaker:

it, not tempering

Speaker:

it, sorry, you

Speaker:

are

Speaker:

compromising it.

Speaker:

So- Yeah, it's

Speaker:

gonna be fairly

Speaker:

dissimated.

Speaker:

Well, the gut is

Speaker:

incredibly

Speaker:

important because

Speaker:

if you're damp

Speaker:

and you've got

Speaker:

Candida, you're

Speaker:

gonna compromise

Speaker:

the adaptive

Speaker:

immune system.

Speaker:

You're gonna

Speaker:

compromise the

Speaker:

liver by way in

Speaker:

which it

Speaker:

increases acetyl

Speaker:

aldehyde

Speaker:

concentration in

Speaker:

the liver, and

Speaker:

subsequently

Speaker:

there by further

Speaker:

compounding

Speaker:

methylation,

Speaker:

not depletion,

Speaker:

but methylation

Speaker:

response,

Speaker:

compromising the

Speaker:

response of

Speaker:

methylation by

Speaker:

way of inhibiting

Speaker:

methionine

Speaker:

synthase, which

Speaker:

is what acetyl

Speaker:

aldehyde does.

Speaker:

So there's so

Speaker:

many sequences of

Speaker:

the gut, but the

Speaker:

gut doesn't one

Speaker:

day wake up and

Speaker:

it's like, okay,

Speaker:

you know, I don't

Speaker:

like you anymore.

Speaker:

Here you go,

Speaker:

enjoy a

Speaker:

shitty life.

Speaker:

Excuse the pun.

Speaker:

(Laughs)

Speaker:

It happens, and

Speaker:

really one needs

Speaker:

to venture into

Speaker:

considering the

Speaker:

Barker

Speaker:

hypothesis.

Speaker:

Within the Barker

Speaker:

hypothesis, it

Speaker:

has been recently

Speaker:

expanded upon.

Speaker:

This Barker

Speaker:

hypothesis was

Speaker:

around, I think

Speaker:

the 60s or so,

Speaker:

and he postulated

Speaker:

the impact of a

Speaker:

lifetime of

Speaker:

exposures to a

Speaker:

person's current

Speaker:

state of health.

Speaker:

And that was

Speaker:

expanded upon in,

Speaker:

I think it was in

Speaker:

2000, or after

Speaker:

2000 and late

Speaker:

90s, in a new

Speaker:

concept, which is

Speaker:

again, just the

Speaker:

evolution of the

Speaker:

Barker hypothesis

Speaker:

and the designs

Speaker:

of health and

Speaker:

disease

Speaker:

hypothesis, which

Speaker:

pretty much looks

Speaker:

at the whole

Speaker:

lifespan as to

Speaker:

how certain

Speaker:

factors may have

Speaker:

influenced the

Speaker:

person's current

Speaker:

state of

Speaker:

microbiome.

Speaker:

And subsequently

Speaker:

what impact that

Speaker:

has on immunology

Speaker:

and so on

Speaker:

and so forth.

Speaker:

So yes, but to

Speaker:

answer your

Speaker:

question, most

Speaker:

certainly a

Speaker:

compromise

Speaker:

gastrointestinal

Speaker:

tract.

Speaker:

I mean, it's the

Speaker:

point of entry

Speaker:

that we have,

Speaker:

it's the most

Speaker:

dramatic point of

Speaker:

entry in terms of

Speaker:

a perceptive

Speaker:

entry that we

Speaker:

have to the

Speaker:

environment.

Speaker:

So yeah, most

Speaker:

certainly it can

Speaker:

induce a

Speaker:

CDR1 state.

Speaker:

It's probably one

Speaker:

of the greater

Speaker:

means in

Speaker:

which to do so.

Speaker:

It's not

Speaker:

the only.

Speaker:

One of the other

Speaker:

ways is actually

Speaker:

by way of simple

Speaker:

things, like

Speaker:

those of you whom

Speaker:

are tattooed, who

Speaker:

have a lot of

Speaker:

tattoos on

Speaker:

the body.

Speaker:

I love tattoos

Speaker:

for the cosmetic

Speaker:

reasons of them,

Speaker:

but they're

Speaker:

really not good

Speaker:

for the

Speaker:

immune system.

Speaker:

They're really

Speaker:

not good for the

Speaker:

immune system

Speaker:

because it

Speaker:

creates a low

Speaker:

grade perpetual

Speaker:

immune activity

Speaker:

based upon the

Speaker:

lead that's in

Speaker:

these tattoos.

Speaker:

And even if you

Speaker:

had lead free

Speaker:

tattoos, there

Speaker:

are other- I was

Speaker:

about to ask.

