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Episode 10

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Published on:

4th Jan 2025

#010 Dr Greg Potter - Sleep: Science and Supplements

vitalityPRO

#010 Dr Greg Potter - Sleep: Science and Supplements

Dr Greg Potter is a health and performance coach specialising in sleep. He has a PhD in Sleep, Nutrition, and Metabolic Health from the University of Leeds and an MSc in Exercise Science from Loughborough University. 

Over the past decade, Greg has worked with individuals facing sleep disorders, obesity, autoimmune diseases and mental health challenges. He has also coached elite athletes across various sports, helping them achieve World Records and win gold medals.

Greg's approach combines evidence-based strategies to improve sleep, fitness, and mental well-being through sustainable lifestyle changes. By addressing root causes and integrating insights from sleep science, circadian rhythms, nutrition, and exercise, he empowers clients to enhance their health and performance.

Outside of work, Greg values exploring nature, cultural experiences, and effective altruism, striving to make a meaningful impact both personally and professionally. He believes in using science to help others thrive in an increasingly challenging world. 


> During our discussion, you’ll discover:


(00:01:13) Who is Greg Potter

(00:03:26) What is sleep?

(00:16:25) Does it matter what time you go to sleep?

(00:25:06) Does lack of melatonin cause Shift Work Disorder?

(00:29:18) How lack of sleep leads to poorer food choices

(00:35:48) How does meal timing affect sleep?

(00:43:18) Using food and meal timing to recover from jet lag

(00:52:34) Melatonin and other sleep aids

(01:03:48) Promote sleep without precursor molecules

(01:13:30) Should you cycle amino acids such as glycine or L-theanine?


The vP life Podcast is brought to you by vitalityPRO, a supplement company based in the UK that provides you with the latest in health, anti-ageing and longevity supplementation. What makes vitalityPRO unique is that it third-party tests every product batch for quality, purity, heavy metals and other contaminants. vitalityPRO’s mission is simple: provide you with confidence in the quality and effectiveness of your longevity supplements that focus on restoring your cellular health.

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Transcript
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Hello everybody and welcome to the VP Life podcast brought to you by Vitality Pro.

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My name's Rob and I'll be your host on today's episode.

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Today we're joined by Dr.

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Greg Potter.

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Greg has a PhD in metabolic health from the University of Leeds and works

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with athletes and other high achievers to help them dial in their health so

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that they can operate at their best.

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While this may seem somewhat the norm in the online coaching

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space, Greg is different.

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See, as part of my job I get to speak to a lot of intellectuals and as you'll

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hear shortly, Greg has an incredible ability, way outside the norm in fact,

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to dissect scientific literature and provide his clients with information

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that actually moves the needle.

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Today I had the opportunity to discuss Greg's passion topic with him.

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Sleep.

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So expect to learn exactly what sleep is, how your nutrition can affect

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your sleep, whether sleep chronos helps are real, and so much more.

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And with that, on with the show.

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Good morning, Greg.

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Thank you very much for joining us on our podcast today.

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I know we're going to be delving into a lot, especially around sleep, but first

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and foremost, would you just like to introduce yourself, who you are, what it

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is you do, and all of that good stuff.

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Sure.

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Yeah, relevant to this conversation, I studied sleep, nutrition,

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and metabolism for my PhD.

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And throughout my studies, both my undergrad, masters, and PhD, I've

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coached people in various capacities.

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Initially, a lot of that work was with athletes, but more recently,

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I've done a lot more work in health coaching in general.

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And some of that is specifically with people who have ongoing sleep

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issues, which are often comorbid with mental health problems.

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But I've been involved in various other businesses along the line too,

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including everything from trying to scale health coaching through

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things like apps to working with a business that runs retreats.

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And I've been involved in several different nutrition businesses.

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And one of the projects I'm working on at the moment is formulating nutrition

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products for a startup, which is bringing to market a product next

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year intended to help increase health span and potentially lifespan too.

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So that's a little bit about me, but the way that I try and help people

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is through lifestyle in a way that's sustainable and a way that accounts

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for all the different moving parts and meet people where they're at.

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So I'll pause there.

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Fair enough.

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Yeah.

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A very sort of functional approach to it.

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You were or are involved in the Human os, is that correct?

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I was, yeah.

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I worked there 2016 to 2019, and I helped Dan with a lot of content creation.

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So while there I made a couple of courses, wrote some blogs, hosted the

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podcast a few times, created some guides.

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And just generally gave lots of feedback on the platform and whatnot.

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And to this day, he's a very good friend of mine, so no longer working

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with him, but on very good terms.

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Uh, it's awesome.

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I, I played around with it a little bit in the past and, uh, I just, I have no

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clue how I know that you were involved.

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Uh, I'm sure I heard it somewhere, but yeah, no, it, it just, uh, Sort of

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jogged my memory as you were saying that.

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Okay, so um, I suppose let's get into the nuts and the bolts of it.

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Bit of a dumb question maybe, but what is sleep?

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Because I actually don't know what sleep is apart from not being awake.

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People have tried to define it.

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And the most commonly cited definition in textbooks and academic papers is a

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definition that's put forward by, I think it was Bill Dement and Mary Karskadan.

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And it's, it's a very descriptive definition.

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And I don't recall it word for word, but it's something along the lines of

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a state of relative inactivity often accompanied by postural recumbence

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in humans, and it's a state in which you are relatively detached from the

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environment, but it's rapidly reversible.

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So that obviously is what sleep is, but I think the thing that

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most people are interested in.

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is what functions does it serve?

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Because superficially sleep is a very strange behavior and you might

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have thought that there'd be strong evolutionary pressure against the

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selection of something like sleep because during sleep you're vulnerable.

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You aren't keeping an eye out for predators.

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You're not eating and therefore supporting your energetic needs

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and Most of the time there are incredibly rare exceptions to this.

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You're not trying to procreate either and so Given all of that the odds would

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surely be stacked against the evolution of sleep, but I think Fundamentally,

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the reason that we do sleep is To pay the price for wakefulness Because

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while we're awake, we're interacting with the environment that exposes

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us to lots of different pathogens.

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We accumulate damage while we're moving around and interacting with

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different organisms and the environment.

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And we also need to integrate the experiences that we've

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had so that we can learn.

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And so sleep is a bit like that.

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the pit stop in a Formula One race and that you need to occasionally change the

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tires and put some fuel in the tank and puts the body in a state that is conducive

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to that type of restoration and learning.

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Fair enough.

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I suppose a good place to go with this is what actually happens

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during sleep, just at a high level.

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I think people often hear about terms such as REM sleep and deep sleep.

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But what actually are they and if we sort of go through the stages of sleep

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and physiologically again, just at a high level, how does sleep play out?

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Yeah, it plays out at a specific time within the biological day.

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So we have the system of clocks throughout our bodies, which

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optimize our bodies for different functions at different times of day.

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And during the biological nighttime, we are disposed to sleeping.

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And during sleep itself, as you alluded to, we cycle through

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different stages of sleep.

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And these cycles are often described as lasting 90 minutes.

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They're actually called sleep cycles.

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Nothing like as orderly as that.

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They change in duration over the course of the night, but they also vary quite

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a lot from one person to the next, and they can be anywhere from about 70

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minutes long to about 120 minutes long.

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And if you look at the stages of sleep, we can broadly classify these into rapid eye

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movement or REM sleep and non REM sleep.

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And if you look at a night of sleep, then you have most of your non REM sleep

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in the first part of the sleep period, and you have most of your REM sleep in

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the second part of the sleep period.

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That's to do with how sleep is regulated, but Looking more closely

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at non REM sleep, when you first fall asleep during the night, you're, you're

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likely to enter what's called stage one non REM sleep, which is like a

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bridge between wakefulness and sleep.