Speaker:

Yeah, there are

Speaker:

other- 10

Speaker:

minutes.

Speaker:

Puts within them.

Speaker:

They're less

Speaker:

impactful, but

Speaker:

they're still

Speaker:

impactful to

Speaker:

some degree.

Speaker:

So those who have

Speaker:

tattoos, you

Speaker:

should always be

Speaker:

using chlorella.

Speaker:

I'm sorry, you

Speaker:

gotta always use

Speaker:

chlorella and

Speaker:

find a way in

Speaker:

which to preserve

Speaker:

your iron.

Speaker:

Because if you

Speaker:

have a lot of

Speaker:

tattoos and

Speaker:

you're

Speaker:

experiencing

Speaker:

reoccurring

Speaker:

anemia, it ties

Speaker:

into what I

Speaker:

mentioned to you

Speaker:

before about this

Speaker:

perpetual

Speaker:

monocyte

Speaker:

reactivation.

Speaker:

That makes total

Speaker:

sense as well.

Speaker:

Rob, I would love

Speaker:

to do a study.

Speaker:

Maybe one of your

Speaker:

audience can find

Speaker:

a way in which we

Speaker:

can actually do

Speaker:

so efficiently,

Speaker:

whereby we

Speaker:

actually map the

Speaker:

correlation

Speaker:

between those

Speaker:

whom have

Speaker:

tattoos, as well

Speaker:

as the extent or

Speaker:

the timeframe of

Speaker:

chronic viral

Speaker:

expression,

Speaker:

fatigue, chronic

Speaker:

viral expression.

Speaker:

And I'm sure, I

Speaker:

hypothesize that

Speaker:

there is an

Speaker:

intimate,

Speaker:

nobody's done the

Speaker:

study, by

Speaker:

the way.

Speaker:

That's why I'm

Speaker:

putting

Speaker:

out there.

Speaker:

No one's done the

Speaker:

study yet.

Speaker:

No one's done the

Speaker:

study to see what

Speaker:

tattoos, how

Speaker:

tattoos increase

Speaker:

the vulnerability

Speaker:

for post-viral

Speaker:

fatigue.

Speaker:

No one's done the

Speaker:

study yet.

Speaker:

Yeah, no, I don't

Speaker:

think anyone's

Speaker:

ever thought of

Speaker:

doing that study.

Speaker:

It's definitely novel.

Speaker:

I mean, maybe we

Speaker:

would have to get

Speaker:

this in front of

Speaker:

Ben Greenfield,

Speaker:

because he's

Speaker:

definitely

Speaker:

well-to-do and

Speaker:

fairly inked up.

Speaker:

So maybe he's

Speaker:

someone to sort

Speaker:

of talk to.

Speaker:

You've really

Speaker:

alluded to this,

Speaker:

Justin, but I

Speaker:

think it's a

Speaker:

great place to

Speaker:

start ending off.

Speaker:

But just this

Speaker:

idea of the

Speaker:

central nervous

Speaker:

system and its

Speaker:

role in

Speaker:

triggering this

Speaker:

sort of

Speaker:

immunological

Speaker:

metabolic

Speaker:

dysfunction.

Speaker:

Again, me just

Speaker:

taking a sort of

Speaker:

a very layman's

Speaker:

approach to it,

Speaker:

but the idea that

Speaker:

when the nervous

Speaker:

system, when the

Speaker:

body is stressed,

Speaker:

it's not going to

Speaker:

sort of really,

Speaker:

it doesn't, okay,

Speaker:

it does to an

Speaker:

extent, but with

Speaker:

stress is

Speaker:

perceived

Speaker:

as stress.

Speaker:

It doesn't matter

Speaker:

if it's

Speaker:

psychological,

Speaker:

broadly speaking,

Speaker:

or physiological.

Speaker:

You're going to

Speaker:

have the sort of

Speaker:

the same

Speaker:

biological

Speaker:

reactions.

Speaker:

There's going to

Speaker:

be a surge in

Speaker:

catecholamines, a

Speaker:

surge in

Speaker:

hormones.

Speaker:

That's going to

Speaker:

increase the

Speaker:

transcription

Speaker:

factors.

Speaker:

And then you're

Speaker:

going to have

Speaker:

this downstream

Speaker:

effect again on

Speaker:

the immune system

Speaker:

and subsequently

Speaker:

on the metabolism

Speaker:

once again.

Speaker:

And we're going

Speaker:

to end up in this

Speaker:

state of being in

Speaker:

CDR1 two or

Speaker:

three, which I'm

Speaker:

not sure, but I'm

Speaker:

sure you can sort

Speaker:

of elucidate that

Speaker:

more succinctly

Speaker:

than I can.

Speaker:

Do you think that

Speaker:

this theory of,

Speaker:

and I suppose it

Speaker:

ties into some of

Speaker:

Leo Primbok's

Speaker:

work, the

Speaker:

psychoneuroimmunology,

Speaker:

do you think

Speaker:

there is merit to

Speaker:

this idea that a

Speaker:

sort of

Speaker:

psychological

Speaker:

stress in general

Speaker:

can drive this

Speaker:

metabolic

Speaker:

dysfunction?

Speaker:

Or is that sort

Speaker:

of more of an

Speaker:

edge case?

Speaker:

An edge case?

Speaker:

Good question.

Speaker:

I think again, it

Speaker:

is dependent upon

Speaker:

the individual as

Speaker:

to what the

Speaker:

individual had

Speaker:

been exposed to

Speaker:

over a course of

Speaker:

a lifespan.

Speaker:

As an example,

Speaker:

you know, on a

Speaker:

swash leg, I'm

Speaker:

going to use him

Speaker:

as an example,

Speaker:

and he even

Speaker:

discusses this in

Speaker:

a couple of his

Speaker:

documentaries,

Speaker:

whereby his, him

Speaker:

and his brother

Speaker:

were exposed to an

Speaker:

abusive father.

Speaker:

His brother ended

Speaker:

up killing

Speaker:

himself in a car

Speaker:

crash because

Speaker:

whilst he was

Speaker:

drunk, whilst he

Speaker:

was intoxicated.

Speaker:

So, you know, in

Speaker:

two

Speaker:

circumstances,

Speaker:

you have one

Speaker:

person utilizing

Speaker:

that stress for

Speaker:

improvement upon

Speaker:

what adaptability

Speaker:

to some degree,

Speaker:

based upon the

Speaker:

circumstances

Speaker:

he was in.

Speaker:

And the other,

Speaker:

where that stress

Speaker:

overwhelmed him

Speaker:

to the point

Speaker:

where he

Speaker:

pretty much

Speaker:

equated to the

Speaker:

state of

Speaker:

destruction.

Speaker:

So it really,

Speaker:

it's not even a

Speaker:

question of just

Speaker:

genetic.

Speaker:

I mean, for sure,

Speaker:

genetics do play

Speaker:

a role in one's

Speaker:

stress tolerance.

Speaker:

However, what

Speaker:

micron RNA is

Speaker:

being expressed

Speaker:

to put upon

Speaker:

certain sequences

Speaker:

of one's life

Speaker:

experiences will

Speaker:

have also a

Speaker:

greater

Speaker:

determining

Speaker:

epigenetic effect

Speaker:

than just that of

Speaker:

DNA alone.

Speaker:

So yes, is stress

Speaker:

a psychological

Speaker:

stress

Speaker:

contributor

Speaker:

for sure.

Speaker:

But what does

Speaker:

that mean?

Speaker:

I think that's

Speaker:

the question that

Speaker:

you're asking.

Speaker:

What does that

Speaker:

really mean?

Speaker:

Like, how can we

Speaker:

quantify this?

Speaker:

And the truth is,

Speaker:

from an

Speaker:

evidence-based

Speaker:

paradigm, you

Speaker:

can't, you can't,

Speaker:

because then

Speaker:

you've got to

Speaker:

bring it into

Speaker:

reductive models

Speaker:

and create the

Speaker:

ducted reasoning,

Speaker:

which doesn't

Speaker:

take into account

Speaker:

every possible

Speaker:

life experience

Speaker:

that the

Speaker:

individual

Speaker:

has had.

Speaker:

Now, I don't know

Speaker:

two people, even

Speaker:

twins, that have

Speaker:

had the exact

Speaker:

identical life

Speaker:

experiences, or

Speaker:

at least have not

Speaker:

perceived the

Speaker:

exact life

Speaker:

experiences

Speaker:

the same.

Speaker:

I think every

Speaker:

individual,

Speaker:

albeit those who

Speaker:

might be a twin

Speaker:

or not,

Speaker:

experience a life

Speaker:

and a individual

Speaker:

from an

Speaker:

individual

Speaker:

perspective.

Speaker:

So what

Speaker:

does that mean?

Speaker:

And now we are

Speaker:

venturing into

Speaker:

the realm of

Speaker:

metaphysics

Speaker:

again, like what

Speaker:

is consciousness?

Speaker:

What is life?

Speaker:

What does this

Speaker:

all mean?

Speaker:

And like, what do

Speaker:

we mean in our

Speaker:

experience?