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It's the lighter stage of sleep.

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It occupies a small proportion of total sleep.

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From there, you drop down into a slightly deeper stage of sleep.

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And by deeper, I mean that it's hard to wake someone.

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And this is called stage two REM sleep.

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Non REM sleep, which makes up the majority of sleep.

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It comprises roughly 50 percent of most people's sleep, and

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it has certain features that make it particularly helpful.

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So during this stage of sleep, for example, you have what are called sleep

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spindles, which are these bursts of electrical activity of a certain frequency

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that are important to maintaining sleep during periods of instability in sleep,

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so periods when you could wake up.

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But they're also important to basically transferring information from a short

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term limited capacity storage depot in a structure in the brain called the

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hippocampus to a much larger capacity storage depot elsewhere in the cortex.

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And in doing so, it frees space in the brain.

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to learn new things the next day.

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Is that the consolidation of memory then?

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Yes, and the reality is it's likely that all stages of sleep are involved in memory

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formation, but that is consolidation.

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And we then go from there into the deeper stage of sleep.

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Which is stage three sleep, sometimes called slow wave sleep because of its

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characteristic high amplitude, slow waves, which basically start around the bridge

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of the nose and then sweep backwards.

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through the brain.

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And these are also important to the formation of memories, but slow wave

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sleep is particularly key for various different housekeeping functions, both in

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the brain and in the rest of the body too.

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So in the brain specifically, your brain has its own waste disposal

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system called the glymphatic system.

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You've probably heard of the lymphatic system, which is your

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immune system in basic terms.

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And your brain has its own immune system and there's a particular

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type of cell that's important to this called glial cells.

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So it's the glial lymphatic or glymphatic system.

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And during the deeper stage of sleep, it's a bit like the

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plumbing in your brain opens up.

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And because of that, various different byproducts of metabolism that have

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accumulated during prior wakefulness can be cleansed from the brain by

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pushing around a certain type of fluid.

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through the brain.

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So in that way, it's important to brain health, but it also has

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similar restorative functions in the rest of the body too.

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So during slow wave sleep.

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You produce much of your growth hormone and this type of pulsatile

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growth hormone production seems to be important to remodeling certain

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tissues like connective tissues.

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It's also relevant to metabolism.

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So during these different stages of sleep, we actually change the

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way that we burn certain fuels.

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And during these deeper stages of sleep, we tend to rely more

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on fat oxidation and carbohydrate metabolism relative to REM sleep.

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And then The deeper stage of sleep is also important to your immune function

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outside of the brain, and actually to the formation of memory in the immune system.

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So you can broadly split your immune system into an innate

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system, which is what you're born with, but also an adaptive system.

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Your immune system has a memory of things that you've been exposed

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to, that you want to rapidly mount immune response to in the future.

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This is obviously the basis of things like vaccinations and slow waves lead

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to, slow wave sleep is very important to some of that memory formation.

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And then typically you'll go from that deeper stage of sleep into rapid eye

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movement sleep, which makes up maybe 20 percent of sleep or so in lots of adults.

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And it's an unusual state.

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It's sometimes called paradoxical sleep, because while if you look at activity in

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the brain going by blood flow, parts of the brain are as much as 20 percent more

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active than they are during wakefulness.

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Most of your muscles, your non essential muscles, so I'm not talking about muscles

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that are involved in breathing, I'm not talking about your myocardium, your

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heart muscle, but many of your other muscles, your biceps, your quadriceps,

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your lumbar, spinae, whatever you want to pick, more or less paralyzed.

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It's not true of everyone.

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There are rare instances where that's not the case.

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But in that way, you're in this strange state where you've got this

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very active brain, and your muscles are paralyzed, which presumably is so

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that you don't act out your dreams.

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And there's a particular sleep disorder where that regulation of

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your skeletal muscles breaks down and people start acting out their dreams

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called REM sleep behavior disorder.

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And during REM sleep, there are also various other changes.

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that make it distinct from other stages.

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So whereas in non REM sleep, if you look at stage one to two to three,

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the deeper in the, it becomes harder to wake someone, but also things like

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the rate at which you're breathing, your respiratory rate slow down.

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In REM sleep, if you look at things like your heart rate, then your

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heart rate can actually fluctuate quite a lot during this time.

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And basically the main functions of REM sleep.

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While disputed, seem to relate to a few things.

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So one of them is that it's very important to emotion regulation.

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It's a kind of emotional first aid that's often described that way.

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Another is that it seems to be very important to creativity.

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So the way that this has sometimes been described by people like Robert Stickgold

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is that REM sleep is helpful to giving you a sense of the gist of things.

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It's the kind of sleep that you'd want before a multiple choice

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questionnaire test where you're not sure what the right answer is.

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But you've got an inclination that it might be this.

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And what seems to be happening during this stage of sleep is that you are

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going back through many different autobiographical memories that have

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taken place, sometimes many years ago.

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And then you're integrating them with recent information and your

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day to day experiences and you're looking for patterns between things.

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And in this way, it seems to be very helpful.

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for creativity and come out with novel solutions to problems that

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previously seemed intractable.

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So that's something about the different stages of sleep.

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But I think it's important to note that it's not entirely clear

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that all of the brain is in a sleep stage at the same time.

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Sleep doesn't seem to be as unitary as that.

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And while this hasn't been well demonstrated yet, there's some

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evidence showing that different parts of the brain can be in different

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sleep states at the same time.

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Which throws a spanner in the works when it comes to making sense of a

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lot of historic sleep literature.

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But this might explain various different unusual phenomena

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that take place during sleep.

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For example, if you think of sleepwalking, it could be that parts of the brain

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that are involved in consciousness and awareness are fast asleep.

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Because sleepwalking is often during quite a deep stage of sleep.

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Whereas the motor cortex, which gives rise to Sleepwalking.

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voluntary movements, is showing wake like behavior.

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Or if you think about lucid dreaming, it could be that part of the brain

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that's involved in consciousness is in a wake like state, whereas many other

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parts of the brain, like the motor cortex, are in a sleep like state.

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So, sleep isn't a monolithic phenomenon, and I think part of the appeal of it

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is that it is so interesting, we learn so much more about it, each year.

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I'll pause there because I realize that was already quite a long

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answer, but hopefully that gives you some background to the different

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sleep stages and, and some of the things that they're important for.

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No, that's perfect.

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And that sort of really underlines, I suppose, why it's sort of

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almost the foundation of health.

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I want to sort of in a minute go into sort of your thoughts on some

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of these sleep trackers, specifically your auras, your whoops, and what

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you think of their deep sleep scores.

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But um, first I, what I'd like to sort of quickly touch on are your

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thoughts on when we go to sleep.

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There's often a lot being said about needing eight hours of

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sleep almost indefinitely.

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I mean, obviously depending on genetics, some people can get

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away with less, some people more.

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But when you get those, just broadly speaking, eight hours

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in, is that important or does it for the most part not matter?

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So if you were to go to bed at 12 a.

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m., what's that p.

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m.?

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I never get that one right, and then wake up at 8 a.

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m., 8 hours later in the morning, 8 a.

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m.

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Is that, is that important?

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Restorative and as physically rewarding as, say, going to bed at eight or nine

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and then getting up at five or six.

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Does that, yeah, does that play a significant role in the quality

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of sleep when you go to sleep?

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Taking a step back, the way that I think that we should think about sleep

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health has been heavily informed by a psychiatrist named Daniel Bicey.

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And a few years ago, a decade ago now, he wrote what has become a

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highly cited paper And it was about how to define what healthy sleep is.

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And in it, he discussed different dimensions of sleep health.

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A lot of people are focused on sleep duration.