Speaker:

Not just what

Speaker:

does that

Speaker:

experience mean

Speaker:

to us, what do we

Speaker:

mean within the

Speaker:

experience?

Speaker:

Like, what is our

Speaker:

essence in

Speaker:

all this?

Speaker:

And I think

Speaker:

regardless of

Speaker:

trying to, once

Speaker:

again, put a

Speaker:

remedy to a

Speaker:

challenge or a scenario

Speaker:

or to a category,

Speaker:

considering

Speaker:

compassionately

Speaker:

the individual

Speaker:

and as to what it

Speaker:

is that they are

Speaker:

reporting, they

Speaker:

are going

Speaker:

through, is

Speaker:

incredibly

Speaker:

important.

Speaker:

Compassion and

Speaker:

cooperation is

Speaker:

the way, I would

Speaker:

love to believe,

Speaker:

is the way of the

Speaker:

future of

Speaker:

medicine.

Speaker:

But in order for

Speaker:

that to come into

Speaker:

complete

Speaker:

fruition, we need

Speaker:

to change the way

Speaker:

in which we

Speaker:

perceive or how

Speaker:

we perceive

Speaker:

others, let alone

Speaker:

how we perceive

Speaker:

ourselves.

Speaker:

I mean, we first

Speaker:

can change how we

Speaker:

perceive

Speaker:

ourselves.

Speaker:

That in its own

Speaker:

right is a rite

Speaker:

of passage, which

Speaker:

I think takes

Speaker:

multiple

Speaker:

lifetimes to do,

Speaker:

in all honesty,

Speaker:

but there's no

Speaker:

reason as to why

Speaker:

we cannot

Speaker:

simultaneously at

Speaker:

least attempt and

Speaker:

try to change our

Speaker:

perception

Speaker:

of others.

Speaker:

And also again,

Speaker:

just venturing

Speaker:

into the

Speaker:

metaphysics here,

Speaker:

again, Professor

Speaker:

Hugh Limb as a

Speaker:

professor who was

Speaker:

treating the

Speaker:

medically, sorry,

Speaker:

the criminally

Speaker:

insane in Hawaii,

Speaker:

and he adopted

Speaker:

this Hawaiian

Speaker:

prayer called

Speaker:

"Upon O'Pono."

Speaker:

And there's a lot

Speaker:

of obviously

Speaker:

rumor around what

Speaker:

it had or had not

Speaker:

done, but by his

Speaker:

own account, he

Speaker:

was able to heal

Speaker:

the criminally

Speaker:

insane by way of

Speaker:

changing his

Speaker:

perception

Speaker:

through this

Speaker:

prayer of what it

Speaker:

is that he

Speaker:

believed these

Speaker:

people to be.

Speaker:

And perhaps that

Speaker:

also ventures

Speaker:

into yet another

Speaker:

question is that

Speaker:

are those we deem

Speaker:

to be faulty, are

Speaker:

those who we deem

Speaker:

to be faulty the

Speaker:

construct of our

Speaker:

ego, trying to

Speaker:

have them fit

Speaker:

into a narrative

Speaker:

of our own

Speaker:

design, or is the

Speaker:

construct of our

Speaker:

ego and the

Speaker:

narrative of our

Speaker:

own design the

Speaker:

problem

Speaker:

over here?

Speaker:

And I'm inclined

Speaker:

to believe that

Speaker:

egoic and

Speaker:

identity of which

Speaker:

the majority of

Speaker:

humanity has

Speaker:

adopted over

Speaker:

throughout its

Speaker:

incarnation,

Speaker:

really is at

Speaker:

fault in that we

Speaker:

have lost, and

Speaker:

I'm hoping that

Speaker:

we can reemerge

Speaker:

the compassionate

Speaker:

understanding of

Speaker:

our fellow man

Speaker:

and what they're

Speaker:

going through.

Speaker:

Because truly

Speaker:

it's only through

Speaker:

understanding

Speaker:

that we can

Speaker:

cultivate

Speaker:

patience to see,

Speaker:

okay, like the

Speaker:

psychology, what

Speaker:

this person is

Speaker:

experiencing

Speaker:

might be trivial

Speaker:

to you or to me

Speaker:

or to somebody

Speaker:

else, but to that

Speaker:

person it's

Speaker:

detrimental,

Speaker:

okay?

Speaker:

It's relative.

Speaker:

Yeah, exactly,

Speaker:

it's relative,

Speaker:

incredibly

Speaker:

relative.