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The sleep duration is important, but sleep timing is important too, as is the

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quality, as is the regularity of sleep.

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And really you could apply regularity to any of those other dimensions.

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So, yes, timing is important, and it's most important within the individual,

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and what I mean by that is that, as I mentioned at the very start, we have

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this network of different clocks in our bodies that prime us for sleep at

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certain times during the 24 hour day.

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And If we try and sleep during the biological nighttime, when our bodies

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are primed for sleep, we're likely to have higher quality sleep than if we try

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to sleep during the biological daytime.

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And this is the perennial problem that shift workers experience.

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On average, they get a bit less sleep than the rest of us, but not

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necessarily that much less sleep.

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And some of them probably don't get much less sleep at all, and one of their issues

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is just that because they're trying to

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sleep during the biological daytime, they really struggle with their sleep quality.

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And there's a sleep disorder named shiftwork disorder that affects

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about a quarter of shift workers, which sure enough is characterized by

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lots of fatigue and sleepiness when awake, because they're often awake

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during the biological nighttime.

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And then exhaustingly, when they try and sleep, They have insomnia symptoms

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and they really struggle to stay asleep.

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So when you sleep absolutely does matter.

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But I think the important thing is when you as an individual are trying to sleep

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relative to your biological nighttime.

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But obviously this interacts with different societal pressures

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that are imposed on you.

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For example, if you are a night owl, then you might have to

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wake up to an alarm clock each morning and left your own devices.

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You might choose to go to bed at 2am, but you have to be up at 7am to get the train

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into the city to be on time for work at 8.

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30.

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And so you have a restricted sleep opportunity because of that.

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And ideally, you would work quite different working hours.

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But the way that your sleep is constrained by those pressures means

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that the onus is on you to try and shift your sleep earlier to give

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yourself a larger sleep opportunity.

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But that might be running counter to your natural disposition because I

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know there's some contention about the veracity of what are called chronotypes.

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So whether you're more of a Yeah, whether you're more of an early

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bird or a night owl, some people will say, Oh, they don't exist.

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They absolutely do exist.

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And the reality is that if you look within a population, they're probably

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distributed relatively evenly.

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There's probably a bell shaped curve.

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If you put people under a standardized light dark cycle and you compared

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people of the same age and biological sex, you would find that naturally

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some people are earlier birds and they would have faster clocks.

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If you left the clocks ticking without any time queues, like light exposure,

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food timing, physical activity, and so on, then some people would be much more hour

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ish and they would have slower clocks.

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Their clocks would tick at a pace substantially longer than 24 hours.

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Yeah.

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Now I was just gonna play Devil's Advocate and just sort of, because I'm

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definitely fallen to the camp of being maybe, yeah, a little on the edge about

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the sort of chronotypes and sort of looking at it more from an ancestral lens.

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Do you not think that when I sort of accounting for a normal wake

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dog cycle, that those individuals who are quote unquote night birds

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or night owls would maybe not sort of shift their circadian rhythm?

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to a more traditional sleeping pattern if they weren't exposed to so many of

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these sort of zygabas as I think they're called that sort of, yeah, interfere with,

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I suppose again, what is traditionally thought to be a normal circadian rhythm.

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Yeah, they, they absolutely would shift.

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And, and the best example that we have of this in my opinion is a couple of studies

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that were done on people going camping for a few days in the rocky mountains and they

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did one experiment during the winter when the nights are long and one experiment

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during the summer when the nights are shorter and they found that before the

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camping there was large dispersion between the earliest birds and the latest owls.

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And after just a few days of camping, the range of sleep timing narrowed

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dramatically, and they were, in general, sleeping in closer synchrony with the

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natural light dark cycle, such that the early birds didn't really shift, but the

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night owls became substantially earlier.

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So, yes, if you gave people strong time cues where they were exposed to

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lots of daylight during the day and minimal light at night, then there

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would be a much smaller gap between the earliest and the latest people.

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That's absolutely the case.

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And the reality is that in our modern context where you've got lots of

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artificial light at night, and many of us spend 90 percent plus of our

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time indoors, We have these weak time cues and that increases the range of

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chronotypes or increases the range of sleep timing being more correct that we

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see in the general population, but to me, chronotype is a biological construct.

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And it's, it's driven by genetics.

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We know something about the genetics that makes some people be much later types than

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others or much earlier types than others.

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And that there are a few mutations in certain clock genes that have

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been identified that make entirely entire families of people much

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earlier than the rest of us.

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And we know less about the genetics.

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that makes some people very owlish, but we know something about those genes.

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So, it's a long way of saying that, yes, if we all lived more ancestral lifestyles,

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the disparity between the earliest and the latest people would be a lot smaller.

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However, it would still be there because of these genetic differences.

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There outliers, it's just that most people would cluster Around the average.

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I just want to take a quick step back towards what you, a quick step

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back towards, a quick step back and talk about shift work again.

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Again, physiologically, do you think that the reason most people who do

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sort of partake in shift work struggle is, is because they aren't producing

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as much melatonin when they should be?

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And is that then sort of resulting in them not being able to sleep

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during the waking part of the day?

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I wouldn't, yes it does.

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I wouldn't focus specifically on melatonin.

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Melatonin is used a lot in biological rhythms research because

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in the right conditions it gives you a very clean readout of when

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it's the biological night time.

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And for that reason it's widely used to assess the timing of the master

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clock in the circadian system, the suprachiasmatic nucleus, because it's

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got relatively direct connection to the pineal gland, which synthesizes

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melatonin during the biological nighttime.

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And so it's used to try to identify where someone is within the course of

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their biological day, biological night.

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So it's helpful.

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However, obviously it can be readily masked by light exposure because you

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can take someone during their biological night time, expose them to a brief bright

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light pulse and their melatonin synthesis would be turned off pretty much entirely.

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And actually a lot of us probably experience that every night because

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we're not particularly particular about our light dark cycles.

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And so we expose ourselves to lots of electric lighting before we go to bed.

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And then we flip the lights off.

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And actually our biological nighttime did start a couple of hours ago, but all

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that light exposure has just squashed any melatonin that would otherwise

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have been synthesized during that time.

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So returning to question, I think.

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Part of the reason why they're struggling so much with their sleep and their

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health is because they are trying to sleep during the biological daytime.

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And obviously melatonin synthesis is relevant to that.

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And it could be that if you looked at the area under the melatonin curve each

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day, so the total amount of melatonin that's circulating in the blood or saliva

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or six alpha toxin melatonins in the urine, then the total amount is lower

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than somebody who is working during the daytime and sleeps in alignment with that.

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with their biological rhythms, and could that contribute to some health issues?

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Yes, potentially.

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But I think in the case of shift work, we can broadly distinguish between

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circadian and sleep disruption that comes with the shift work, and then other

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stresses that they might face that might distinguish them from the rest of us.

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Because if you think about shift workers, then they're trying to maintain

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relationships with non shift workers.

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That's tricky.

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and their lives are out of sync with the rest of environment.

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And so that plus the fact that there are probably differences between

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things like the amount of money that they earn and so on and therefore

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access to healthy foods and healthcare between them and non shift workers.

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Those factors do contribute to some of the health disparities that we see.

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But then certainly, the disruption to sleep, trying to sleep during

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the biological daytime, and also things like mistimed eating, and

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mistimed light exposure, and mistimed physical activity, all of those

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things probably do contribute.

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And they also make it harder to make healthy lifestyle decisions, because

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if you're forever short on sleep, then if you look at the research on how that

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influences things like decision making, you're going to find it harder to make

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good health choices because you're probably going to be a bit more impulsive.

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You're likely going to be slightly more disposed to engaging in risky

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behaviors than the rest of us.

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And so you might find it harder to say no to the donuts that

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someone brings into work.