Speaker:

And bringing it

Speaker:

back to the

Speaker:

theory of

Speaker:

relativity here,

Speaker:

(Laughs)

Speaker:

and the

Speaker:

perspective

Speaker:

influence that

Speaker:

that has on life

Speaker:

and the speed of

Speaker:

life and

Speaker:

everything that

Speaker:

that can have

Speaker:

from a

Speaker:

perspective of

Speaker:

physics,

Speaker:

biophysics

Speaker:

in the body,

Speaker:

relative

Speaker:

perspective most

Speaker:

certainly has an

Speaker:

impact on

Speaker:

biophysics,

Speaker:

undoubtedly.

Speaker:

And there are

Speaker:

actually some

Speaker:

documented

Speaker:

studies of this

Speaker:

matter as well.

Speaker:

And there is the

Speaker:

Institute of

Speaker:

Noetic Sciences

Speaker:

that was founded

Speaker:

by an astronaut,

Speaker:

his name is Dr.

Speaker:

Edgar Mitchell,

Speaker:

of which they

Speaker:

actually mapped

Speaker:

out

Speaker:

scientifically

Speaker:

the impact of

Speaker:

relative

Speaker:

consciousness to

Speaker:

biophysics, the

Speaker:

movement of

Speaker:

particles in the

Speaker:

body itself.

Speaker:

So it's, yes, to

Speaker:

answer your

Speaker:

question, most

Speaker:

certainly it can

Speaker:

lead into a CDR1,

Speaker:

but as to what

Speaker:

measure that, as

Speaker:

to what point

Speaker:

within a measure

Speaker:

it could induce

Speaker:

that is variable

Speaker:

to the

Speaker:

individual.

Speaker:

It is not a set

Speaker:

standard, it's

Speaker:

not a set

Speaker:

universal

Speaker:

standard that

Speaker:

everybody would

Speaker:

be

Speaker:

susceptible to.

Speaker:

There's a varying

Speaker:

degree of

Speaker:

susceptibility

Speaker:

across the board.

Speaker:

Yeah, it would

Speaker:

probably require

Speaker:

a bit more than

Speaker:

sort of an HRV

Speaker:

intervention, I'd

Speaker:

imagine to sort

Speaker:

of try and

Speaker:

ascertain that

Speaker:

level of data.

Speaker:

Justin, I think,

Speaker:

to be honest,

Speaker:

we've been going

Speaker:

on for nearly

Speaker:

three hours.

Speaker:

(Laughs) So what I'd love

Speaker:

to- Are you

Speaker:

kidding me?

Speaker:

Wow, this is

Speaker:

incredible,

Speaker:

fantastic, good.

Speaker:

It's been

Speaker:

absolutely

Speaker:

amazing,

Speaker:

thank you.

Speaker:

To end off with,

Speaker:

I'd love to ask

Speaker:

you a few rapid

Speaker:

fire questions,

Speaker:

and then, yeah,

Speaker:

let's call it a

Speaker:

day, and we can

Speaker:

then point people

Speaker:

to where they can

Speaker:

find you.

Speaker:

But to start off

Speaker:

with, what do you

Speaker:

think is the most

Speaker:

underrated

Speaker:

nutrient from an

Speaker:

immunological

Speaker:

health

Speaker:

standpoint?

Speaker:

Most underrated

Speaker:

nutrient.

Speaker:

I know we had

Speaker:

discussed this

Speaker:

briefly before,

Speaker:

and I wrote

Speaker:

garlic, but I'm

Speaker:

not sure.

Speaker:

It's a really

Speaker:

difficult

Speaker:

question

Speaker:

to answer.

Speaker:

Within the

Speaker:

context of CDR1,

Speaker:

or in the context

Speaker:

of, in what

Speaker:

context?

Speaker:

Let me ask you

Speaker:

that, let me ask

Speaker:

your question to

Speaker:

your question, in

Speaker:

what context?

Speaker:

Okay.

Speaker:

Let's go with,

Speaker:

yeah, let's go

Speaker:

with CDR1.

Speaker:

It's what we've

Speaker:

discussed most

Speaker:

today, I think,

Speaker:

so it's probably

Speaker:

most relevant.

Speaker:

Contextual,

Speaker:

because CDR1 has

Speaker:

many contributory

Speaker:

factors to it.

Speaker:

So I'm gonna go

Speaker:

through those

Speaker:

factors, and then

Speaker:

I'll give you

Speaker:

some indication.

Speaker:

So if it's a

Speaker:

question of

Speaker:

compromised

Speaker:

histamine

Speaker:

intolerance in

Speaker:

terms of a

Speaker:

dietary histamine

Speaker:

intolerance,

Speaker:

those whom are

Speaker:

able to

Speaker:

metabolize

Speaker:

sulfur, onion, I

Speaker:

mean, works

Speaker:

incredibly well,

Speaker:

has a natural

Speaker:

source of

Speaker:

kerstin, and

Speaker:

kerstin is the

Speaker:

molecule, the

Speaker:

nutrient in

Speaker:

question, that

Speaker:

helps a lot with

Speaker:

modulating the

Speaker:

mast cells.

Speaker:

If it's a

Speaker:

question of

Speaker:

estrogen

Speaker:

dominance that

Speaker:

might be fueling

Speaker:

the histamine, or

Speaker:

perpetuating the

Speaker:

histamine

Speaker:

response, then

Speaker:

broccoli and

Speaker:

subsequent indole

Speaker:

methane also

Speaker:

support the

Speaker:

modulation to the

Speaker:

CDR1 response.

Speaker:

If it's a

Speaker:

question of

Speaker:

prostate gladdon

Speaker:

imbalance, I'm

Speaker:

not a big fan of

Speaker:

fish roll, but I

Speaker:

am a big fan of

Speaker:

perzolving

Speaker:

mediators.

Speaker:

Perzolving

Speaker:

mediators.

Speaker:

Yeah, so that

Speaker:

there is a great,

Speaker:

if there's an

Speaker:

imbalance of

Speaker:

lipid utility,

Speaker:

that would be a

Speaker:

place to start.

Speaker:

If there's

Speaker:

imbalance of

Speaker:

methylation

Speaker:

imbalance, then

Speaker:

determining

Speaker:

exactly whether

Speaker:

or not, if it's a

Speaker:

beta oxidative

Speaker:

issue, then

Speaker:

pantothenin can

Speaker:

work

Speaker:

incredibly well.

Speaker:

If it's a pyrol

Speaker:

issue, then

Speaker:

pyrolyloxin can

Speaker:

work really well.

Speaker:

If it is a

Speaker:

question of poor

Speaker:

glutathione

Speaker:

recycling and

Speaker:

your GSSG levels

Speaker:

being higher,

Speaker:

then rubber

Speaker:

flabbing can work

Speaker:

incredibly well.

Speaker:

I think I gave

Speaker:

enough examples.

Speaker:

I think so.

Speaker:

You answered that

Speaker:

as only an

Speaker:

academic could,

Speaker:

is that already

Speaker:

possible?

Speaker:

Yeah, it's a

Speaker:

broad question.

Speaker:

It's like, you

Speaker:

know, within,

Speaker:

even in the

Speaker:

subject of CDR1

Speaker:

or TH2 dominance,

Speaker:

what, you know,

Speaker:

there's so many

Speaker:

contradictory

Speaker:

factors that can

Speaker:

have an influence

Speaker:

on that.

Speaker:

Like, one can

Speaker:

even venture into

Speaker:

amino acids now,

Speaker:

like theanine, to

Speaker:

prove a polygonal

Speaker:

response, and

Speaker:

thereby hopefully

Speaker:

mitigating

Speaker:

glutamate

Speaker:

dominance, which

Speaker:

also by way,

Speaker:

influences CDR1

Speaker:

expression,

Speaker:

glutamate

Speaker:

dominance.

Speaker:

So yeah, which, like

Speaker:

polysaccharides

Speaker:

have an influence

Speaker:

on activating

Speaker:

NMDA receptors,

Speaker:

which are one of

Speaker:

the subsets of,

Speaker:

there's two

Speaker:

classes of

Speaker:

glutamate

Speaker:

receptors.

Speaker:

It's one of the

Speaker:

subsets of the

Speaker:

main class of

Speaker:

glutamate

Speaker:

receptors.

Speaker:

So, you know,

Speaker:

theanine, green

Speaker:

tea, could have

Speaker:

sort of

Speaker:

contextual

Speaker:

importance

Speaker:

as well.

Speaker:

That's

Speaker:

incredible,

Speaker:

thank you.

Speaker:

Okay, next one.

Speaker:

What's one

Speaker:

supplement you

Speaker:

personally could

Speaker:

not go without?

Speaker:

Again, another

Speaker:

contextual

Speaker:

question.

Speaker:

Can I not go

Speaker:

within which,

Speaker:

within which

Speaker:

scenario?

Speaker:

Just generally,

Speaker:

if you got stuck

Speaker:

in a desert

Speaker:

island with one

Speaker:

bottle of

Speaker:

something.

Speaker:

Yeah, my friend

Speaker:

Dominic

Speaker:

Nischwitz, he

Speaker:

told me to say

Speaker:

chlorella.

Speaker:

(Laughing)

Speaker:

I'm sorry for it.

Speaker:

Chlorella,

Speaker:

chlorella.