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And because of that, it has knock on effects.

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And those are then amplified by the fact that now, in this instance, your

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digestion and your metabolism have been scuppered by your recent sleep

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loss and circadian misalignment.

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That's a brilliant sort of point, actually.

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And I'd like to discuss it in a bit more detail, but sort of sleep

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and metabolism, sleep and appetite.

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What exactly are the mechanisms there that are driving dysregulated appetite

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when somebody is not getting enough sleep?

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Because, yeah, it's often said that, uh, a poor night's sleep will result

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in you making poorer food choices.

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But what, what's going on there specifically?

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I think there are a few things going on.

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One of them is very obvious and it's simply that the less sleep you get and

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the shorter your sleep opportunity, the more hours you are awake and therefore

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the more hours you have access to food.

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And so you might distribute your food intake over more hours each

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day, and that in turn increases your total energy intake.

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Even controlling for that though, people probably do tend to eat slightly more.

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If you look across studies of either sleep deprivation, where they're not

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allowed any sleep whatsoever, or sleep restriction, where they might have

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several nights of insufficient sleep, so perhaps they only have a five

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hour sleep opportunity for instance.

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than on average people.

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consume roughly 250 more calories each day when they're short on sleep.

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Some people actually consume less calories, but on average,

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most people do consume more.

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And beside the fact that they're spreading their food intake over a longer period,

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there are probably a few things at play.

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So naturally a lot of people have looked at the endocrinology of this.

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So is this driven by changes in hormones that are involved in

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appetite regulation and satiety?

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And frankly, the research on that is a little bit all over the place.

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If you look at meta analyses, then looking at ghrelin, for example,

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doesn't seem to be a clear effect on ghrelin when you might've expected

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there to be an increase in ghrelin because it tends to promote food intake.

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And likewise, the data on leptin, which is this hormone that's largely produced

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by fat tissue, which is representative of your long term energy status,

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although it does respond somewhat to short term fluctuations in energy

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intake and energy availability, and it in turn tends to reduce food intake.

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The data on leptin again aren't that consistent.

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It could be that the ratio between the matters, it could be that there

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are some other hormones that are affected by insufficient sleep.

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So people have looked at things like certain endocannabinoids,

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so these endogenous cannabinoids that tend to promote food intake.

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This is why you get the munchies after you smoke cannabis.

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Some of the cannabinoids tend to promote food intake.

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But overall, it's quite hard to parse the literature.

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There might also be some small differences between the biological sexes.

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And I won't, I won't go into the details of that, because I think it's probably a

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level of detail that's not necessary here.

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But putting aside changes in, in hormones, if there are any, and I think

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there probably are some, but I don't think they're a massive contributor.

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then there probably are differences in what's called

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hedonic or non homeostatic eating.

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where you're not eating because you're really hungry, you're eating because foods

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are harder to say no to at that time.

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And there have been lots of imaging studies where people have looked

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at patterns of electrical activity in the brain, patterns of blood

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flow in the brain, in response to things like food images.

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And in general, the brain that has been sleep deprived seems to respond

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differently to food related cues in ways that make it a bit more impulsive around

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food and therefore more likely to go for a short term reward like delicious food.

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than a longer term reward like saying no to the food for now because

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your health is important to you and you're trying to lose some body fat.

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So is it not just a dopamine issue do you think?

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Is it not maybe a result of less sleep resulting potentially and I'm

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just stringing mechanisms together here, but more oxidative stress, more

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inflammation and potentially less dopamine that is then driving that um,

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desire to find a, find a dopamine hit.

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Yeah, I wouldn't focus on, on dopamine because obviously the, the

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neurochemistry of it is very complicated and that's also just one piece of

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the puzzle, but, but certainly.

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The brain seems to be very motivated by food when it is short on sleep.

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And that's no surprise because extended wakefulness continues

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to tax the brain's energy stores.

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And so your brain wants energy to refuel itself.

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It's just that it tends to try to gain more energy than is needed

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to actually replace any additional losses that have taken place as a

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result of the insufficient sleep.

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And if you look at some of the literature on how the brain responds

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to insufficient sleep, then there are changes in things like the limbic system.

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There are changes in some of those reward pathways too.

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There are lots of different changes that take place, but one of the commonalities

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seems to be that the frontal cortex, which is the most evolutionarily

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recent part of the brain, which is very important to things like reasoning,

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long term planning, self control seems to communicate less effectively than

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some of the more primitive deeper parts of the brain that are more

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responsive to things like different types of stresses that make the brain

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fearful or worried or hungry or horny.

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And so it seems that The ability of the frontal cortex to exert control over the

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limbic system and some of these other parts of the brain that are involved

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in, in things like responding to food is compromised by the insufficient sleep.

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And I think that might turn out to be more important than any hormonal

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changes that are taking place.

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What are your thoughts, I suppose, sort of tacking on from that on food timing

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with regards to sleep, especially sort of, Yeah, again, healthy levels of sleep.

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Um, there's a lot being said about sort of restricting your calories.

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Uh, or your consumption of food too early in the day and then

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providing a buffer between your last meal and when you go to sleep.

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Personally, I find that if I go to bed hungry, I just, um,

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there's just an increase in catecholamines and I cannot sleep.

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Whereas other people, the opposite seems to be true.

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There's an increase in metabolism and then they, yeah, can't sleep

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for almost the opposite reason.

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Do you think that food timing, to repeat what I've just said, relative to when

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you go to sleep is important or is it sort of somewhat blown up in proportion?

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I think, I think it is important.

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I think how important it is depends on the person.

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And I also think that when people should stop consuming anything

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that contains calories varies a lot between different people.

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And to give you a few examples of this, if you take somebody who's got lots of

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energy stored on their body, they could probably go days without eating, without

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the recent low energy availability.

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dramatically, negatively affecting their sleep.

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However, if you are already lean and you go to bed hungry, then it makes sense

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that that would impair your sleep more.

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So I think some of this depends on things like baseline levels of body

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fat and physical activity in your recent physical activity history.

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So taking another instance, think of an athlete who's training twice a day

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in an energetically demanding sport.

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with good body composition.

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For them, if they try and use early time restricted eating and they finish

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their food intake at 3pm, that might not be a good thing for their sleep.

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Similarly, if you think about a child that's growing that needs lots of

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energy to invest in building new bones and muscle tissue and the nervous

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system and so on, then early time restricted eating is not the way to go.

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So I think the eating window depends on a variety of factors, but there are

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probably a few simple heuristics that apply to most people, and probably

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to everyone listening to this.

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So, first, you don't want to go to bed either feeling

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stuffed or feeling famished.

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There might be instances when you're on a fat loss diet, and you have been

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on that diet for weeks or months, and you're generally hungry where

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occasionally you do go to bed feeling hungry but it might be worth that for you.

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And also it's important to note that your hunger patterns are

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entrained by your food intake.

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So one of the interesting things that we see in the research on early

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time restricted eating, which often involves having people restrict their

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food intake between 8am and 3pm, is that They don't actually have

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a massive surge in hunger in the evening, which you might have expected.

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Because if you look at circadian rhythms and appetite, circadian rhythms

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and appetite tend to promote food intake most relatively late in the

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evening, at about 8pm for a lot of us.

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But with early time restricted eating, Initially, you might find the evening

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really hard because you're used to eating at that time, and therefore

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you have lots of hunger at that time.

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But after a few days, you might find that your body is no longer

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expecting food at that time, and therefore your hunger levels over

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the course of a 24 hour day increase.

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So just know that when you eat does influence your patterns of hunger,

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and in some instances it's worth going through a few difficult days because

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things will actually get easier.

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But going back to what I was saying, going to bed, neither stuffed nor

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hungry, and I think for most people not consuming any calories in two hours

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before lights off is a good rule of thumb.

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I don't think that's overly restrictive.

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There might be rare exceptions, like athletes with late training sessions, for

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instance, who need to, say, top up their muscle glycogen stores and support protein

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synthesis after the training session, which would mean that that particular

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recommendation is out the window.

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And the same could go for, for children and adolescents during

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certain stages of their development.

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But I think for most adults, that's reasonable.

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And part of the reason for this is just that if you look at circadian

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regulation and metabolic control.

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It's such that in general, the body does tend to respond worse to food

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intake late in the biological date.

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So looking at glucose tolerance, for instance, so how much your blood sugar

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swings in response to a standardized bolus of glucose, it's substantially worse at

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8pm than at 8am on average across people.

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And there are various factors that we go into as to why that's the case.

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But that's why, especially for people who are relatively sedentary, I

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think front loading a lot of their carbohydrate and fat intake within

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the waking day is a good way to go.

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If, however, you've got very good metabolic health, or if you do very

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strenuous exercise late in the day, so let's say that you finish work at 5.

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30pm and you go straight to the gym, and in the gym you do a full body resistance

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training workout for 45 minutes, and then you do 15 minutes of installs.

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You've just depleted lots of muscle glycogen and you might want to replenish

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those stores after your workout.

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If you've got good metabolic health, then that's a, that's a great

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time to have lots of carbohydrate.

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So there are exceptions, but I think those general recommendations

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work well for a lot of people.

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And then, of course, based on what I just said, you can start to think

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about this in terms of different days.

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So in the sports nutrition world, In the last decade or so, there's been

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quite a lot of talk of periodized nutrition, not just periodized training.

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And so there might be days within a micro cycle, which lasts a week, where

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you eat very differently to other days.

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So you have those strenuous workouts where performance is a priority and recovery

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from those workouts is a priority.

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You might consume a lot more food in total on those days.

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And a lot of that might be.

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a bit later in the day too.

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Whereas other days that are rest days or active recovery days, you might

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be consuming much less late in the day and a little bit less in total.

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So another long winded answer, but as usual, it depends, but neither

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hungry nor full and two hour cutoff, I think is reasonable for most people.

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Fair enough.

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Yeah, that was an amazing answer.

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Thank you.

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I'm going to listen to that again.

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Moving forwards, um, looking at sleep and specifically jet lag, it's sort of

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something that's been of interest to me of late, and then utilizing, and utilizing

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food potentially as a zeitgeist, but something to reset the circadian rhythm.

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Um, when you sort of moved into a new time zone, do you think

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it's an effective tool to sort of help reset this circadian rhythm?

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Or is this where compounds such as melatonin are, are generally

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sort of utilized more effectively?

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So just to step back, a Zeitgeber, that's from a German word that means time giver.

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These are different stimuli.

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that can change the timing of circadian rhythms because you need to reset

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your circadian clocks each day because they don't tick at precisely 24 hours.

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And the most important of these for humans is the light dark cycle,

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and that's particularly important to the timing of the master clock

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and in turn your sleep timing.

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But there are other zeitgebers too.

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So I mentioned physical activity and that seems to be one.

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Probably mostly for skeletal muscle clocks, maybe for bone clocks,

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possibly for cardiovascular system.

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A little bit for the central clock too.

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But it seems likely that nutrition is a time cue as well.

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In particular for organs that are involved in digesting, and metabolizing food.

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The little research that's been done so far shows, for instance,

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that if you take two groups of mice and you feed one of them from 6 a.

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m.

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to 6 p.

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m.

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and another from 6 p.

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m.

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to 6 a.

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m.

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I hope I said that correctly, then within days if you, if you take samples of a

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tissue like the liver, the timing of gene expression is 12 hours out of phase.

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between the two groups.

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It's completely inverted and there's preliminary evidence showing that some

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of these peripheral clocks in humans, so all the clocks that exist outside the

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master clock in the brain, and here I'm talking about fat cells specifically,

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but maybe it's true of the pancreas and the liver and the gut tissue and so on as

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well, do respond to food intake as well.

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And so really what we're looking for to organize our circadian clocks

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appropriately is high amplitude cycles that are characterized by lots of

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daylight during the day, physical activity during the day, food intake

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during the day, and then resting and fasting in darkness at night.

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And of course, in the case of jet lag, You travel across many time zones and

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initially your body's clock is stuck back at home and all these different clocks

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are trying to catch up to the new time zone and they do so at different rates

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and this is why for instance you might find that your digestive issues that

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you experience in the new time zone, maybe you get a bit constipated for

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instance, they resolve quite quickly.

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but your sleep takes longer to catch up with the new time zone.

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And so what we're trying to do is give ourselves appropriate Zeitgeber

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schedules to entrain our clocks to the new time zone as quickly as possible.

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And for the master clock in the brain, the way that we do that

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is appropriate exposure to light.

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And you can use melatonin as well to speed the rate at which the master

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clock adjusts the new time zone.

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But in the case of peripheral clocks, we're trying to shift the timing of

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our nutrition such that we can get those clocks on time with the new time

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zone as quickly as possible as well.

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So in terms of where the rubber meets the road, what I would say

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is that being pragmatic, there's an excellent app called Time Shifter.

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I have no affiliation with it whatsoever, but you can try.

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I think they give one free trip, and you just enter your flight details,

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and it gives you a personalized schedule of when to experience bright

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light, when to avoid light, when to take naps, when to use caffeine.

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The caffeine is less about the circadian system, but it probably does affect

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the circadian system a little bit.

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It's more about homeostatic sleep drive, which is like the hunger

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for sleep that grows in your body the longer that you've been awake.

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So you can use that to address light schedules, naps, and you can also use that

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to give recommendations about when to use melatonin if you want to use melatonin.

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In general, melatonin is more helpful if you're traveling east than if

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you're traveling west, although there are rare exceptions to that.

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In terms of food intake, it's really tricky to be prescriptive

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at the moment because we don't have what are called phase response

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curves established for food intake.

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And a phase response curve is basically a diagrammatic representation of, of how a

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particular clock responds to a Zeitgeber at different times during its cycle.

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So if you're listening to this, you could, you could look up the phase response

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curve for bright light, for example.

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Or the phase response curve for melatonin.

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In the case of the phase response curve for melatonin, you'll see that if you

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take someone who's got a 10:00 PM sleep onset and a 6:00 AM sleep offset, if they

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take melatonin in the few hours before sleep, they'll tend to accelerate their

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clock and pull their sleep earlier.

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Whereas if they take it in the few hours after they wake up in the morning, that

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will tend to to push their clock later.

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We don't have that plotted for food intake because the necessary

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experiments haven't been done.

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So what do we do for the time being?

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What I would say is, while you're in transit, moving between the

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different time zones, frankly, your digestion and metabolism is

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likely to be a little bit of a mess.

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And in part because of that, if you want to be particular about

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this stuff, you don't have to, you can just enjoy plain food.

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If it doesn't bother you that you're going to have a couple of days where things

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go a bit haywire, but If you are really prioritizing your health during this

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transitional stage, you could actively look for high protein items that are

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lower in carbohydrate, probably a little bit lower in fat too, and you consume

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slightly less energy in total because your blood sugar and your blood lipids

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probably as well are going to swing more in response to food intake during

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the state of metabolic dysregulation.

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So during that time, you're trying to hold onto your fat free mass using the

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protein, have things which are relatively easy to digest to avert any gut issues,

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and keep carbohydrates and fats a little bit lower because of that dysregulation.

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And so this could include things like certain high protein snacks.

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It could be protein bars.

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There are a few good ones nowadays.

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It could be things like jerky, cheese.