Speaker:

Which is right, I

Speaker:

think chlorella

Speaker:

is incredible

Speaker:

compound.

Speaker:

Amazing, so many,

Speaker:

it's got a great

Speaker:

source of iodine,

Speaker:

great binder,

Speaker:

great B vitamin

Speaker:

profile, great

Speaker:

selenium profile,

Speaker:

really is a

Speaker:

super sweet.

Speaker:

Supplement, could

Speaker:

I not go without?

Speaker:

You've got

Speaker:

phosphatidylcholine

Speaker:

here, I

Speaker:

think, PC.

Speaker:

Yeah, I think in

Speaker:

my particular

Speaker:

case, having

Speaker:

historically

Speaker:

having had issues

Speaker:

with bioacid

Speaker:

activity,

Speaker:

and also

Speaker:

subsequent

Speaker:

certain cognitive

Speaker:

memory recall

Speaker:

issues, certain

Speaker:

points when I had

Speaker:

my water

Speaker:

immunity,

Speaker:

phosphatidylcholine

Speaker:

was certainly

Speaker:

mitigated a lot

Speaker:

of this.

Speaker:

So

Speaker:

phosphatidylcholine

Speaker:

is different, be

Speaker:

on the top

Speaker:

of the list.

Speaker:

And I also do

Speaker:

have certain PEMT

Speaker:

genome that makes

Speaker:

me more

Speaker:

vulnerable to

Speaker:

deficiency of

Speaker:

cholera,

Speaker:

phosphatidylcholine.

Speaker:

So let's go with

Speaker:

that one, let's

Speaker:

go with that one.

Speaker:

Okay, perfect.

Speaker:

Emerging therapies you're

Speaker:

most excited

Speaker:

about or therapy?

Speaker:

I always forget

Speaker:

how, because I

Speaker:

always wanted to

Speaker:

say

Speaker:

ionotrophysis,

Speaker:

but it's not how

Speaker:

you, it's

Speaker:

ionophoresis.

Speaker:

That was Newton,

Speaker:

I must admit.

Speaker:

Yeah, it's quite

Speaker:

an interesting

Speaker:

technology,

Speaker:

almost works like

Speaker:

on a battery type

Speaker:

of a dark man

Speaker:

concept in terms

Speaker:

of the positive

Speaker:

and

Speaker:

negative charge.

Speaker:

And what it does

Speaker:

by inducing this

Speaker:

ionic

Speaker:

displacement, it

Speaker:

opens up the

Speaker:

membranes to be

Speaker:

more accepting of

Speaker:

nutrient

Speaker:

delivery.

Speaker:

So it's quite an

Speaker:

interesting

Speaker:

model.

Speaker:

There's a few

Speaker:

companies, Ion

Speaker:

Layer, and there

Speaker:

are others as

Speaker:

well, that

Speaker:

provide this

Speaker:

technology by way

Speaker:

of delivering NAD

Speaker:

and glutathione.

Speaker:

Molecules that

Speaker:

are highly

Speaker:

susceptible to

Speaker:

the gastric

Speaker:

environment as an

Speaker:

example.

Speaker:

So it's quite

Speaker:

cool, I'm working

Speaker:

with a scientist,

Speaker:

his name's also

Speaker:

Justin, Justin

Speaker:

Kirkland,

Speaker:

incredible mind.

Speaker:

He's got some

Speaker:

real cool

Speaker:

innovative

Speaker:

technologies that

Speaker:

he's busy with at

Speaker:

the moment.

Speaker:

And I'm hopeful

Speaker:

that in due

Speaker:

course, majority

Speaker:

of the nutrients

Speaker:

that we prescribe

Speaker:

within our

Speaker:

practice can

Speaker:

actually be given

Speaker:

by way of patch

Speaker:

delivery rather

Speaker:

than

Speaker:

ingesting it.

Speaker:

Obviously, albeit

Speaker:

things like

Speaker:

lipids, I think

Speaker:

it would be more

Speaker:

difficult to do.

Speaker:

And the larger

Speaker:

particles might

Speaker:

be a little bit

Speaker:

more challenging.

Speaker:

Binders, we're

Speaker:

certainly gonna

Speaker:

wanna ingest for

Speaker:

the purpose of

Speaker:

the need to

Speaker:

buy toxins.

Speaker:

But yeah, I think

Speaker:

it's an

Speaker:

interesting tech

Speaker:

because it does

Speaker:

pave the way and

Speaker:

the potential for

Speaker:

not to have to

Speaker:

consume so many

Speaker:

pills, so many

Speaker:

capsules and

Speaker:

supplements,

Speaker:

whilst still

Speaker:

getting the

Speaker:

benefit in the

Speaker:

increase of

Speaker:

biological

Speaker:

availability.