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For fat and fiber rich sources, you could have things like

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mixed nuts and low sugar fruits.

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And you can pack those items with you and take them with you.

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to skip plane food.

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In terms of timing while you're in that transitional stage, one of the things

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that I've played with, in my mind at least, is the idea that there's, there

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are certain times during which it's when you would be eating both at your

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origin and at your destination too.

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So if I take the example of flying from the UK to the West coast of America,

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it's an eight hour time zone difference.

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And so if you normally spread out your food and take over 10 hours each day, your

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final meal of the day in the UK coincides with your breakfast in the new time zone.

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So I think it makes a little bit of sense to concentrate a lot of your

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food and take around that time, because I think you're less likely

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to experience digestive issues.

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And then when you get to new time zone, wherever you are, whichever direction

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you're going, after your first full day, full night of sleep, so complete

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sleep opportunity, I would fully switch your meals to the new time zone.

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And that's going to help speed the rate at which some of those peripheral

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clocks adjust the new time zone.

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It could be that we'll get more granular than that in the future as

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we establish phase response curves.

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But I think for now, that's a reasonable recommendation.

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So, just to summarize, time shifter for light, nap, caffeine,

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and melatonin schedules.

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If you're going to use melatonin, you don't need a huge dose.

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A lot of the literature has used doses of about three to five milligrams.

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I actually think that you probably don't need a dose that's that high necessarily.

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Just a milligram of melatonin or so is likely to do the trick and

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most helpful if you're flying east.

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And then for nutrition, pack high protein snacks that are familiar.

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Easy to digest, concentrate your food intake at times when you would be eating

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in both time zones, and after your first full night of sleep in a new time

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zone, fully shift your food intake.

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Another amazing answer.

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What are your thoughts, I suppose, on melatonin as a general sleep

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aid and sleep aids in general?

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We discussed melatonin a lot in the last couple of minutes, and a

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lot of people utilize it daily as a crush to help get them to sleep.

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Obviously, that melatonin is a hormone.

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It doesn't seem to have a negative feedback loop as say some of the sex

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hormones do, but by sort of taking it exogenously or from external source,

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you're still going to be interfering with your body's ability to potentially

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produce it, at least in the short term.

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Do you think it's something you should be taking daily or can take daily or?

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Yeah.

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And I suppose other compounds in that, in that same category.

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So your, um, Your amino acids, your tryptophans that are sort of

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augmenting or supporting the production of that same, that same hormone.

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Do you think there's a place for those or should we really sort

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of be trying to improve our sleep more through lifestyle means.

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So I think in general, it makes sense to start with other things that are

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often low hanging fruit that will more potently affect sleep issues

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in the short term and the long term than melatonin Or nutraceuticals.

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However, you can do both.

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And I think that there are certain supplements that can

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be helpful for sleep issues.

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Melatonin is definitely one of them.

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And, interestingly, if you look at how melatonin is prescribed, there's

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one particular form that's given on prescription in the UK called circadian,

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which is a time released formulation which is prescribed for older adults

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with sleep maintenance issues.

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So if they have insomnia symptoms where they struggle to maintain sleep during the

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night, they might be prescribed circadian.

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Sorry, is that a result of the, the odds you get potentially the less

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melatonin you produce as a result of calcification of the pineal gland or

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is that a bit of an old wives tale?

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Yeah, I think that there's a lot more at play than that alone.

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And melatonin, it does have some roles in sleep, but really it's more important

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to the circadian system in general.

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And there's a, there's a large array of different neuromodulators that are

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involved in sleep and the different stages of sleep that we go through.

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And chemically the brain is in very different states during different

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stages of sleep, which is part of the reason why, honestly, I'm not

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a huge fan of tryptophan or 5 HTP.

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Because it could be The 5 HTP, for instance, is, is strongly

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promoting serotonin synthesis, and serotonin in large part is a

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weight promoting neuromodulator.

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There are lots of nuances there.

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Serotonin has many different receptors.

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and the combination of different receptors that you agonize in different

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parts of the brain is going to differentially affect sleep and stages

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of sleep and wakefulness and so on.

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But I'm not honestly a big fan of that particular strategy.

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I do like that general approach where you're giving the body precursors for a

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particular neuromodulator of interest and then there might be times when your body

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is turning over and so on and so forth.

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those chemicals faster, and therefore it uses that additional substrate to help

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maintain levels of that neuromodulator at near optimal levels, and a good

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example of that is using L tyrosine during periods of insufficient sleep

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or total sleep deprivation to help maintain catecholaminergic signaling,

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so levels of dopamine and noradrenaline specifically, and for that reason

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L tyrosine can be quite helpful at maintaining certain cognitive functions

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during sleep loss, but in the case of sleep I don't think that the data

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regarding HTP are very compelling, but it's likely they do affect certain stages

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of sleep more than others, and there are some interesting potential use cases.

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So there's been some work relatively recently looking at 5 HTP in

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Parkinson's disease, for example, and a lot of people with Parkinson's

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have REM sleep behavior disorder.

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It's kind of prodromal for Parkinson's and it could be that 5 HTP is

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useful in that particular context.

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But, going back to melatonin, while melatonin is used on prescription for

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sleep maintenance issues in the UK, I actually think that regular melatonin is,

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is really helpful, um, and more so than time release, but specifically for certain

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circadian rhythm sleep wake disorders.

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familial advanced, all familial delayed sleep phase syndrome where you

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have these entire families of people with very late sleep timing, and you

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want to shift their clocks earlier.

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Melatonin can help with that.

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Jet lag disorder.

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Shift work disorder.

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These are all instances where the system of clocks is disrupted,

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either exogenously or endogenously, and melatonin can be helpful.

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And like you say, there's not good evidence of that kind of inhibition

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of melatonin synthesis by regular use.

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It hasn't been that well studied, but right now there's not

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really any evidence of that.

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And in that way, as you said, it's very much unlike something like

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taking testosterone, where quite quickly you will shut down your body's

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own synthesis of the testosterone.

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So that's interesting.

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And looking at the long term safety of melatonin, it seems to be very good.

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And there have been studies of various different clinical populations.

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kids with autism, older adults with various different neurodegenerative

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conditions, or people just with sleep issues, showing that

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people can take moderate doses of melatonin for several years without

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any obvious untoward effects.

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And I think we're realizing with melatonin that while historically

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it's been treated as a sleep hormone, it does a lot more than that.

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It's important to circadian organization, obviously it's, it's potent antioxidant,

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various different tissues, and now it's being studied therapeutically for uses

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and everything from long COVID to PCOS, diabetes and various other things too.

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So, so I am all for smart use of melatonin provided that it's.

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used appropriately, it's sourced well as well, because I think the

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reality is that a lot of people are sourcing their own melatonin.

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And there have been these slightly esoteric studies where researchers will

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take a bunch of melatonin from supplement shops and then test those products.

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And then they find that the concentrations of melatonin range

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from 80 percent less than to 480 percent more than what's on the label.

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And some of them are contaminated with serotonin.

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So you've got to be careful with the melatonin that you source.

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And for that reason, I think in the right hands, it has its place, but it's

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not something I would recommend to the masses, even if I think that for a lot

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of people, it is likely to be beneficial.

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I think with sleep supplements in general, so if you put aside drugs,

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we need to bear in mind that a lot of these are acting on the same pathways

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as drugs, and Some of them could produce tolerance and withdrawal effects over

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time, theoretically, and so we need to use them in very targeted ways,

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and we need to consider the totality of effects of the supplements.

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And what I mean by that is, maybe, for instance, Someone is training

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hard, and they're trying to build some muscle and burn some fat.

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And their sleep is okay, but they've got some mild insomnia

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issues, and they're a bit anxious.

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For that person, something like ashwagandha is a really interesting

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choice, because there's some evidence showing that it might slightly

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speed the rate at which people build muscle and gain strength in

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response to resistance training.

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And also, of all the different supplements that have been studied, it's probably one

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of the two best at lowering cortisol, at least when the cortisol has been sampled.

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Whereas, you can take someone else who's got a completely different sleep issue.

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So, take someone who has Restless Leg Syndrome, where they have this tingling

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sensation that comes on in their limbs, and it's normally just the legs, but

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for some people it's their arms as well.

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It comes on shortly before sleep, and it makes getting to sleep really

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hard, and it's really frustrating.

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Often that's driven by insufficient iron in some parts of the brain.

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And the way that that is therefore treated, is through iron supplementation.

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So no one's speaking about iron as a sleep aid, but for that

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person, iron is what they need.

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That is the best sleep supplement they could possibly take.

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For somebody else, something else is likely a better choice.

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So you take the example of someone, I'll take it an unusual example,

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someone doing an ultramarathon run.

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They don't have enough time in which to sleep and they're running

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for several days on the trot.

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And they're experiencing massive amounts of muscle damage each day because some

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of the running is downhill as well.

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And they're going to carry all that stuff with them.

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They therefore want to fall asleep quickly, have high quality sleep, and they

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want something that's going to support the recovery of their muscles and connective

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tissues between bouts of running.

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For them, something like tart cherry juice is going to be a really good

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choice because it's been shown to help with recovery from damaging exercise.

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improve various different metrics of sleep quality.

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And it's quite possibly slightly ergogenic in general, like it can promote

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endurance performance in certain contexts.

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So what I'm saying is you need to think about all of the effects of the product.

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For me personally, I would never recommend anything that doesn't have good randomized

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controlled clinical trials on it.

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I'm talking about well conducted studies of humans and

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therefore excellent safety data.

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And if not, then you can just use common sense.

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Tart cherry juice is going to be perfectly safe.

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It's.

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It's juice from cherries, like you, you don't need a long term safety

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study of tart cherry juice or tomatoes would be another instance, but

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for some things you do need that.

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So think about all of these different variables that are at play and then be

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meticulous about sourcing good products and look for products that have been

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third party testing, which I know is something that you guys do at Vitality

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Pro and I really commend you for that.

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Yeah, very much.

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That is definitely something that we.

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Well, we sort of built our business upon, and it's something that we've

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definitely noted in the industry.

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As you mentioned earlier, uh, what is said on the label is oftentimes completely

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wrong, whether it's the active ingredient in there is completely absent, or just

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in there, the dose that is completely, um, what's the word I'm looking for?

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Not reflective of, uh, of a clinically useful dosage.

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Just before we go on, I'd just love to get your thoughts on other ways to sort

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of promote sleep that don't necessarily utilize these sort of precursor molecules.

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So, things like glycine and phosphatidylserine compounds that help to

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sort of manipulate other systems in the body that can lower stress hormones such

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as cortisol or lower body temperature.

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Do you think those are an effective strategy, an effective tool?

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Or again, is it very much context dependent?

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Yeah,

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I think it does come back to the sleep phenotype.

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So what is this person presenting with?

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What is their particular sleep issue?

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And what's likely to be upstream of that?

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However, I also think that there are certain things that a lot of people

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who have sleep issues struggle with.

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And so there are certain candidates that work really well for a lot of people.

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And there are also supplements which might, based on the existing research,

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be good for sleep in some contexts, but the research quality is quite weak

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and there hasn't been that much of it.

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However, if you look at the totality of research on the supplement, then

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it seems to be a smart thing to add to your daily routine regardless.

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And personally, I'd put glycine in that category.

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I think glycine is a fascinating amino acid and it's come into the

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spotlight in the last few years for its potential pro longevity effects.

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It's one of a few supplements identified that's been studied in the ITP, the

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interventions testing program that's been shown to extend lifespan of a particular

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type of genetically diverse mouse and that's the gold standard way of Assessing

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candidate longevity interventions in mammals at this point in time.

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How Glycine is doing that.

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We don't fully understand, frankly, and a lot of people think that that's to do

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with some of its antioxidant and anti inflammatory actions, but surely it's

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due to a diversity of different actions.

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In the case of sleep, the existing clinical trials I don't

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find particularly compelling.

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They're small, they're underpowered, and with that said, they, they have

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so far shown some positive effects on sleep quality, quality and next

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day cognitive function too, during periods of insufficient sleep.

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And then As you're alluding to mechanistically, some of that seems

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to relate to glycine affecting neuromodulation at the master clock in

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the brain, and then in turn affecting regulation of body temperature

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by facilitating distal heat loss.

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So for me, I look at glycine and I think, is it something that's

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going to be a potent sleep aid?

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I don't know.

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Probably not.

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I think it's going to mildly improve sleep in many people, probably

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won't improve sleep in everyone.

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Is it something that most people benefit from consuming more of?

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Yes, I think it absolutely is.

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And so, for me, it's one of not that many ingredients where I

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give it a thumbs up regardless.

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Because most people have a kind of glycine gap where the total amount

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of glycine they consume each day is probably insufficient to meet their

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metabolic needs at certain times.

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Some people would define it as a conditionally essential amino acid.

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Sorry, Rob, for what you're going to say.

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Yeah, I was just going to say, especially when you look at how sort of dominant

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people's diets are in terms of methionine content, you oftentimes get a pretty

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stark sort of drop off in glycine, which is again going to then, yeah, result in,

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inability among other things to, yeah, uh, regulate that sort of not traumatic.

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And yeah, your body's ability to sort of regulate temperature in the evening.

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Yeah.

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So, so I think, I think glycine is a, is a good supplement

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for a lot of people to take.

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And I think we need more research on its effects on sleep specifically, but I'd

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feel relatively comfortable saying that if most people add three to five grams,

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a day to their diet, that's a good move.

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And a lot of people will be adding that anyway by taking

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10 grams of collagen powder.

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Collagen is about 30 percent glycine on average.

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And interestingly, there has actually been a study in the last year or

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so showing that when people consume collagen late in the day, they do see a

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small improvement in some sleep health metrics, which the authors chalked

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up to the collagen's glycine content.

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And mechanistically, mechanistically that does make some sense.

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Regarding phosphatidylserine, I'm not, I'm not a big fan, to be honest.

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I don't find the research particularly compelling.

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I think it's, it's perfectly safe.

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I think it's, it's an interesting adjunct intervention in particular

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for some older people who might be experiencing mild cognitive impairment.

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I think that some particular types of phosphatidylserine might be slightly

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good for brain health in general because of their incorporation into the brain.

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So membranes, there haven't been any good clinical trials

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showing any effects on sleep.

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Does it affect people's stress responses to things?

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Again, the jury is somewhat out.

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A lot of the early work looked at exercise training and whether it influenced

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things like cortisol and noradrenaline and adrenaline responses to exercise.

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And some of those studies showed that it did somewhat diminish

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those stress hormone responses.

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Thank you But others didn't find that.

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So, the literature is relatively inconsistent.

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I think the form does matter in this instance.

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And again, I think that for brain health in general, it's, it's probably weakly

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beneficial for a lot of people, but there are other candidate ingredients

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that I find much more interesting.

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And if we were focusing on how stress specifically might affect sleep, then

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there are things that I would reach for much sooner than phosphatidylserine.

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I've actually never recommended phosphatidylserine to someone, not

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phosphatidylserine specifically, but in the case of stress related sleep

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issues, I think L theanine is a good candidate because It has an excellent

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safety profile, as far as we can tell.

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It's something that's part of the human diet anyway, by way of consuming tea.

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It's also present in small amounts in some mushrooms.