Speaker:

Yeah, no, that's

Speaker:

an interesting

Speaker:

one and one I'll

Speaker:

definitely be

Speaker:

exploring.

Speaker:

Okay, let's end

Speaker:

off with one

Speaker:

about the gut.

Speaker:

What's the

Speaker:

biggest myth

Speaker:

about gut health

Speaker:

that you

Speaker:

regularly

Speaker:

encounter?

Speaker:

It must be, it

Speaker:

must certainly

Speaker:

must have to do

Speaker:

with fermented

Speaker:

fruits,

Speaker:

fermented fruits.

Speaker:

People have this

Speaker:

being told, I

Speaker:

mean, it's only

Speaker:

natural.

Speaker:

Every time you,

Speaker:

well, when you

Speaker:

used to look at

Speaker:

least in social

Speaker:

media, it was all

Speaker:

about kimchi and

Speaker:

sauerkrauts and

Speaker:

kefir and

Speaker:

everything else.

Speaker:

Now I'm not

Speaker:

saying these are

Speaker:

bad, they come

Speaker:

textual again.

Speaker:

But particularly

Speaker:

in a TH2 dominant

Speaker:

state, you do not

Speaker:

wanna be

Speaker:

consuming a lot

Speaker:

of these foods

Speaker:

because by nature

Speaker:

of them being

Speaker:

fermented,

Speaker:

they're gonna

Speaker:

have a high

Speaker:

histamine blow.

Speaker:

Okay, so it's

Speaker:

really like, it's

Speaker:

such a myth like,

Speaker:

eat more

Speaker:

sauerkraut and

Speaker:

you're gonna have

Speaker:

healthy

Speaker:

microbiome or

Speaker:

drink more kefir

Speaker:

and you're gonna

Speaker:

have healthy

Speaker:

microbiome.

Speaker:

Or if you have

Speaker:

stomach issues,

Speaker:

please drink

Speaker:

more kefir.

Speaker:

No, like if you

Speaker:

have stomach

Speaker:

issues that it's

Speaker:

been instigated

Speaker:

by muscle

Speaker:

activation

Speaker:

syndrome, please

Speaker:

do not drink more

Speaker:

fucking kefir.

Speaker:

Flipping,

Speaker:

flipping,

Speaker:

kefir, kanao.

Speaker:

Like this, yeah,

Speaker:

just a context, a

Speaker:

context, content

Speaker:

and context.

Speaker:

Yeah, Justin,

Speaker:

those are perfect

Speaker:

answers.

Speaker:

Thank you again.

Speaker:

Answered only as

Speaker:

an

Speaker:

academic could.

Speaker:

I've said this

Speaker:

once before, that

Speaker:

was to Tyler

Speaker:

Pansner, but I

Speaker:

think I might be

Speaker:

in love with

Speaker:

your brain.

Speaker:

I really can't

Speaker:

thank you enough

Speaker:

for your time.

Speaker:

You've already

Speaker:

alluded to

Speaker:

autonomic

Speaker:

coaching, but

Speaker:

where can people

Speaker:

find you if

Speaker:

they'd like to

Speaker:

connect?

Speaker:

Instagram

Speaker:

autonomic_coaching

Speaker:

through our

Speaker:

website,

Speaker:

www.autonomiccoaching.com.

Speaker:

Else you can drop

Speaker:

us an email, info

Speaker:

at

Speaker:

autonomiccoaching.com.

Speaker:

Do keep an eye

Speaker:

out for my book

Speaker:

that is gonna be

Speaker:

provisionally

Speaker:

going to be

Speaker:

launched at the

Speaker:

end of September.

Speaker:

And within that,

Speaker:

there'll be even

Speaker:

more details as

Speaker:

to how you can

Speaker:

connect with us.

Speaker:

That's perfect,

Speaker:

and we'll be

Speaker:

short-linked to

Speaker:

all of that in

Speaker:

the show notes.

Speaker:

Justin, thank you

Speaker:

so much for

Speaker:

your time.

Speaker:

Thank you, Rob.

Speaker:

Take care.

All Episodes Previous Episode

Listen for free

Show artwork for vP life

About the Podcast

vP life
Discussions on the latest in longevity science, health and functional medicine
vP Life, brought to you by vitalityPRO, provides you with expert advice from leading voices in the functional and integrative medicine world.

Irrespective of the guest and topic, our discussions will aim to educate and provide you with the tools and information you need to create change in your life.

About your host

Profile picture for Robert Underwood

Robert Underwood