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And if you look at the research on L theanine and different forms of

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psychological distress that people are experiencing, It quite consistently

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has a small positive effect on how people feel in response to stress.

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And it hasn't been that well studied in this context, but

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it, it, it might mildly reduce.

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people's stress hormone responses as well.

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And there have been a few studies, and there's one good one in

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particular showing that L theanine can improve some sleep metrics, in

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particular rates of sleep quality.

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And then if you look at all of the effects of L theanine, it's probably

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weakly good for cardiovascular health.

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It also seems to affect a subset of immune cells in a way that's

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probably beneficial for most people.

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So, given the safety data, and given all of the effects of L theanine, including

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those on cognitive function too, because a lot of people take it early in the

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day with caffeine, and relates to that, and this actually is something that is

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really underappreciated, and it might be the biggest benefit of L theanine.

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L theanine might slightly offset the adverse effects of caffeine on sleep.

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And so in a society where a lot of us are mainlining caffeine, if

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there's something that you can take that's good for you in general.

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and it slightly diminishes the effects of caffeine on your sleep.

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That's an easy win.

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And that's where L theanine comes in.

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And then I mentioned ashwagandha earlier, and ashwagandha is interesting as

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something that can perhaps slightly more potently affect cortisol specifically.

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It also seems to have some effects on some of the sex steroids.

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So quite consistently increases testosterone in men.

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the magnitude of that increase over time seems to be something like 10 to 15

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percent from other people, but ashwagandha is a very promiscuous molecule.

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It seems to affect lots of different targets and there are some minor

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concerns related to some case studies that reported liver issues after taking

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certain types of ashwagandha extracts.

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Again, I think the form matters.

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I think we need more research on that specifically because it's just

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a series of individual reports.

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where people have experienced liver issues, but with ashwagandha it's

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definitely something that I would cycle.

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I wouldn't have any reservation saying that someone could take

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glycine or l theanine in modest doses, probably indefinitely,

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without any issues whatsoever regarding toxicity or what have you.

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That is not the case for ashwagandha and I probably wouldn't recommend

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that someone takes ashwagandha for longer than about a week.

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16 weeks at a time at the upper end of the range.

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A lot of the studies are 8 to 12 weeks.

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So I think 12 weeks is an appropriate period of use before you take

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a similar amount of time off.

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Yeah, no, I think you're completely right.

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Adaptogens in general need to be cycled.

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Just with regarding tolerance and some of these amino acids, do you

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think those need to be cycled?

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Uh, again, your, uh, your compounds like your L thene and your glycine, especially

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for their sort of, uh, psychoactive properties, are you going to develop

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a tolerance to some of these compounds do you think or less so than maybe your

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precursors like again, 5 HTP, et cetera?

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I think less so than something like 5 HTP or L tyrosine where there's clearly

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A known metabolic pathway and you're providing a precursor within that

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pathway, which has been shown to in some instances quite potently affect

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levels of an intermediary of interest like serotonin in the case of 5 HTP

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or dopamine in the case of L tyrosine.

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So, while they are amino acids, and they're influencing levels

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of certain neuromodulators.

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I don't think that glycine intake or taurine intake, say, are as

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big concerns as those others.

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Should people therefore cycle them?

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I think some of this relates to, to your personal risk tolerance.

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I personally, and I, I'm, I'm quite, I would say that I'm, I'm relatively

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particular about not taking things for extended periods if there are

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any safety concerns whatsoever.

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I wouldn't personally, based on the literature that I've seen, have any

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reservation about taking glycine, taurine, L theanine in the long term.

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I would, taking 5 HTP or L tyrosine, or possibly tryptophan as well.

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So I think you need to take it on an ingredient by ingredient basis.

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But the reality is that we don't have those long term intervention

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studies that will give us that information about whether certain

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pathways are downregulated.

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And whether that is a concern and therefore these

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things do need to be cycled.

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But looking at the existing literature, I think that we do know

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something about the safety of a lot of these different substances.

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And there are bigger questions regarding some of them, like 5

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HTP or ashwagandha, than there are concerning others like L theanine.

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or glycine and obviously dose is really important here too.

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So in the case of glycine, if you look at some of the research on glycine, a lot

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of it, the majority of, and this probably isn't appreciated because I think in a

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lot of podcasts, people just think, Oh, glycine is that great sleep supplement.

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You've got to take three grams an hour before bed.

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And then that will sort your sleep issues.

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And that's what most of the research has shown.

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Most of the research on glycine has been on psychiatric patients.

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And a lot of it has used very, very high doses and using glycine in that way.

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That is probably an intervention that needs to be cycled,

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those types of high doses.

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3 grams of glycine, however, you get that from 10 grams of collagen, which you might

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consume by way of gnawing on the ends of your chicken bones at dinner each day.

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Would you be concerned about the 3 grams of glycine you get from that food matrix?

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No, you wouldn't.

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It's within the realms of what you'll get from your diet anyway.

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So, you contrast that with taking a large dose of 5 HTP.

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Would you get that from your diet?

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Maybe if you're eating a very large dose of certain plants?

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But, but probably not.

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So, I think we also just need to, to consider what's, what's normal

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in the context of, of the human diet and, and absent specific studies,

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think about what might make sense.

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I think a lot of this is just common sense.

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Three grams of glycine, I'm not personally concerned.

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100 milligrams of L theanine, not at all concerned.

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You know, that's a couple of cups of green tea.

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400 milligrams of L theanine, I start thinking about it.

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200 milligrams of L theanine, probably fine.

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So the dose makes the poison.

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Yeah, definitely.

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I think, as you said, it just comes down to common sense.

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And there's definitely nothing in my, what's your, uh, saying?

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There's no free lunch in biology.

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Uh, the moment you start, uh, moving one metric, you're gonna move another,

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and you're gonna skew amino acid profiles and create all sorts of

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imbalances upstream that can cause neurotransmitter issues potentially.

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Um, so, yeah, no, I couldn't agree more.

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Greg, I want to be respectful of your, of your time and thank you for it.

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I, I've definitely learned a lot.

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And, um, that's something I often say, but this time round, I really mean it.

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So thank you.

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Where's the best place people can find you at the moment?

Speaker:

You seem to be involved in a lot, but, uh, for you, what

Speaker:

is your lowest com, If you're

Speaker:

listening to this, then you must like podcasts.

Speaker:

And last year I started my own podcast, which is Reason and Wellbeing.

Speaker:

So if you're interested in health and performance and critical

Speaker:

thinking, then you might enjoy that.

Speaker:

So that's Reason and Wellbeing.

Speaker:

And there's also a YouTube channel, which is Ackroyd Potter PhD.

Speaker:

It's the same handle that I use for Instagram and Twitter.

Speaker:

People want to follow me there, but the podcast episodes go up on YouTube as well,

Speaker:

and I'll probably add some additional content to the YouTube channel over time.

Speaker:

So I'd probably funnel people in that direction.

Speaker:

But yeah, if you do check out the podcast and let me know your

Speaker:

thoughts and do feel free to send me spam via Instagram as well.

Speaker:

And if I like your spam, I'll respond.

Speaker:

And if I don't, then I won't.

Speaker:

Fair enough.

Speaker:

Well, thanks a lot.

Speaker:

I really do or we really do appreciate it.

Speaker:

And yeah, we'll have to do this again soon.

Speaker:

But yeah, thanks a lot.

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About the Podcast

vP life
Discussions on the latest in longevity science, health and functional medicine
vP Life, brought to you by vitalityPRO, provides you with expert advice from leading voices in the functional and integrative medicine world.

Irrespective of the guest and topic, our discussions will aim to educate and provide you with the tools and information you need to create change in your life.

About your host

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Robert Underwood